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  1. AU="Pinheiro, Martha Valéria Tavares"
  2. AU="Barres, Ben"
  3. AU="García-Cenador, M B"
  4. AU="Youssef B. Fawaz"
  5. AU="Mohamed, Dina Mahmoud"
  6. AU="Asante-Addo, Collins"
  7. AU="Belluti, Federica"
  8. AU="Sebastian Fetscher"
  9. AU="Reshef, Yakir A"
  10. AU="Gerstenberger, John"
  11. AU="Bilbul, Melanie" AU="Bilbul, Melanie"
  12. AU="Martínez-Vernaza, Samuel"
  13. AU="Takenoya, Takashi"
  14. AU="Russell, Roslin"
  15. AU=Kim Ka Young
  16. AU="Mateja, Allyson"
  17. AU="Todorov, Alexander B."
  18. AU=Mosallanezhad Behzad
  19. AU=Rochman Yrina AU=Rochman Yrina
  20. AU="Wang, Hong-Bo"
  21. AU="Zhong, Boyu"
  22. AU=Gimeno-Costa Ricardo AU=Gimeno-Costa Ricardo
  23. AU="Wu, Jiangbo"
  24. AU="MacIntyre, Michael F"
  25. AU="Moon, H K"
  26. AU="Clark, Mindie"
  27. AU="Nichols, Aaron L"
  28. AU="Cash-Goldwasser, Shama"
  29. AU="Christopher B. Daniels"
  30. AU="Wakama, Hitoshi"
  31. AU="Crowe, K"
  32. AU="Merz, Sabine"
  33. AU=Rossolatos George
  34. AU="Nalla, Shahed"
  35. AU="Alvarado, Miriam"
  36. AU="Garduño-Sánchez, Marco"
  37. AU="Khan, Sherbano"
  38. AU="Kakava, Felicia"

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  1. Artikel ; Online: Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease.

    de Oliveira, Renée Sarmento / Moll-Bernardes, Renata / de Brito, Adriana Xavier / Pinheiro, Martha Valéria Tavares / de Almeida, Sergio Altino / da Silva Gomes, Natália Lins / de Oliveira Terzi, Flavia Vernin / Moreira, Otacílio Cruz / Xavier, Sergio Salles / Rosado-de-Castro, Paulo Henrique / de Sousa, Andréa Silvestre

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Band 30, Heft 6, Seite(n) 2702–2711

    Abstract: Background: Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia ... ...

    Abstract Background: Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia might be related to the persistence of parasitemia or inflammation in the myocardium in late-stage CHD. Positron emission tomography/computed tomography (PET/CT) has been used to detect myocardial inflammation in non-ischemic cardiomyopathies, such as sarcoidosis, and might be useful for risk prediction in patients with CHD.
    Methods and results: Twenty-four outpatients with chronic CHD were enrolled in this prospective cross-sectional study between May 2019 and March 2022. The patients were divided into two groups: those with sustained ventricular tachycardia and/or aborted sudden cardiac death who required implantable cardioverter-defibrillators, and those with the same stages of CHD and no complex ventricular arrhythmia. Patients underwent
    Conclusion: 18
    Mesh-Begriff(e) Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods ; Gallium Radioisotopes ; Cross-Sectional Studies ; Parasitemia ; Prospective Studies ; Myocarditis/diagnostic imaging ; Arrhythmias, Cardiac/diagnostic imaging ; Inflammation/diagnostic imaging ; Heart Diseases ; Death, Sudden, Cardiac ; Chagas Disease/complications ; Chagas Disease/diagnostic imaging
    Chemische Substanzen Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
    Sprache Englisch
    Erscheinungsdatum 2023-08-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03350-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease.

    Terzi, Flavia Vernin de Oliveira / Camargo, Gabriel Cordeiro / Parente, Daniella Braz / Pittella, Ana Maria / Silva-Junior, Gilberto / de Novaes, Gabrielle Gonçalves / Oliveira Neto, Jaime Araújo / Barroso, Julia Machado / Pinheiro, Martha Valéria Tavares / Xavier de Brito, Adriana Soares / de Oliveira, Renée Sarmento / Rodrigues, Rosana Souza / de Mello Perez, Renata / de Sousa, Andréa Silvestre / Moll-Bernardes, Renata Junqueira

    Journal of clinical medicine

    2023  Band 12, Heft 23

    Abstract: 1) Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic and ... ...

