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Article ; Online: Heavy Metals and Essential Elements in Association with Oxidative Stress in Women with Polycystic Ovary Syndrome—A Systematic Review

Srnovršnik, Tinkara / Virant-Klun, Irma / Pinter, Bojana

Antioxidants. 2023 July 07, v. 12, no. 7

2023

Abstract: Altered levels of heavy metals and essential elements have been associated with oxidative stress (OS) and metabolic and hormonal changes in women with polycystic ovary syndrome (PCOS). We aimed to summarize the knowledge on the association of heavy ... ...

Abstract	Altered levels of heavy metals and essential elements have been associated with oxidative stress (OS) and metabolic and hormonal changes in women with polycystic ovary syndrome (PCOS). We aimed to summarize the knowledge on the association of heavy metals and essential elements with OS in PCOS. An electronic literature search using PubMed for studies published between January 2008 and April 2023 was conducted. We evaluated heavy metals and essential elements in relation to OS in PCOS in 15 articles. PCOS women had increased antimonium (Sb), cadmium (Cd), lead (Pb), mercury (Hg), arsenic (As), tellurium (Te), thallium (Tl) and osmium (Os) blood levels and decreased zinc (Zn) blood levels; the results of copper (Cu) blood levels were conflicting. Some studies showed a significant correlation between heavy metals (Sb, Cd, Pb, Hg, As, Te and Tl) and essential elements (Se, Zn, Cr, Ca, Mg and Cu) and markers of OS and chronic inflammation. Heavy metals (Sb, Cd, Pb and Hg) and essential elements (Zn, Cr, Se, Ca, Mg and Cu) were associated with metabolic and hormonal characteristics in PCOS. There might be a possible benefit from supplementation therapy in reducing OS and endocrinological problems related to PCOS. Our review confirmed an association between heavy metals and essential elements with OS in PCOS women. This systematic review is registered in PROSPERO under number CRD42023418453.
Keywords	arsenic ; blood ; cadmium ; copper ; inflammation ; lead ; mercury ; osmium ; oxidative stress ; polycystic ovary syndrome ; systematic review ; tellurium ; thallium ; therapeutics ; zinc
Language	English
Dates of publication	2023-0707
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12071398
Database	NAL-Catalogue (AGRICOLA)

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Article: Polycystic Ovary Syndrome and Endocrine Disruptors (Bisphenols, Parabens, and Triclosan)-A Systematic Review.

Srnovršnik, Tinkara / Virant-Klun, Irma / Pinter, Bojana

Life (Basel, Switzerland)

2023 Volume 13, Issue 1

Abstract: Exposure to endocrine disrupting chemicals (EDCs) can result in alterations of the female reproductive system, including polycystic ovary syndrome (PCOS). The aim of this review was to summarize the knowledge about the association of EDCs (bisphenols, ... ...

Abstract	Exposure to endocrine disrupting chemicals (EDCs) can result in alterations of the female reproductive system, including polycystic ovary syndrome (PCOS). The aim of this review was to summarize the knowledge about the association of EDCs (bisphenols, parabens, and triclosan) with PCOS. We conducted an electronic literature search using PubMed for studies published between January 2007 and October 2022 on EDCs related to PCOS, and evaluated the association of PCOS with bisphenols, parabens and triclosan in 15 articles. Most studies revealed significantly higher plasma, urinary or follicular fluid levels of bisphenol A (BPA) in women with PCOS, and some showed a positive correlation of BPA with insulin resistance, polycystic morphology on ultrasound, hepatic steatosis, bilirubin levels, as well as free androgen index, androstenedione and testosterone serum levels, and markers of low-grade chronic inflammation. There was a negative correlation of BPA with markers of ovarian reserve, sex hormone binding globulin and vitamin D-binding protein. Parabens and triclosan have been studied in only one study each, with no significant associations with PCOS observed. Our review revealed an association of BPA with PCOS and negative effects of BPA on human ovaries; more research is needed to assess the potential associations of parabens and triclosan with PCOS.
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13010138
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Article: Heavy Metals and Essential Elements in Association with Oxidative Stress in Women with Polycystic Ovary Syndrome-A Systematic Review.

