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  1. Article ; Online: Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp

    Xinyang Li / Jinzhong Xu / Pinmei Wang / Wanjing Ding

    Mycology, Vol 14, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: ABSTRACTFour dimeric diketopiperazine stereoisomers (1–4) including two new ones (1–2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner ... ...

    Abstract ABSTRACTFour dimeric diketopiperazine stereoisomers (1–4) including two new ones (1–2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey’s method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.
    Keywords Indole diketopiperazine ; dimer ; stereoisomers ; gut fungus ; Biology (General) ; QH301-705.5 ; Microbiology ; QR1-502
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters

    Wenjie Wang / Yuchao Yu / Nancy P. Keller / Pinmei Wang

    International Journal of Molecular Sciences, Vol 22, Iss 8709, p

    2021  Volume 8709

    Abstract: Fungal secondary metabolites are renowned toxins as well as valuable sources of antibiotics, cholesterol-lowering drugs, and immunosuppressants; hence, great efforts were levied to understand how these compounds are genetically regulated. The genes ... ...

    Abstract Fungal secondary metabolites are renowned toxins as well as valuable sources of antibiotics, cholesterol-lowering drugs, and immunosuppressants; hence, great efforts were levied to understand how these compounds are genetically regulated. The genes encoding for the enzymes required for synthesizing secondary metabolites are arranged in biosynthetic gene clusters (BGCs). Often, BGCs contain a pathway specific transcription factor (PSTF), a valuable tool in shutting down or turning up production of the BGC product. In this review, we present an in-depth view of PSTFs by examining over 40 characterized BGCs in the well-studied fungal species Aspergillus nidulans and Aspergillus fumigatus . Herein, we find BGC size is a predictor for presence of PSTFs, consider the number and the relative location of PSTF in regard to the cluster(s) regulated, discuss the function and the evolution of PSTFs, and present application strategies for pathway specific activation of cryptic BGCs.
    Keywords pathway specific transcription factor ; transcription factor ; Aspergillus ; regulation ; evolution ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Recent Advances in the Heterologous Expression of Biosynthetic Gene Clusters for Marine Natural Products

    Yushan Xu / Xinhua Du / Xionghui Yu / Qian Jiang / Kaiwen Zheng / Jinzhong Xu / Pinmei Wang

    Marine Drugs, Vol 20, Iss 341, p

    2022  Volume 341

    Abstract: Marine natural products (MNPs) are an important source of biologically active metabolites, particularly for therapeutic agent development after terrestrial plants and nonmarine microorganisms. Sequencing technologies have revealed that the number of ... ...

    Abstract Marine natural products (MNPs) are an important source of biologically active metabolites, particularly for therapeutic agent development after terrestrial plants and nonmarine microorganisms. Sequencing technologies have revealed that the number of biosynthetic gene clusters (BGCs) in marine microorganisms and the marine environment is much higher than expected. Unfortunately, the majority of them are silent or only weakly expressed under traditional laboratory culture conditions. Furthermore, the large proportion of marine microorganisms are either uncultivable or cannot be genetically manipulated. Efficient heterologous expression systems can activate cryptic BGCs and increase target compound yield, allowing researchers to explore more unknown MNPs. When developing heterologous expression of MNPs, it is critical to consider heterologous host selection as well as genetic manipulations for BGCs. In this review, we summarize current progress on the heterologous expression of MNPs as a reference for future research.
    Keywords marine natural products ; heterologous expression ; heterologous hosts ; biosynthetic gene clusters ; genetic manipulation ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  4. Article ; Online: Two Novel Aspochalasins from the Gut Fungus Aspergillus sp. Z4

    Xinyang Li / Wanjing Ding / Pinmei Wang / Jinzhong Xu

    Marine Drugs, Vol 16, Iss 10, p

    2018  Volume 343

    Abstract: Two novel aspochalasins, tricochalasin A (1) and aspochalasin A2 (2), along with three known compounds (3–5) have been isolated from the different culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. Compound 1 ... ...

    Abstract Two novel aspochalasins, tricochalasin A (1) and aspochalasin A2 (2), along with three known compounds (3–5) have been isolated from the different culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. Compound 1 contains a rare 5/6/6 tricyclic ring fused with the aspochalasin skeleton. The structures were determined on the basis of electrospray ionisation mass spectroscopy (ESIMS), nuclear magnetic resonance (NMR) spectral data, and the absolute configurations were further confirmed by modified Mosher’s method. Cytotoxicity against the prostate cancer PC3 cell line were assayed by the MTT method. Compound 3 showed strong activity while the remaining compounds showed weak activity.
    Keywords aspochalasin ; tricyclic fused ; gut fungus ; cytotoxicity ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Letenketals A and B, two novel spirocyclic polyketides from a marine crab-derived Letendraea sp. fungus

    Huang, Ruibao / Bin Ye / Jinzhong Xu / Pinmei Wang / Wanjing Ding / Yan Xu

    Phytochemical Society of Europe Phytochemistry letters. 2019 Apr., v. 30

    2019  

    Abstract: Two novel spiroketals, named as letenketals A and B, had been isolated from the cultural broth of marine fungal Letendraea sp. Two compounds were stereoisomers and contained the new carbon skeleton including benzodihydropyran ring and one tetrahydrofuran ...

