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Article ; Online: Ordering hard-sphere particle suspensions by medium crystallization: Effect of size and interaction strength.

Gimenez-Pinto, Vianney

2022 Volume 105, Issue 3, Page(s) L032601

Abstract: While microstructure in soft materials is usually given by the self-assembly of their constituting building blocks, colloidal assembly can also be obtained via templating a morphology in a disordered suspension of particles by solidification of the melt. ...

Abstract	While microstructure in soft materials is usually given by the self-assembly of their constituting building blocks, colloidal assembly can also be obtained via templating a morphology in a disordered suspension of particles by solidification of the melt. This order-templating process is applicable to different soft-matter systems with a variety of characteristic length scales, including particle suspensions in water, liquid-crystal materials, and polymer melts. In this work, we numerically investigate the effect of particle size and solvent size in the process of solidification templating by implementing a coarse-grain model of hard-sphere particles at a moving melt-crystal interface. This approach captures the dependence of crystallization templating on speed of crystal growth, showing the existence of a threshold speed for crystallization templating to occur. Results in this work show that the threshold speed changes following a power form as solvent size and particle size change. Furthermore, this work analyzes and reports the effect of particle-crystal interaction strength in combination with size effects. This scaling study from a numerical perspective sets a starting point for the development of hybrid soft materials via structural templating, allowing solidification-driven particle ordering in different systems with a variety of length scales.
Language	English
Publishing date	2022-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.105.L032601
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Technical note: pre-positioning lower limb SSEP during semi-sitting positioning in posterior fossa surgery- does it matter?

Pinto, Vania / Liebsch, Marina

Journal of clinical monitoring and computing

2023 Volume 37, Issue 6, Page(s) 1627–1633

Abstract: Intra-operative monitoring has been a crucial tool in modern neurosurgery as it allows to optimize surgical outcome whilst reducing neurological deficits. Somatosensory evoked potentials are routinely monitored in most spinal and brain surgeries due to ... ...

Abstract	Intra-operative monitoring has been a crucial tool in modern neurosurgery as it allows to optimize surgical outcome whilst reducing neurological deficits. Somatosensory evoked potentials are routinely monitored in most spinal and brain surgeries due to providing invaluable information regarding the functional integrity of sensory pathways. The use of this neurophysiological technique is particular useful when positioning patients in semi-sitting position during posterior fossa surgery. However, there is general agreement within the intra-operative neuromonitoring community that either upper or lower limb SSEPs monitoring typically suffice. Nonetheless, we report a case study of a patient in whom lower limb SSEPs were independently affected from upper limb SSEPs during positioning. In this respect, we suggest that both upper and lower limb SSEPs monitoring should be considered during semi-sitting positioning in patients undergoing posterior fossa surgery.
MeSH term(s)	Humans ; Sitting Position ; Evoked Potentials, Somatosensory/physiology ; Spine/surgery ; Monitoring, Intraoperative/methods ; Neurosurgical Procedures/methods
Language	English
Publishing date	2023-06-23
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1418733-4
ISSN	1573-2614 ; 1387-1307 ; 0748-1977
ISSN (online)	1573-2614
ISSN	1387-1307 ; 0748-1977
DOI	10.1007/s10877-023-01041-1
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Article ; Online: Renaissance of VDAC: New Insights on a Protein Family at the Interface between Mitochondria and Cytosol.

De Pinto, Vito

Biomolecules

2021 Volume 11, Issue 1

Abstract: It has become impossible to review all the existing literature on Voltage-Dependent Anion selective Channel (VDAC) in a single article. A real Renaissance of studies brings this protein to the center of decisive knowledge both for cell physiology and ... ...

Abstract	It has become impossible to review all the existing literature on Voltage-Dependent Anion selective Channel (VDAC) in a single article. A real Renaissance of studies brings this protein to the center of decisive knowledge both for cell physiology and therapeutic application. This review, after highlighting the similarities between the cellular context and the study methods of the solute carriers present in the inner membrane and VDAC in the outer membrane of the mitochondria, will focus on the isoforms of VDAC and their biochemical characteristics. In particular, the possible reasons for their evolutionary onset will be discussed. The variations in their post-translational modifications and the differences between the regulatory regions of their genes, probably the key to understanding the current presence of these genes, will be described. Finally, the situation in the higher eukaryotes will be compared to that of yeast, a unicellular eukaryote, where there is only one active isoform and the role of VDAC in energy metabolism is better understood.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cytosol/metabolism ; Mitochondria/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Processing, Post-Translational ; Voltage-Dependent Anion Channels/chemistry ; Voltage-Dependent Anion Channels/genetics ; Voltage-Dependent Anion Channels/metabolism
Chemical Substances	Protein Isoforms ; Voltage-Dependent Anion Channels
Language	English
Publishing date	2021-01-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11010107
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Article: Understanding the Barriers in Delirium Care in an Intensive Care Unit: A Survey of Knowledge, Attitudes, and Current Practices among Medical Professionals Working in Intensive Care Units in Teaching Hospitals of Central Province, Sri Lanka.

