Artikel ; Online: Association of renin-angiotensin-aldosterone system inhibitors with best COVID-19 outcomes in a diabetic population of the Veneto region (north-east Italy): A lesson for endemic phase?
2023
Abstract: Diabetes mellitus is a prevalent chronic disease in patients who die of COVID-19. The aim of this study was to investigate the clinical and metabolic characteristics of diabetic patients with COVID-19 during the pre-vaccination phase. A retrospective ... ...
| Abstract | Diabetes mellitus is a prevalent chronic disease in patients who die of COVID-19. The aim of this study was to investigate the clinical and metabolic characteristics of diabetic patients with COVID-19 during the pre-vaccination phase. A retrospective cohort study was conducted from February 2020 to February 2021 to examine the clinical and metabolic profiles of unvaccinated diabetic patients affected by COVID-19. Data were collected from claim databases, hospital discharge records, and clinical records within a healthcare district located in northeastern Italy with a population of 936,000. Potential prognostic indicators including sex, age, Body Mass Index (BMI), duration and type of diabetes, metabolic control, and the use of antidiabetic, antihypertensive, lipid-lowering, and antiplatelet therapies were investigated. For hospitalized patients, additional variables were recorded, such as length of hospital stay, blood pressure at admission, comorbidities, D-dimer levels, blood glucose (BG), in-hospital insulin and corticosteroid therapies, requirement for mechanical ventilation (i.e., orotracheal or tracheostomy), admission to the Intensive Care Unit (ICU), and mortality. Diabetic patients hospitalized for COVID-19 with a poorer prognosis were characterized by advanced age, longer diabetes duration, hypertension, higher usage of sulfonylureas, and lower usage of dietotherapy alone, metformin, Glucagon-Like Peptide-1 Receptor agonists (GLP1-Ra), and Renin-Angiotensin-Aldosterone System inhibitors (RAAS-i). Considering the potential for COVID-19 to become endemic, special care should be taken in managing older diabetic patients’ treatments. |
|---|---|
| Schlagwörter | COVID-19 infection ; adrenal cortex hormones ; blood glucose ; blood pressure ; body mass index ; chronic diseases ; cohort studies ; diabetes mellitus ; elderly ; glucagon-like peptide 1 ; health services ; hospitals ; hypertension ; insulin ; metabolism ; metformin ; mortality ; nutrition ; prognosis ; sulfonylureas ; Italy ; Diabetes ; COVID-19 ; Metabolic control ; RAAS-i ; ACE2 ; ACEi ; AH1N1 ; ARBs ; BG ; BMI ; CI ; DPP-4 ; DPP-4i ; GLP1-Ra ; HDR ; HR ; ICD9-CM ; ICU ; INIH ; MERS-CoV ; SARS ; SD ; SGLT2-i |
| Sprache | Englisch |
| Erscheinungsverlauf | 2023-0624 |
| Erscheinungsort | Elsevier B.V. |
| Dokumenttyp | Artikel ; Online |
| Anmerkung | Pre-press version |
| ZDB-ID | 1067704-5 |
| ISSN | 0939-4753 |
| ISSN | 0939-4753 |
| DOI | 10.1016/j.numecd.2023.06.016 |
| Datenquelle | NAL Katalog (AGRICOLA) |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Zs.A 3149: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.