    Abstract Two novel spiroketals, named as letenketals A and B, had been isolated from the cultural broth of marine fungal Letendraea sp. Two compounds were stereoisomers and contained the new carbon skeleton including benzodihydropyran ring and one tetrahydrofuran ring, which connected as spiro-fused ring system through one ketal carbon. Their relative and absolute configurations were determined by the 2D-NMR analysis together with single-crystal X-ray diffraction. The antibacterial and cytotoxic activities of letenketals were tested.
    Keywords carbon ; cytotoxicity ; fungi ; nuclear magnetic resonance spectroscopy ; polyketides ; stereoisomers ; tetrahydrofuran ; X-ray diffraction
    Language English
    Dates of publication 2019-04
    Size p. 165-168.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2019.01.033
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: New asymmetrical bispyrrolidinoindoline diketopiperazines from the marine fungus Aspergillus sp. DX4H

    Xu, Jinzhong / Pinmei Wang / Qian Hu / Wanjing Ding / Yanan Di

    Natural product research. 2018 Apr. 3, v. 32, no. 7

    2018  

    Abstract: Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1–3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques ... ...

    Abstract Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1–3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey’s method. Their inhibitory activity against PC3 cell line had been tested.
    Keywords Aspergillus ; cell lines ; culture media ; digestive system ; diketopiperazines ; marine fungi ; nuclear magnetic resonance spectroscopy ; stereochemistry ; stereoisomers
    Language English
    Dates of publication 2018-0403
    Size p. 815-820.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2017.1363752
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2

    Yan Xu / Ruibao Huang / Hongwei Liu / Tingting Yan / Wanjing Ding / Yongjun Jiang / Pinmei Wang / Daoqiong Zheng / Jinzhong Xu

    Marine Drugs, Vol 18, Iss 1, p

    2019  Volume 18

    Abstract: Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D−G ( 1 − ...

    Abstract Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D−G ( 1 − 4 ) and letendronols A−C ( 5 − 7 )) as well as one known xylarinol ( 8 ) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher’s method. Compound 2 showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC 50 value of 86 μM.
    Keywords marine-derived fungus ; letendraea sp ; polyketide ; phomopsiketone ; letendronol ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Aspochalazine A, a Novel Polycyclic Aspochalasin From the Fungus Aspergillus sp. Z4

    Li, Xinyang / Zhanhai Zhao / Wanjing Ding / Bin Ye / Pinmei Wang / Jinzhong Xu

    Tetrahedron letters. 2017,

    2017  

    Abstract: A novel polycyclic aspochalasin, aspochalazine A (1), was isolated along with three related known compounds 2-4 from the culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the ...

    Abstract A novel polycyclic aspochalasin, aspochalazine A (1), was isolated along with three related known compounds 2-4 from the culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of ESI-MS, NMR spectrum data and single-crystal X-ray diffraction. This is the first report about aspochalasin derivative with an azabicyclo. Cytotoxicity against the prostate cancer PC3 cell line was assayed by MTT method. Aspochalazine A showed weak activity. A plausible biosynthetic pathway for aspochalazine A was proposed.
    Keywords Aspergillus ; Ligia ; X-ray diffraction ; biochemical pathways ; chemical reactions ; chemical structure ; culture media ; cytotoxicity ; digestive system ; electrospray ionization mass spectrometry ; fungi ; nuclear magnetic resonance spectroscopy ; organic compounds ; prostatic neoplasms
    Language English
    Size p. .
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2017.04.071
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  9. Article ; Online: Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.

    Ying Liu / Shizhe Zhao / Wanjing Ding / Pinmei Wang / Xianwen Yang / Jinzhong Xu

    Marine Drugs, Vol 12, Iss 10, Pp 5124-

    2014  Volume 5131

    Abstract: Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were ... ...

    Abstract Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively.
    Keywords gut fungi ; Aspergillus sp ; aspochalasin ; methylthiol ; cytotoxicity ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2014-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A novel strategy to construct yeast Saccharomyces cerevisiae strains for very high gravity fermentation.

    Xianglin Tao / Daoqiong Zheng / Tianzhe Liu / Pinmei Wang / Wenpeng Zhao / Muyuan Zhu / Xinhang Jiang / Yuhua Zhao / Xuechang Wu

    PLoS ONE, Vol 7, Iss 2, p e

    2012  Volume 31235

    Abstract: Very high gravity (VHG) fermentation is aimed to considerably increase both the fermentation rate and the ethanol concentration, thereby reducing capital costs and the risk of bacterial contamination. This process results in critical issues, such as ... ...

    Abstract Very high gravity (VHG) fermentation is aimed to considerably increase both the fermentation rate and the ethanol concentration, thereby reducing capital costs and the risk of bacterial contamination. This process results in critical issues, such as adverse stress factors (ie., osmotic pressure and ethanol inhibition) and high concentrations of metabolic byproducts which are difficult to overcome by a single breeding method. In the present paper, a novel strategy that combines metabolic engineering and genome shuffling to circumvent these limitations and improve the bioethanol production performance of Saccharomyces cerevisiae strains under VHG conditions was developed. First, in strain Z5, which performed better than other widely used industrial strains, the gene GPD2 encoding glycerol 3-phosphate dehydrogenase was deleted, resulting in a mutant (Z5ΔGPD2) with a lower glycerol yield and poor ethanol productivity. Second, strain Z5ΔGPD2 was subjected to three rounds of genome shuffling to improve its VHG fermentation performance, and the best performing strain SZ3-1 was obtained. Results showed that strain SZ3-1 not only produced less glycerol, but also increased the ethanol yield by up to 8% compared with the parent strain Z5. Further analysis suggested that the improved ethanol yield in strain SZ3-1 was mainly contributed by the enhanced ethanol tolerance of the strain. The differences in ethanol tolerance between strains Z5 and SZ3-1 were closely associated with the cell membrane fatty acid compositions and intracellular trehalose concentrations. Finally, genome rearrangements in the optimized strain were confirmed by karyotype analysis. Hence, a combination of genome shuffling and metabolic engineering is an efficient approach for the rapid improvement of yeast strains for desirable industrial phenotypes.
    Keywords Medicine ; R ; Science ; Q
    Subject code 660
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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