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Article ; Online: Lithium-induced parkinsonism associated with vocal cord paralysis: an atypical presentation.

Raia, Accursio / Montalbano, Clara / Caruso, Valerio / Pacciardi, Bruno / Pini, Stefano

2023 Volume 10, Issue 2, Page(s) 107–109

Abstract: Drug-induced parkinsonism has been commonly studied and discussed regarding antipsychotic agents, but lithium-induced parkinsonism should also be considered when patients present with parkinsonian symptoms and chronic lithium use. There are several ... ...

Abstract	Drug-induced parkinsonism has been commonly studied and discussed regarding antipsychotic agents, but lithium-induced parkinsonism should also be considered when patients present with parkinsonian symptoms and chronic lithium use. There are several reports of parkinsonism arising during lithium administration and regressing following its reduction or discontinuation. Our case is, to date, the first case in the literature in which vocal cord paralysis occurred as the first symptom of lithium-induced parkinsonism, contributing to confuse doctors and patients and to delay diagnosis and treatment. In our clinical case prompt withdrawal of lithium and its reintroduction at lower doses led to complete resolution of this disabling clinical presentation. This report emphasizes the importance of careful monitoring of lithium levels, especially in elderly subjects, and the need to consider lithium-induced parkinsonism even when unusual motor symptoms appear in chronic lithium users.
Language	English
Publishing date	2023-06-23
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2788093-X
ISSN	2360-6975 ; 2360-6975
ISSN (online)	2360-6975
ISSN	2360-6975
DOI	10.22551/2023.39.1002.10252
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Presence and correlates of autistic traits among patients with social anxiety disorder.

Carpita, Barbara / Nardi, Benedetta / Bonelli, Chiara / Massimetti, Enrico / Amatori, Giulia / Cremone, Ivan Mirko / Pini, Stefano / Dell'Osso, Liliana

Frontiers in psychiatry

2024 Volume 14, Page(s) 1320558

Abstract: Introduction: Due to their similar behavioral presentation, it can sometimes be challenging to distinguish between a social anxiety disorder (SAD) and the social avoidance that is frequently described in autism spectrum disorder (ASD). Moreover, a ... ...

Abstract	Introduction: Due to their similar behavioral presentation, it can sometimes be challenging to distinguish between a social anxiety disorder (SAD) and the social avoidance that is frequently described in autism spectrum disorder (ASD). Moreover, a growing body of evidences is reporting that a significant proportion of subjects with ASD also meet the requirements for SAD and, vice versa, subjects with SAD tend to exhibit a higher prevalence of autistic traits. Aim: In this framework, the current study aims to evaluate prevalence and correlates of autistic traits in a sample of adult subjects diagnosed with SAD and healthy controls (HC), also evaluating which autism spectrum dimensions may statistically predict higher SAD symptoms. Methods: 56 subjects with a clinical diagnosis of SAD and 56 gender and age matched HC were recruited from the Psychiatric Clinic of the University of Pisa. Subjects were assessed with the SCID-5, the Social Anxiety Spectrum - Short Version (SHY- SV) and the Adult Autism Subthreshold Spectrum (AdAS Spectrum). Results: SAD group scored significantly higher in all AdAS Spectrum and SHY-SV domains and total score compared to the HC group with no significant gender difference. SHY-SV total and domain scores, were strongly and positively and strongly correlated with all AdAS Spectrum domains and total score. AdAS Spectrum total score and Conclusion: Our results confirm the link between SAD and autistic traits also in adult population, describing not only high levels of autistic traits in SAD adults, but also significant correlations between many core features of the two disorders and a predictive role of autistic traits on higher SAD symptoms.
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1320558
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Article: Rethinking Clozapine: Lights and Shadows of a Revolutionary Drug.

Dell'Osso, Liliana / Bonelli, Chiara / Nardi, Benedetta / Giovannoni, Federico / Pronestì, Cristiana / Cremone, Ivan Mirko / Amatori, Giulia / Pini, Stefano / Carpita, Barbara

Brain sciences

2024 Volume 14, Issue 1

Abstract: The current literature globally highlights the efficacy of Clozapine in several psychiatric disorders all over the world, with an FDA indication for reducing the risk of repeated suicidal behavior in patients with schizophrenia or schizoaffective ... ...

