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  1. Article: Neural Infection by Oropouche Virus in Adult Human Brain Slices Induces an Inflammatory and Toxic Response.

    Almeida, Glaucia M / Souza, Juliano P / Mendes, Niele D / Pontelli, Marjorie C / Pinheiro, Nathalia R / Nogueira, Giovanna O / Cardoso, Ricardo S / Paiva, Isadora M / Ferrari, Gustavo D / Veras, Flávio P / Cunha, Fernando Q / Horta-Junior, Jose A C / Alberici, Luciane C / Cunha, Thiago M / Podolsky-Gondim, Guilherme G / Neder, Luciano / Arruda, Eurico / Sebollela, Adriano

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 674576

    Abstract: Oropouche virus (OROV) is an emerging arbovirus in South and Central Americas with high spreading potential. OROV infection has been associated with neurological complications and OROV genomic RNA has been detected in cerebrospinal fluid from patients, ... ...

    Abstract Oropouche virus (OROV) is an emerging arbovirus in South and Central Americas with high spreading potential. OROV infection has been associated with neurological complications and OROV genomic RNA has been detected in cerebrospinal fluid from patients, suggesting its neuroinvasive potential. Motivated by these findings, neurotropism and neuropathogenesis of OROV have been investigated
    Language English
    Publishing date 2021-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.674576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.

    Sebollela, Adriano / Cline, Erika N / Popova, Izolda / Luo, Kevin / Sun, Xiaoxia / Ahn, Jay / Barcelos, Milena A / Bezerra, Vanessa N / Lyra E Silva, Natalia M / Patel, Jason / Pinheiro, Nathalia R / Qin, Lei A / Kamel, Josette M / Weng, Anthea / DiNunno, Nadia / Bebenek, Adrian M / Velasco, Pauline T / Viola, Kirsten L / Lacor, Pascale N /
    Ferreira, Sergio T / Klein, William L

    Journal of neurochemistry

    2017  Volume 142, Issue 6, Page(s) 934–947

    Abstract: Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) is increasingly considered a key early event in the pathogenesis of Alzheimer's disease (AD). A variety of AβO species have been identified, both in vitro and in vivo, ranging from ... ...

    Abstract Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) is increasingly considered a key early event in the pathogenesis of Alzheimer's disease (AD). A variety of AβO species have been identified, both in vitro and in vivo, ranging from dimers to 24mers and higher order oligomers. However, there is no consensus in the literature regarding which AβO species are most germane to AD pathogenesis. Antibodies capable of specifically recognizing defined subpopulations of AβOs would be a valuable asset in the identification, isolation, and characterization of AD-relevant AβO species. Here, we report the characterization of a human single chain antibody fragment (scFv) denoted NUsc1, one of a number of scFvs we have identified that stringently distinguish AβOs from both monomeric and fibrillar Aβ. NUsc1 readily detected AβOs previously bound to dendrites in cultured hippocampal neurons. In addition, NUsc1 blocked AβO binding and reduced AβO-induced neuronal oxidative stress and tau hyperphosphorylation in cultured neurons. NUsc1 further distinguished brain extracts from AD-transgenic mice from wild type (WT) mice, and detected endogenous AβOs in fixed AD brain tissue and AD brain extracts. Biochemical analyses indicated that NUsc1 targets a subpopulation of AβOs with apparent molecular mass greater than 50 kDa. Results indicate that NUsc1 targets a particular AβO species relevant to AD pathogenesis, and suggest that NUsc1 may constitute an effective tool for AD diagnostics and therapeutics.
    Language English
    Publishing date 2017-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.14118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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