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  1. Article: Juvenile Primary Sjögren Syndrome in a 15-Year-Old Boy with Renal Involvement: A Case Report and Review of the Literature.

    Bouchalova, Katerina / Flögelova, Hana / Horak, Pavel / Civrny, Jakub / Mlcak, Petr / Pink, Richard / Michalek, Jaroslav / Camborova, Petra / Mikulkova, Zuzana / Kriegova, Eva

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: Juvenile primary Sjögren syndrome (pSS) with renal involvement is extremely rare, reported approximately in 50 children, predominantly girls. Here, we present the first reported case of a male child with juvenile pSS with ocular surface disease ( ... ...

    Abstract Juvenile primary Sjögren syndrome (pSS) with renal involvement is extremely rare, reported approximately in 50 children, predominantly girls. Here, we present the first reported case of a male child with juvenile pSS with ocular surface disease (previously keratoconjunctivitis sicca), submandibular salivary gland involvement, and tubulointerstitial nephritis. First, two symptoms were clinically apparent at presentation. We illustrate here that kidney involvement in pSS should be actively looked for, as juvenile pSS may be associated with asymptomatic renal involvement. Immunophenotyping of peripheral blood cells using multicolor flow cytometry revealed at the time of diagnosis changes in both adaptive (T memory cells and B memory cells), and innate immunity (an increased activation of natural killer cells, as well as monocytes and neutrophils, and an increased representation of intermediate monocytes). Our case report points to the importance of kidney examination, early diagnosis and therapy in juvenile pSS, as well as highlights international collaboration to obtain more data for this rare disease.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14030258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rare syringoid eccrine carcinoma of the upper lip and nasal base treated with resection and subsequent innovative reconstruction using an Abbé flap, turbinate flaps and three-stage forehead flap: a case report.

    Dvořák, Zdeněk / Pink, Richard / Heinz, Petr / Michálek, Jaroslav / Krsička, Petr

    World journal of surgical oncology

    2022  Volume 20, Issue 1, Page(s) 288

    Abstract: Background: Although syringoma is a common benign tumour of the sudoriferous gland, there is also an extremely rare malignant form known as syringoid eccrine carcinoma (SEC). SEC usually exhibits slow growth with deep invasion and a frequent tendency to ...

    Abstract Background: Although syringoma is a common benign tumour of the sudoriferous gland, there is also an extremely rare malignant form known as syringoid eccrine carcinoma (SEC). SEC usually exhibits slow growth with deep invasion and a frequent tendency to relapse. The treatment of choice is radical wide resection, which poses a difficult reconstructive problem, especially when the tumour is located in the centre of the face.
    Case presentation: In this case, a 70-year-old man was diagnosed with an SEC at the same location as a benign syringoma of the upper lip and nasal base that had undergone primary excision 7 years prior. Primary radical resection was performed with immediate Abbé flap reconstruction. Nevertheless, histology revealed positive margins, and 3 additional re-excisions were needed to achieve clear margins. Four months after the initial resection, the patient had undergone an innovative reconstruction technique including not only the Abbé flap but also a turbinate flap harvested with functional endonasal surgery and a three-stage forehead flap.
    Conclusion: To the best of our knowledge, this is the first case report of a suspect malignant transformation of a benign syringoma after 7 years. In addition, from oncoplastic and reconstructive points of view, the bilateral use of the turbinate flap for reconstructing the intranasal lining of the alar base is unusual, and the use of functional endonasal surgery in nasal reconstruction for reducing the risk of damaging the vascular supply of the flap is innovative.
    MeSH term(s) Aged ; Carcinoma/surgery ; Forehead/surgery ; Humans ; Lip/surgery ; Male ; Neoplasm Recurrence, Local/surgery ; Neoplasms, Adnexal and Skin Appendage ; Reconstructive Surgical Procedures/methods ; Skin Neoplasms ; Sweat Gland Neoplasms/surgery ; Syringoma/surgery ; Turbinates/surgery
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-022-02754-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Bone invasion by oral squamous cell carcinoma.

    Král, David / Pink, Richard / Šašková, Lenka / Michálek, Jaroslav / Tvrdý, Peter

    Acta chirurgiae plasticae

    2021  Volume 63, Issue 3, Page(s) 139–144

    Abstract: Background: With regards to the anatomical relationships in the mouth, oral squamous cell carcinoma can invade the maxilla or the mandible. According to the TNM system, tumours that invade through cortical bone are classified as T4a, stage IVA. Bone ... ...