Arachchi, Tilani M Jayasinghe / Pinto, Vasanthi

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2022 Volume 25, Issue 12, Page(s) 1413–1420

Abstract: ... of educational exposure.: How to cite this article: Arachchi TMJ, Pinto V. Understanding the Barriers ...

Abstract	Background: Delirium is a common, underdiagnosed, and undertreated condition that increases morbidity and mortality in ICU patients which has an incidence up to 80%. Barriers that hinder optimum care of delirium include inadequate knowledge, poor attitudes, and low perceived importance of delirium care. Aim: To assess attitudes, knowledge, and current practices related to delirium care among medical professionals working in intensive care units (ICUs) in all teaching hospitals in Central Province, Sri Lanka, as there are no Sri Lankan studies on this regard. Method: A descriptive cross-sectional study was carried out among all medical professionals working in nine ICUs in all ( Results: Eighty-eight questionnaires were analyzed. More than 80% of PGs and non-PG-MOs regarded ICU delirium as significant problem that should be screened and prevented. Forty-one percent stated confidence in diagnosing delirium. However, more than 75% of non-PG-MOs failed to recognize features of hypoactive delirium. Only 30-50% subjects in incorporated preventive methods in usual practice and more than 60% non-PG-MOs had poor knowledge and experience on delirium screening. More than 80% of the participants did not routinely screen their patients. More than 90% non-PG-MOs ( Conclusion: A positive attitude toward the importance of management of delirium was observed. However, there is a discrepancy between the perceived importance and the current practice related to screening and prevention. Participants, especially non-PG-MOs, lacked knowledge on delirium screening, diagnosis, and identification of risk factors, probably related to a lack of educational exposure. How to cite this article: Arachchi TMJ, Pinto V. Understanding the Barriers in Delirium Care in an Intensive Care Unit: A Survey of Knowledge, Attitudes, and Current Practices among Medical Professionals Working in Intensive Care Units in Teaching Hospitals of Central Province, Sri Lanka. Indian J Crit Care Med 2021;25(12):1413-1420.
Language	English
Publishing date	2022-01-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24040
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Article ; Online: VDAC as a Cellular Hub: Docking Molecules and Interactions.

Kmita, Hanna / Messina, Angela Anna / De Pinto, Vito

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: The voltage-dependent anion channel (VDAC) is the primary regulating pathway of water-soluble metabolites and ions across the mitochondrial outer membrane [ ... ]. ...

Abstract	The voltage-dependent anion channel (VDAC) is the primary regulating pathway of water-soluble metabolites and ions across the mitochondrial outer membrane [...].
MeSH term(s)	Voltage-Dependent Anion Channels/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondria/metabolism ; Ions/metabolism
Chemical Substances	Voltage-Dependent Anion Channels ; Ions
Language	English
Publishing date	2023-04-02
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076649
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Article ; Online: La parte di Tersite. Verità e democrazia dopo la democrazia

Pinto, Valeria

Laboratorio dell'ISPF, Vol XVI, Iss

2019 Volume 9

Abstract: The Part of Thersitis. Truth and Democracy after Democracy]. This article presents the crisis of governability due to an “excess of democracy” diagnosed by the 1975 report The Crisis of Democracy as a crisis of control and shows how its corrective in ... ...

Abstract	[The Part of Thersitis. Truth and Democracy after Democracy]. This article presents the crisis of governability due to an “excess of democracy” diagnosed by the 1975 report The Crisis of Democracy as a crisis of control and shows how its corrective in the neoliberal transformation of the State coincides with a “revolution of control”. The passage from the traditional bureaucratic control of legitimacy to the automation of control generates what Foucault called the “society of the norm”, marked by the invisibility of the decision. Here the “oligarchic alliance between wealth and science” (Ranciére) constitutes the backbone of the neoliberal program of “digitalization of politics” and leads to an “algorithmic governmentality” approaching a “pure governmentality”: the empire of the intangible and inevitable evidence that both Lyotard and Foucault prefigured as the “terror” – the condition where truth paralyzes.
Keywords	democracy ; algorithmic governmentality ; neoliberalism ; evidence-based policy ; terror ; History of scholarship and learning. The humanities ; AZ20-999 ; Philosophy (General) ; B1-5802
Subject code	320
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Consiglio Nazionale delle Ricerche (CNR)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Spinal Intradural Extramedullary Tumors: A Retrospective Analysis on Ten-Years' Experience of Minimally Invasive Surgery and a Comparison with the Open Approach.

