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  1. Article ; Online: Detection of Circulating and Tissue Myeloid-Derived Suppressor Cells (MDSC) by Flow Cytometry.

    Sanchez-Pino, Maria Dulfary

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2422, Page(s) 247–261

    Abstract: Flow cytometry allows the multiparameter analysis of heterogeneous cell populations and is an essential tool for detecting and characterizing different cell populations from peripheral blood and dissociated tissues. Myeloid-derived suppressor cells (MDSC) ...

    Abstract Flow cytometry allows the multiparameter analysis of heterogeneous cell populations and is an essential tool for detecting and characterizing different cell populations from peripheral blood and dissociated tissues. Myeloid-derived suppressor cells (MDSC) are a heterogeneous and plastic group of myeloid precursors with immune-suppressive capacity, which are a characteristic feature of chronic inflammation, such as cancer. The optimal measurement of MDSC levels could be used as a biomarker for clinicians for prognosis and/or management and for researchers to track and understand the role of MDSC in different pathological diseases.The criteria for defining MDSC include phenotypic surface markers, but ideally should also include the functional immunosuppressive effect on T cells, and, if possible, assessing the main biochemical and molecular features. Two major functional mechanisms to suppress T cell responses are the production of arginase-1 and reactive oxygen species (ROS) molecules. Here is presented a nine-parameter seven-color flow cytometric assay to identify and quantify MDSC from both peripheral blood mononuclear cells (PBMC) and dissociated tissue (e.g., tumor) by using fluorescence-tagged antibodies against surface markers. Also, the intracellular levels of arginase-1 and superoxide (O
    MeSH term(s) Arginase ; Biomarkers ; Flow Cytometry ; Humans ; Leukocytes, Mononuclear ; Myeloid-Derived Suppressor Cells ; Neoplasms
    Chemical Substances Biomarkers ; Arginase (EC 3.5.3.1)
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1948-3_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: To Boost or Not to Boost: Acceptability of a COVID-19 Booster Dose among Osteopathic Medical Students: A Cross-Sectional Study from a Medical School in New York.

    Al Janabi, Taysir / Pino, Maria

    Epidemiolgia (Basel, Switzerland)

    2022  Volume 3, Issue 2, Page(s) 218–228

    Abstract: The COVID-19 pandemic continues to evolve, with new variants emerging and vaccine-induced immunity waning. Protecting and retaining the healthcare force remains crucial in fighting this pandemic, as healthcare workers (HCWs) are a critical driver in ... ...

    Abstract The COVID-19 pandemic continues to evolve, with new variants emerging and vaccine-induced immunity waning. Protecting and retaining the healthcare force remains crucial in fighting this pandemic, as healthcare workers (HCWs) are a critical driver in increasing vaccine uptake among the public. This study explored the uptake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) booster shots among medical students at the New York Institute of Technology College of Osteopathic Medicine (NYITCOM). Predictors for actual booster uptake were also examined. An electronic survey was distributed to Osteopathic Medical Students (OMS I-IV) in January 2022. The survey was distributed to 1762 students total, with 319 responses received (18%). Of those who responded, 70.2% (224/319) reported that they had already received a booster, while 29.5% (94/319) reported they had not yet received it. We identified that pharmaceutical mistrust, building long-lasting immunity via vaccines, and vaccines' adverse effects were the most significant predictors for how willing participants were to accept a booster dose. Vaccine hesitancy around the COVID-19 booster was prevalent during the surge of the highly transmissible variant Omicron. This finding necessitates some evidence-based approaches to enhance booster uptake among a population subgroup whose impact is critical.
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3986
    ISSN (online) 2673-3986
    DOI 10.3390/epidemiologia3020017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Association between Working Memory and Divergent Thinking: The Moderating Role of Formal Musical Background.

    Pino, Maria Chiara / Giancola, Marco / Palmiero, Massimiliano / D'Amico, Simonetta

    Brain sciences

    2024  Volume 14, Issue 1

    Abstract: Divergent thinking (DT) is widely considered an essential cognitive dimension of creativity, which involves goal-oriented processes, including working memory (WM), which allows for retrieving and loading of information into the attentional stream and, ... ...

    Abstract Divergent thinking (DT) is widely considered an essential cognitive dimension of creativity, which involves goal-oriented processes, including working memory (WM), which allows for retrieving and loading of information into the attentional stream and, consequently, enhancing divergence of thinking. Despite the critical role of WM in DT, little work has been done on the mechanism affecting this interplay. The current study addressed the involvement of a formal musical background in the relationship between WM and DT and was conducted with 83 healthy young adults (M = 19.64 years; SD = 0.52 years; 33 females). The participants were requested to indicate if they had a formal background in music in the conservatory (M = 4.78 years; SD = 5.50 years) as well as perform the digit span forward test (DSFT) and the alternative uses task-AUT from the Torrance test of creative thinking (TTCT). The results indicated that years of formal musical background moderated the association between WM and DT. These findings suggest that music enhances the positive effect of high-order cognitive processes, such as WM, on the ability to think divergently. Theoretical and practical implications as well as limitations were discussed.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14010061
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  4. Article: The Association between Music and Language in Children: A State-of-the-Art Review.

