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Article ; Online: An aggressive physician and a conservative surgeon: the ideal combination for the management of IBD in the age of biologics?

Pinkney, Thomas D

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2018 Volume 20, Issue 4, Page(s) 277–278

MeSH term(s)	Attitude of Health Personnel ; Biological Products/therapeutic use ; Conservative Treatment/psychology ; Humans ; Inflammatory Bowel Diseases/therapy ; Physicians/psychology ; Surgeons/psychology
Chemical Substances	Biological Products
Language	English
Publishing date	2018-04-02
Publishing country	England
Document type	Editorial
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.14055
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Article ; Online: A vascular multi-arm multi-stage trial to prevent groin wound surgical site infection: A feasibility survey.

Popplewell, Matthew A / Gwilym, Brenig L / Benson, Ruth A / Juszczak, Maciej / Bosanquet, David / Pinkney, Thomas D / Chetter, Ian / Wall, Michael

International wound journal

2023 Volume 20, Issue 8, Page(s) 2998–3005

Abstract: Surgical site infection (SSI) is common following arterial surgery involving a groin incision. There is a lack of evidence regarding interventions to prevent groin wound SSI, therefore, a survey of vascular clinicians was undertaken to assess current ... ...

Abstract	Surgical site infection (SSI) is common following arterial surgery involving a groin incision. There is a lack of evidence regarding interventions to prevent groin wound SSI, therefore, a survey of vascular clinicians was undertaken to assess current opinion and practice, equipoise and feasibility of a randomised controlled trial (RCT). Participants at the Vascular Society of Great Britain and Ireland 2021 Annual Scientific Meeting were surveyed regarding three separate interventions designed to prevent SSI in the groin; impregnated incise drapes, diakylcarbomoyl chloride dressings and antibiotic impregnated collagen sponges. Results were collated via an online survey using the Research Electronic Data Capture platform. Seventy-five participants completed the questionnaire, most were consultant vascular surgeons (50/75, 66.7%). The majority agree that groin wound SSI is a major problem (73/75, 97.3%), and would be content using either of the three interventions (51/61, 83.6%) and had clinical equipoise to randomise patients to any of the three interventions versus standard of care (70/75, 93.3%). There was some reluctance to not use impregnated incise drapes as may be considered "standard of care". Groin wound SSI is perceived as major problem in vascular surgery, and a multicentre RCT of three preventative interventions appears acceptable to vascular surgeons.
MeSH term(s)	Humans ; Groin/surgery ; Surgical Wound Infection/prevention & control ; Feasibility Studies ; Vascular Surgical Procedures/adverse effects ; Surveys and Questionnaires ; Surgical Wound
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14170
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Article ; Online: Clinical statistical analysis plan for the ACCURE trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicentre trial.

Visser, Eva / Heuthorst, Lianne / Pathmakanthan, Shri / Bemelman, Willem A / D'Haens, Geert R / Handley, Kelly / Fakis, Apostolos / Pinkney, Thomas D / Buskens, Christianne J / Dijkgraaf, Marcel G W

Trials

2024 Volume 25, Issue 1, Page(s) 218

Abstract: Background: The primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the clinical course of UC, decreasing the incidence of relapses and reducing need for medication. The ... ...

