LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16

Search options

  1. Article ; Online: The rehabilitation of object agnosia and prosopagnosia: A systematic review.

    Gobbo, Silvia / Calati, Raffaella / Silveri, Maria Caterina / Pini, Elisa / Daini, Roberta

    Restorative neurology and neuroscience

    2022  Volume 40, Issue 4-6, Page(s) 217–240

    Abstract: Background: Agnosia for objects is often overlooked in neuropsychology, especially with respect to rehabilitation. Prosopagnosia has been studied more extensively, yet there have been few attempts at training it. The lack of training protocols may ... ...

    Abstract Background: Agnosia for objects is often overlooked in neuropsychology, especially with respect to rehabilitation. Prosopagnosia has been studied more extensively, yet there have been few attempts at training it. The lack of training protocols may partially be accounted for by their relatively low incidence and specificity to sensory modality. However, finding effective rehabilitations for such deficits may help to reduce their impact on the social and psychological functioning of individuals.
    Objective: Our aim in this study was to provide clinicians and researchers with useful information with which to conduct new studies on the rehabilitation of object agnosia and prosopagnosia. To accomplish this, we performed a systematic and comprehensive review of the effect of neuropsychological rehabilitation on visual object and prosopagnosia.
    Methods: The Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines were followed. In addition, the Single-Case Experimental Design (SCED) and the Critical Appraisal Skills Programme (CASP) scales were used to assess the quality of reporting.
    Results: Seven articles regarding object agnosia, eight articles describing treatments for prosopagnosia, and two articles describing treatments for both deficits were included.
    Conclusions: In the light of the studies reviewed, treatments based on analysis of parts seem effective for object agnosia, while prosopagnosia appears to benefit most from treatments relying on holistic/configural processing. However, more attempts at rehabilitation of face and object agnosia are needed to clarify the mechanisms of these processes and possible rehabilitations. Moreover, a publication bias could mask a broader attempt to find effective treatments for visual agnosia and leaving out studies that are potentially more informative.
    Language English
    Publishing date 2022-09-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1017098-4
    ISSN 1878-3627 ; 0922-6028
    ISSN (online) 1878-3627
    ISSN 0922-6028
    DOI 10.3233/RNN-211234
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Altered neural oscillations and connectivity in the beta band underlie detail-oriented visual processing in autism.

    Ronconi, Luca / Vitale, Andrea / Federici, Alessandra / Pini, Elisa / Molteni, Massimo / Casartelli, Luca

    NeuroImage. Clinical

    2020  Volume 28, Page(s) 102484

    Abstract: Sensory and perceptual anomalies may have a major impact on basic cognitive and social skills in humans. Autism Spectrum Disorder (ASD) represents a special perspective to explore this relationship, being characterized by both these features. The present ...

    Abstract Sensory and perceptual anomalies may have a major impact on basic cognitive and social skills in humans. Autism Spectrum Disorder (ASD) represents a special perspective to explore this relationship, being characterized by both these features. The present study employed electroencephalography (EEG) to test whether detail-oriented visual perception, a recognized hallmark of ASD, is associated with altered neural oscillations and functional connectivity in the beta frequency band, considering its role in feedback and top-down reentrant signalling in the typical population. Using a visual crowding task, where participants had to discriminate a peripheral target letter surrounded by flankers at different distances, we found that detail-oriented processing in children with ASD, as compared to typically developing peers, could be attributed to anomalous oscillatory activity in the beta band (15-30 Hz), while no differences emerged in the alpha band (8-12 Hz). Altered beta oscillatory response reflected in turn atypical functional connectivity between occipital areas, where the initial stimulus analysis is accomplished, and infero-temporal regions, where objects identity is extracted. Such atypical beta connectivity predicted both ASD symptomatology and their detail-oriented processing. Overall, these results might be explained by an altered feedback connectivity within the visual system, with potential cascade effects in visual scene parsing and higher order functions.
    MeSH term(s) Autism Spectrum Disorder ; Autistic Disorder ; Child ; Cognition ; Electroencephalography ; Humans ; Visual Perception
    Language English
    Publishing date 2020-10-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2020.102484
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Comparison of Oxford Cognitive Screen and Montreal Cognitive Assessment feasibility in the stroke unit setting. A pilot study.

