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Article ; Online: Genome-Wide Association Mapping of QTL Underlying Groat Protein Content of a Diverse Panel of Oat Accessions

Honghai Yan / Haixu Zhang / Pingping Zhou / Changzhong Ren / Yuanying Peng

International Journal of Molecular Sciences, Vol 24, Iss 5581, p

2023 Volume 5581

Abstract: Groat protein content (GPC) is a key quality trait attribute in oat. Understanding the variation of GPC in oat germplasms and identifying genomic regions associated with GPC are essential for improving this trait. In this study, the GPC of 174 diverse ... ...

Abstract	Groat protein content (GPC) is a key quality trait attribute in oat. Understanding the variation of GPC in oat germplasms and identifying genomic regions associated with GPC are essential for improving this trait. In this study, the GPC of 174 diverse oat accessions was evaluated in three field trials. The results showed a wide variation in GPC, ranging from 6.97% to 22.24% in this panel. Hulless oats displayed a significantly higher GPC compared to hulled oats across all environments. A GWAS analysis was performed based on 38,313 high-quality SNPs, which detected 27 non-redundant QTLs with 41 SNPs significantly associated with GPC. Two QTLs on chromosome 6C (QTL16) and 4D (QTL11) were consistently detected in multiple environments, with QTL16 being the most significant and explaining the highest proportion of the phenotypical variation in all tested environments except in CZ20. Haplotype analysis showed that the favorable haplotypes for GPC are more prevalent in hulless oats. These findings provide a foundation for future efforts to incorporate favorable alleles into new cultivars through introgression, fine mapping, and cloning of promising QTLs.
Keywords	oat ; groat protein content ; GWAS ; favorable alleles ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Efficacy of Glucocorticoids in the Treatment of Nonarteritic Anterior Ischemic Optic Neuropathy

Pingping Zhou / Jian Zhang / Yanxiu Qi

Computational and Mathematical Methods in Medicine, Vol

A Systematic Review and Meta-Analysis

2022 Volume 2022

Abstract: Background. To evaluate the clinical effects and safety of glucocorticoids for patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. The databases MEDLINE, Embase, PubMed, Cochrane Database, and Web of Science were used to ... ...

Abstract	Background. To evaluate the clinical effects and safety of glucocorticoids for patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. The databases MEDLINE, Embase, PubMed, Cochrane Database, and Web of Science were used to search for the relevant studies, and full-text articles that reported on the evaluation of glucocorticoids vs. no-treatment or placebo for patients with NAION. Review Manager 5.4 was used to estimate the pooled effects of the results among selected studies. Forest plots, funnel plots, and Begg’s rank correlation were also performed on the included articles. Results. A total of 983 patients were contained in the 9 studies that satisfied the eligibility criteria. The meta-analysis showed that, compared with the control group, the glucocorticoid group had significantly improved the VA (MD: -0.25, 95% CI [-0.45, -0.05], P=0.02), VF (MD: -0.50, 95% CI [-0.94, -0.07], P=0.02), and RNFL (MD: -14.10, 95% CI [-26.41, -1.79], P=0.02) in NAION patients and had a high improvement rate of VA (RR 1.31, 95% CI [1.12, 1.52], P=0.0005). No significant publication bias was observed in our study. Discussion. Our research preliminarily confirmed the effectiveness of glucocorticoids for NAION treatment, but more high-quality RCTs focusing on the hormone adverse reactions should be performed to verify our conclusions.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Study on the Characteristics of Traditional Chinese Medicine Syndromes in Patients with Erosive Gastritis Based on Metabolomics.

Shixiong, Zhang / Shaowei, Liu / Zeqi, Yang / Miaochan, Xu / Pingping, Zhou / Haiyan, Bai / Jingjing, Lv / Yangang, Wang

International journal of analytical chemistry

2024 Volume 2024, Page(s) 6684677

Abstract: According to traditional Chinese medicine theory, tongue coatings reflect changes in the body. The goal of this study was to identify a metabolite or a set of metabolites capable of classifying characteristics of traditional Chinese medicine syndromes in ...

