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  1. Article ; Online: An aggressive physician and a conservative surgeon: the ideal combination for the management of IBD in the age of biologics?

    Pinkney, Thomas D

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2018  Volume 20, Issue 4, Page(s) 277–278

    MeSH term(s) Attitude of Health Personnel ; Biological Products/therapeutic use ; Conservative Treatment/psychology ; Humans ; Inflammatory Bowel Diseases/therapy ; Physicians/psychology ; Surgeons/psychology
    Chemical Substances Biological Products
    Language English
    Publishing date 2018-04-02
    Publishing country England
    Document type Editorial
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14055
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    Zs.A 5799: Show issues Location:
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  2. Article ; Online: A vascular multi-arm multi-stage trial to prevent groin wound surgical site infection: A feasibility survey.

    Popplewell, Matthew A / Gwilym, Brenig L / Benson, Ruth A / Juszczak, Maciej / Bosanquet, David / Pinkney, Thomas D / Chetter, Ian / Wall, Michael

    International wound journal

    2023  Volume 20, Issue 8, Page(s) 2998–3005

    Abstract: Surgical site infection (SSI) is common following arterial surgery involving a groin incision. There is a lack of evidence regarding interventions to prevent groin wound SSI, therefore, a survey of vascular clinicians was undertaken to assess current ... ...

    Abstract Surgical site infection (SSI) is common following arterial surgery involving a groin incision. There is a lack of evidence regarding interventions to prevent groin wound SSI, therefore, a survey of vascular clinicians was undertaken to assess current opinion and practice, equipoise and feasibility of a randomised controlled trial (RCT). Participants at the Vascular Society of Great Britain and Ireland 2021 Annual Scientific Meeting were surveyed regarding three separate interventions designed to prevent SSI in the groin; impregnated incise drapes, diakylcarbomoyl chloride dressings and antibiotic impregnated collagen sponges. Results were collated via an online survey using the Research Electronic Data Capture platform. Seventy-five participants completed the questionnaire, most were consultant vascular surgeons (50/75, 66.7%). The majority agree that groin wound SSI is a major problem (73/75, 97.3%), and would be content using either of the three interventions (51/61, 83.6%) and had clinical equipoise to randomise patients to any of the three interventions versus standard of care (70/75, 93.3%). There was some reluctance to not use impregnated incise drapes as may be considered "standard of care". Groin wound SSI is perceived as major problem in vascular surgery, and a multicentre RCT of three preventative interventions appears acceptable to vascular surgeons.
    MeSH term(s) Humans ; Groin/surgery ; Surgical Wound Infection/prevention & control ; Feasibility Studies ; Vascular Surgical Procedures/adverse effects ; Surveys and Questionnaires ; Surgical Wound
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14170
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    Zs.A 6006: Show issues Location:
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  3. Article ; Online: Clinical statistical analysis plan for the ACCURE trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicentre trial.

    Visser, Eva / Heuthorst, Lianne / Pathmakanthan, Shri / Bemelman, Willem A / D'Haens, Geert R / Handley, Kelly / Fakis, Apostolos / Pinkney, Thomas D / Buskens, Christianne J / Dijkgraaf, Marcel G W

    Trials

    2024  Volume 25, Issue 1, Page(s) 218

    Abstract: Background: The primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the clinical course of UC, decreasing the incidence of relapses and reducing need for medication. The ... ...

    Abstract Background: The primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the clinical course of UC, decreasing the incidence of relapses and reducing need for medication. The objective of the ACCURE trial is to assess the efficacy of laparoscopic appendectomy in addition to standard medical treatment in maintaining remission in UC patients. This article presents the statistical analysis plan to evaluate the outcomes of the ACCURE trial.
    Design and methods: The ACCURE trial was designed as a multicentre, randomised controlled trial. UC patients with a new diagnosis or a disease relapse within the past 12 months, treated with 5-ASA, corticosteroids, or immunomodulators until complete clinical and endoscopic remission (defined as total Mayo score < 3 with endoscopic subscore of 0 or 1), were counselled for inclusion. Also, patients previously treated with biologicals who had a washout period of at least 3 months were considered for inclusion. Patients were randomised (1:1) to laparoscopic appendectomy plus maintenance treatment or a control group (maintenance therapy only). The primary outcome is the 1-year UC relapse rate (defined as a total Mayo-score ≥ 5 with endoscopic subscore of 2 or 3, or clinically as an exacerbation of symptoms and rectal bleeding or FCP > 150 or intensified medical therapy other than 5-ASA therapy). Secondary outcomes include number of relapses per patient, time to first relapse, disease activity, number of colectomies, medication usage, and health-related quality of life.
    Discussion: The ACCURE trial will provide comprehensive evidence whether adding an appendectomy to maintenance treatment is superior to maintenance treatment only in maintaining remission in UC patients.
    Trial registration: Dutch Trial Register (NTR) NTR2883 . Registered May 3, 2011. ISRCTN, ISRCTN60945764 . Registered August 12, 2019.
    MeSH term(s) Humans ; Colitis, Ulcerative/drug therapy ; Appendectomy ; Quality of Life ; Remission Induction ; Neoplasm Recurrence, Local ; Mesalamine ; Recurrence ; Disease Progression
    Chemical Substances Mesalamine (4Q81I59GXC)
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-024-08037-5
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  4. Article ; Online: Ulcerative Colitis Is Associated With an Increased Risk of Venous Thromboembolism in the Postoperative Period.