    Brambilla, Michela / Cerasetti, Martina / Pepe, Fulvio / Pini, Elisa / Pomati, Simone / Magni, Eugenio / Berlingeri, Manuela / Pantoni, Leonardo

    Cerebral circulation - cognition and behavior

    2021  Volume 2, Page(s) 100021

    Abstract: Background: :: Methods: :: Results: Both tests were feasible in the stroke unit setting and had a high level of acceptability by patients. MoCA test was fully completed by 25 patients, OCS by 21 patients. The OCS administration time was longer ... ...

    Abstract Background: :
    Methods: :
    Results: Both tests were feasible in the stroke unit setting and had a high level of acceptability by patients. MoCA test was fully completed by 25 patients, OCS by 21 patients. The OCS administration time was longer than that of the MoCA. However, OCS was perceived less demanding than MoCA by patients. Twenty patients completed both the MoCA and the OCS entirely, and only 2 of them did not show any impairment in both tests. Seventeen patients showed at least an impaired domain on the OCS and 15 patients presented with a MoCA global score below cut-off for cognitive impairment.
    Conclusions: Our preliminary study did not show a superiority of the OCS over the widely used MoCA, and suggests the need for further validation in larger samples of stroke patients, exploring tests accuracy in detecting cognitive post-stroke impairment.
    Language English
    Publishing date 2021-07-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2450
    ISSN (online) 2666-2450
    DOI 10.1016/j.cccb.2021.100021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Patient-reported outcome and cognitive measures to be used in vascular and brain tumor surgery: proposal for a minimum set.

    Schiavolin, Silvia / Mariniello, Arianna / Broggi, Morgan / Abete-Fornara, Giorgia / Bollani, Alessandra / G, Giulio Palmas / Bottini, Gabriella / Querzola, Matteo / Scarpa, Pina / Casarotti, Alessandra / De Michele, Sara / Isella, Valeria / Mauri, Ilaria / Maietti, Alessandra / Miramonti, Valentina / Orru, Maria Immacolata / Pertichetti, Marta / Pini, Elisa / Regazzoni, Rossana /
    Subacchi, Sara / Ferroli, Paolo / Leonardi, Matilde

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 43, Issue 8, Page(s) 5143–5151

    Abstract: Background: The standardization of outcome measures is needed for comparing studies and using common measures in clinical practice. We aimed to identify cognitive and patient-reported outcomes and timing of assessment for glioma, meningioma, and ... ...

    Abstract Background: The standardization of outcome measures is needed for comparing studies and using common measures in clinical practice. We aimed to identify cognitive and patient-reported outcomes and timing of assessment for glioma, meningioma, and vascular surgery.
    Method: A consensus study was conducted. Participants selected cognitive and patient-reported measures among a list of instruments identified through a literature search.
    Results: Seventeen cognitive tests for the glioma and meningioma's evaluation, 8 for the vascular diseases, and one questionnaire on quality of life and one on emotional distress were identified. The timing of outcome assessment selected was before surgery, at discharge, and after 3 and 12 months for glioma; before surgery and after 3 months for meningioma; before surgery, at discharge, and after 6 months for vascular diseases.
    Conclusion: The identification of common outcome measures is the first step toward a shared data collection improving the quality and comparability of future studies.
    MeSH term(s) Brain Neoplasms/surgery ; Cognition ; Glioma ; Humans ; Meningeal Neoplasms ; Meningioma/surgery ; Patient Reported Outcome Measures ; Quality of Life ; Vascular Diseases
    Language English
    Publishing date 2022-06-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-022-06162-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Memofilm project: "Man's memory. Cinema against the pathologies of memory".

    Savorani, Giancarlo / Pini, Elisa / Tondi, Lucio / Ribani, Valeria / Tedesco, Ruggero / Melloni, Eugenio / Bertolucci, Giuseppe

    Journal of the American Geriatrics Society

    2013  Volume 61, Issue 5, Page(s) 826–828

    MeSH term(s) Aged ; Aged, 80 and over ; Dementia/complications ; Dementia/physiopathology ; Dementia/rehabilitation ; Disability Evaluation ; Disabled Persons/psychology ; Disabled Persons/rehabilitation ; Female ; Humans ; Male ; Memory/physiology ; Memory Disorders/etiology ; Memory Disorders/physiopathology ; Memory Disorders/rehabilitation ; Middle Aged ; Motion Pictures/utilization
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.12248
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Centenarians' offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview.

