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  1. Article ; Online: Metaverse in Mental Health: The Beginning of a Long History.

    Cerasa, Antonio / Gaggioli, Andrea / Pioggia, Giovanni / Riva, Giuseppe

    Current psychiatry reports

    2024  

    Abstract: Purpose of review: We review the first pilot studies applying metaverse-related technologies in psychiatric patients and discuss the rationale for using this complex federation of technologies to treat mental diseases. Concerning previous virtual- ... ...

    Abstract Purpose of review: We review the first pilot studies applying metaverse-related technologies in psychiatric patients and discuss the rationale for using this complex federation of technologies to treat mental diseases. Concerning previous virtual-reality applications in medical care, metaverse technologies provide the unique opportunity to define, control, and shape virtual scenarios shared by multi-users to exploit the "synchronized brains" potential exacerbated by social interactions.
    Recent findings: The application of an avatar-based sexual therapy program conducted on a metaverse platform has been demonstrated to be more effective concerning traditional sexual coaching for treating female orgasm disorders. Again, a metaverse-based social skills training program has been tested on children with autism spectrum disorders, demonstrating a significant impact on social interaction abilities. Metaverse-related technologies could enable us to develop new reliable approaches for treating diseases where behavioral symptoms can be addressed using socio-attentive tasks and social-interaction strategies.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055376-6
    ISSN 1535-1645 ; 1523-3812
    ISSN (online) 1535-1645
    ISSN 1523-3812
    DOI 10.1007/s11920-024-01501-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5520: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Exploring the Therapeutic Potential of

    Cancemi, Gabriella / Caserta, Santino / Gangemi, Sebastiano / Pioggia, Giovanni / Allegra, Alessandro

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal ... ...

    Abstract Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal fungus
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors.

    Allegra, Alessandro / Mirabile, Giuseppe / Caserta, Santino / Stagno, Fabio / Russo, Sabina / Pioggia, Giovanni / Gangemi, Sebastiano

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This ...

    Abstract The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This aberrant protein affects several signaling pathways connected to both apoptosis and cell proliferation. It has been demonstrated that tyrosine kinase inhibitor treatment in chronic myeloid leukemia acts by inducing oxidative stress and, depending on its level, can activate signaling pathways responsible for either apoptosis or survival in leukemic cells. Additionally, oxidative stress and reactive oxygen species generation also mediate apoptosis through genomic activation. Furthermore, it was shown that oxidative stress has a role in both BCR-ABL-independent and BCR-ABL-dependent resistance pathways to tyrosine kinases, while patients with chronic myeloid leukemia were found to have a significantly reduced antioxidant level. The ideal environment for tyrosine kinase inhibitor therapy is produced by a favorable oxidative status. We discuss the latest studies that aim to manipulate the redox system to alter the apoptosis of cancerous cells.
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Potential New Therapies "ROS-Based" in CLL: An Innovative Paradigm in the Induction of Tumor Cell Apoptosis.

    Sciaccotta, Raffaele / Gangemi, Sebastiano / Penna, Giuseppa / Giordano, Laura / Pioggia, Giovanni / Allegra, Alessandro

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease; the majority of patients eventually acquire resistance to treatment through relapses. In all subtypes of chronic lymphocytic leukemia, the disruption of normal ... ...

    Abstract Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease; the majority of patients eventually acquire resistance to treatment through relapses. In all subtypes of chronic lymphocytic leukemia, the disruption of normal B-cell homeostasis is thought to be mostly caused by the absence of apoptosis. Consequently, apoptosis induction is crucial to the management of this illness. Damaged biological components can accumulate as a result of the oxidation of intracellular lipids, proteins, and DNA by reactive oxygen species. It is possible that cancer cells are more susceptible to apoptosis because of their increased production of reactive oxygen species. An excess of reactive oxygen species can lead to oxidative stress, which can harm biological elements like DNA and trigger apoptotic pathways that cause planned cell death. In order to upset the balance of oxidative stress in cells, recent therapeutic treatments in chronic lymphocytic leukemia have focused on either producing reactive oxygen species or inhibiting it. Examples include targets created in the field of nanomedicine, natural extracts and nutraceuticals, tailored therapy using biomarkers, and metabolic targets. Current developments in the complex connection between apoptosis, particularly ferroptosis and its involvement in epigenomics and alterations, have created a new paradigm.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Artificial Intelligence: A Snapshot of Its Application in Chronic Inflammatory and Autoimmune Skin Diseases.

    Li Pomi, Federica / Papa, Vincenzo / Borgia, Francesco / Vaccaro, Mario / Pioggia, Giovanni / Gangemi, Sebastiano

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Immuno-correlated dermatological pathologies refer to skin disorders that are closely associated with immune system dysfunction or abnormal immune responses. Advancements in the field of artificial intelligence (AI) have shown promise in enhancing the ... ...

