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  1. Article: RE: Technical considerations in obtaining platelet-rich fibrin for clinical and periodontal research.

    Mourão, Carlos Fernando / Pinto, Nelson

    Journal of oral biology and craniofacial research

    2023  Volume 14, Issue 1, Page(s) 61–62

    Abstract: Image 1. ...

    Abstract Image 1.
    Language English
    Publishing date 2023-12-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-4268
    ISSN 2212-4268
    DOI 10.1016/j.jobcr.2023.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Africa Agriculture Transformation Scorecard

    Zavale, H. / Matchaya, Greenwell / Manuvanga, K. / Pinto, N.

    performance and lessons. Angola

    2023  

    Abstract: The Malabo Declaration on accelerated agricultural growth and transformation for shared prosperity and improved livelihoods is a set of goals that were adopted by Heads of State and Government of the African Union in 2014 in Malabo, Equatorial Guinea ( ... ...

    Abstract The Malabo Declaration on accelerated agricultural growth and transformation for shared prosperity and improved livelihoods is a set of goals that were adopted by Heads of State and Government of the African Union in 2014 in Malabo, Equatorial Guinea (AUC 2014). To translate the seven Malabo commitments into results, a call for action was made by the Heads of State and Governments, by calling upon the AU Commission and the NEPAD Planning and Coordinating Agency, in collaboration with partners, to initiate a review process to be conducted on a biennial basis starting 2017, with an objective of tracking, measuring, and reporting progress towards achieving the Malabo Declaration commitments by 2025. Three Biennial Reviews (BR) have been conducted—the inaugural BR in 2017, the second BR in 2019, and the third and most recent BR in 2021. This brief draws on the third BR report to summarize the performance of Angola toward meeting the Malabo Declaration commitments across the three BR cycles, highlights challenges and lessons from the third BR, and outlines policy and programmatic measures required for Angola to meet the Malabo Declaration commitment targets by 2025. The third BR indicates that Angola is not on track to achieve any of the Malabo Declaration commitments by 2025. Despite the improvements in performance between the first and second BRs, the overall scores for Angola for all three BR rounds were below the benchmark scores. A key recommendation from the analysis is for Angola to enhance public financial management to improve the quality of public agricultural expenditure and to promote planning of public investments in the agricultural sector, including donor-funded projects. This should be done in close partnership with key stakeholders in the agricultural sector, resulting in an increased allocation of public resources to the sector.
    Keywords agricultural development ; declarations ; indicators ; policies ; finance ; investment ; hunger ; poverty ; accountability ; resilience ; sadc countries
    Language English
    Publishing date 2023-05-31T13:07:31Z
    Publisher Regional Strategic Analysis and Knowledge Support System for Eastern and Southern Africa (ReSAKSS-ESA)
    Publishing country fr
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Playing the Long Game: Therapeutic Hypothermia's Impact on Quality-of-Life After Pediatric Cardiac Arrest.

    Pinto, Neethi / Topjian, Alexis A

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2022  Volume 23, Issue 1, Page(s) 68–70

    MeSH term(s) Child ; Humans ; Heart Arrest/therapy ; Hypothermia, Induced/adverse effects ; Quality of Life
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exploring the Insomnia-Ischemic Stroke Nexus: A Comprehensive Review.

    Matas, Andreia / Pinto, Nuno / Conde, Bebiana / Vaz Patto, Maria

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Decoding the molecular phylogenetics of ornamental catfishes (siluriformes) of North East India using DNA barcoding approach.

    Patil, Grishma S / Pinto, Nevil / Nath, Rupak / Goswami, Mukunda

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 528

    Abstract: Background: Catfishes (order Siluriformes) are among the most diverse and widely distributed fish groups in the world. They are not only used for human consumption but are also a major part of the ornamental fish trade. Being a Biodiversity Hotspot, the ...