Abstract	According to traditional Chinese medicine theory, tongue coatings reflect changes in the body. The goal of this study was to identify a metabolite or a set of metabolites capable of classifying characteristics of traditional Chinese medicine syndromes in erosive gastritis. In this study, we collected tongue coatings of patients with erosive gastritis with damp-heat syndrome (DHS), liver depression and qi stagnation syndrome (LDQSS), and healthy volunteers. Then, we analyzed the differences in metabolic characteristics between the two groups based on metabolomics. We identified 14 potential biomarkers related to the DHS group, and six metabolic pathways were enriched. The differential pathways included pyrimidine metabolism, pantothenate and CoA biosynthesis, citrate cycle (TCA cycle), pyruvate metabolism, glycolysis/gluconeogenesis, and purine metabolism. Similarly, in the LDQSS group, we identified 25 potential biomarkers and 18 metabolic pathways were enriched. The top five pathways were the TCA cycle, sphingolipid metabolism, fatty acid biosynthesis, pantothenate and CoA biosynthesis, and the pentose phosphate pathway. In conclusion, the DHS group and the LDQSS group have different characteristics.
Language	English
Publishing date	2024-01-02
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2494714-3
ISSN	1687-8779 ; 1687-8760
ISSN (online)	1687-8779
ISSN	1687-8760
DOI	10.1155/2024/6684677
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Virtual Restoration of Stained Chinese Paintings Using Patch-Based Color Constrained Poisson Editing with Selected Hyperspectral Feature Bands

Pingping Zhou / Miaole Hou / Shuqiang Lv / Xuesheng Zhao / Wangting Wu

Remote Sensing, Vol 11, Iss 11, p

2019 Volume 1384

Abstract: Stains, as one of most common degradations of paper cultural relics, not only affect paintings’ appearance, but sometimes even cover the text, patterns, and colors contained in the relics. Virtual restorations based on common red−green−blue images (RGB) ... ...

Abstract	Stains, as one of most common degradations of paper cultural relics, not only affect paintings’ appearance, but sometimes even cover the text, patterns, and colors contained in the relics. Virtual restorations based on common red−green−blue images (RGB) which remove the degradations and then fill the lacuna regions with the image’s known parts with the inpainting technology could produce a visually plausible result. However, due to the lack of information inside the degradations, they always yield inconsistent structures when stains cover several color materials. To effectively remove the stains and restore the covered original contents of Chinese paintings, a novel method based on Poisson editing is proposed by exploiting the information inside the degradations of selected three feature bands as the auxiliary information to guide the restoration since the selected feature bands captured fewer stains and could expose the covered information. To make the Poisson editing suitable for stain removal, the feature bands were also exploited to search for the optimal patch for the pixels in the stain region, and the searched patch was used to construct the color constraint on the original Poisson editing to ensure the restoration of the original color of paintings. Specifically, this method mainly consists of two steps: feature band selection from hyperspectral data by establishing rules and reconstruction of stain contaminated regions of RGB image with color constrained Poisson editing. Four Chinese paintings (‘Fishing’, ‘Crane and Banana’, ‘the Hui Nationality Painting’, and ‘Lotus Pond and Wild Goose’) with different color materials were used to test the performance of the proposed method. Visual results show that this method can effectively remove or dilute the stains while restoring a painting’s original colors. By comparing values of restored pixels with nonstained pixels (reference of their same color materials), images processed by the proposed method had the lowest average root mean square error ( RMSE ), ...
Keywords	virtual restoration ; Chinese paintings’ stains ; feature bands ; searched patch ; color constrained Poisson editing ; Science ; Q
Subject code	930
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fermentative production of Vitamin E tocotrienols in Saccharomyces cerevisiae under cold-shock-triggered temperature control

Bin Shen / Pingping Zhou / Xue Jiao / Zhen Yao / Lidan Ye / Hongwei Yu

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 14

Abstract: Tocotrienols are valuable supplementations to α-tocopherol-dominated Vitamin E products. Here, the authors engineer baker’s yeast by combining the heterologous genes from photosynthetic organisms with the endogenous pathway for the production of ... ...

Abstract	Tocotrienols are valuable supplementations to α-tocopherol-dominated Vitamin E products. Here, the authors engineer baker’s yeast by combining the heterologous genes from photosynthetic organisms with the endogenous pathway for the production of tocotrienols under cold-shock-triggered temperature control.
Keywords	Science ; Q
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New evidence confirming the CD genomic constitutions of the tetraploid Avena species in the section Pachycarpa Baum.

Honghai Yan / Zichao Ren / Di Deng / Kehan Yang / Chuang Yang / Pingping Zhou / Charlene P Wight / Changzhong Ren / Yuanying Peng

PLoS ONE, Vol 16, Iss 1, p e

2021 Volume 0240703

Abstract: The tetraploid Avena species in the section Pachycarpa Baum, including A. insularis, A. maroccana, and A. murphyi, are thought to be involved in the evolution of hexaploid oats; however, their genome designations are still being debated. Repetitive DNA ... ...

