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  1. Article ; Online: Response to ketamine article.

    Pirrello, Rosene D

    Journal of palliative medicine

    2012  Volume 15, Issue 7, Page(s) 734–735

    MeSH term(s) Analgesics/administration & dosage ; Biomedical Research ; Female ; Humans ; Infusions, Intravenous ; Ketamine/administration & dosage ; Male ; Neoplasms/physiopathology ; Pain, Intractable/drug therapy ; Palliative Care
    Chemical Substances Analgesics ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2012.9574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5440: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A Case-Based Approach to Integrating Opioid Pharmacokinetic and Pharmacodynamic Concepts in Cancer Pain Management.

    Lam, Lisa H / Pirrello, Rosene D / Ma, Joseph D

    Journal of clinical pharmacology

    2016  Volume 56, Issue 7, Page(s) 785–793

    Abstract: Opioids are prescribed for cancer pain. Over the past decade, the annual increase in opioid prescriptions has been accompanied by an increase in opioid-associated deaths. Health care professionals must be proficient in proper dosing, titrating, and ... ...

    Abstract Opioids are prescribed for cancer pain. Over the past decade, the annual increase in opioid prescriptions has been accompanied by an increase in opioid-associated deaths. Health care professionals must be proficient in proper dosing, titrating, and monitoring of opioid medications. With the numerous opioid medications and formulations available, an understanding of pharmacokinetic (PK) and pharmacodynamic (PD) concepts is necessary to appropriately individualize opioid-based cancer pain regimens. The purpose of this review is to highlight PK/PD concepts that are clinically relevant to the use of opioids. By way of a cancer pain patient case scenario, PK/PD concepts that are relevant in the initiation, titration, and rotation of an opioid regimen are discussed.
    MeSH term(s) Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/pharmacokinetics ; Cancer Pain/drug therapy ; Cancer Pain/metabolism ; Drug Administration Routes ; Drug Substitution/methods ; Female ; Humans ; Middle Aged ; Pain Management/methods
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2016
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.676
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  3. Article ; Online: Laxative tasting.

    Morrison, Katherine T / Pirrello, Rosene D

    Journal of palliative medicine

    2011  Volume 14, Issue 3, Page(s) 268–269

    MeSH term(s) Consumer Behavior ; Humans ; Laxatives/standards ; Palliative Care ; Taste
    Chemical Substances Laxatives
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Letter
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2010.0433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5440: Show issues Location:
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  4. Article ; Online: Strategic planning by the palliative care steering committee of the Middle East Cancer Consortium.

    Moore, Shannon Y / Pirrello, Rosene D / Christianson, Sonya K / Ferris, Frank D

    Journal of pediatric hematology/oncology

    2011  Volume 33 Suppl 1, Page(s) S39–46

    Abstract: High quality comprehensive palliative care is a critical need for millions of patients and families, but remains only a dream in many parts of the world. The failure to do a strategic planning process is one obstacle to advancing education and pain ... ...

    Abstract High quality comprehensive palliative care is a critical need for millions of patients and families, but remains only a dream in many parts of the world. The failure to do a strategic planning process is one obstacle to advancing education and pain prevention and relief. The Middle Eastern Cancer Consortium Steering Committee attendees completed an initial strategic planning process and identified "developmental steps" to advance palliative care. Underscoring the multi-disciplinary nature of comprehensive palliative care, discipline-specific planning was done (adult and pediatric cancer and medicine, pharmacy, nursing) in a separate process from country-specific planning. Delineating the layers of intersection and differences between disciplines and countries was very powerful. Finding the common strengths and weaknesses in the status quo creates the potential for a more powerful regional response to the palliative care needs. Implementing and refining these preliminary strategic plans will augment and align the efforts to advance palliative care education and pain management in the Middle East. The dream to prevent and relieve suffering for millions of patients with advanced disease will become reality with a powerful strategic planning process well implemented.
    MeSH term(s) Humans ; Middle East ; Neoplasms/therapy ; Palliative Care/methods ; Palliative Care/organization & administration ; Palliative Care/standards ; Professional Staff Committees
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0b013e3182121d91
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clarifying delirium management: practical, evidenced-based, expert recommendations for clinical practice.

    Irwin, Scott A / Pirrello, Rosene D / Hirst, Jeremy M / Buckholz, Gary T / Ferris, Frank D

    Journal of palliative medicine

    2013  Volume 16, Issue 4, Page(s) 423–435

    Abstract: Delirium is highly prevalent in those with serious or advanced medical illnesses. It is associated with many adverse consequences, including significant patient, family, and health care provider distress. This article suggests a novel approach to ... ...

