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  1. AU="Pintore, Giorgio"
  2. AU="Signorini C."
  3. AU="Mameli, Maria Sabrina"
  4. AU="Yong-ming GAO"
  5. AU="Paquette, Kimberly"
  6. AU="Sharawat, Indar Kumar"
  7. AU="Alexandre Alanio"
  8. AU="Caron, Jeffrey G"
  9. AU="Lubisi, Baratang A"
  10. AU="Edelman, Robert R."
  11. AU="van der Werf, Steffie"
  12. AU="Sam, Andrew"

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  1. Article ; Online: Chemical characterization, antioxidant and cytotoxic activity of hydroalcoholic extract from the albedo and flavedo of Citrus limon var. pompia Camarda

    Rosa, Antonella / Petretto, Giacomo Luigi / Maldini, Mariateresa / Tirillini, Bruno / Chessa, Mario / Pintore, Giorgio / Sarais, Giorgia

    Food Measure. 2023 Feb., v. 17, no. 1 p.627-635

    2023  

    Abstract: Due to the high nutritional value as well as the appreciated sensory characteristic Citrus crop is one of the most popular fruits over the world. Albedo and flavedo are commonly discarded as waste and could represent an important by-product of food ... ...

    Abstract Due to the high nutritional value as well as the appreciated sensory characteristic Citrus crop is one of the most popular fruits over the world. Albedo and flavedo are commonly discarded as waste and could represent an important by-product of food industry. In a circular economy contest we carried out a characterization of albedo and flavedo of Citrus limon var pompia (pompia) followed by the evaluation of antioxidant potential and cytotoxic activity. The chemical analysis showed the presence of several functional ingredients such as the flavanones, naringin, neohesperidin, nereriocitrin and hesperidin while quinic acid resulted the main phenolic acid detected. The flavedo extract exerted a complete inhibition of the cholesterol oxidative process from 25 μg of extract. Pompia extracts showed an inhibition of lipid oxidation in the β-carotene-linoleate system with an activity equivalent to about 0.31% (albedo) and 0.34% (flavedo) of the BHT activity, while the antiradical activity resulted equivalent to that of 62.90% (albedo) and 60.72% (flavedo) of the trolox activity. Finally, all extracts did not show any cytotoxic effect on differentiated Caco-2 cells by the AlamarBlue assay while exhibited, by MTT assay, a significant decrease in colon cancer Caco-2 cell viability.
    Keywords Citrus limon ; antioxidant activity ; antioxidants ; byproducts ; cell viability ; chemical analysis ; cholesterol ; circular economy ; colorectal neoplasms ; cytotoxicity ; flavanones ; food industry ; human cell lines ; lipid peroxidation ; naringin ; neohesperidin ; nutritive value ; phenolic acids ; quinic acid ; sensory properties ; toxicity testing
    Language English
    Dates of publication 2023-02
    Size p. 627-635.
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 2754612-3
    ISSN 2193-4134 ; 2193-4126
    ISSN (online) 2193-4134
    ISSN 2193-4126
    DOI 10.1007/s11694-022-01659-w
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Classification of Pummelo (Citrus grandis) Extracts through UV-VIS-Based Chemical Fingerprint

    Petretto, Giacomo Luigi / Di Pietro, Maria Enrica / Piroddi, Marzia / Pintore, Giorgio / Mannu, Alberto

    Beverages. 2022 June 13, v. 8, no. 2

    2022  

    Abstract: Cold extraction methods with ethanol applied to the flavedo of Citrus fruits have been commonly applied for the preparation of several liquors. In order to obtain the extraction optimization and then the best ratio of functional ingredients in the ... ...