Abstract	Background: The primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the clinical course of UC, decreasing the incidence of relapses and reducing need for medication. The objective of the ACCURE trial is to assess the efficacy of laparoscopic appendectomy in addition to standard medical treatment in maintaining remission in UC patients. This article presents the statistical analysis plan to evaluate the outcomes of the ACCURE trial. Design and methods: The ACCURE trial was designed as a multicentre, randomised controlled trial. UC patients with a new diagnosis or a disease relapse within the past 12 months, treated with 5-ASA, corticosteroids, or immunomodulators until complete clinical and endoscopic remission (defined as total Mayo score < 3 with endoscopic subscore of 0 or 1), were counselled for inclusion. Also, patients previously treated with biologicals who had a washout period of at least 3 months were considered for inclusion. Patients were randomised (1:1) to laparoscopic appendectomy plus maintenance treatment or a control group (maintenance therapy only). The primary outcome is the 1-year UC relapse rate (defined as a total Mayo-score ≥ 5 with endoscopic subscore of 2 or 3, or clinically as an exacerbation of symptoms and rectal bleeding or FCP > 150 or intensified medical therapy other than 5-ASA therapy). Secondary outcomes include number of relapses per patient, time to first relapse, disease activity, number of colectomies, medication usage, and health-related quality of life. Discussion: The ACCURE trial will provide comprehensive evidence whether adding an appendectomy to maintenance treatment is superior to maintenance treatment only in maintaining remission in UC patients. Trial registration: Dutch Trial Register (NTR) NTR2883 . Registered May 3, 2011. ISRCTN, ISRCTN60945764 . Registered August 12, 2019.
MeSH term(s)	Humans ; Colitis, Ulcerative/drug therapy ; Appendectomy ; Quality of Life ; Remission Induction ; Neoplasm Recurrence, Local ; Mesalamine ; Recurrence ; Disease Progression
Chemical Substances	Mesalamine (4Q81I59GXC)
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-024-08037-5
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Article ; Online: Ulcerative Colitis Is Associated With an Increased Risk of Venous Thromboembolism in the Postoperative Period.

Nepogodiev, Dmitri / Ward, Stephen T / Pinkney, Thomas D

Annals of surgery

2017 Volume 265, Issue 4, Page(s) e43–e44

Language	English
Publishing date	2017-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000001253
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Article ; Online: Ulcerative Colitis Is Associated With an Increased Risk of Venous Thromboembolism in the Postoperative Period.

Nepogodiev, Dmitri / Ward, Stephen T / Pinkney, Thomas D

Annals of surgery

2015

Language	English
Publishing date	2015-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000001253
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Article ; Online: Importance of clinical research for the UK's 10-year cancer plan.

Lee, Richard W / Danson, Sarah / Elliot, Martin / Park, Ed I / Pinkney, Thomas D / Shaw, Clare E / Vimalachandran, Dale / Maughan, Tim / Seymour, Matt / Corrie, Pippa / Wadsley, Jonathan

The Lancet. Oncology

2022 Volume 23, Issue 8, Page(s) 975–978

MeSH term(s)	Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; United Kingdom/epidemiology
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(22)00292-3
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 460: Show issues

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Article ; Online: A pilot observational study measuring acute sarcopenia in older colorectal surgery patients.

Welch, Carly / Greig, Carolyn A / Hassan-Smith, Zaki K / Pinkney, Thomas D / Lord, Janet M / Jackson, Thomas A

BMC research notes

2019 Volume 12, Issue 1, Page(s) 24

Abstract: Objective: To explore variability in acute changes in muscle mass and function in older patients undergoing elective colorectal surgery, as well as feasibility of measures, in order to refine study processes to inform the protocol for a larger study.: ...

Abstract	Objective: To explore variability in acute changes in muscle mass and function in older patients undergoing elective colorectal surgery, as well as feasibility of measures, in order to refine study processes to inform the protocol for a larger study. Results: Results are presented for seven participants recruited to this pilot study. It is possible to perform serial measurements of bilateral anterior thigh thickness (BATT) and handgrip strength prior to, within 24 h of surgery, and 1 week postoperatively. Gait speed can be reliably measured preoperatively and at 1 week postoperatively. In this pilot study, BATT and gait speed declined at 1 week postoperatively (median BATT 4.17 cm, 3.47 cm, p = 0.028; median gait speed 0.89 m/s, 0.83 m/s, p = 0.043). Baseline hsCRP correlated with change in BATT (τb = 0.73, p = 0.04) and baseline DHEA-S correlated with change in gait speed (τb = 0.87, p = 0.02). This pilot study has assisted to refine the protocol for our larger study, which will further characterise these changes.
MeSH term(s)	Acute Disease ; Aged ; Biomarkers ; Colorectal Surgery/adverse effects ; Feasibility Studies ; Female ; Follow-Up Studies ; Geriatric Assessment ; Humans ; Male ; Pilot Projects ; Postoperative Complications/blood ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Sarcopenia/blood ; Sarcopenia/diagnostic imaging ; Sarcopenia/etiology ; Sarcopenia/physiopathology ; Walking Speed/physiology
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-01-14
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-019-4049-y
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Article ; Online: Protocol for the UK cohort study to investigate the prevention of parastomal hernia (the CIPHER study).