Srnovršnik, Tinkara / Virant-Klun, Irma / Pinter, Bojana

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract	Altered levels of heavy metals and essential elements have been associated with oxidative stress (OS) and metabolic and hormonal changes in women with polycystic ovary syndrome (PCOS). We aimed to summarize the knowledge on the association of heavy metals and essential elements with OS in PCOS. An electronic literature search using PubMed for studies published between January 2008 and April 2023 was conducted. We evaluated heavy metals and essential elements in relation to OS in PCOS in 15 articles. PCOS women had increased antimonium (Sb), cadmium (Cd), lead (Pb), mercury (Hg), arsenic (As), tellurium (Te), thallium (Tl) and osmium (Os) blood levels and decreased zinc (Zn) blood levels; the results of copper (Cu) blood levels were conflicting. Some studies showed a significant correlation between heavy metals (Sb, Cd, Pb, Hg, As, Te and Tl) and essential elements (Se, Zn, Cr, Ca, Mg and Cu) and markers of OS and chronic inflammation. Heavy metals (Sb, Cd, Pb and Hg) and essential elements (Zn, Cr, Se, Ca, Mg and Cu) were associated with metabolic and hormonal characteristics in PCOS. There might be a possible benefit from supplementation therapy in reducing OS and endocrinological problems related to PCOS. Our review confirmed an association between heavy metals and essential elements with OS in PCOS women. This systematic review is registered in PROSPERO under number CRD42023418453.
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12071398
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Article: From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality.

Virant-Klun, Irma / Imamovic-Kumalic, Senka / Pinter, Bojana

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 8

Abstract: Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction and development. In male reproductive health, EDCs have been related to impaired ... ...

Abstract	Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction and development. In male reproductive health, EDCs have been related to impaired reproductive function and male infertility, altered fetal development, and testicular germ-cell, prostate, and breast cancers. We conducted an electronic search using PubMed on endocrine disruptors related to oxidative stress and male infertility, and evaluated their association with endocrine-disrupting chemicals (bisphenols, phthalates, and parabens) in 25 articles. Higher levels of urinary bisphenols showed correlation with impaired semen quality and increased DNA damage. Considering phthalates and their metabolites, all studies found a positive association between urinary levels of phthalates and at least one semen parameter indicative of low semen quality; some studies also revealed sperm DNA damage. The studies on parabens less often revealed correlation of urinary parabens concentrations with a decrease in sperm count, as well as motility and DNA damage. Moreover, EDCs can elevate ROS production and lipid peroxidation, increase apoptosis, induce epigenetic modifications, and change the Y:X sperm chromosome ratio and sperm protein composition. Our review revealed detrimental effects of EDCs on semen quality and sperm DNA integrity-especially in BPA and phthalates, but also in parabens.
Language	English
Publishing date	2022-08-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11081617
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Article: From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality

Virant-Klun, Irma / Imamovic-Kumalic, Senka / Pinter, Bojana

Antioxidants. 2022 Aug. 20, v. 11, no. 8

2022

Abstract	Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction and development. In male reproductive health, EDCs have been related to impaired reproductive function and male infertility, altered fetal development, and testicular germ-cell, prostate, and breast cancers. We conducted an electronic search using PubMed on endocrine disruptors related to oxidative stress and male infertility, and evaluated their association with endocrine-disrupting chemicals (bisphenols, phthalates, and parabens) in 25 articles. Higher levels of urinary bisphenols showed correlation with impaired semen quality and increased DNA damage. Considering phthalates and their metabolites, all studies found a positive association between urinary levels of phthalates and at least one semen parameter indicative of low semen quality; some studies also revealed sperm DNA damage. The studies on parabens less often revealed correlation of urinary parabens concentrations with a decrease in sperm count, as well as motility and DNA damage. Moreover, EDCs can elevate ROS production and lipid peroxidation, increase apoptosis, induce epigenetic modifications, and change the Y:X sperm chromosome ratio and sperm protein composition. Our review revealed detrimental effects of EDCs on semen quality and sperm DNA integrity—especially in BPA and phthalates, but also in parabens.
Keywords	DNA ; DNA damage ; apoptosis ; breasts ; chromosomes ; epigenetics ; fetal development ; human reproduction ; humans ; lipid peroxidation ; male sterility ; males ; metabolites ; oxidative stress ; phthalates ; protein composition ; semen quality ; spermatozoa ; testes
Language	English
Dates of publication	2022-0820
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11081617
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vitamin D Supplementation During the COVID-19 Pandemic.

Siuka, Darko / Pfeifer, Marija / Pinter, Bojana

Mayo Clinic proceedings

2020 Volume 95, Issue 8, Page(s) 1804–1805

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/etiology ; Coronavirus Infections/prevention & control ; Dietary Supplements ; Global Health ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/etiology ; Pneumonia, Viral/prevention & control ; Risk Factors ; SARS-CoV-2 ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Keywords	covid19
Language	English
Publishing date	2020-06-06
Publishing country	England
Document type	Letter
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2020.05.036
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Article ; Online: Pathology of the Placenta in Singletons after Assisted Reproductive Technology Compared to Singletons after Spontaneous Conception: A Systematic Review.