    Pino, Maria Chiara / Giancola, Marco / D'Amico, Simonetta

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 5

    Abstract: Music and language are two complex systems that specifically characterize the human communication toolkit. There has been a heated debate in the literature on whether music was an evolutionary precursor to language or a byproduct of cognitive faculties ... ...

    Abstract Music and language are two complex systems that specifically characterize the human communication toolkit. There has been a heated debate in the literature on whether music was an evolutionary precursor to language or a byproduct of cognitive faculties that developed to support language. The present review of existing literature about the relationship between music and language highlights that music plays a critical role in language development in early life. Our findings revealed that musical properties, such as rhythm and melody, could affect language acquisition in semantic processing and grammar, including syntactic aspects and phonological awareness. Overall, the results of the current review shed further light on the complex mechanisms involving the music-language link, highlighting that music plays a central role in the comprehension of language development from the early stages of life.
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10050801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Predictors for Actual COVID-19 Vaccine Uptake and Intended Booster Dosage among Medical Students of an Osteopathic Medical School in New York.

    Al Janabi, Taysir / Pino, Maria

    Epidemiolgia (Basel, Switzerland)

    2021  Volume 2, Issue 4, Page(s) 553–563

    Abstract: Exploring future physicians' attitudes toward vaccination is crucial as physicians' recommendation is the top predictor for individuals to receive vaccines. This study explored the uptake of COVID-19 vaccines and the intention for future booster dose ... ...

    Abstract Exploring future physicians' attitudes toward vaccination is crucial as physicians' recommendation is the top predictor for individuals to receive vaccines. This study explored the uptake of COVID-19 vaccines and the intention for future booster dose uptake among students at the New York Institute of Technology College of Osteopathic Medicine (NYITCOM). Predictors for actual vaccine and intended booster uptake were also examined. An electronic survey was distributed to Osteopathic Medical Students (OMS I-IV) in the Spring of 2021. A total of 1331 students received the survey, with 316 responses received (24%). In total, 95.3% (301/316) of the respondents reported that they already received vaccines, while 3.1% (13/316) reported that they had not yet received a vaccine. Moreover, 88.9% of the respondents (281/316) were in favor of a booster dose, which was a strong predictor for actual vaccine uptake. We identified that the Asian race, pharmaceutical mistrust, building immunity via vaccines, adequate vaccine testing, and willingness to get non-U.S. manufactured vaccines are the most significant predictors for willingness to accept a booster dose. A very high COVID-19 vaccine uptake among NYITCOM OMS was found in our study. The study also observed a high acceptance of an additional dose of the COVID-19 vaccine in the future.
    Language English
    Publishing date 2021-11-20
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3986
    ISSN (online) 2673-3986
    DOI 10.3390/epidemiologia2040038
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  6. Article: How Do Children "Think outside the Box"? Fluid Intelligence and Divergent Thinking: A Moderated Mediation Study of Field Dependent-Independent Cognitive Style and Gender.

    Giancola, Marco / Palmiero, Massimiliano / Pino, Maria Chiara / Sannino, Marta / D'Amico, Simonetta

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 1

    Abstract: The interplay between fluid intelligence (Gf) and divergent thinking (DT) has widely characterized current research in the psychology of creativity. Nevertheless, the evidence on the main factors involved in this association during childhood remains a ... ...

    Abstract The interplay between fluid intelligence (Gf) and divergent thinking (DT) has widely characterized current research in the psychology of creativity. Nevertheless, the evidence on the main factors involved in this association during childhood remains a matter of debate. Present research has addressed the interplay between Gf and DT, exploring the mediating role of a field dependent-independent cognitive style (FDI) and the moderating effect of gender in 101 children (M
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11010089
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  7. Article ; Online: Long-term impact of spinal cord stimulation in FBSS patients: A retrospective ten-year analysis.