    Abstract (1) Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic and cardiac fibrosis are important markers of mortality, but the correlation between these markers in patients with NAFLD has not been well studied. Our main objective was to determine the degree of myocardial fibrosis in patients with NAFLD and its correlation with the severity of liver fibrosis. (2) Methods: In this cross-sectional study, patients with NAFLD were allocated to two groups according to the stage of liver fibrosis assessed using MRI: no or mild fibrosis (F0-F1) and significant fibrosis (F2-F4). Framingham risk scores were calculated to evaluate cardiovascular risk factors, and patients underwent multiparametric cardiac and abdominal MRIs. (3) Results: The sample comprised 44 patients (28 with no or mild liver fibrosis and 16 with significant liver fibrosis). The mean age was 57.9 ± 12 years, and 41% were men. Most patients had high cardiac risk factors and carotid disease. Relative to patients with no or mild liver fibrosis, those with significant fibrosis had a higher median calcium score (
    Sprache Englisch
    Erscheinungsdatum 2023-11-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237381
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy.

    de Brito, Adriana Soares Xavier / Moll-Bernardes, Renata Junqueira / Pinheiro, Martha Valéria Tavares / Camargo, Gabriel Cordeiro / Siqueira, Fabio Paiva Rossini / Oliveira, Renee Sarmento / Glavam, Adriana Pereira / de Almeida, Sergio Altino / de Holanda, Marcelo Teixeira / Sangenis, Luiz Henrique Conde / Mendes, Fernanda de Souza Nogueira Sardinha / Rosado-de-Castro, Paulo Henrique / de Sousa, Andrea Silvestre

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Band 30, Heft 6, Seite(n) 2379–2388

    Abstract: Background: Sudden cardiac death (SCD) can be the first clinical event of Chagas heart disease (CHD). However, current guidelines contain no clear recommendation for early cardioverter-defibrillator implantation. Using imaging modalities, we evaluated ... ...

    Abstract Background: Sudden cardiac death (SCD) can be the first clinical event of Chagas heart disease (CHD). However, current guidelines contain no clear recommendation for early cardioverter-defibrillator implantation. Using imaging modalities, we evaluated associations among autonomic denervation, myocardial hypoperfusion, fibrosis and ventricular arrhythmia in CHD.
    Methods and results: Twenty-nine patients with CHD and preserved left ventricular function underwent 123I-metaiodobenzylguanidine (MIBG) scintigraphy, 99mTc-methoxyisobutylisonitrile (MIBI) myocardial perfusion and cardiac magnetic resonance imaging (MRI). They were divided into arrhythmic (≥ 6 ventricular premature complexes/h and/or non-sustained ventricular tachycardia on 24-hour Holter, n = 15) and non-arrhythmic (< 6 ventricular premature complexes/h and no ventricular tachycardia; n = 14) groups. The arrhythmic group had higher denervation scores from MIBG imaging (23.2 ± 18.7 vs 5.6 ± 4.9; P < .01), hypoperfusion scores from MIBI SPECT (4.7 ± 6.8 vs 0.29 ± 0.6: P = .02), innervation/perfusion mismatch scores (18.5 ± 17.5 vs 5.4 ± 4.8; P = .01) and fibrosis by late gadolinium enhancement on MRI (14.3% ± 13.5% vs 4.0% ± 2.9%; P = .04) than the non-arrhythmic group.
    Conclusion: These imaging parameters were associated with ventricular arrhythmia in early CHD and may enable risk stratification and the implementation of primary preventive strategies for SCD.
    Mesh-Begriff(e) Humans ; Chagas Cardiomyopathy/complications ; Chagas Cardiomyopathy/diagnostic imaging ; 3-Iodobenzylguanidine ; Contrast Media ; Ventricular Premature Complexes ; Gadolinium ; Myocardial Ischemia ; Coronary Artery Disease ; Death, Sudden, Cardiac/prevention & control ; Fibrosis ; Chagas Disease/complications ; Chagas Disease/diagnostic imaging ; Autonomic Denervation
    Chemische Substanzen 3-Iodobenzylguanidine (35MRW7B4AD) ; Contrast Media ; Gadolinium (AU0V1LM3JT)
    Sprache Englisch
    Erscheinungsdatum 2023-05-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03281-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  4. Artikel ; Online: Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease.