    Bucci, Laura / Ostan, Rita / Cevenini, Elisa / Pini, Elisa / Scurti, Maria / Vitale, Giovanni / Mari, Daniela / Caruso, Calogero / Sansoni, Paolo / Fanelli, Flaminia / Pasquali, Renato / Gueresi, Paola / Franceschi, Claudio / Monti, Daniela

    Aging

    2016  Volume 8, Issue 3, Page(s) 510–519

    Abstract: Within the scenario of an increasing life expectancy worldwide it is mandatory to identify determinants of healthy aging. Centenarian offspring (CO) is one of the most informative model to identify trajectories of healthy aging and their determinants ( ... ...

    Abstract Within the scenario of an increasing life expectancy worldwide it is mandatory to identify determinants of healthy aging. Centenarian offspring (CO) is one of the most informative model to identify trajectories of healthy aging and their determinants (genetic and environmental), being representative of elderly in their 70th whose lifestyle can be still modified to attain a better health. This study is the first comprehensive investigation of the health status of 267 CO (mean age: 70.2 years) and adopts the innovative approach of comparing CO with 107 age-matched offspring of non-long-lived parents (hereafter indicated as NCO controls), recruited according to strict inclusion demographic criteria of Italian population. We adopted a multidimensional approach which integrates functional and cognitive assessment together with epidemiological and clinical data, including pro- and anti-inflammatory cytokines and adipokines, lipid profile, and insulin resistance. CO have a lower prevalence of stroke, cerebral thrombosis-hemorrhage, hypertension, hypercholesterolemia, and other minor diseases, lower BMI and waist circumference, a better functional and cognitive status and lower plasma level of FT4 compared to NCO controls. We conclude that a multidimensional approach is a reliable strategy to identify the health status of elderly at an age when interventions to modify their health trajectory are feasible.
    MeSH term(s) Aged ; Case-Control Studies ; Female ; Health Status ; Humans ; Italy ; Longevity/physiology ; Male
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.100912
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Inflammaging and Cancer: A Challenge for the Mediterranean Diet

    Ostan, Rita / Lanzarini, Catia / Pini, Elisa / Scurti, Maria / Vianello, Dario / Bertarelli, Claudia / Fabbri, Cristina / Izzi, Massimo / Palmas, Giustina / Biondi, Fiammetta / Martucci, Morena / Bellavista, Elena / Salvioli, Stefano / Capri, Miriam / Franceschi, Claudio / Santoro, Aurelia

    Nutrients. 2015 Apr. 09, v. 7, no. 4

    2015  

    Abstract: Aging is considered the major risk factor for cancer, one of the most important mortality causes in the western world. Inflammaging, a state of chronic, low-level systemic inflammation, is a pervasive feature of human aging. Chronic inflammation ... ...

    Abstract Aging is considered the major risk factor for cancer, one of the most important mortality causes in the western world. Inflammaging, a state of chronic, low-level systemic inflammation, is a pervasive feature of human aging. Chronic inflammation increases cancer risk and affects all cancer stages, triggering the initial genetic mutation or epigenetic mechanism, promoting cancer initiation, progression and metastatic diffusion. Thus, inflammaging is a strong candidate to connect age and cancer. A corollary of this hypothesis is that interventions aiming to decrease inflammaging should protect against cancer, as well as most/all age-related diseases. Epidemiological data are concordant in suggesting that the Mediterranean Diet (MD) decreases the risk of a variety of cancers but the underpinning mechanism(s) is (are) still unclear. Here we review data indicating that the MD (as a whole diet or single bioactive nutrients typical of the MD) modulates multiple interconnected processes involved in carcinogenesis and inflammatory response such as free radical production, NF-κB activation and expression of inflammatory mediators, and the eicosanoids pathway. Particular attention is devoted to the capability of MD to affect the balance between pro- and anti-inflammaging as well as to emerging topics such as maintenance of gut microbiota (GM) homeostasis and epigenetic modulation of oncogenesis through specific microRNAs.
    Keywords Mediterranean diet ; carcinogenesis ; eicosanoids ; epigenetics ; free radicals ; homeostasis ; humans ; inflammation ; intestinal microorganisms ; metastasis ; microRNA ; mortality ; mutation ; neoplasms ; nutrients ; risk factors ; transcription factor NF-kappa B
    Language English
    Dates of publication 2015-0409
    Size p. 2589-2621.
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note Review
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu7042589
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Inflammaging and cancer: a challenge for the Mediterranean diet.

