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Article ; Online: Colonic bacterial diversity and dysbiosis in active microscopic colitis as compared to chronic diarrhoea and healthy controls: effect of polyethylene glycol after bowel lavage for colonoscopy.

Batista, Lissette / Robles, Virginia / Manichanh, Chaysavanh / Ruiz, Laura / Guagnozzi, Danila / Pinsach, Ferran / Guarner, Francisco / Fernández-Bañares, Fernando

BMC gastroenterology

2022  Volume 22, Issue 1, Page(s) 320

Abstract: Background: Most microbiota studies in microscopic colitis patients are performed after diagnostic colonoscopy without considering the potential effect of colonic lavage. Patients may achieve clinical remission after colonoscopy and it is unknown ... ...

Abstract Background: Most microbiota studies in microscopic colitis patients are performed after diagnostic colonoscopy without considering the potential effect of colonic lavage. Patients may achieve clinical remission after colonoscopy and it is unknown whether lavage-induced changes play a role.
Aim: To assess the effect of polyethylene glycol (PEG) colonic lavage on clinical remission rate, microbial diversity, microbial dysbiosis index and specific microbial changes in patients with active microscopic colitis as compared to other diarrhoeal diseases and healthy controls.
Methods: Fifty-five consecutive patients presenting chronic watery diarrhoea and 12 healthy controls were included. Faecal samples were collected three days before and 30 days after PEG in patients and controls for microbiome analysis.
Results: Clinical remission was observed in 53% of microscopic colitis patients, and in 32% of non-microscopic colitis patients (p = 0.16). Considering patients with persisting diarrhoea after colonoscopy, 71% of non-microscopic colitis patients had bile acid diarrhoea. Baseline Shannon Index was lower in diarrhoea groups than in healthy controls (p = 0.0025); there were no differences between microscopic colitis, bile-acid diarrhoea and functional diarrhoea. The microbial dysbiosis index was significantly higher in microscopic colitis than in bile acid diarrhoea plus functional diarrhoea (p = 0.0095), but no bacterial species showed a significantly different relative abundance among the diarrheal groups.
Conclusions: Dysbiosis is a feature in active microscopic colitis, but loss of microbial diversity was similar in all diarrheal groups, suggesting that faecal microbial changes are not due to microscopic colitis itself but associated with stool form. A considerable number of microscopic colitis patients achieved clinical remission after colonoscopy, but we were unable to demonstrate related PEG-induced changes in faecal microbiome.
MeSH term(s) Bile Acids and Salts ; Colitis, Microscopic ; Colonoscopy ; Diarrhea/complications ; Dysbiosis ; Humans ; Polyethylene Glycols/therapeutic use ; Therapeutic Irrigation
Chemical Substances Bile Acids and Salts ; Polyethylene Glycols (3WJQ0SDW1A)
Language English
Publishing date 2022-06-28
Publishing country England
Document type Journal Article
ZDB-ID 2041351-8
ISSN 1471-230X ; 1471-230X
ISSN (online) 1471-230X
ISSN 1471-230X
DOI 10.1186/s12876-022-02392-w
Database MEDical Literature Analysis and Retrieval System OnLINE

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