    Pinheiro, Martha Valéria Tavares / Moll-Bernardes, Renata Junqueira / Camargo, Gabriel Cordeiro / Siqueira, Fabio Paiva / Azevedo, Clerio Francisco de / Holanda, Marcelo Teixeira de / Mendes, Fernanda de Souza Nogueira Sardinha / Sangenis, Luiz Henrique Conde / Mediano, Mauro Felippe Felix / Sousa, Andréa Silvestre de

    The American journal of tropical medicine and hygiene

    2020  Band 103, Heft 2, Seite(n) 745–751

    Abstract: Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients to sudden cardiac death through ventricular arrhythmia. The associations of myocardial fibrosis detected by cardiac magnetic resonance (CMR) ...

    Abstract Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients to sudden cardiac death through ventricular arrhythmia. The associations of myocardial fibrosis detected by cardiac magnetic resonance (CMR) parameters with non-sustained ventricular tachycardia (NSVT) were evaluated. This cross-sectional study included patients in early stages of Chagas disease (
    Mesh-Begriff(e) Aged ; Area Under Curve ; Case-Control Studies ; Chagas Cardiomyopathy/complications ; Chagas Cardiomyopathy/diagnostic imaging ; Chagas Cardiomyopathy/physiopathology ; Chagas Disease/complications ; Chagas Disease/diagnostic imaging ; Chagas Disease/physiopathology ; Cross-Sectional Studies ; Echocardiography ; Electrocardiography, Ambulatory ; Extracellular Space ; Female ; Fibrosis ; Heart/diagnostic imaging ; Humans ; Logistic Models ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Myocardium/pathology ; Organ Size ; ROC Curve ; Stroke Volume ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/physiopathology ; Ventricular Function, Right
    Sprache Englisch
    Erscheinungsdatum 2020-05-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0122
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Case Report: Malignant Ventricular Arrhythmias Mimicking Acute Coronary Syndrome in Chagas Disease.

    Moll-Bernardes, Renata Junqueira / Saraiva, Roberto Magalhães / Oliveira, Renée Sarmento de / Pinheiro, Martha Valéria Tavares / Camargo, Gabriel Cordeiro / Brito, Adriana Soares Xavier de / Almeida, Sergio Altino de / Siqueira, Fabio Paiva Rossini de / Mendes, Fernanda de Souza Nogueira Sardinha / Barbosa, Rodrigo Minati / Xavier, Sergio Salles / Rosado de Castro, Paulo Henrique / Sousa, Andréa Silvestre de

    The American journal of tropical medicine and hygiene

    2020  Band 102, Heft 4, Seite(n) 797–799

    Abstract: Chronic Chagas heart disease has different clinical manifestations including arrhythmias, heart failure, and stroke. Chest pain is one of the most common symptoms and when associated with changes in the electrocardiogram, such as T-wave changes, ... ...

    Abstract Chronic Chagas heart disease has different clinical manifestations including arrhythmias, heart failure, and stroke. Chest pain is one of the most common symptoms and when associated with changes in the electrocardiogram, such as T-wave changes, electrically inactive areas, and segmental wall motion abnormalities, may lead to a misdiagnosis of acute coronary syndrome (ACS). Here, we describe two patients with Chagas heart disease and syncope due to sustained ventricular tachycardia who were misdiagnosed with ACS, and discuss the role of novel imaging modalities in the differential diagnosis and risk stratification.
    Mesh-Begriff(e) Aged ; Amiodarone/administration & dosage ; Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/etiology ; Chagas Cardiomyopathy/complications ; Clopidogrel/administration & dosage ; Clopidogrel/therapeutic use ; Defibrillators, Implantable ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/therapeutic use
    Chemische Substanzen Anti-Arrhythmia Agents ; Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Amiodarone (N3RQ532IUT)
    Sprache Englisch
    Erscheinungsdatum 2020-02-10
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.19-0920
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.61: Hefte anzeigen Standort:
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