Belak, Urška / Pinter, Bojana / Ban Frangež, Helena / Velikonja, Mojca / Korošec, Sara

Fetal and pediatric pathology

2022 Volume 42, Issue 3, Page(s) 438–449

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Pregnancy ; Female ; Humans ; Placenta ; Reproductive Techniques, Assisted/adverse effects ; Pregnancy Outcome ; Pregnancy Complications
Language	English
Publishing date	2022-12-29
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2165508-X
ISSN	1551-3823 ; 1551-3815 ; 1522-7952
ISSN (online)	1551-3823
ISSN	1551-3815 ; 1522-7952
DOI	10.1080/15513815.2022.2157228
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Article ; Online: Counselling before first trimester abortion and acceptability of the procedure: results from a Slovenian cross-sectional study.

Vodopivec, Sara / Bokal, Eda Vrtacnik / Pinter, Bojana

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

2019 Volume 24, Issue 6, Page(s) 487–493

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Abortifacient Agents/administration & dosage ; Abortifacient Agents/adverse effects ; Abortion, Induced/adverse effects ; Abortion, Induced/methods ; Abortion, Induced/psychology ; Adult ; Counseling/methods ; Cross-Sectional Studies ; Decision Making ; Female ; Hospitals, Public ; Humans ; Patient Participation ; Patient Satisfaction ; Pregnancy ; Pregnancy Trimester, First ; Slovenia ; Socioeconomic Factors
Chemical Substances	Abortifacient Agents
Language	English
Publishing date	2019-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1397560-2
ISSN	1473-0782 ; 1362-5187
ISSN (online)	1473-0782
ISSN	1362-5187
DOI	10.1080/13625187.2019.1670346
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Article ; Online: Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia: a randomized double-blind placebo-controlled trial.

Kumalic, Senka Imamovic / Klun, Irma Virant / Bokal, Eda Vrtacnik / Pinter, Bojana

Radiology and oncology

2020 Volume 55, Issue 1, Page(s) 97–105

Abstract: Background: Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. ... ...

Abstract	Background: Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy studies on astaxanthin in patients with oligospermia with/without astheno- or teratozoospermia (O±A±T) have not yet been reported. Our aim was to evaluate the effect of the oral intake of astaxanthin on semen parameters. Patients and methods: In a randomized double-blind trial, 80 men with O±A±T were allocated to intervention with 16 mg astaxanthin orally daily or placebo. At baseline and after three months basic semen parameters, sperm deoxyribonucleic acid (DNA) fragmentation and mitochondrial membrane potential (MMP) of spermatozoa and serum follicle-stimulating hormone (FSH) value were measured. Results: Analysis of the results of 72 patients completing the study (37 in the study group, 35 in the placebo group) did not show any statistically significant change, in the astaxanthin group no improvements in the total number of spermatozoa, concentration of spermatozoa, total motility of spermatozoa, morphology of spermatozoa, DNA fragmentation and mitochondrial membrane potential of spermatozoa or serum FSH were determined. In the placebo group, statistically significant changes in the total number and concentration of spermatozoa were determined. Conclusions: The oral intake of astaxanthin did not affect any semen parameters in patients with O±A±T.
MeSH term(s)	Administration, Oral ; Adult ; Asthenozoospermia/drug therapy ; Double-Blind Method ; Humans ; Male ; Prospective Studies ; Reactive Oxygen Species/analysis ; Semen/chemistry ; Semen/drug effects ; Xanthophylls/administration & dosage
Chemical Substances	Reactive Oxygen Species ; Xanthophylls ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2020-10-23
Publishing country	Poland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1128829-2
ISSN	1581-3207 ; 0485-893X ; 1318-2099
ISSN (online)	1581-3207
ISSN	0485-893X ; 1318-2099
DOI	10.2478/raon-2020-0062
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Article ; Online: Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia

Kumalic Senka Imamovic / Klun Irma Virant / Bokal Eda Vrtacnik / Pinter Bojana

Radiology and Oncology, Vol 55, Iss 1, Pp 97-

a randomized double-blind placebo-controlled trial

2020 Volume 105

Abstract: Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy ... ...

Abstract	Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy studies on astaxanthin in patients with oligospermia with/without astheno- or teratozoospermia (O±A±T) have not yet been reported. Our aim was to evaluate the effect of the oral intake of astaxanthin on semen parameters.
Keywords	antioxidant ; male infertility ; oligo-astheno-teratozoospermia ; semen quality ; dna fragmentation ; cancer ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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