Kitumba, D / Reinas, R / Pereira, L / Pinto, V / Alves, O L

Acta neurochirurgica. Supplement

2022 Volume 135, Page(s) 357–360

Abstract: Spinal intradural extramedullary (ID-EM) tumors are pathologies widely treated through a classical open approach. However, minimally invasive surgery is gaining traction as a comparable treatment option because it carries less morbidity and may reduce ... ...

Abstract	Spinal intradural extramedullary (ID-EM) tumors are pathologies widely treated through a classical open approach. However, minimally invasive surgery is gaining traction as a comparable treatment option because it carries less morbidity and may reduce healthcare costs.This study aimed to compare the clinical and functional outcomes of open versus minimally invasive approaches for patients with ID-EM tumors. We performed a retrospective analysis on prospectively collected data from patients with ID-EM tumors submitted to surgery. Baseline features and operative variables were compared, including surgery duration and estimated blood loss (EBL). Postoperative data covered tumor histology, length of stay (LOS), complication(s), and neurological status (Medical Research Council (MRC) scale) at the last follow-up.In total, 46 patients were included: 30 (65.2%) operated through an open approach and 16 (34.8%) through a minimally invasive surgical (MIS) approach. The predominant histology type was schwannomas (43.5%). Lesions more frequently affected the lumbar spine (34.8%). The tumor dimensions were similar in both cohorts. The minimally invasive approach was on average 76.7 min faster and correlated positively with less EBL (140 mL less than that of the open approach). Patients in the MIS group had shorter LOSs (5.63 days vs. 17.27 days) and had fewer postoperative complications. No significant difference in functional outcome was found.MIS is as effective as the traditional approach in achieving comparable functional outcomes, with advantages such as shorter surgery durations, less blood loss, and shorter hospital LOSs.
MeSH term(s)	Humans ; Retrospective Studies ; Spinal Cord Neoplasms/surgery ; Spinal Neoplasms ; Central Nervous System Neoplasms ; Minimally Invasive Surgical Procedures
Language	English
Publishing date	2022-10-29
Publishing country	Austria
Document type	Journal Article
ISSN	0065-1419
ISSN	0065-1419
DOI	10.1007/978-3-031-36084-8_54
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Article: Minimally Invasive Posterior Cervical Fusion: A Handsome Option.

Pinto, V / Pereira, L / Reinas, R / Kitumba, D / Alves, O L

Acta neurochirurgica. Supplement

2022 Volume 135, Page(s) 351–356

Abstract: Cervical spondylosis is the leading cause of cervical myelopathy. When surgery is indicated, it is commonly addressed through an anterior or posterior cervical approach, such as cervical discectomy and fusion (ACDF) or laminectomy and fusion (LMF). ... ...

Abstract	Cervical spondylosis is the leading cause of cervical myelopathy. When surgery is indicated, it is commonly addressed through an anterior or posterior cervical approach, such as cervical discectomy and fusion (ACDF) or laminectomy and fusion (LMF). Besides their own merits, each one has specific approach- or device-related complications, such as dysphagia, significant postoperative pain, wound infection, adjacent segment degeneration (ASD), and pseudoarthrosis. Through a tissue-sparing minimally invasive technique, posterior cervical fusion (PCF) has shown unfolding compelling evidence of biomechanical stability, good clinical outcomes, and high fusion rates, with fewer complications and better econometrics. On the basis of our own experience, we discuss here the indications, advantages, and drawbacks of minimally invasive PCF.
MeSH term(s)	Humans ; Spondylosis/diagnostic imaging ; Spondylosis/surgery ; Spinal Fusion ; Spinal Cord Diseases ; Laminectomy ; Neck
Language	English
Publishing date	2022-10-29
Publishing country	Austria
Document type	Journal Article
ISSN	0065-1419
ISSN	0065-1419
DOI	10.1007/978-3-031-36084-8_53
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Article: Long-Term Clinical and Radiological Evaluation of Low-Grade Lumbar Spondylolisthesis Stabilization with Rigid Percutaneous Pedicle Screws.