Abstract	The tetraploid Avena species in the section Pachycarpa Baum, including A. insularis, A. maroccana, and A. murphyi, are thought to be involved in the evolution of hexaploid oats; however, their genome designations are still being debated. Repetitive DNA sequences play an important role in genome structuring and evolution, so understanding the chromosomal organization and distribution of these sequences in Avena species could provide valuable information concerning genome evolution in this genus. In this study, the chromosomal organizations and distributions of six repetitive DNA sequences (including three SSR motifs (TTC, AAC, CAG), one 5S rRNA gene fragment, and two oat A and C genome specific repeats) were investigated using non-denaturing fluorescence in situ hybridization (ND-FISH) in the three tetraploid species mentioned above and in two hexaploid oat species. Preferential distribution of the SSRs in centromeric regions was seen in the A and D genomes, whereas few signals were detected in the C genomes. Some intergenomic translocations were observed in the tetraploids; such translocations were also detected between the C and D genomes in the hexaploids. These results provide robust evidence for the presence of the D genome in all three tetraploids, strongly suggesting that the genomic constitution of these species is DC and not AC, as had been thought previously.
Keywords	Medicine ; R ; Science ; Q
Subject code	590
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Determination of the protective effects of Hua‐Zhuo‐Jie‐Du in chronic atrophic gastritis by regulating intestinal microbiota and metabolites

Pingping Zhou / Xinyu Hao / Yu Liu / Zeqi Yang / Miaochan Xu / Shaowei Liu / Shixiong Zhang / Tianxiao Yang / Xiaomei Wang / Yangang Wang

Chinese Medicine, Vol 16, Iss 1, Pp 1-

combination of liquid chromatograph mass spectrometer metabolic profiling and 16S rRNA gene sequencing

2021 Volume 19

Abstract: Abstract Background Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes ...

Abstract	Abstract Background Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes in CAG rats. Methods The CAG rat models were induced by 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) combined with irregular fasting and 2% sodium salicylate, which was intragastrically administrated in fasted animals for 24 weeks. The CAG rats in the Chinese medicine (CM) group were administered a daily dose of 14.81 g/kg/day HZJD, and the vitacoenzyme (V) group were administered a daily dose of 0.08 g/kg/day vitacoenzyme. All animals were treated for 10 consecutive weeks, consecutively. Hematoxylin and eosin (H&E) staining was used to assess the histopathological changes in the gastric tissues. An integrated approach based on liquid chromatograph mass spectrometer (LC-MS) metabolic profiling combined with 16S rRNA gene sequencing was carried out to assess the effects of HZJD on CAG rats. Spearman analysis was used to calculate the correlation coefficient between the different intestinal microbiota and the metabolites. Results The H&E results indicated that HZJD could improve the pathological condition of CAG rats. The LC–MS results indicated that HZJD could significantly improve 21 gastric mucosal tissue perturbed metabolites in CAG rats; the affected metabolites were found to be involved in multiple metabolic pathways, such as the central carbon metabolism in cancer. The results of 16S rRNA gene sequencing indicated that HZJD could regulate the diversity, microbial composition, and abundance of the intestinal microbiota of CAG rats. Following HZJD treatment, the relative abundance of Turicibacter was increased, and the relative abundance of Desulfococcus and Escherichia were decreased in the CM group when compared with the M group. Spearman analysis revealed that perturbed intestinal microbes had a strong correlation with differential metabolites, ...
Keywords	Hua‐Zhuo‐Jie‐Du ; Chronic atrophic gastritis ; LC–MS ; 16S rRNA gene sequencing ; Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extraction of Hidden Information under Sootiness on Murals Based on Hyperspectral Image Enhancement

Miaole Hou / Ning Cao / Li Tan / Shuqiang Lyu / Pingping Zhou / Chenqi Xu

Applied Sciences, Vol 9, Iss 17, p

2019 Volume 3591

Abstract: Changes in the environment and human activities can cause serious deterioration of murals. Hyperspectral imaging technology can observe murals in the range of visible to near infrared light, providing a scientific and non-destructive way for mural ... ...

Abstract	Changes in the environment and human activities can cause serious deterioration of murals. Hyperspectral imaging technology can observe murals in the range of visible to near infrared light, providing a scientific and non-destructive way for mural digital preservation. An effective method to extract hidden information from the sootiness of murals in order to enhance the visual value of patterns in ancient murals using hyperspectral imaging is proposed in this paper. Firstly, Minimum Noise Fraction transform was applied to reduce sootiness features in the background of the mural. Secondly, analysis of spectral characteristics and image subtraction were used to achieve feature enhancement of the murals. Finally, density slicing was performed to extract the patterns under the sootiness. The results showed that the extraction of hidden information was achieved with an overall accuracy of 88.97%.
Keywords	hidden information ; mural ; sootiness ; hyperspectral imaging ; visual enhancement ; Minimum Noise Fraction transform ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	006
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanisms of Huazhuojiedu Decoction to Treat Chronic Atrophic Gastritis

Xinyu Hao / Yu Liu / Pingping Zhou / Qian Jiang / Zeqi Yang / Miaochan Xu / Shaowei Liu / Shixiong Zhang / Yangang Wang

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Background. Chronic atrophic gastritis (CAG) is an important stage in the normal gastric mucosa’s transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese herbal preparation, has proven clinically effective to treat CAG. However, few ... ...