    Ostan, Rita / Lanzarini, Catia / Pini, Elisa / Scurti, Maria / Vianello, Dario / Bertarelli, Claudia / Fabbri, Cristina / Izzi, Massimo / Palmas, Giustina / Biondi, Fiammetta / Martucci, Morena / Bellavista, Elena / Salvioli, Stefano / Capri, Miriam / Franceschi, Claudio / Santoro, Aurelia

    Nutrients

    2015  Volume 7, Issue 4, Page(s) 2589–2621

    Abstract: Aging is considered the major risk factor for cancer, one of the most important mortality causes in the western world. Inflammaging, a state of chronic, low-level systemic inflammation, is a pervasive feature of human aging. Chronic inflammation ... ...

    Abstract Aging is considered the major risk factor for cancer, one of the most important mortality causes in the western world. Inflammaging, a state of chronic, low-level systemic inflammation, is a pervasive feature of human aging. Chronic inflammation increases cancer risk and affects all cancer stages, triggering the initial genetic mutation or epigenetic mechanism, promoting cancer initiation, progression and metastatic diffusion. Thus, inflammaging is a strong candidate to connect age and cancer. A corollary of this hypothesis is that interventions aiming to decrease inflammaging should protect against cancer, as well as most/all age-related diseases. Epidemiological data are concordant in suggesting that the Mediterranean Diet (MD) decreases the risk of a variety of cancers but the underpinning mechanism(s) is (are) still unclear. Here we review data indicating that the MD (as a whole diet or single bioactive nutrients typical of the MD) modulates multiple interconnected processes involved in carcinogenesis and inflammatory response such as free radical production, NF-κB activation and expression of inflammatory mediators, and the eicosanoids pathway. Particular attention is devoted to the capability of MD to affect the balance between pro- and anti-inflammaging as well as to emerging topics such as maintenance of gut microbiota (GM) homeostasis and epigenetic modulation of oncogenesis through specific microRNAs.
    MeSH term(s) Aging ; Chronic Disease ; Diet, Mediterranean ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; Humans ; Inflammation/prevention & control ; Neoplasms/prevention & control
    Language English
    Publishing date 2015-04-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu7042589
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Towards a common language in neurosurgical outcome evaluation: the NEON (NEurosurgical Outcome Network) proposal.

    Ferroli, Paolo / Schiavolin, Silvia / Mariniello, Arianna / Acerbi, Francesco / Restelli, Francesco / Schiariti, Marco / LA Corte, Emanuele / Falco, Jacopo / Levi, Vincenzo / Dimeco, Francesco / Assietti, Roberto / Bongetta, Daniele / Colombo, Elena V / Bellocchi, Silvio / Sangiorgi, Simone / Bistazzoni, Simona / Polosa, Maria / Orru, Maria I / Spena, Giannantonio /
    Bernucci, Claudio / Sicignano, Angelo M / Fanti, Andrea / Brembilla, Carlo / Resmini, Bruno / Costi, Emanuele / Cenzato, Marco / Talamonti, Giuseppe / Bottini, Gabriella / Scarpa, Pina / Bollani, Alessandra / Querzola, Matteo / Palmas, Giulio / DE Gonda, Federico / Bosio, Lorenzo / Egidi, Marcello / Tardivo, Valentina / Fioravanti, Antonio / Subacchi, Sara / Fontanella, Marco / Biroli, Antonio / Cereda, Claudio / Panciani, Pier Paolo / Bergomi, Riccardo / Pertichetti, Marta / Tancioni, Flavio / Bona, Alberto / Tartara, Fulvio A / Fornari, Maurizio / Pessina, Federico / Lasio, Giovanni / Cardia, Andrea / Servadei, Franco / Riva, Marco / Casarotti, Alessandra / Giussani, Carlo / Fiori, Leonardo / Mazzoleni, Fabio / Vaiani, Simona / Carrabba, Giorgio / DI Cristofori, Andrea / Sganzerla, Erik P / Vimercati, Alberto / Isella, Valeria / Mauri, Ilaria / Incerti, Michele / Sicuri, Giovanni / Miramonti, Valentina / Stefini, Roberto / Spagnoli, Diego / Piparo, Maurizio / Grimod, Gianluca / Regazzoni, Rossana / Vismara, Daniela / Mazzeo, Lucio / Monti, Emanuele / Franzin, Alberto / Vivaldi, Oscar / Maietti, Alessandra / Pini, Elisa / Servello, Domenico / Zekaj, Edvin / DE Michele, Sara / Locatelli, Marco / Borsa, Stefano / Grimoldi, Nadia / Caroli, Manuela / Tariciotti, Leonardo / Abete-Fornara, Giorgia / Vitale, Mario / Leonardi, Matilde / Broggi, Morgan

    Journal of neurosurgical sciences

    2023  Volume 67, Issue 3, Page(s) 263–272

    Abstract: Background: The aim of this study was to achieve a consensus on the minimum set of outcome measures and predictors to be used in the neurosurgical practice and on the timing of outcome assessment.: Methods: A consensus building approach was employed. ...