Abstract	The current literature globally highlights the efficacy of Clozapine in several psychiatric disorders all over the world, with an FDA indication for reducing the risk of repeated suicidal behavior in patients with schizophrenia or schizoaffective disorder. A growing field of research is also stressing a possible broader beneficial effect of Clozapine in promoting neuroprotection and neurotrophism. However, this drug is linked to several life-threatening side effects, such as agranulocytosis, myocarditis and seizures, that limit its use in daily clinical practice. For this work, a search was performed on PubMed using the terms "Clozapine indications", "Clozapine adverse effects", "Clozapine regenerative effects", and "Clozapine neuroplasticity" with the aim of reviewing the scientific literature on Clozapine's treatment indications, adverse effects and potential regenerative role. The results confirmed the efficacy of clozapine in clinical practice, although limited by its adverse effects. It appears crucial to raise awareness among clinicians about the potential benefits of using Clozapine, as well educating medical personnel about its risks and the early identification of possible adverse effects and their management.
Language	English
Publishing date	2024-01-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14010103
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Article: Autistic Traits as Predictors of Increased Obsessive-Compulsive Disorder Severity: The Role of Inflexibility and Communication Impairment.

Dell'Osso, Liliana / Nardi, Benedetta / Bonelli, Chiara / Amatori, Giulia / Pereyra, Maria Alessandra / Massimetti, Enrico / Cremone, Ivan Mirko / Pini, Stefano / Carpita, Barbara

Brain sciences

2024 Volume 14, Issue 1

Abstract: Due to similar manifestations, some authors have proposed a potential correlation between autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD). This link has long been recognized and debated, with some authors arguing that these ... ...

Abstract	Due to similar manifestations, some authors have proposed a potential correlation between autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD). This link has long been recognized and debated, with some authors arguing that these disorders frequently occur comorbid but distinct while others believe they are part of the same spectrum. The aim of our study was to explore the prevalence and correlates of autistic traits in 55 OCD patients and 55 matched controls and to assess possible autistic dimensions predictive of higher OCD symptoms. All participants were assessed with the Obsessive-Compulsive Spectrum-Short Version (OBS-SV) and the Adult Autism Subthreshold Spectrum (AdAS Spectrum). The OCD group scored significantly higher in both questionnaires. Total OBS-SV scores and domains were significantly correlated with all AdAS Spectrum domains and total score. The AdAS Spectrum total,
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14010064
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Article: The Role of Vortioxetine in the Treatment of Depressive Symptoms in General Hospital Psychiatry: A Case-Series and PRISMA-Compliant Systematic Review of the Literature.

Weiss, Francesco / Pacciardi, Bruno / D'Alessandro, Giulia / Caruso, Valerio / Maremmani, Icro / Pini, Stefano / Perugi, Giulio

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Depressive symptoms are a customary finding in hospitalized patients, particularly those who are undergoing long hospitalizations, underwent major surgical procedures or suffer from high levels of multimorbidity and frailty. The patients included in this ...

Abstract	Depressive symptoms are a customary finding in hospitalized patients, particularly those who are undergoing long hospitalizations, underwent major surgical procedures or suffer from high levels of multimorbidity and frailty. The patients included in this case series shared high degrees of frailty-complexity and were evaluated within the ordinary consultation and liaison psychiatry service of the University Hospital in Pisa, Italy, from September 2021 to June 2023. Patients were administered at least one follow-up evaluation after a week and before discharge. To relate this case series to the extant literature, a comprehensive systematic review of vortioxetine safety and efficacy was performed. None of the six patients included developed serious safety issues, but one patient complained of mild-to-moderate nausea for some days after the vortioxetine introduction. Five out of six patients exhibited at least a slight clinical benefit as measured by the clinical global impression scale. Of the 858 entries screened via Scopus and Medline/PubMed, a total of 134 papers were included in our review. The present case series provides preliminary evidence for vortioxetine's safety in this healthcare domain. The literature reviewed in this paper seems to endorse a promising safety profile and a very peculiar efficacy niche for vortioxetine in consultation and liaison psychiatry.
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020531
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Article: Admixture Analysis of Age of Onset in Bipolar Disorder and Impact of Anxiety Comorbidity.