Abstract	Background. Chronic atrophic gastritis (CAG) is an important stage in the normal gastric mucosa’s transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese herbal preparation, has proven clinically effective to treat CAG. However, few studies have explored the mechanism of HZJD in CAG treatment. Purpose. This study aimed to shed light on the mechanisms underlying HZJD decoction CAG treatment using a network pharmacology approach and experimental validation. Methods. The active components of HZJD decoction were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. Their targets were predicted through the SwissTargetPrediction database. Disease targets were screened using the GeneCards database. The disease and drug prediction targets were intersected to select the common potential therapeutic targets, which then were input into the Search Tool for the Retrieval of Interacting Genes to build a protein-protein interaction network. The “herb-compound-target-disease” and the “herb-target-pathway” network diagrams were constructed in Cytoscape 3.3.0. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of effective targets were performed using the Database for Annotation, Visualization, and Integrated Discovery. Finally, the core targets were preliminarily verified by CAG rat model. The gastric mucosa’s histopathological changes were observed via hematoxylin-eosin staining. The expressions of MAPK1, AKT1, TNF, VEGFA, and EGFR were detected by western blot and quantitative real-time reverse transcription-polymerase chain reaction. Results. A total of 155 nodes, including 20 putative targets of HZJD decoction, were selected as core hubs based on topological importance and were closely associated with the regulation of cell proliferation, apoptotic process, and cancer-related pathways (AKT1, TNF, VEGFA, and EGFR) in CAG. Further animal experiments showed that the expression of AKT1 in CAG rats was significantly increased, ...
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dietary exposure to fatty acid esters of monochloropropanediols and glycidol of 2- to 3-year-old children attending nursery schools from two areas in China using the duplicate-diet collection method

Jiang, Liang / Jing, Zhou / Yibaina, Wang / Yan, Song / Lili, Xu / Yanxu, Zhong / Ling, Yong / Pingping, Zhou / Haixia, Sui / Lei, Zhang

Food Additives & Contaminants: Part A. 2021 Jan. 02, v. 38, no. 1 p.70-80

2021

Abstract: The dietary exposures to fatty esters of 3- and 2-monochloropropanediol (MCPD) and glycidol were estimated for children aged 2- to 3-year-old from two areas of China using duplicate diet collection method. The 24-h daily duplicate diet samples over three ...

Abstract	The dietary exposures to fatty esters of 3- and 2-monochloropropanediol (MCPD) and glycidol were estimated for children aged 2- to 3-year-old from two areas of China using duplicate diet collection method. The 24-h daily duplicate diet samples over three consecutive days were collected from 40 healthy children aged between 26 and 36 months. The analysis of these contaminates in food samples was measured by an indirect method that entails MCPD/glycidol cleavage from their esterified forms for GC-MS analysis. Over 71% of the mixed diet and dairy products samples were found to be contaminated with 3-MCPD and glycidyl esters. The estimated daily exposure to bound 3-MCPD (mean: 0.48–0.49 μg kg⁻¹ bw day⁻¹; P95: 1.00–1.11 μg kg⁻¹ bw day⁻¹) were well below the health guidance values and were considered of low safety concern. The daily exposure to bound 2-MCPD was estimated to be 0.031–0.038 μg kg⁻¹ bw day⁻¹ on average and 0.12–0.14 μg kg⁻¹ bw day⁻¹ for the P95 exposure. However, it was not possible to assess its risk due to the lack of health guidance value of 2-MCPD. The margin of exposure (MOE) estimates for the mean exposure to bound glycidol (0.10–0.12 μg kg⁻¹ bw day⁻¹) were far above 10000 and were considered of low safety concern. However, the margin of exposure estimates for the P95 bound glycidol exposure (0.41–0.45 μg kg⁻¹ bw day⁻¹) were below 10000 and indicated a health concern. Our data indicated that the mixed diet accounted for nearly 76% to 91% of bound MCPD and glycidol exposure. In addition, the follow-on formula was also an important source for the children aged 2–3 years.
Keywords	alpha-chlorohydrin ; diet ; dietary exposure ; esterification ; fatty acids ; glycidol ; risk ; China ; 3-monochloropropane-1 ; 2-diol esters ; 2-monochloropropane-1 ; 3-diol esters ; glycidyl esters ; duplicate-diet
Language	English
Dates of publication	2021-0102
Size	p. 70-80.
Publishing place	Taylor & Francis
Document type	Article ; Online
Note	NAL-AP-2-clean
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2020.1843718
Database	NAL-Catalogue (AGRICOLA)

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