    Abstract Background: Catfishes (order Siluriformes) are among the most diverse and widely distributed fish groups in the world. They are not only used for human consumption but are also a major part of the ornamental fish trade. Being a Biodiversity Hotspot, the North Eastern Region of India is home to a diverse population of ornamental fishes. Catfishes contain a humongous number of species; in this study, the authors have tried to elucidate the phylogenetic relationship of some important ornamental catfishes found in North East India using DNA barcodes.
    Methods and results: In this study, we have tried to explore the phylogenetic history of 13 species (41 specimens) of ornamental catfishes spanning 12 genera and 9 families of Siluriformes using DNA barcoding. Pairwise genetic distances using Kimura 2-Parameter (K2P) were calculated at intra-specific and inter-specific levels. A Neighbor-Joining tree was constructed to understand the phylogenetic relationship among the nine different catfish families. All the specimens under this study clustered with their respective species under the same family and formed three sub-clades. However, Olyra longicaudata, belonging to the Bagridae family, did not cluster with other species from the same family. In this study, the authors have suggested a revision of the classification of O. longicaudata back to its original family, Olyridae.
    Conclusions: In this study, the maximum intraspecific genetic distance of 0.03 and the minimum interspecific genetic distance of 0.14 were observed among the species. Therefore, it is evident that there is a barcoding gap among the species, which helped in the correct identification of the species. Thus, DNA barcoding helped complement the phenetic approach and also revealed a different phylogenetic relationship among the catfishes belonging to the Bagridae family.
    MeSH term(s) Animals ; Humans ; Catfishes/genetics ; DNA Barcoding, Taxonomic/methods ; Phylogeny ; DNA ; India
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09487-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Relationship between event-related potentials and cognitive dysfunction in multiple sclerosis: A systematic review.

    Ferreira, Joana Almeida / Pinto, Nuno / Maricoto, Tiago / Pato, Maria Vaz

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2024  Volume 163, Page(s) 174–184

    Abstract: Objective: This systematic review aimed to evaluate if event-related potentials (ERPs) can be a relevant tool for cognitive dysfunction diagnosis in Multiple Sclerosis (MS).: Methods: Four databases were consulted (PubMed, Embase, Scielo, and Web of ... ...

    Abstract Objective: This systematic review aimed to evaluate if event-related potentials (ERPs) can be a relevant tool for cognitive dysfunction diagnosis in Multiple Sclerosis (MS).
    Methods: Four databases were consulted (PubMed, Embase, Scielo, and Web of Science). The included studies should include adults with clear MS diagnoses, independently of having cognitive complaints, and all should have been submitted to ERPs (P300, N400 or mismatch negativity (MMN)). The main outcomes evaluated were ERPs' amplitude and/or latency.
    Results: 425 studies were obtained initially from all databases, with 26 studies fulfilling the eligibility criteria. P300 was the most used ERP (25 studies), showing a reduced amplitude or an increased latency in 84% of those. N400 was evaluated in one study, showing also abnormal results. MMN was addressed in two studies with inconsistent findings. Some studies further suggest that ERPs may show earlier abnormal results compared with neuropsychological tests.
    Conclusions: Most MS patient groups revealed ERP abnormalities, suggesting that these neurophysiological tests may be a relevant and appropriate diagnostic aid method for cognitive impairment in MS.
    Significance: The use of ERPs in MS patients seems able to demonstrate cognitive impairment and its use should be considered as part of the regular patient evaluation.
    Language English
    Publishing date 2024-05-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2024.04.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells.

    Hali, Mirabela / Pinto, Nelson / Gleason, Noah / Kowluru, Anjaneyulu

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: CARD9, a scaffolding protein, has been implicated in the pathogenesis of metabolic diseases, including obesity and diabetes. We recently reported novel roles for CARD9 in islet β-cell dysregulation under duress of gluco (HG)- and glucolipotoxic (GLT) ... ...