    Abstract Cold extraction methods with ethanol applied to the flavedo of Citrus fruits have been commonly applied for the preparation of several liquors. In order to obtain the extraction optimization and then the best ratio of functional ingredients in the extract, the flavedo of Citrus grandis Osbeck (pummelo) was subjected to a maceration with absolute ethanol at room temperature as well as at 40 °C. The kinetics of the extraction methods were monitored by UV–VIS spectroscopy, and a chemical fingerprint characteristic of each extract was determined by statistical multivariate analysis of the UV–VIS raw data. Additionally, the extracts were qualitatively characterized by NMR spectroscopy as well as by solid phase micro extraction followed by gas chromatography/mass spectrometry (GC/MS). NMR analysis confirmed the presence of the typical flavanones of Citrus such as naringin and naringenin, while the GC/MS analysis showed that the headspace of the liquor is characterized by two main compounds represented by β-myrcene and limonene. At the end, the temperature seems to not affect the time of extraction, which is complete after 25 h; however, UV–VIS-based multivariate analysis revealed that a different overall chemical composition is obtained depending on the temperature, probably due to the extraction of minor chemicals as well as due to different levels of the same compounds in the two extracts.
    Keywords Citrus maxima ; ambient temperature ; chemical composition ; cold ; ethanol ; headspace analysis ; limonene ; maceration ; multivariate analysis ; naringenin ; naringin ; nuclear magnetic resonance spectroscopy ; pummelos ; ultraviolet-visible spectroscopy
    Language English
    Dates of publication 2022-0613
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2785444-9
    ISSN 2306-5710
    ISSN 2306-5710
    DOI 10.3390/beverages8020034
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Waste Citrus limon Leaves as Source of Essential Oil Rich in Limonene and Citral: Chemical Characterization, Antimicrobial and Antioxidant Properties, and Effects on Cancer Cell Viability

    Petretto, Giacomo Luigi / Vacca, Giuseppe / Addis, Roberta / Pintore, Giorgio / Nieddu, Mariella / Piras, Franca / Sogos, Valeria / Fancello, Francesco / Zara, Severino / Rosa, Antonella

    Antioxidants. 2023 June 08, v. 12, no. 6

    2023  

    Abstract: This study investigated chemical composition, cytotoxicity in normal and cancer cells, and antimicrobial and antioxidant activity of the essential oil (EO) isolated by hydrodistillation from the discarded leaves of lemon (Citrus limon) plants cultivated ... ...

    Abstract This study investigated chemical composition, cytotoxicity in normal and cancer cells, and antimicrobial and antioxidant activity of the essential oil (EO) isolated by hydrodistillation from the discarded leaves of lemon (Citrus limon) plants cultivated in Sardinia (Italy). The volatile chemical composition of lemon leaf EO (LLEO) was analyzed with gas chromatography-mass spectrometry combined with flame ionization detection (GC/MS and GC/FID). The most abundant component of LLEO was limonene (260.7 mg/mL), followed by geranial (102.6 mg/mL) and neral (88.3 mg/mL). The antimicrobial activity of LLEO was tested using eight bacterial strains and two types of yeasts by a microdilution broth test. Candida albicans showed the greatest susceptibility (MIC = 0.625 μL/mL) and Listeria monocytogenes and Staphylococcus aureus were inhibited at low LLEO concentration (MIC values from 2.5 to 5 μL/mL). The C. limon leaf EO displayed radical scavenging ability (IC₅₀ value of 10.24 mg/mL) in the 2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH) assay. Furthermore, the LLEO impact on cell viability was explored by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in cancer HeLa cells, A375 melanoma cell line, normal fibroblasts (3T3 cells), and keratinocytes (HaCaT cells). LLEO, at 24 h of incubation, significantly reduced viability from 25 μM in Hela cells (33% reduction) and A375 cells (27%), greatly affecting cell morphology, whereas this effect was found from 50 μM on 3T3 fibroblasts and keratinocytes. LLEO’s pro-oxidant effect was also established in HeLa cells by 2′,7′-dichlorodihydrofluorescein diacetate assay.
    Keywords Candida albicans ; Citrus limon ; Listeria monocytogenes ; Staphylococcus aureus ; antimicrobial properties ; antioxidant activity ; antioxidants ; cell lines ; cell structures ; cell viability ; chemical composition ; cytotoxicity ; essential oils ; fibroblasts ; flame ionization ; gas chromatography-mass spectrometry ; geranial ; hydrodistillation ; keratinocytes ; leaves ; lemons ; limonene ; melanoma ; neoplasm cells ; neral ; volatile compounds ; Italy ; Sardinia
    Language English
    Dates of publication 2023-0608
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061238
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Geographical variation of the chemical composition in essential oils extracted from Sardinian Salvia verbenaca

    Mannu, Alberto / Melito, Sara / Petretto, Giacomo Luigi / Manconi, Paola / Pintore, Giorgio Mario / Chessa, Mario

    Natural product research. 2021 Dec. 22, v. 36, no. 1

    2021  

    Abstract: Salvia verbenaca is a perennial herbaceous plant well appreciated as medicinal herb which can be found in Mediterranean area, Europe, Africa and Asia. In this study, S. verbenaca flowers and leaves were collected in six different geographical areas of ... ...