    Title translation Kostní invaze u orálního spinocelulárního karcinomu.
    Abstract Background: With regards to the anatomical relationships in the mouth, oral squamous cell carcinoma can invade the maxilla or the mandible. According to the TNM system, tumours that invade through cortical bone are classified as T4a, stage IVA. Bone invasion by oral squamous cell carcinoma most often occurs in tumours close to the bone or in larger and more advanced tumours. It is considered an adverse prognostic factor and it is often a diagnostic and therapeutic problem. Destruction of the bone tissue is mediated by activated osteoclasts rather than directly by carcinoma. Tumor necrosis factors - receptor activator of NF-kB (RANK), receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) - play an important role in osteoclastogenesis. According to histological point of view, there are three patterns of bone invasion - erosive, mixed and infiltrative. The most commonly used imaging techniques when evaluating bone invasion by oral squamous cell carcinoma include CT and MRI.
    Purpose: This review is focused on the cellular and molecular mechanisms, histological patterns and detection methods of bone invasion caused by oral squamous cell carcinoma.
    MeSH term(s) Bone Neoplasms/secondary ; Carcinoma, Squamous Cell/pathology ; Humans ; Mandible ; Mouth Neoplasms/pathology
    Language English
    Publishing date 2021-11-22
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 428718-6
    ISSN 1805-4404 ; 0001-5423 ; 0323-0414
    ISSN (online) 1805-4404
    ISSN 0001-5423 ; 0323-0414
    DOI 10.48095/ccachp2021139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Development of a questionnaire for a patient-reported outcome after nasal reconstruction.

    Dvořák, Zdeněk / Křenková, Vlasta / Hudcová, Lucie / Knoz, Martin / Kubát, Martin / Pink, Richard

    Acta chirurgiae plasticae

    2022  Volume 64, Issue 1, Page(s) 24–30

    Abstract: Introduction: Our face plays an important role in communication and social life. Defects of the face have a big impact on socializing and psychics of patients with its deformities. A good esthetic outcome is an important task of each reconstructive ... ...

    Title translation Vývoj dotazníku pro zhodnocení výsledku rekonstrukce nosu pacientem.
    Abstract Introduction: Our face plays an important role in communication and social life. Defects of the face have a big impact on socializing and psychics of patients with its deformities. A good esthetic outcome is an important task of each reconstructive surgery. With a modern concept of nose reconstruction, it is possible to achieve a better esthetic and functional outcome than it was possible with one phase reconstructions before. There was a specific tool missing to measure patients reported outcome and objectively evaluate benefits of nose reconstruction from a patients point of view and get reliable feedback about the whole procedure.  The goal of this paper is to develop such a questionnaire.
    Materials and methods: A pilot questionnaire was developed with literature input. The questionnaire was tested on five patients. Based on patients feedback and a review from a psychologist, the second version of the questionnaire was made. It was sent to 39 patients, who underwent nose reconstruction in the years 2016-2020. After two appeals, 34 completed questionnaires were sent back (87,2%). The final version of the questionnaire was developed after a thorough mathematic and statistical analysis of collected data.
    Results: The group of patients who completed the questionnaire consisted of 16 females (47%) and 18 males (53%). On average, the patients were 69 years old (17-88 years). The final questionnaire is structured into six categories from A to F: A - general information defining the patient and purpose for reconstruction, B - satisfaction with esthetic outcome, C - satisfaction with function and stability, D - satisfaction with medical treatment, E - social and psychological impact, F - overall satisfaction. Most of the questions use a 5-point rating scale.
    Conclusion: The questionnaire enables the patients to provide feedback on particular aspects of the treatment and their overall satisfaction with the whole procedure and its outcome. With statistical analysis, it is possible to discover specific treatment aspects that have crucial impact on overall satisfaction with the whole procedure. A patient-reported outcome helps to improve the quality of provided health care and the quality of patient life.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Nose/surgery ; Patient Reported Outcome Measures ; Patient Satisfaction ; Rhinoplasty/adverse effects ; Rhinoplasty/methods ; Surveys and Questionnaires ; Treatment Outcome
    Language English
    Publishing date 2022-04-06
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 428718-6
    ISSN 1805-4404 ; 0001-5423 ; 0323-0414
    ISSN (online) 1805-4404
    ISSN 0001-5423 ; 0323-0414
    DOI 10.48095/ccachp202224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma.

    Michalek, Jaroslav / Brychtova, Svetlana / Pink, Richard / Dvorak, Zdenek

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2019  Volume 163, Issue 4, Page(s) 302–308

    Abstract: Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall ... ...