    Abstract CARD9, a scaffolding protein, has been implicated in the pathogenesis of metabolic diseases, including obesity and diabetes. We recently reported novel roles for CARD9 in islet β-cell dysregulation under duress of gluco (HG)- and glucolipotoxic (GLT) stress. CARD9 expression was also increased in β-cells following exposure to HG and GLT stress. The current study is aimed at understanding the putative roles of histone deacetylation in HG- and GLT-induced expression of CARD9. Using two structurally distinct inhibitors of histone deacetylases (HDACs), namely trichostatin (TSA) and suberoylanilide hydroxamic acid (SAHA), we provide the first evidence to suggest that the increased expression of CARD9 seen under duress of HG and GLT stress is under the regulatory control of histone deacetylation. Interestingly, the expression of protein kinase Cδ (PKCδ), a known upstream regulator of CARD9 activation, is also increased under conditions of metabolic stress. However, it is resistant to TSA and SAHA, suggesting that it is not regulated via histone deacetylation. Based on these data, we propose that targeting the appropriate HDACs, which mediate the expression (and function) of CARD9, might be the next step to further enhance our current understanding of the roles of CARD9 in islet dysfunction under metabolic stress and diabetes.
    MeSH term(s) Humans ; Histone Deacetylase Inhibitors/pharmacology ; Histones/metabolism ; Hydroxamic Acids/pharmacology ; Caspase Activation and Recruitment Domain ; Vorinostat ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Stress, Physiological ; Diabetes Mellitus ; CARD Signaling Adaptor Proteins/metabolism
    Chemical Substances Histone Deacetylase Inhibitors ; Histones ; Hydroxamic Acids ; Vorinostat (58IFB293JI) ; Histone Deacetylases (EC 3.5.1.98) ; CARD9 protein, human ; CARD Signaling Adaptor Proteins
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Doing primary care integration: a qualitative study of meso-level collaborative practices.

    Leslie, Myles / Fadaak, Raad / Pinto, Nicole

    BMC primary care

    2023  Volume 24, Issue 1, Page(s) 149

    Abstract: Background: The integration of Primary Care (PC) into broader health systems has been a goal in jurisdictions around the world. Efforts to achieve integration at the meso-level have drawn particular attention, but there are few actionable ... ...

    Abstract Background: The integration of Primary Care (PC) into broader health systems has been a goal in jurisdictions around the world. Efforts to achieve integration at the meso-level have drawn particular attention, but there are few actionable recommendations for how to enact a 'pro-integration culture' amongst government and PC governance bodies. This paper describes pragmatic integration activity undertaken by meso-level participants in Alberta, Canada, and suggests ways this activity may be generalizable to other health systems.
    Methods: 11 semi-structured interviews with nine key informants from meso-level organizations were selected from a larger qualitative study examining healthcare policy development and implementation during the COVID-19 pandemic. Selected interviews focused on participants' experiences and efforts to 'do' integration as they responded to Alberta's first wave of the Omicron variant in September 2021. An interpretive descriptive approach was used to identify repeating cycles in the integration context, and pragmatic integration activities.
    Results: As Omicron arrived in Alberta, integration and relations between meso-level PC and central health system participants were tense, but efforts to improve the situation were successfully made. In this context of cycling relationships, staffing changes made in reaction to exogenous shocks and political pressures were clear influences on integration. However, participants also engaged in specific behaviours that advanced a pro-integration culture. They did so by: signaling value through staffing and resource choices; speaking and enacting personal and group commitments to collaboration; persevering; and practicing bi-directional communication through formal and informal channels.
    Conclusions: Achieving PC integration involves not just the reactive work of responding to exogenous factors, but also the proactive work of enacting cultural, relationship, and communication behaviors. These behaviors may support integration regardless of the shocks, staff turnover, and relational freeze-thaw cycles experienced by any health system.
    MeSH term(s) Humans ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Alberta ; Primary Health Care
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2731-4553
    ISSN (online) 2731-4553
    DOI 10.1186/s12875-023-02104-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Body posture as a factor determining sleep quality in patients using non-invasive ventilation.

    Alfaiate, Daniel / Pereira, Alexandre / Guerra, Patrícia / Pinto, Nuno

    Sleep & breathing = Schlaf & Atmung

    2023  Volume 27, Issue 6, Page(s) 2437–2442

    Abstract: Objective: Sleep quality is influenced by multiple factors. Slow-wave sleep and REM sleep play a key role in homeostasis and are useful indicators of sleep quality. Studies indicate that obstructive sleep apnea (OSA) in the supine position correlates ... ...