    Abstract Delirium is highly prevalent in those with serious or advanced medical illnesses. It is associated with many adverse consequences, including significant patient, family, and health care provider distress. This article suggests a novel approach to delirium assessment and management and provides useful, practical guidance for clinicians based on a complete review of the existing literature and the expert clinical opinion of the authors and their colleagues, derived from over a decade of collective bedside experience. Comprehensive assessment includes careful description of observed symptoms, signs, and behaviors; and an understanding of the patient's situation, including primary diagnosis, associated comorbidities, functional status, and prognosis. The importance of incorporating goals of care for the patient and family is discussed. The concepts of potential reversibility versus irreversible delirium and delirium subtype are proffered, with a description of how diagnostic and management strategies follow from these concepts. Pharmacological interventions that provide rapid, effective, and safe relief are presented. Employing both pharmacological and nonpharmacological interventions, including patient and family education, improves symptoms and relieves patient and family distress, whether the delirium is reversible or irreversible, hyperactive or hypoactive. All interventions can be provided in any setting of care, including patients' homes.
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Delirium/diagnosis ; Delirium/drug therapy ; Evidence-Based Medicine ; Humans ; Practice Patterns, Physicians' ; Terminally Ill/psychology ; Treatment Outcome
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2013-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2012.0319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5440: Show issues Location:
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  6. Article: Initial experiences with subcutaneous recombinant human hyaluronidase.

    Pirrello, Rosene D / Ting Chen, Christina / Thomas, Sandra H

    Journal of palliative medicine

    2007  Volume 10, Issue 4, Page(s) 861–864

    Abstract: We report here our retrospective observations on the use of recombinant human hyaluronidase (rHuPH20) for the facilitation of subcutaneous hydration and drug infusion. Thirty-two patients were treated with rHuPH20 in a hospice setting over a 6-month ... ...

    Abstract We report here our retrospective observations on the use of recombinant human hyaluronidase (rHuPH20) for the facilitation of subcutaneous hydration and drug infusion. Thirty-two patients were treated with rHuPH20 in a hospice setting over a 6-month period. Of these, 26 received this agent to enhance hypodermoclysis with standard hydration fluids for symptom control of delirium, myoclonus and mild to moderate dehydration. Flow rates up to 500 mL/hr were attained without difficulty. Electrolyte replacement in hydration fluid was achieved without incident in 5 patients receiving potassium and in 1 patient receiving both potassium and magnesium. In addition to use for hydration, 6 patients received recombinant human hyaluronidase to enhance subcutaneous infusion of 9 medications, primarily because the medication dosage required subcutaneous flow rates greater than the standard 3 mL/hr. There were no significant adverse events. Induration at the infusion site occurred in 1 patient receiving hydration and higher than expected serum lidocaine concentration was observed in another patient. Based on our positive initial experience with recombinant human hyaluronidase, there is interest in expanding its use in our facility in both the inpatient and outpatient settings.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; California ; Cell Adhesion Molecules ; Dehydration/therapy ; Female ; Hospices ; Humans ; Hyaluronoglucosaminidase/administration & dosage ; Hyaluronoglucosaminidase/metabolism ; Hyaluronoglucosaminidase/therapeutic use ; Infusions, Intravenous ; Male ; Medical Audit ; Middle Aged ; Protein Engineering ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/metabolism ; Recombinant Proteins/therapeutic use ; Retrospective Studies
    Chemical Substances Cell Adhesion Molecules ; Recombinant Proteins ; Hyaluronoglucosaminidase (EC 3.2.1.35) ; hyaluronidase PH-20 (EC 3.2.1.35)
    Language English
    Publishing date 2007-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427361-5
    ISSN 1096-6218
    ISSN 1096-6218
    DOI 10.1089/jpm.2007.0037
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5440: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: New opioids: expensive distractions or important additions to practice?

    von Gunten, Charles F / Bruera, Eduardo / Pirrello, Rosene D / Portenoy, Russell K

    Journal of palliative medicine

    2010  Volume 13, Issue 5, Page(s) 505–511

    MeSH term(s) Administration, Sublingual ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/economics ; Analgesics, Opioid/therapeutic use ; Attitude of Health Personnel ; Guidelines as Topic ; Harm Reduction ; Humans ; Pain/drug therapy ; Pain/economics ; Practice Patterns, Physicians' ; Risk Factors ; Substance-Related Disorders/epidemiology
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2010-05
    Publishing country United States
    Document type Consensus Development Conference ; Journal Article ; Review
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2010.9815
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