    Abstract Immuno-correlated dermatological pathologies refer to skin disorders that are closely associated with immune system dysfunction or abnormal immune responses. Advancements in the field of artificial intelligence (AI) have shown promise in enhancing the diagnosis, management, and assessment of immuno-correlated dermatological pathologies. This intersection of dermatology and immunology plays a pivotal role in comprehending and addressing complex skin disorders with immune system involvement. The paper explores the knowledge known so far and the evolution and achievements of AI in diagnosis; discusses segmentation and the classification of medical images; and reviews existing challenges, in immunological-related skin diseases. From our review, the role of AI has emerged, especially in the analysis of images for both diagnostic and severity assessment purposes. Furthermore, the possibility of predicting patients' response to therapies is emerging, in order to create tailored therapies.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Corrigendum to "The promise of the metaverse in mental health: The new era of MEDverse"[Heliyon Volume 8, Issue 11, November 2022, Article e11762].

    Cerasa, Antonio / Gaggioli, Andrea / Marino, Flavia / Riva, Giuseppe / Pioggia, Giovanni

    Heliyon

    2023  Volume 9, Issue 3, Page(s) e14399

    Abstract: This corrects the article DOI: 10.1016/j.heliyon.2022.e11762.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.heliyon.2022.e11762.].
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival.

    Allegra, Alessandro / Caserta, Santino / Genovese, Sara / Pioggia, Giovanni / Gangemi, Sebastiano

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of sex differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research and cancer ... ...

    Abstract Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of sex differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research and cancer registries have revealed over the past few years that there are definite sex variations in cancer incidence, progression, and survival. However, oxidative stress and mitochondrial dysfunction also have a significant impact on the response to treatment of neoplastic diseases. Young women may be more protected from cancer than men because most of the proteins implicated in the regulation of redox state and mitochondrial function are under the control of sexual hormones. In this review, we describe how sexual hormones control the activity of antioxidant enzymes and mitochondria, as well as how they affect several neoplastic diseases. The molecular pathways that underlie the gender-related discrepancies in cancer that have been identified may be better understood, which may lead to more effective precision medicine and vital information on treatment options for both males and females with neoplastic illnesses.
    Language English
    Publishing date 2023-06-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: When patients don't tell, clinicians don't ask: The need for assessing sexuality in the rehabilitation setting.

    Calabrò, Rocco Salvatore / Cerasa, Antonio / Pioggia, Giovanni

    Annals of physical and rehabilitation medicine

    2022  Volume 65, Issue 2, Page(s) 101610

    MeSH term(s) Humans ; Sexuality
    Language English
    Publishing date 2022-02-10
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2480363-7
    ISSN 1877-0665 ; 1877-0657
    ISSN (online) 1877-0665
    ISSN 1877-0657
    DOI 10.1016/j.rehab.2021.101610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1857: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival

    Allegra, Alessandro / Caserta, Santino / Genovese, Sara / Pioggia, Giovanni / Gangemi, Sebastiano

    Antioxidants. 2023 June 11, v. 12, no. 6

    2023  

    Abstract: Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of sex differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research and cancer ... ...

    Abstract Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of sex differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research and cancer registries have revealed over the past few years that there are definite sex variations in cancer incidence, progression, and survival. However, oxidative stress and mitochondrial dysfunction also have a significant impact on the response to treatment of neoplastic diseases. Young women may be more protected from cancer than men because most of the proteins implicated in the regulation of redox state and mitochondrial function are under the control of sexual hormones. In this review, we describe how sexual hormones control the activity of antioxidant enzymes and mitochondria, as well as how they affect several neoplastic diseases. The molecular pathways that underlie the gender-related discrepancies in cancer that have been identified may be better understood, which may lead to more effective precision medicine and vital information on treatment options for both males and females with neoplastic illnesses.
    Keywords gender ; mitochondria ; oxidative stress ; precision medicine
    Language English
    Dates of publication 2023-0611
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061255
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Dynamics of astrocytes Ca

    Musotto, Rosa / Wanderlingh, Ulderico / D'Ascola, Angela / Spatuzza, Michela / Catania, Maria Vincenza / De Pittà, Maurizio / Pioggia, Giovanni

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1320672

    Abstract: In an effort to help reduce the costs of fluorescence microscopy and expand the use of this valuable technique, we developed a low-cost platform capable of visualising and analysing the spatio-temporal dynamics of intracellular ... ...

    Abstract In an effort to help reduce the costs of fluorescence microscopy and expand the use of this valuable technique, we developed a low-cost platform capable of visualising and analysing the spatio-temporal dynamics of intracellular Ca
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1320672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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