    Abstract Background: The aim of this study was to achieve a consensus on the minimum set of outcome measures and predictors to be used in the neurosurgical practice and on the timing of outcome assessment.
    Methods: A consensus building approach was employed. All neurosurgical departments in Lombardy (Italy) were invited to participate by the Carlo Besta Neurologic Institute IRCCS Foundation. Three workshops were organized during which a multidisciplinary group called Neurosurgical Outcome Network (NEON) was created and the methodology to select outcome measures, predictors, and timing of outcome assessment was established. Eight working groups were created for the different neurosurgical diseases (neuro-oncological, skull base, vascular, traumatic, spinal, peripheral nervous system, malformation, functional) and 8 workshops were organized to identify the outcome measures and predictors specific for each of the neurosurgical diseases based on the experts' clinical practice and the existing literature.
    Results: A total of 20 neurosurgical departments participated in this study. Specific outcome measures, predictors and the timing of outcome assessment were identified for each of the 8 neurosurgical diseases. Moreover, a list of variables common to all pathologies were identified by the NEON group as further data to be collected.
    Conclusions: A consensus on the minimum set of outcome measures and predictors and the timing of outcome assessments for 8 neurosurgical diseases was achieved by a group of neurosurgeons of the Lombardy region, called NEON. These sets could be used in future studies for a more homogeneous data collection and as a starting point to reach further agreement also at national and international level.
    MeSH term(s) Humans ; Neon ; Neurosurgeons ; Outcome Assessment, Health Care ; Italy
    Chemical Substances Neon (4VB4Y46AHD)
    Language English
    Publishing date 2023-03-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.23.05968-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.241: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Space/population and time/age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age.

    Pirazzini, Chiara / Giuliani, Cristina / Bacalini, Maria G / Boattini, Alessio / Capri, Miriam / Fontanesi, Elisa / Marasco, Elena / Mantovani, Vilma / Pierini, Michela / Pini, Elisa / Luiselli, Donata / Franceschi, Claudio / Garagnani, Paolo

    Aging

    2012  Volume 4, Issue 7, Page(s) 509–520

    Abstract: Little is known about the impact of space (geography/ancestry) and time (age of the individuals) on DNA methylation variability in humans. We investigated DNA methylation of the imprinted IGF2/H19 locus in: i) a cohort of individuals homogeneous for age ... ...

    Abstract Little is known about the impact of space (geography/ancestry) and time (age of the individuals) on DNA methylation variability in humans. We investigated DNA methylation of the imprinted IGF2/H19 locus in: i) a cohort of individuals homogeneous for age and gender (males with restricted age range: 30-50 years) belonging to four Italian districts representative of the major genetic clines, informative for the geographical dimension; ii) a cohort of monozygotic (MZ) and dizygotic (DZ) twins of different ages (age-range: 22-97 years), informative for the temporal dimension. DNA methylation of the analyzed regions displayed high levels of inter-individual variability that could not be ascribed to any geographical cline. In MZ twins we identified two IGF2/H19 regions where the intra-couple variations significantly increased after the age of 60 years. The analysis of twins' individual life histories suggests that the within twin pairs difference is likely the result of the aging process itself, as sharing a common environment for long periods had no effect on DNA methylation divergence. On the whole, the data here reported suggest that: i) aging more than population genetics is responsible for the inter-individual variability in DNA methylation patterns in humans; ii) DNA methylation variability appears to be highly region-specific.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Aging/metabolism ; DNA Methylation ; Environment ; Female ; Geography ; Humans ; Insulin-Like Growth Factor II/genetics ; Italy ; Male ; Middle Aged ; RNA, Long Noncoding/genetics ; Twins, Dizygotic/genetics ; Twins, Monozygotic/genetics ; Young Adult
    Chemical Substances H19 long non-coding RNA ; IGF2 protein, human ; RNA, Long Noncoding ; Insulin-Like Growth Factor II (67763-97-7)
    Language English
    Publishing date 2012-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Twin Study
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.100476
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top