    Nepogodiev, Dmitri / Ward, Stephen T / Pinkney, Thomas D

    Annals of surgery

    2017  Volume 265, Issue 4, Page(s) e43–e44

    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000001253
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  5. Article ; Online: Bioabsorbable mesh use in midline abdominal wall prophylaxis and repair achieving fascial closure: a cross-sectional review of stage of innovation.

    Kamarajah, S K / Smart, N J / Daniels, I R / Pinkney, T D / Harries, R L

    Hernia : the journal of hernias and abdominal wall surgery

    2020  Volume 25, Issue 1, Page(s) 3–12

    Abstract: Background: Achieving stable closure of complex or contaminated abdominal wall incisions remains challenging. This study aimed to characterise the stage of innovation for bioabsorbable mesh devices used during both midline closure prophylaxis and ... ...

    Abstract Background: Achieving stable closure of complex or contaminated abdominal wall incisions remains challenging. This study aimed to characterise the stage of innovation for bioabsorbable mesh devices used during both midline closure prophylaxis and complex abdominal wall reconstruction and to evaluate the quality of current evidence.
    Methods: A systematic review of published and ongoing studies was performed until 31st December 2019. Inclusion criteria were studies where bioabsorbable mesh was used to support fascial closure either prophylactically after midline laparotomy or for repair of incisional hernia with midline incision. Exclusion criteria were: (1) study design was a systematic review, meta-analysis, letter, review, comment, or conference abstract; (2) included less than p patients; (3) only evaluated biological, synthetic or composite meshes. The primary outcome measure was the IDEAL framework stage of innovation. The key secondary outcome measure was the risk of bias in non-randomised studies of interventions (ROBINS-I) criteria for study quality.
    Results: Twelve studies including 1287 patients were included. Three studies considered mesh prophylaxis and nine studies considered hernia repair. There were only two published studies of IDEAL 2B. The remainder was IDEAL 2A studies. The quality of the evidence was categorised as having a risk of bias of a moderate, serious or critical level in nine of the twelve included studies using the ROBINS-I tool.
    Conclusion: The evidence base for bioabsorbable mesh is limited. Better reporting and quality control of surgical techniques are needed. Although new trial results over the next decade will improve the evidence base, more trials in emergency and contaminated settings are required to establish the limits of indication.
    MeSH term(s) Abdominal Wall/surgery ; Abdominal Wound Closure Techniques ; Absorbable Implants ; Cross-Sectional Studies ; Herniorrhaphy ; Humans ; Incisional Hernia/prevention & control ; Incisional Hernia/surgery ; Male ; Prospective Studies ; Retrospective Studies ; Surgical Mesh
    Language English
    Publishing date 2020-05-24
    Publishing country France
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1388125-5
    ISSN 1248-9204 ; 1265-4906
    ISSN (online) 1248-9204
    ISSN 1265-4906
    DOI 10.1007/s10029-020-02217-3
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  6. Article ; Online: Meta-analysis protocols should be prospectively registered.

    Nepogodiev, D / Chapman, S J / Smart, N J / Pinkney, T D

    Techniques in coloproctology

    2017  Volume 21, Issue 6, Page(s) 483–485

    Language English
    Publishing date 2017
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-017-1602-3
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  7. Article ; Online: Ulcerative Colitis Is Associated With an Increased Risk of Venous Thromboembolism in the Postoperative Period.

    Nepogodiev, Dmitri / Ward, Stephen T / Pinkney, Thomas D

    Annals of surgery

    2015  

    Language English
    Publishing date 2015-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000001253
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  8. Article ; Online: Novel approaches to surgical trials and the assessment of new surgical technologies.

    Pinkney, T D / Morton, D G M

    The British journal of surgery

    2015  Volume 102, Issue 2, Page(s) e10–1

    MeSH term(s) Biomedical Technology/trends ; Humans ; Multicenter Studies as Topic/trends ; Randomized Controlled Trials as Topic/trends ; Surgical Procedures, Operative/trends ; Technology Assessment, Biomedical/trends ; Therapies, Investigational/trends
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.9705
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  9. Article ; Online: Importance of clinical research for the UK's 10-year cancer plan.

    Lee, Richard W / Danson, Sarah / Elliot, Martin / Park, Ed I / Pinkney, Thomas D / Shaw, Clare E / Vimalachandran, Dale / Maughan, Tim / Seymour, Matt / Corrie, Pippa / Wadsley, Jonathan

    The Lancet. Oncology

    2022  Volume 23, Issue 8, Page(s) 975–978

    MeSH term(s) Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00292-3
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  10. Article ; Online: Operating theatre attire (scrub suits) worn outside the operating theatre: infection risk or not?

    Humphreys, H / Bak, A / Mugglestone, M A / Pinkney, T D / Skelton, L / Vos, M C / Ridgway, E

    The Journal of hospital infection

    2020  Volume 108, Page(s) 209–211

    MeSH term(s) Cross Infection/etiology ; Cross Infection/prevention & control ; Equipment Contamination ; Humans ; Infection Control ; Operating Rooms ; Protective Clothing
    Language English
    Publishing date 2020-12-05
    Publishing country England
    Document type Letter
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2020.12.002
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