Tabusa, Hana / Blazeby, Jane M / Blencowe, Natalie / Callaway, Mark / Daniels, Ian R / Gunning, Amanda / Hollingworth, William / McNair, Augus G / Murkin, Charlotte / Pinkney, Thomas D / Rogers, Chris A / Smart, Neil J / Reeves, Barnaby C

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 7, Page(s) 1900–1908

Abstract: Aim: Abdominal surgery sometimes necessitates the creation of a stoma, which can cause future complications including parastomal hernia (PSH), an incisional hernia adjacent to and related to the stoma. PSH affects approximately 40% of patients within 2 ... ...

Abstract	Aim: Abdominal surgery sometimes necessitates the creation of a stoma, which can cause future complications including parastomal hernia (PSH), an incisional hernia adjacent to and related to the stoma. PSH affects approximately 40% of patients within 2 years of stoma formation. Complications of PSH reduce a patient's quality of life and can be severe (e.g. bowel obstruction). PSHs are difficult to manage and can recur after surgical repair. Therefore, it is very important to prevent a PSH. Surgeons create stomas in different ways and both patient and surgical factors are believed to influence the development of PSH. The aim of the CIPHER study is to investigate the influence of different surgical techniques on the development of PSH. Method: The UK cohort study to investigate the prevention of parastomal hernia (the CIPHER study) aims to recruit 4000 patients undergoing elective or expedited surgery with the intention of forming an ileostomy or colostomy, irrespective of the primary indication for the planned surgery. For each patient, surgeons will describe their methods of trephine formation, mesh reinforcement of the stoma trephine, use of the stoma as a specimen extraction site and wound closure. The primary outcome will be incident PSH during follow-up, defined as symptoms of PSH (custom-designed questionnaire) and anatomical PSH, ascertained by independent reading of usual care CT scans. Secondary outcomes will include surgical site infection, the Comprehensive Complication Index, quality of life (EQ-5D-5L and SF-12), PSH repair and use of NHS resources. Results: Results of the study will be submitted for publication in peer-reviewed journals. All publications relating to the results of CIPHER will use a corporate authorship, 'The CIPHER Study Investigators' with named writing committee members. Conclusion: The CIPHER study will be the first to investigate detailed surgical methods of stoma formation in a large, representative cohort of patients with a range of primary indications, both cancer and noncancer.
MeSH term(s)	Cohort Studies ; Colostomy ; Hernia, Ventral/etiology ; Hernia, Ventral/surgery ; Humans ; Incisional Hernia/etiology ; Incisional Hernia/prevention & control ; Neoplasm Recurrence, Local ; Quality of Life ; Surgical Mesh ; Surgical Stomas/adverse effects ; United Kingdom
Language	English
Publishing date	2021-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15621
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Article ; Online: Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study.

Myrelid, Pär / Landerholm, Kalle / Nordenvall, Caroline / Pinkney, Thomas D / Andersson, Roland E

The American journal of gastroenterology

2017 Volume 112, Issue 8, Page(s) 1311–1319

Abstract: Objectives: Ulcerative colitis (UC) is a chronic inflammatory disease usually responding well to anti-inflammatory drugs but many patients will still need colectomy. Appendectomy is associated with a lower risk of later developing UC. We aimed to assess ...