Pini, Stefano / Carpita, Barbara / Nardi, Benedetta / Abelli, Marianna / Amatori, Giulia / Cremone, Ivan / Dell'Osso, Liliana

Cureus

2024 Volume 16, Issue 3, Page(s) e55803

Abstract: Background: The present study aimed to examine clinical differences between subjects with early-onset ( ... 30 years) bipolar I disorder, in particular, in relation to anxiety comorbidity.: Method: Subjects were selected from ...

Abstract	Background: The present study aimed to examine clinical differences between subjects with early-onset (<21 years) and adult-onset (>30 years) bipolar I disorder, in particular, in relation to anxiety comorbidity. Method: Subjects were selected from a cohort of 161 consecutive patients with bipolar disorder type I as diagnosed by the Structured Clinical Interview for DSM Disorder (SCID-I). Clinical characteristics and axis I comorbidity were compared between those whose illness first emerged before the age of 21 years (n=58) and those whose first episode occurred after the age of 30 years (n=27). Psychopathology was assessed using the 18-item version of the Brief Psychiatric Rating Scale (BPRS). The frequency of delusions, hallucinations, and formal thought disorders was evaluated with the SCID-I. Overall, social and occupational functioning was assessed by the Global Assessment of Functioning (GAF). Results: Most subjects with early-onset bipolar disorder were males, had panic disorder and substance abuse comorbidity, longer duration of illness, exhibited mood-incongruent delusions, and presented with a mixed episode at onset more frequently than the later adult-onset subjects. Mixed mania at the first episode of illness and lifetime panic disorder comorbidity predicted mixed polarity at the first hospitalization episode in the early-onset subjects. Conclusions: Overall, early age at onset seems to delineate a distinct bipolar I disorder subtype characterized by a greater likelihood of mixed episodes, lifetime panic disorder comorbidity, and schizophrenia-like delusions.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55803
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Article: Autistic Traits and Somatic Symptom Disorders: What Is the Link?

Carpita, Barbara / Nardi, Benedetta / Tognini, Valeria / Poli, Francesca / Amatori, Giulia / Cremone, Ivan Mirko / Pini, Stefano / Dell'Osso, Liliana

Brain sciences

2024 Volume 14, Issue 3

Abstract: Alterations in sensory processing, a key component of autism spectrum disorder (ASD), have recently attracted increasing attention as they result in peculiar responses to sensory stimuli, possibly representing a risk factor for the development of somatic ...

Abstract	Alterations in sensory processing, a key component of autism spectrum disorder (ASD), have recently attracted increasing attention as they result in peculiar responses to sensory stimuli, possibly representing a risk factor for the development of somatic symptom disorder (SSD). Contextually, other features also associated with ASD, such as alexithymia, camouflaging and altered verbal, and non-verbal communication, have been suggested to represent risk factors for the occurrence and worsening of somatic symptomatology. The aim of this work was to review the available literature about the association between SSD and the autism spectrum. The results highlighted not only a higher prevalence of autistic features in patients suffering from SSD and a higher prevalence of reported somatic symptomatology in subjects with ASD but also how ASD subjects with co-occurrent somatic symptoms exhibit more severe autism-linked symptomatology. From the paper reviewed also emerged many shared features between the two conditions, such as alexithymia, altered sensitivity to sensory stimuli, cognitive inflexibility, intolerance of uncertainty, and an increased risk of experiencing stressful life events, which may provide an explanation for the correlation reported. Even though studies on the topic are still scant, the evidence reported suggests the importance of further assessing the correlation between the two disorders.
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14030274
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Article ; Online: A reevaluation of mixed depressive states from the DSM-5- TR perspective: a series of prototypical cases.

Pini, Stefano / Raia, Accursio / Amatori, Giulia / Nardi, Benedetta / Carpita, Barbara / Tundo, Antonio / Dell'Osso, Liliana

Archive of clinical cases

2024 Volume 11, Issue 1, Page(s) 22–28

Abstract: Mixed depressive states are defined by the co-presence of depressive and manic symptoms. They represent extremely variable conditions from the point of view of clinical expressiveness and are difficult to recognize, ranging from clear schizophrenic-like ... ...

