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  1. Article ; Online: Author response to: Laparoscopic versus open colectomy for locally advanced T4 colonic cancer: meta-analysis of clinical and oncological outcomes.

    Podda, Mauro / Pisanu, Adolfo / Di Saverio, Salomone

    The British journal of surgery

    2022  Volume 109, Issue 8, Page(s) e96

    MeSH term(s) Colectomy ; Colonic Neoplasms/surgery ; Humans ; Laparoscopy ; Treatment Outcome
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac137
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  2. Article ; Online: Tobacco Smoking Is a Strong Predictor of Failure of Conservative Treatment in Hinchey IIa and IIb Acute Diverticulitis-A Retrospective Single-Center Cohort Study.

    Murzi, Valentina / Locci, Eleonora / Carta, Alessandro / Pilia, Tiziana / Frongia, Federica / Gessa, Emanuela / Podda, Mauro / Pisanu, Adolfo

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 7

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Abscess/complications ; Retrospective Studies ; Diverticulitis, Colonic/complications ; Conservative Treatment/methods ; Cohort Studies ; Diverticulitis
    Language English
    Publishing date 2023-07-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59071236
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  3. Article ; Online: Endoscopic retrograde appendicitis therapy: the true proof of the pudding is in the eating.

    Podda, Mauro / Di Saverio, Salomone / Agresta, Ferdinando / Pisanu, Adolfo

    Gastrointestinal endoscopy

    2020  Volume 92, Issue 6, Page(s) 1278–1279

    MeSH term(s) Acute Disease ; Appendicitis/diagnostic imaging ; Appendicitis/surgery ; Endoscopy ; Humans
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2020.07.016
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  4. Article ; Online: Well-differentiated mesenteric liposarcoma: report of two cases.

    Poillucci, Gaetano / Podda, Mauro / Pisanu, Adolfo / Gomes, Carlos Augusto / Gallo, Gaetano / Di Saverio, Salomone / De Angelis, Renato

    Acta bio-medica : Atenei Parmensis

    2022  Volume 92, Issue S1, Page(s) e2022121

    Abstract: Liposarcoma is a rare tumor that can be treated by surgery in the absence of distant metastases. Management of liposarcoma, including diagnosis and therapy, is challenging because it has no characteristic symptoms and no established effective treatment. ... ...

    Abstract Liposarcoma is a rare tumor that can be treated by surgery in the absence of distant metastases. Management of liposarcoma, including diagnosis and therapy, is challenging because it has no characteristic symptoms and no established effective treatment. Here, we report two rare cases of primary mesenteric liposarcoma. In the first case, the tumor caused small bowel obstruction, and the patient presented with abdominal distention and severe abdominal pain. The second case is an occasional finding that occurred during laparoscopic surgery for incisional hernia. Both patients underwent successful resection of the tumor. Histopathology found a well-differentiated liposarcoma in both cases.
    MeSH term(s) Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intestine, Small ; Lipoma ; Liposarcoma/diagnosis ; Liposarcoma/pathology ; Liposarcoma/surgery ; Mesentery/pathology
    Language English
    Publishing date 2022-03-08
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v92iS1.12010
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    Zs.B 925: Show issues Location:
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  5. Article ; Online: Robotic-assisted Pancreaticoduodenectomy: Technique Description and Performance Evaluation After 60 Cases.

    Marino, Marco V / Podda, Mauro / Pisanu, Adolfo / di Saverio, Salomone / Fleitas, Manuel G

    Surgical laparoscopy, endoscopy & percutaneous techniques

    2020  Volume 30, Issue 2, Page(s) 156–163

    Abstract: Purpose: Robotic pancreaticoduodenectomy (RPD) remains one of the most challenging abdominal operations. During the implementation of new surgical technologies, safety and efficacy outcomes must be rigorously monitored and the learning curve clearly ... ...

    Abstract Purpose: Robotic pancreaticoduodenectomy (RPD) remains one of the most challenging abdominal operations. During the implementation of new surgical technologies, safety and efficacy outcomes must be rigorously monitored and the learning curve clearly identified.
    Materials and methods: The authors investigated their experience during the adoption of RPD, analyzing the outcomes of our first 60 consecutive cases, divided into group A (1 to 30) and group B (31 to 60). The cumulative sum (CUSUM) analysis was used to define the learning curve.
    Results: The authors observed a reduction in operative time (125 min) and estimated blood loss (185 mL) between the firsts 1 to 30 and the latest 30 cases. The overall rate of complications showed the tendency to decrease during the experience (46.7% vs. 23.3%, P=0.02), conversely, severe complications and the rate of clinically relevant postoperative pancreatic fistula did not show a significant reduction in the incidence (P=0.37 and P=0.67, respectively). The mean number of lymph nodes harvested improved significantly after 30 cases (P=0.004).
    Conclusion: Surgical performance improved significantly after the first 30 cases.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Learning Curve ; Length of Stay ; Male ; Middle Aged ; Operative Time ; Pancreatic Diseases/mortality ; Pancreatic Diseases/pathology ; Pancreatic Diseases/surgery ; Pancreaticoduodenectomy/adverse effects ; Pancreaticoduodenectomy/methods ; Postoperative Complications/epidemiology ; Retrospective Studies ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Treatment Outcome
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1475108-2
    ISSN 1534-4908 ; 1530-4515 ; 1051-7200
    ISSN (online) 1534-4908
    ISSN 1530-4515 ; 1051-7200
    DOI 10.1097/SLE.0000000000000751
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    Zs.A 3200: Show issues Location:
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  6. Article ; Online: Endoscopic retrograde appendicitis therapy versus appendectomy or antibiotics in the modern approach to uncomplicated acute appendicitis: A systematic review and meta-analysis.