Pereira, L / Pinto, V / Reinas, R / Kitumba, D / Alves, O L

Acta neurochirurgica. Supplement

2022 Volume 135, Page(s) 417–423

Abstract: The armamentarium of surgical treatment options for lumbar spondylolisthesis (LS) includes decompression alone, stabilization with interlaminar devices, or instrumented fusion, through open or minimally invasive approaches. Despite its safe profuse use ... ...

Abstract	The armamentarium of surgical treatment options for lumbar spondylolisthesis (LS) includes decompression alone, stabilization with interlaminar devices, or instrumented fusion, through open or minimally invasive approaches. Despite its safe profuse use in distinctive lumbar spine disorders, using percutaneous pedicle screws (PPSs) alone to stabilize LS has never been described before. We performed a retrospective study of prospectively collected data, enrolling 24 patients with LS and scrutinizing clinical and radiological outcomes. A statistically significant decrease in visual analog scale (VAS) scores (p < 0.001) and Oswestry Disability Index (ODI) scores (p < 0.001) was observed, as was a reduction in the intake of acetaminophen after surgery (p = 0.022). In the long-term, PPS effectively reduced the index-level range of motion (p < 0.001), reduced preoperative slippage (p = 0.03), and maintained foraminal height, thus accounting for the positive clinical outcomes. It induced a significant segmental kyphotic effect (p < 0.001) that was compensated for by a favorable increase in the pelvic incidence minus lumbar lordosis (PI-LL) index (0.028).
MeSH term(s)	Animals ; Humans ; Pedicle Screws ; Retrospective Studies ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/surgery ; Radiography ; Acetaminophen
Chemical Substances	Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2022-10-29
Publishing country	Austria
Document type	Journal Article
ISSN	0065-1419
ISSN	0065-1419
DOI	10.1007/978-3-031-36084-8_64
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Article: Comparison Between Sagittal Balance Outcomes After Corpectomy, Laminectomy, and Fusion for Cervical Spondylotic Myelopathy: A Matched Cohort Study.

Reinas, R / Kitumba, D / Pereira, L / Pinto, V / Alves, O L

Acta neurochirurgica. Supplement

2022 Volume 135, Page(s) 345–349

Abstract: Cervical spondylotic myelopathy (CSM) can be successfully decompressed via either anterior cervical corpectomy and fusion (ACCF) or posterior laminectomy with fusion (LMF). However, few studies have compared the isolated effect of both techniques on ... ...

Abstract	Cervical spondylotic myelopathy (CSM) can be successfully decompressed via either anterior cervical corpectomy and fusion (ACCF) or posterior laminectomy with fusion (LMF). However, few studies have compared the isolated effect of both techniques on cervical sagittal balance, a surrogate end point for clinical outcomes.We aimed to compare the sagittal balance radiological outcomes of ACCF against LMF. A case-matched controlled study of radiological cervical alignment parameters (C0-2, C2-3, index angles, T1 slope, and sagittal vertical axis (SVA)) in two groups of patients was performed by using pre- and postoperative neutral cervical X-rays.In total, 34 patients were enrolled (ACCF n = 17; LMF n = 17). The mean preoperative C2-7 angle was similar (11.58 ± 16.00° for ACCF; 13.36 ± 12.21° for LMF) in both cohorts. Both led to a loss of lordosis (-2.68 ± 13.8°, p = 0.43; -2.94 ± 11.5°, p = 0.31, respectively). At the C0-2, the two operations induced opposite variations (-0.9 ± 8.0°, p = 0.709 for ACCF; 3.5 ± 15.4°, p = 0.357 for LMF). ACCF led to a significant increase in SVA (7.1 ± 11.9 mm, p = 0.002). The C2-3 disk angle more pronouncedly increased with LMF.Both techniques show an equivalent kyphotic effect, with a greater disadvantage for ACCF. The negative impact on SVA changes is greater with ACCF. Both affect the C0-2 unit, with a tendency for kyphosis with ACCF and one for lordosis with LMF. When choosing the appropriate decompression and fusion technique, preoperative sagittal balance parameters should be included in the decision-making process.
MeSH term(s)	Animals ; Humans ; Cohort Studies ; Laminectomy ; Lordosis ; Neck ; Spinal Cord Diseases/diagnostic imaging ; Spinal Cord Diseases/surgery
Language	English
Publishing date	2022-10-29
Publishing country	Austria
Document type	Journal Article
ISSN	0065-1419
ISSN	0065-1419
DOI	10.1007/978-3-031-36084-8_52
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