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  1. Article ; Online: miRNA Regulation of Cell Phenotype and Parietal Remodeling in Atherosclerotic and Non-Atherosclerotic Aortic Aneurysms: Differences and Similarities.

    Terriaca, Sonia / Ferlosio, Amedeo / Scioli, Maria Giovanna / Coppa, Francesca / Bertoldo, Fabio / Pisano, Calogera / Belmonte, Beatrice / Balistreri, Carmela Rita / Orlandi, Augusto

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Aortic aneurysms are a serious health concern as their rupture leads to high morbidity and mortality. Abdominal aortic aneurysms (AAAs) and thoracic aortic aneurysms (TAAs) exhibit differences and similarities in their pathophysiological and pathogenetic ...

    Abstract Aortic aneurysms are a serious health concern as their rupture leads to high morbidity and mortality. Abdominal aortic aneurysms (AAAs) and thoracic aortic aneurysms (TAAs) exhibit differences and similarities in their pathophysiological and pathogenetic features. AAA is a multifactorial disease, mainly associated with atherosclerosis, characterized by a relevant inflammatory response and calcification. TAA is rarely associated with atherosclerosis and in some cases is associated with genetic mutations such as Marfan syndrome (MFS) and bicuspid aortic valve (BAV). MFS-related and non-genetic or sporadic TAA share aortic degeneration with endothelial-to-mesenchymal transition (End-Mt) and fibrosis, whereas in BAV TAA, aortic degeneration with calcification prevails. microRNA (miRNAs) contribute to the regulation of aneurysmatic aortic remodeling. miRNAs are a class of non-coding RNAs, which post-transcriptionally regulate gene expression. In this review, we report the involvement of deregulated miRNAs in the different aortic remodeling characterizing AAAs and TAAs. In AAA, miRNA deregulation appears to be involved in parietal inflammatory response, smooth muscle cell (SMC) apoptosis and aortic wall calcification. In sporadic and MFS-related TAA, miRNA deregulation promotes End-Mt, SMC myofibroblastic phenotypic switching and fibrosis with glycosaminoglycan accumulation. In BAV TAA, miRNA deregulation sustains aortic calcification. Those differences may support the development of more personalized therapeutic approaches.
    MeSH term(s) Humans ; Aortic Valve/pathology ; MicroRNAs/metabolism ; Aortic Aneurysm/complications ; Aortic Aneurysm, Thoracic/genetics ; Bicuspid Aortic Valve Disease ; Marfan Syndrome/genetics ; Calcinosis/pathology ; Phenotype ; Atherosclerosis/metabolism ; Fibrosis
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-02-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cerebrovascular events after cardiovascular surgery: diagnosis, management and prevention strategies.

    Ferrante, Maria Sabrina / Pisano, Calogera / Van Rothem, Jérôme / Ruvolo, Giovanni / Abouliatim, Issam

    Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

    2023  Volume 20, Issue 2, Page(s) 118–122

    Abstract: Introduction: Cerebrovascular events after cardiac surgery are among the most serious complications, related to a greater risk of patient mortality. This problem can occur following the formation of gas emboli during open heart surgery.: Aim: To ... ...

    Abstract Introduction: Cerebrovascular events after cardiac surgery are among the most serious complications, related to a greater risk of patient mortality. This problem can occur following the formation of gas emboli during open heart surgery.
    Aim: To address all the mechanisms that can lead to embolic events after cardiovascular surgery, how to manage them and how to possibly prevent them.
    Material and methods: A search of the PubMed database was conducted. We reviewed the clinical literature and examined all aspects to identify the root causes that can lead to the formation of emboli.
    Results: Among the studies reviewed, it was found that the main causes include manipulation of the aorta, inadequate deaeration after cardiac surgery, and blood-component contact of extracorporeal circulation. It has been reported that gas emboli can lead to deleterious damage such as damage to the cerebral vascular endothelium, disruption of the blood-brain barrier, complement activation, leukocyte aggregation, increased platelet adhesion, and fibrin deposition in the microvascular system.
    Conclusions: Stroke after cardiovascular surgery is one of the most important complications, with a great impact on operative mortality and patient survival. Efforts have been made over time to understand all the pathophysiological mechanisms related to this complication, with the aim of reducing its incidence. One of the goals should be to improve both the surgical technique and the perfusion modality and minimize the formation of air bubbles or to facilitate their elimination during the cardiopulmonary bypass procedure.
    Language English
    Publishing date 2023-07-26
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2237053-5
    ISSN 1897-4252 ; 1731-5530
    ISSN (online) 1897-4252
    ISSN 1731-5530
    DOI 10.5114/kitp.2023.130020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A promising therapeutic peptide and preventive/diagnostic biomarker for age-related diseases: The Elabela/Apela/Toddler peptide.

    Monastero, Roberto / Magro, Daniele / Venezia, Marika / Pisano, Calogera / Balistreri, Carmela Rita

    Ageing research reviews

    2023  Volume 91, Page(s) 102076

    Abstract: Elabela (ELA), Apela or Toddler peptide is a hormone peptide belonging to the adipokine group and a component of apelinergic system, discovered in 2013-2014. Given its high homology with apelin, the first ligand of APJ receptor, ELA likely mediates ... ...