    Abstract Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. One possible explanation for this is the formation of microenvironment in the perineural space which may contain cellular factors that act on both nerve tissue and some types of tumor tissues. Bone invasion by OSCC has major implications for tumor staging, choice of treatment, outcome and quality of life. Oral SCCs invade the mandibular or maxillary bone through an erosive, infiltrative or mixed pattern that correlates with clinical behavior. Bone resorption by osteoclasts is an important step in the process of bone invasion by oral SCCs. Some cytokines (e.g. TNFα and PTHrP) lead to receptor activator of NF-κB ligand (RANKL) expression or osteoprotegerin (OPG) suppression in oral SCC cells and in cancer stromal cells to induce osteoclastogenesis. Oral SCCs provide a suitable microenvironment for osteoclastogenesis to regulate the balance of RANKL and OPG. A more molecular-based clinical staging and tailor-made therapy would benefit patients with bone invasion by OSCC.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Bone Neoplasms/etiology ; Bone Neoplasms/physiopathology ; Carcinoma, Squamous Cell/complications ; Carcinoma, Squamous Cell/physiopathology ; Cytokines/blood ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/complications ; Mouth Neoplasms/physiopathology ; Neoplasm Invasiveness/physiopathology ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/physiopathology ; Nerve Sheath Neoplasms/etiology ; Nerve Sheath Neoplasms/physiopathology ; Predictive Value of Tests ; Prognosis
    Chemical Substances Biomarkers, Tumor ; Cytokines
    Language English
    Publishing date 2019-08-21
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2019.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part II: Clinical application.

    Molitor, Martin / Mestak, Ondrej / Pink, Richard / Foltan, Rene / Sukop, Andrej / Lucchina, Stefano

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2021  Volume 165, Issue 2, Page(s) 131–138

    Abstract: Despite the high success rate of micro-vascular flaps, anastomosis compromise occurs in 5-10% and that can lead to flap failure. Reliable monitoring of the flap is therefore of similar importance to that of the precise surgical procedure itself. Multiple ...

    Abstract Despite the high success rate of micro-vascular flaps, anastomosis compromise occurs in 5-10% and that can lead to flap failure. Reliable monitoring of the flap is therefore of similar importance to that of the precise surgical procedure itself. Multiple methods have been reported for monitoring of the flap vitality, the first one being direct visual monitoring. In buried flaps direct visualisation is not feasible or is unreliable. In these cases we can extend the buried flap to expose a segment of it to act as a monitoring sentinel. For the purpose of this review we used our clinical experience as a starting point, and for the extended information and expertise we conducted a search of the PubMed database. Over 40 monitoring techniques have been reported to-date. Direct visual monitoring is still generally used method with a reliability of up to 100% and an overall success rate of up to 99%. Direct visualisation remains as the simplest, cheapest and yet a very reliable method of flap monitoring. In this review we provide a description of various possible techniques for externalising part of a buried flap, define the tissues that can be used for this purpose and we summarise the procedures that should be followed to achieve the best reliability and validity of monitoring the skin island.
    MeSH term(s) Humans ; Postoperative Complications ; Reproducibility of Results ; Skin ; Surgical Flaps
    Language English
    Publishing date 2021-03-31
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2021.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part I: Summary and brief description of monitoring methods.

    Molitor, Martin / Mestak, Ondrej / Pink, Richard / Foltan, Rene / Sukop, Andrej / Lucchina, Stefano

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2021  Volume 165, Issue 2, Page(s) 113–130

    Abstract: Micro-vascular flaps have been used for the repair of challenging defects for over 45 years. The risk of failure is reported to be around 5-10% which despite medical and technical advances in recent years remains essentially unchanged. Precise, ... ...

    Abstract Micro-vascular flaps have been used for the repair of challenging defects for over 45 years. The risk of failure is reported to be around 5-10% which despite medical and technical advances in recent years remains essentially unchanged. Precise, continuous, sensitive and specific monitoring together with prompt notification of vascular compromise is crucial for the success of the procedure. In this review, we provide a classification and brief description of the reported methods for monitoring the micro-vascular flap and a summary of the benefits over direct visual monitoring. Over 40 different monitoring techniques have been reported but their comparative merits are not always obvious. One looks for early detection of a flap's compromise, improved flap salvage rate and a minimal false-positive or false-negative rate. The cost-effectiveness of any method should also be considered. Direct visualisation of the flap is the method most generally used and still seems to be the simplest, cheapest and most reliable method for flap monitoring. Considering the alternatives, only implantable Doppler ultrasound probes, near infrared spectroscopy and laser Doppler flowmetry have shown any evidence of improved flap salvage rates over direct visual monitoring.
    MeSH term(s) Humans ; Islands ; Laser-Doppler Flowmetry ; Skin ; Surgical Flaps
    Language English
    Publishing date 2021-03-31
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2021.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx.