    Abstract Objective: Sleep quality is influenced by multiple factors. Slow-wave sleep and REM sleep play a key role in homeostasis and are useful indicators of sleep quality. Studies indicate that obstructive sleep apnea (OSA) in the supine position correlates with anatomical changes that exacerbate respiratory events and influence the effectiveness of ventilation therapy. This study aimed to evaluate the correlation of body posture with polysomnographic data and adherence of patients using continuous positive airway pressure (CPAP).
    Material and methods: This was a retrospective study of patients with OSA who had polysomnography in Rainha Santa Isabel Hospital's sleep laboratory in Torres Novas, Portugal, and met all the inclusion and exclusion criteria. Sociodemographic, polysomnographic, and ventilation therapy variables were collected from that sleep laboratory database between 2015 and 2019.
    Results: In 30 patients with OSA, residual apnea-hypopnea index (AHIr) and arousal index were lower in the non-supine position compared to the supine position (p value 0.005 and 0.009 respectively). As measures of sleep quality, total sleep time in SWS and REM sleep were greater in the non-supine position compared to the supine position (p value of 0.002 and 0.010 respectively).
    Conclusion: The findings suggest that a supine position significantly impairs sleep quality mainly by increasing the number of respiratory events and associated sleep fragmentation. The findings also suggest that the difference in AHIr between supine and non-supine positions may contribute to non-adherence with CPAP in patients with OSA.
    MeSH term(s) Humans ; Sleep Quality ; Retrospective Studies ; Noninvasive Ventilation ; Posture ; Sleep ; Sleep Apnea, Obstructive/therapy ; Supine Position
    Language English
    Publishing date 2023-03-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-023-02817-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pattern electroretinography response in amblyopic adults.

    Fernandes, Andresa / Pinto, Nuno / Tuna, Ana Rita / Brardo, Francisco Miguel / Pato, Maria Vaz

    International ophthalmology

    2024  Volume 44, Issue 1, Page(s) 86

    Abstract: Introduction: Amblyopia is generally a unilateral disorder, defined by at least a difference of two lines of visual acuity between both eyes with the best-corrected visual acuity, a decrease in contrast sensitivity, and a decrease in stereopsis. Pattern ...

    Abstract Introduction: Amblyopia is generally a unilateral disorder, defined by at least a difference of two lines of visual acuity between both eyes with the best-corrected visual acuity, a decrease in contrast sensitivity, and a decrease in stereopsis. Pattern electroretinogram (PERG) is a noninvasive technique that provides a retinal biopotential and is a highly sensitive indicator of changes in the macular area. Our aim was to evaluate if there are differences in the retinal response of an amblyopic eye compared with a normal eye (NE).
    Methods: We evaluated twenty-four adult volunteers, twelve amblyopes (mean 43.42 ± 12.72 years old), and twelve subjects with NE (mean 35.58 ± 12.85 years old). None of the subjects in the two groups had comorbidities. A complete optometric examination was performed including parameters such as visual acuity (VA) by far and near with ETDRS chart, eye alignment with cover test, and evaluation of retinal cells response with PERG.
    Results: The refractive error found in the NE group of subjects had a mean of - 0.95 ± 1.65D, while the amblyopic group showed a mean of - 2.03 ± 4.29D. The VA in amblyopic eyes had a mean of 0.38 ± 0.20 logMAR. Analyzing PERG data, we observed significant differences in the P50-N95 amplitudes of the amblyopic group compared with the NE group (p < 0.0001-amblyopic eye vs. NE; p = 0.039-fellow eye vs. NE).
    Discussion: These findings suggest that amblyopic patients may also present other impairments beyond the visual cortex. PERGs seem to be an important complementary examination in the diagnosis of other impairments in amblyopia.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Young Adult ; Amblyopia/diagnosis ; Electroretinography ; Visual Acuity ; Retina/diagnostic imaging ; Refractive Errors
    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-024-03042-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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