    Abstract Salvia verbenaca is a perennial herbaceous plant well appreciated as medicinal herb which can be found in Mediterranean area, Europe, Africa and Asia. In this study, S. verbenaca flowers and leaves were collected in six different geographical areas of Sardinia (Italy). Information about the variation of the chemical composition of plants grown in different locations were obtained from gas chromatography analysis of the extracted essential oils. Gas chromatography analysis detected 33 compounds, which have been grouped in oxygenated monoterpenes, monoterpene hydrocarbons, sesquiterpenes and other compounds. The chemical composition of each group resulted significantly affected by sampling site in terms of geography and altitude. Concerning the geographical distribution of the detected chemicals, sesquiterpenes were found in considerable amount in three localities, monoterpenes hydrocarbons in two and other compounds were predominant only in one site. Regarding the altitude level, monoterpenes, sesquiterpenes and other compounds were predominant, respectively, at medium and medium-high altitude.
    Keywords Salvia verbenaca ; altitude ; chemical composition ; gas chromatography ; geographical distribution ; geographical variation ; herbaceous plants ; medicinal plants ; monoterpenoids ; research ; sesquiterpenoids ; Africa ; Asia ; Italy ; Mediterranean region ; Sardinia
    Language English
    Dates of publication 2021-1222
    Size p. 367-370.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2020.1788021
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging.

    Serra, Diletta / Garroni, Giuseppe / Cruciani, Sara / Coradduzza, Donatella / Pashchenko, Aleksei / Amler, Evzen / Pintore, Giorgio / Satta, Rosanna / Montesu, Maria Antonietta / Kohl, Yvonne / Ventura, Carlo / Maioli, Margherita

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines ... ...

    Abstract The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovative drugs. The main targets of nanotechnological approaches are wound healing, regeneration, and rejuvenation of skin tissue. The skin barrier is not easily permeable, and the creation of modern nanodevices is a way to improve the passive penetration of substances. In this study,
    MeSH term(s) Humans ; Nanofibers ; Skin Aging ; Biological Products/pharmacology ; Skin ; Wound Healing ; Polyvinyl Alcohol
    Chemical Substances Biological Products ; Polyvinyl Alcohol (9002-89-5)
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Identifying a Role of Red and White Wine Extracts in Counteracting Skin Aging: Effects of Antioxidants on Fibroblast Behavior

    Cruciani, Sara / Trenta, Margherita / Rassu, Giovanna / Garroni, Giuseppe / Petretto, Giacomo Luigi / Ventura, Carlo / Maioli, Margherita / Pintore, Giorgio

    Antioxidants. 2021 Feb. 03, v. 10, no. 2

    2021  

    Abstract: Dermal fibroblasts are the main actor in many proteins’ secretion, including collagen, preserving skin function. Free radicals are involved in skin aging and damages involving different cellular components. The imbalance between reactive oxygen species ( ... ...

    Abstract Dermal fibroblasts are the main actor in many proteins’ secretion, including collagen, preserving skin function. Free radicals are involved in skin aging and damages involving different cellular components. The imbalance between reactive oxygen species (ROS) amount and natural antioxidant enzymes negatively affects skin homeostasis. Natural compounds have recently emerged as a potential anti-aging tool in tissue regeneration. In the present paper we evaluated the antioxidant activity of white and red wines, considering their probable use, as raw materials, for the formulation of cosmetic products with anti-aging properties. We studied a method that would allow the removal of the alcoholic fraction of wines and determined their composition by LC-MS analysis. We then tested the possible cytotoxic effects of red and white wines on fibroblasts by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, and their antioxidant activity by the catalase activity test in stressing conditions. Finally, we evaluated their anti-aging potential through the β-galactosidase colorimetric assay. Our results showed that wine extracts exhibit a remarkable antioxidant and anti-aging activity, especially on cells exposed to a marked stressful event. These properties could suggest their possible application as cosmetical products for skin regeneration.
    Keywords anti-aging properties ; antioxidant activity ; catalase ; collagen ; colorimetry ; cytotoxicity ; fibroblasts ; homeostasis ; reactive oxygen species ; secretion ; tissue repair ; white wines
    Language English
    Dates of publication 2021-0203
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10020227
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Geographical variation of the chemical composition in essential oils extracted from Sardinian

    Mannu, Alberto / Melito, Sara / Petretto, Giacomo Luigi / Manconi, Paola / Pintore, Giorgio Mario / Chessa, Mario

    Natural product research

    2020  Volume 36, Issue 1, Page(s) 367–370

    Abstract: ... Salvia ... ...