    Pink, Richard / Michalek, Jaroslav / Kral, David / Mozola, Michal / Benes, Pavel / Lenka, Saskova / Dvorak, Zdenek

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2021  Volume 167, Issue 2, Page(s) 139–144

    Abstract: Aims: The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors.: Methods: The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 ... ...

    Abstract Aims: The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors.
    Methods: The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker.
    Results: The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group.
    Conclusion: Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type.
    MeSH term(s) Humans ; Carcinoma, Squamous Cell ; Mouth Neoplasms ; Neoplasm Recurrence, Local/pathology ; Head and Neck Neoplasms ; Oropharynx/pathology ; Prognosis
    Language English
    Publishing date 2021-11-15
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2021.062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Arthrocentesis of the temporomandibular joint: a review.

    Tvrdy, Peter / Heinz, Petr / Pink, Richard

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2015  Volume 159, Issue 1, Page(s) 31–34

    Abstract: Background: Arthrocentesis is a very gentle method for lavage of the joint space. The principle consists in the introduction of a pair of needles into the upper joint space and subsequent lavage using physiological saline or Ringer's solution. ... ...

    Abstract Background: Arthrocentesis is a very gentle method for lavage of the joint space. The principle consists in the introduction of a pair of needles into the upper joint space and subsequent lavage using physiological saline or Ringer's solution. Arthrocentesis of the temporomandibular joint is used in both cases of acute closed lock and treatment of various temporomandibular disorders.
    Methods: A literature search in Pubmed database, using key words: Temporomandibular joint (TMJ), Arthrocentesis, indications, technique, results.
    Conclusion: Arthrocentesis of the temporomandibular joint is a minimally invasive treatment method at the boundary between conservative and surgical therapy. It is usually performed on an out-patient basis under local anaesthesia. It is used both in cases of acute block caused by displacement of the articular disc and also to treat degenerative inflammatory diseases of the joints. The main objective of arthrocentesis is to wash out inflammatory mediators, release the disc, break adhesions, eliminate pain and improve joint mobility. It is a method with a minimum number of complications, it is simple and not demanding in terms of instruments, and it can be performed repeatedly. For this reason, it has become widespread and very popular in the treatment of internal disorders of the temporomandibular joint.
    MeSH term(s) Arthrocentesis/methods ; Humans ; Isotonic Solutions/pharmacology ; Temporomandibular Joint Disorders/surgery ; Therapeutic Irrigation/methods
    Chemical Substances Isotonic Solutions ; Ringer's solution (8026-10-6)
    Language English
    Publishing date 2015-03
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2013.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effect of combination therapy of arthrocentesis and occlusal splint on nonreducing temporomandibular joint disk displacement.

    Tvrdy, Peter / Heinz, Petr / Zapletalova, Jana / Pink, Richard / Michl, Petr

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2015  Volume 159, Issue 4, Page(s) 677–680

    Abstract: Objective: Arthrocentesis of the temporomandibular joint is a minimally invasive method of treatment located at the boundary between conservative and surgical therapy. It is usually performed on an out-patient basis under local anaesthesia. These days, ... ...

    Abstract Objective: Arthrocentesis of the temporomandibular joint is a minimally invasive method of treatment located at the boundary between conservative and surgical therapy. It is usually performed on an out-patient basis under local anaesthesia. These days, arthrocentesis of the temporomandibular joint is used not only in cases of acute closed lock but also in the treatment of various temporomandibular disorders. The most frequent indication is acute anterior displacement of the articular disc without reduction. Treatment using occlusal splint is one of the most frequently used methods of conservative treatment. It is used mainly in the case of discopathies and myofascial pain.
    Aim: The aim of the study was to confirm that simultaneous use of the occlusal splint and arthrocentesis makes the treatment more effective in the case of detected disc dislocation without reduction.
    Materials, methods and results: From 2008 to 2013, 144 patients underwent arthrocentesis simultaneously using occlusal splint in the treatment of chronic closed lock. The study group consisted of a 130 (90.3%) women and 14 (9.7%) men. After 3 months of therapy, a good treatment outcome was found in 98 (68.1%) patients, 12 (85.7%) men and 86 (66.2%) women. The treatment did not have any effect in 46 (31.9%) patients, 2 (14.3%) men and 44 (33.8%) women.
    Conclusion: The simultaneous use of the occlusal splint and arthrocentesis makes the treatment more effective in the case of detected joint disc dislocation without reduction.
    MeSH term(s) Adolescent ; Adult ; Arthrocentesis/methods ; Combined Modality Therapy ; Female ; Humans ; Joint Dislocations/therapy ; Male ; Middle Aged ; Occlusal Splints ; Range of Motion, Articular ; Temporomandibular Joint Disc ; Temporomandibular Joint Disorders/therapy ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2015-12
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2014.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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