Abstract	Objectives: Ulcerative colitis (UC) is a chronic inflammatory disease usually responding well to anti-inflammatory drugs but many patients will still need colectomy. Appendectomy is associated with a lower risk of later developing UC. We aimed to assess the longitudinal relationship between appendectomy, appendicitis, and disease course in UC patients. Methods: A national cohort of UC patients with a diagnosis in 1964-2010 was identified from the Swedish National Patient Register that also provided information regarding appendicitis and/or appendectomy before or after the UC diagnosis. The risk for colectomy and UC-related hospital admissions was evaluated. Results: Among 63,711 UC patients, 2,143 had appendectomy and 7,690 underwent colectomy. Appendectomy for appendicitis before 20 years of age and for non-appendicitis at all ages before UC diagnosis was associated with a lower risk of colectomy (hazard ratio (HR) 0.44, 0.27-0.72 and HR 0.62, 0.43-0.90, respectively), and fewer hospital admissions (incidence rate ratio (IRR) 0.68, 95% confidence interval (CI) 0.64-0.73 and IRR 0.54, 0.47-0.63, respectively). Appendectomy for appendicitis after the UC diagnosis was associated with a higher risk of colectomy (HR 1.56, 1.20-2.03), whereas no such association was found for other pathology (HR 1.40, 0.79-2.47). Conclusions: Appendectomy early in life and before developing UC is associated with a lower risk of colectomy as well as UC-related hospital admissions. Appendectomy for appendicitis after established UC appears associated with a worse disease course, with an increased rate of subsequent colectomy.
MeSH term(s)	Adult ; Age Factors ; Aged ; Appendectomy ; Cohort Studies ; Colectomy ; Colitis, Ulcerative/surgery ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Patient Admission ; Protective Factors ; Registries ; Risk Factors ; Young Adult
Language	English
Publishing date	2017-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.1038/ajg.2017.183
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Article ; Online: Adapting to ulcerative colitis to try to live a 'normal' life: a qualitative study of patients' experiences in the Midlands region of England.

McMullan, Christel / Pinkney, Thomas D / Jones, Laura L / Magill, Laura / Nepogodiev, Dmitri / Pathmakanthan, Shri / Cooney, Rachel / Mathers, Jonathan M

BMJ open

2017 Volume 7, Issue 8, Page(s) e017544

Abstract: Objective: To provide a framework that is able to categorise whether patients are able to adapt to and lead a 'normal' life with ulcerative colitis (UC) and to detail the factors that influence this.: Design: Qualitative research study using in-depth ...

Abstract	Objective: To provide a framework that is able to categorise whether patients are able to adapt to and lead a 'normal' life with ulcerative colitis (UC) and to detail the factors that influence this. Design: Qualitative research study using in-depth semi-structured interviews. Setting: Four clinical sites in the West and East Midlands regions of England. Participants: 28 adult patients diagnosed with UC for years between 1 and 22. Results: Medication was rarely sufficient for patients to adapt to UC and live as 'normal' a life as possible. Virtually all patients tested and adopted non-medical adaptation methods to improve physical and psychological well-being, to help them carry on working and to prevent embarrassment. In addition, some patients benefited from outside support providing them with practical, emotional and/or financial help. In conjunction with adaptation strategies and the time to adapt, this meant that some patients with severe clinical disease were able to maintain a sense of normality in life. Patients reported that clinicians were not always receptive to discussion of the broader context of life with UC. Conclusions: Patients' experience of UC and their ability to adapt in order to maintain a sense of normality in life is a complex interplay of symptoms, adaptation strategies and outside support. Over time patients test out a variety of non-medical adaptation strategies. Awareness of this may help clinicians and researchers to understand patients' views on the role of medical and other therapies. Further research around the utility of this framework in clinical practice and research is now required. Trial registration number: ISRCTN56523019, results.
MeSH term(s)	Adalimumab/therapeutic use ; Adaptation, Psychological ; Adolescent ; Adult ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/psychology ; England ; Female ; Humans ; Infliximab/therapeutic use ; Interviews as Topic ; Male ; Middle Aged ; Qualitative Research ; Quality of Life ; Young Adult
Chemical Substances	Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2017-08-21
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2017-017544
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