    Abstract Salvia verbenaca
    MeSH term(s) Gas Chromatography-Mass Spectrometry ; Geography ; Monoterpenes ; Oils, Volatile ; Plant Oils ; Salvia ; Sesquiterpenes
    Chemical Substances Monoterpenes ; Oils, Volatile ; Plant Oils ; Sesquiterpenes
    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2020.1788021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Waste

    Petretto, Giacomo Luigi / Vacca, Giuseppe / Addis, Roberta / Pintore, Giorgio / Nieddu, Mariella / Piras, Franca / Sogos, Valeria / Fancello, Francesco / Zara, Severino / Rosa, Antonella

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: This study investigated chemical composition, cytotoxicity in normal and cancer cells, and antimicrobial and antioxidant activity of the essential oil (EO) isolated by hydrodistillation from the discarded leaves of lemon ( ...

    Abstract This study investigated chemical composition, cytotoxicity in normal and cancer cells, and antimicrobial and antioxidant activity of the essential oil (EO) isolated by hydrodistillation from the discarded leaves of lemon (
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Electrospun Nanofibers Encapsulated with Natural Products

    Serra, Diletta / Garroni, Giuseppe / Cruciani, Sara / Coradduzza, Donatella / Pashchenko, Aleksei / Amler, Evzen / Pintore, Giorgio / Satta, Rosanna / Montesu, Maria Antonietta / Kohl, Yvonne Lydia / Ventura, Carlo / Maioli, Margherita

    A Novel Strategy to Counteract Skin Aging

    2024  

    Abstract: The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines ... ...

    Abstract The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovative drugs. The main targets of nanotechnological approaches are wound healing, regeneration, and rejuvenation of skin tissue. The skin barrier is not easily permeable, and the creation of modern nanodevices is a way to improve the passive penetration of substances. In this study, Helichrysum italicum oil (HO) was combined with different types of electrospun nanofibers to study their protective activity on the skin and to evaluate their future application for topical treatments. In the present research, we used biodegradable polymers, including polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), which were characterized by a scanning electron microscope (SEM). All results show a positive trend in cell proliferation and viability of human skin stem cells (SSCs) and BJ fibroblasts pre-treated with combined nanofibers and then exposed to UV stress. Gene expression analysis revealed the activation of a molecular rejuvenation program in SSCs treated with functionalized nanofibers before UV exposure. Understanding the mechanisms involved in skin changes during aging allows for the future application of nanomaterials combined with HO directly to the patients.

    25

    3
    Keywords bioactive molecules ; drug delivery ; Helichrysum italicum ; molecular mechanisms ; nanofibers ; nanosystem ; skin aging ; stem cells
    Subject code 571
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Antimicrobial Activity and Chemical Characterization of a Non-Polar Extract of Saffron Stamens in Food Matrix.

    Zara, Severino / Petretto, Giacomo L / Mannu, Alberto / Zara, Giacomo / Budroni, Marilena / Mannazzu, Ilaria / Multineddu, Chiara / Pintore, Giorgio / Fancello, Francesco

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 4

    Abstract: The production of saffron spice generates large quantities of plant by-products: over 90% of the plant material collected is discarded, and a consideration fraction of this waste is plant stamens. This work investigated the chemical composition and the ... ...

    Abstract The production of saffron spice generates large quantities of plant by-products: over 90% of the plant material collected is discarded, and a consideration fraction of this waste is plant stamens. This work investigated the chemical composition and the antimicrobial activities of the non-polar fraction extracted from four different saffron flower stamens. The chemical composition of ethereal extracts of the saffron stamens was qualitatively assessed by means of gas-chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) analyses. These analyses revealed ethereal extracts to possess a high polyunsaturated fatty acid content. In vitro antibacterial activity of stamen extracts showed no large differences between Gram-positive and Gram-negative bacteria in terms of minimal inhibitory concentration (MIC). In food matrix microbial analysis of the bacterial strains belonging to the main foodborne pathogen species, including
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10040703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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