Abstract	Mixed depressive states are defined by the co-presence of depressive and manic symptoms. They represent extremely variable conditions from the point of view of clinical expressiveness and are difficult to recognize, ranging from clear schizophrenic-like psychoses and pseudodemented pictures to subsyndromal psychopathology. At the basis of the extreme variability of depressive pictures with mixed features are the different combinations that depressive and manic symptoms can assume. Furthermore, the intensity of depressive symptoms and manic symptoms, combined, can be variable, a factor that contributes to making the picture even more variable. Each form of mixed depressive state therefore presents its own specific symptomatic characteristics and specific difficulties in differential diagnosis and each form requires a different therapeutic strategy. In this work we have distinguished four possible specific subtypes of mixed depressive states, describing their specific clinical presentation and the therapeutic options most supported by the literature with the aim of contributing to a better recognition of mixed depressive states, to avoid incorrect diagnoses at patient and treatments that are useless if not worsening.
Language	English
Publishing date	2024-04-30
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2788093-X
ISSN	2360-6975 ; 2360-6975
ISSN (online)	2360-6975
ISSN	2360-6975
DOI	10.22551/2024.42.1101.10282
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Valproate-induced burning mouth syndrome in a male with fibromyalgia and bipolar spectrum disorder.

Raia, Accursio / Caruso, Valerio / Montalbano, Clara / Migli, Lavinia / Raia, Calogero / Pini, Stefano

Archive of clinical cases

2023 Volume 10, Issue 3, Page(s) 125–127

Abstract: Burning mouth syndrome is a chronic painful condition characterized by a subjective intraoral pain and burning sensations in the absence of an identifiable medical, dental, or psychiatric cause. Although the underlying etiology is currently unclear, an ... ...

Abstract	Burning mouth syndrome is a chronic painful condition characterized by a subjective intraoral pain and burning sensations in the absence of an identifiable medical, dental, or psychiatric cause. Although the underlying etiology is currently unclear, an idiopathic (or primary) form and a secondary form to other conditions are formally recognized. However, as several authors have suggested, it might be of clinical utility to consider the existence of a third clinical entity, namely Drug-Induced Burning mouth syndrome, for its therapeutic implications. The latter has been reported with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antiretrovirals, anticoagulants, chemotherapy, and drugs commonly used in the treatment of neuropsychiatric disorders such as antidepressants, benzodiazepines, and antipsychotics. Regarding anticonvulsants a literature search found a previous case of Topiramate-Induced Burning mouth syndrome but no previous report of valproate-induced Burning mouth syndrome. Our case is, to date, the first case in the literature of Burning mouth syndrome onset following the administration of valproate to a patient suffering from fibromyalgia and bipolar spectrum disorder. Symptoms resolved completely when the drug was stopped, and the association between symptoms and drug was replicated after drug re-administration.
Language	English
Publishing date	2023-09-20
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2788093-X
ISSN	2360-6975 ; 2360-6975
ISSN (online)	2360-6975
ISSN	2360-6975
DOI	10.22551/2023.40.1003.10257
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Semi-Perspective Decoupled Heatmaps for 3D Robot Pose Estimation from Depth Maps

Simoni, Alessandro / Pini, Stefano / Borghi, Guido / Vezzani, Roberto

2022

Abstract: Knowing the exact 3D location of workers and robots in a collaborative environment enables several real applications, such as the detection of unsafe situations or the study of mutual interactions for statistical and social purposes. In this paper, we ... ...

Abstract	Knowing the exact 3D location of workers and robots in a collaborative environment enables several real applications, such as the detection of unsafe situations or the study of mutual interactions for statistical and social purposes. In this paper, we propose a non-invasive and light-invariant framework based on depth devices and deep neural networks to estimate the 3D pose of robots from an external camera. The method can be applied to any robot without requiring hardware access to the internal states. We introduce a novel representation of the predicted pose, namely Semi-Perspective Decoupled Heatmaps (SPDH), to accurately compute 3D joint locations in world coordinates adapting efficient deep networks designed for the 2D Human Pose Estimation. The proposed approach, which takes as input a depth representation based on XYZ coordinates, can be trained on synthetic depth data and applied to real-world settings without the need for domain adaptation techniques. To this end, we present the SimBa dataset, based on both synthetic and real depth images, and use it for the experimental evaluation. Results show that the proposed approach, made of a specific depth map representation and the SPDH, overcomes the current state of the art. Comment: IROS2022 and IEEE Robotics and Automation Letters (RA-L). Accepted June, 2022
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Robotics
Subject code	629
Publishing date	2022-07-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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