    Cipollina, Giuseppe / Brunasso, Lara / Basile, Luigi / Pino, Maria Angela / Iacopino, Domenico Gerardo / Maugeri, Rosario

    Pain practice : the official journal of World Institute of Pain

    2024  

    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Letter
    ZDB-ID 2151272-3
    ISSN 1533-2500 ; 1530-7085
    ISSN (online) 1533-2500
    ISSN 1530-7085
    DOI 10.1111/papr.13343
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5928: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Conference proceedings: Proceedings of the XIV International Symposium on Processing Tomato

    Argerich, Cosme A. / Cámara Hurtado, Montaña / Piño, María Teresa / Colvine, Sophie

    Santiago, Chile, March 6 - 9, 2016

    (Acta horticulturae ; 1159)

    2017  

    Title variant XIV International Symposium on Processing Tomato
    Institution International Society for Horticultural Science / Section Vegetables, Quality Production Systems, Leafy Green and Non-Root Vegetables
    International Society for Horticultural Science / Working Group on Production of Vegetables for Processing
    Event/congress International Symposium on Processing Tomato (14., 2016, Santiago)
    Author's details [editors C. Argerich, M. Cámara, S. Colvine]. Conveners C. Argerich, M. Cámara, M. T. Piño. ISHS Section Vegetables, Quality Production Systems, Leafy Green and Non-Root Vegetables, ISHS Working Group Production of Vegetables for Processing
    Series title Acta horticulturae ; 1159
    Collection
    Language English
    Size xxii, 236 Seiten, Illustrationen, Diagramme
    Publisher ISHS Secretariat
    Publishing place Leuven, Belgium
    Publishing country Belgium
    Document type Book ; Conference proceedings
    HBZ-ID HT019370343
    ISBN 978-94-6261-154-2 ; 94-6261-154-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    178/303 available for loan (reading room) Freihandmagazin (U1)

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  9. Article: Preschoolers' Perceptual Analogical Reasoning and Map Reading: A Preliminary Study on the Mediating Effect of Spatial Language.

    Giancola, Marco / Pino, Maria Chiara / Riccio, Valentina / Piccardi, Laura / D'Amico, Simonetta

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 4

    Abstract: Reading and interpreting a map represents an essential part of daily life, enabling appropriate orientation and navigation through space. Based on the idea that perceptual analogical reasoning is critical in aligning the spatial structure of the map with ...

    Abstract Reading and interpreting a map represents an essential part of daily life, enabling appropriate orientation and navigation through space. Based on the idea that perceptual analogical reasoning is critical in aligning the spatial structure of the map with the spatial structure of the space and given the critical role of language, especially spatial language, in encoding and establishing spatial relations among elements in the environment, the present study investigated the joint contribution of perceptual analogical reasoning and spatial language in map reading. The study was conducted with 56 typically developing 4- to 6-year-old children, and the results indicated that perceptual abstract reasoning affected map reading through the mediating effect of spatial language. These findings yielded theoretical and practical implications regarding the role of perceptual abstract reasoning and spatial language in shaping map-reading abilities in the early stages of life, highlighting that domain-specific language competencies are necessary to improve the encoding of spatial relations, to establish object correspondences, and to ensure successful navigation. Limitations and future research directions were discussed.
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10040630
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  10. Article: Soluble guanylyl cyclase beta1 subunit targets epithelial-to-mesenchymal transition and downregulates Akt pathway in human endometrial and cervical cancer cells.

    Acosta, Lucas H / Pino, María Teresa L / Rocca, María Victoria / Cabilla, Jimena P

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23927

    Abstract: Endometrial and cervical cancer are among the most frequently diagnosed malignancies globally. Nitric oxide receptor-soluble guanylyl cyclase (sGC) is a heterodimeric enzyme composed of two subunits, α1 and β1. Previously we showed that sGCα1 subunit ... ...

    Abstract Endometrial and cervical cancer are among the most frequently diagnosed malignancies globally. Nitric oxide receptor-soluble guanylyl cyclase (sGC) is a heterodimeric enzyme composed of two subunits, α1 and β1. Previously we showed that sGCα1 subunit promotes cell survival, proliferation, and migration, but the role of sGCβ1 subunit has not been addressed. The aim of the present work was to study the impact of sGCβ1 restoration in proliferation, survival, migration, and cell signaling in endometrial and cervical cancer cells. We found that sGCβ1 transcript levels are reduced in endometrial and cervical tumors vs normal tissues. We confirmed nuclear enrichment of sGCβ1, unlike sGCα1. Overexpression of sGCβ1 reduced cell viability and augmented apoptotic index. Cell migration and invasion were also negatively affected. All these sGCβ1-driven effects were independent of sGC enzymatic activity. sGCβ1 reduced the expression of epithelial-to-mesenchymal transition factors such as N-cadherin and β-catenin and increased the expression of E-cadherin. sGCβ1 impacted signaling in endometrial and cervical cancer cells through significant downregulation of Akt pathway affecting some of its main targets such as GSK-3β and c-Raf. Our results show for the first time that sGCβ1 exerts several antiproliferative actions in ECC-1 and HeLa cell lines by targeting key regulatory pathways.
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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