    Abstract Elabela (ELA), Apela or Toddler peptide is a hormone peptide belonging to the adipokine group and a component of apelinergic system, discovered in 2013-2014. Given its high homology with apelin, the first ligand of APJ receptor, ELA likely mediates similar effects. Increasing evidence shows that ELA has a critical function not only in embryonic development, but also in adulthood, contributing to physiological and pathological conditions, such as the onset of age-related diseases (ARD). However, still little is known about the mechanisms and molecular pathways of ELA, as well as its precise functions in ARD pathophysiology. Here, we report the mechanisms by which ELA/APJ signaling acts in a very complex network of pathways for the maintenance of physiological functions of human tissue and organs, as well as in the onset of some ARD, where it appears to play a central role. Therefore, we describe the possibility to use the ELA/APJ pathway, as novel biomarker (predictive and diagnostic) and target for personalized treatments of ARD. Its potentiality as an optimal peptide candidate for therapeutic ARD treatments is largely described, also detailing potential current limitations.
    MeSH term(s) Pregnancy ; Female ; Humans ; Peptide Hormones/chemistry ; Peptide Hormones/metabolism ; Apelin Receptors/metabolism ; Signal Transduction ; Aging
    Chemical Substances Peptide Hormones ; Apelin Receptors
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.102076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms.

    Pisano, Calogera / Benedetto, Umberto / Ruvolo, Giovanni / Balistreri, Carmela Rita

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is ... ...

    Abstract Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and potential solutions and approaches, as well as some potential treatments.
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: How Refined Surgical Technical Solutions Can Make Bentall Operation a Low-Risk Procedure: 20-Year Personal Experience at the "Root" of the Aortic Diseases-It Is Time to Change Surgical Guidelines.

    Ruvolo, Giovanni / Altieri, Claudia / Bassano, Carlo / Buioni, Dario / Nardi, Paolo / Pisano, Calogera

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: 1) Objective: Twenty years' experience of Bentall-De Bono operations by one surgeon. (2) Methods: From January 2003 to September 2023, four-hundred-and-two patients aged 65.9 ± 15 years underwent a Bentall operation. The EuroScore-2 was 5.0% ± 3.8%. ... ...

    Abstract (1) Objective: Twenty years' experience of Bentall-De Bono operations by one surgeon. (2) Methods: From January 2003 to September 2023, four-hundred-and-two patients aged 65.9 ± 15 years underwent a Bentall operation. The EuroScore-2 was 5.0% ± 3.8%. Associated procedures were performed on 113 patients (28.1%). Results: Operative mortality was 1.2% (
    Language English
    Publishing date 2023-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy.

    Terriaca, Sonia / Scioli, Maria Giovanna / Pisano, Calogera / Ruvolo, Giovanni / Ferlosio, Amedeo / Orlandi, Augusto

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: Marfan syndrome (MFS) is a connective tissue disorder caused ... ...

    Abstract Marfan syndrome (MFS) is a connective tissue disorder caused by
    MeSH term(s) Humans ; Marfan Syndrome/complications ; Marfan Syndrome/genetics ; Marfan Syndrome/metabolism ; beta Catenin ; Fibrosis ; Transforming Growth Factor beta/metabolism ; MicroRNAs/genetics ; Nerve Tissue Proteins ; Molecular Chaperones ; HSP40 Heat-Shock Proteins/genetics
    Chemical Substances beta Catenin ; Transforming Growth Factor beta ; MicroRNAs ; DNAJB6 protein, human ; Nerve Tissue Proteins ; Molecular Chaperones ; HSP40 Heat-Shock Proteins ; MIRN632 microRNA, human
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms

    Pisano, Calogera / Benedetto, Umberto / Ruvolo, Giovanni / Balistreri, Carmela Rita

    Antioxidants. 2022 Jan. 18, v. 11, no. 2

    2022  

    Abstract: Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is ... ...

    Abstract Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and potential solutions and approaches, as well as some potential treatments.
    Keywords aneurysm ; aorta ; biomarkers ; oxidative stress ; pathogenesis ; pathophysiology ; therapeutics
    Language English
    Dates of publication 2022-0118
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020182
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Right ventricular inflow obstruction related to late Candida albicans infection of implantable cardioverter-defibrillator leads.

    Buioni, Dario / Pisano, Calogera / Altieri, Claudia / Ruvolo, Giovanni

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2020  Volume 58, Issue 5, Page(s) 1101

    MeSH term(s) Candida albicans ; Candidiasis/diagnosis ; Cardiac Resynchronization Therapy ; Defibrillators, Implantable/adverse effects ; Heart Ventricles/diagnostic imaging ; Humans
    Language English
    Publishing date 2020-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezaa209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The Need for the STS Score Risk Stratification System for Aortic Root Aneurysms Surgery.

    Nardi, Paolo / Pisano, Calogera / Ruvolo, Giovanni

    The Annals of thoracic surgery

    2020  Volume 110, Issue 5, Page(s) 1780

    MeSH term(s) Aneurysm ; Aortic Valve ; Cardiac Surgical Procedures ; Humans ; North America ; Risk Assessment
    Language English
    Publishing date 2020-05-04
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2020.03.083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: A rare localization of papillary fibroelastoma.

    Trombetti, Daniele / Nardi, Paolo / Asta, Laura / Pisano, Calogera / Altieri, Claudia / Ruvolo, Giovanni

    Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

    2022  Volume 19, Issue 2, Page(s) 103–104

    Language English
    Publishing date 2022-06-29
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2237053-5
    ISSN 1897-4252 ; 1731-5530
    ISSN (online) 1897-4252
    ISSN 1731-5530
    DOI 10.5114/kitp.2022.117501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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