    Pata, Francesco / Nardo, Bruno / Ielpo, Benedetto / Di Martino, Marcello / Murzi, Valentina / Di Saverio, Salomone / Yang, Baohong / Ortenzi, Monica / Pisanu, Adolfo / Pellino, Gianluca / Podda, Mauro

    Surgery

    2023  Volume 174, Issue 6, Page(s) 1292–1301

    Abstract: Introduction: Endoscopic retrograde appendicitis therapy has been proposed as an alternative strategy for treating appendicitis, but debate exists on its role compared with conventional treatment.: Methods: This systematic review was performed on ... ...

    Abstract Introduction: Endoscopic retrograde appendicitis therapy has been proposed as an alternative strategy for treating appendicitis, but debate exists on its role compared with conventional treatment.
    Methods: This systematic review was performed on MEDLINE, Cochrane Central Register of Controlled Trials, and EMBASE. The last search was in April of 2023. The risk ratio with a 95% confidence interval was calculated for dichotomous variables, and the mean difference with a 95% confidence interval for continuous variables. The risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool (randomized controlled trials) and the Risk of Bias in Non-Randomized Studies of Intervention tool (non-randomized controlled trials).
    Results: Six studies met the eligibility criteria. Four studies compared endoscopic retrograde appendicitis therapy (n = 236 patients) and appendectomy (n = 339) and found no differences in technical success during index admission (risk ratio 0.97, 95% confidence interval [0.92,1.02]). Appendectomy showed superior outcomes for recurrence at 1-year follow-up (risk ratio 11.28, 95% confidence interval [2.61,48.73]). Endoscopic retrograde appendicitis therapy required shorter procedural time (mean difference -14.38, 95% confidence interval [-20.17, -8.59]) and length of hospital stay (mean difference -1.19, 95% confidence interval [-2.37, -0.01]), with lower post-intervention abdominal pain (risk ratio 0.21, 95% confidence interval [0.14,0.32]). Two studies compared endoscopic retrograde appendicitis therapy (n = 269) and antibiotic treatment (n = 280). Technical success during admission (risk ratio 1.11, 95% confidence interval [0.91,1.35]) and appendicitis recurrence (risk ratio 1.07, 95% confidence interval [0.08,14.87]) did not differ, but endoscopic retrograde appendicitis therapy decreased the length of hospitalization (mean difference -1.91, 95% confidence interval [-3.18, -0.64]).
    Conclusion: This meta-analysis did not identify significant differences between endoscopic retrograde appendicitis therapy and appendectomy or antibiotics regarding technical success during index admission and treatment efficacy at 1-year follow-up. However, a high risk of imprecision limits these results. The advantages of endoscopic retrograde appendicitis therapy in terms of reduced procedural times and shorter lengths of stay must be balanced against the increased risk of having an appendicitis recurrence at one year.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Appendectomy/adverse effects ; Appendicitis/drug therapy ; Appendicitis/surgery ; Hospitalization ; Length of Stay ; Abdominal Pain ; Acute Disease
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.08.029
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    Uk I Zs.129: Show issues Location:
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  7. Article ; Online: Updates on the multidisciplinary management of elderly patients with rectal cancer: a narrative review.

    Poillucci, Gaetano / Ortenzi, Monica / Pilia, Tiziana / Murzi, Valentina / DI Saverio, Salomone / Segalini, Edoardo / Locci, Eleonora / Cois, Alessandro / Pisanu, Adolfo / Podda, Mauro

    Minerva surgery

    2023  Volume 78, Issue 3, Page(s) 267–282

    Abstract: Introduction: The burden of rectal cancer in the elderly population continues to increase. The aim of this narrative review is to assess evidence updates on the management of elderly patients with rectal cancer.: Evidence acquisition: The subject of ... ...

    Abstract Introduction: The burden of rectal cancer in the elderly population continues to increase. The aim of this narrative review is to assess evidence updates on the management of elderly patients with rectal cancer.
    Evidence acquisition: The subject of rectal cancer in patients ≥70 years old was divided into different topics and, based on the research items, the literature review searched relevant studies from MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials, and EMBASE between January 2000 and November 2022. Systematic reviews with or without meta-analyses, narrative reviews, randomized trials, and non-randomized cohort studies were included.
    Evidence synthesis: For the fit elderly patient with preserved sphincter tone, standard-of-care surgical therapy should be pursued, whereas frail patients with more advanced disease could benefit from local excision as a palliative approach in combination with neoadjuvant chemoradiotherapy or more intensive radiotherapy options. Laparoscopic total mesorectal excision is recommended after carefully evaluating the patient's medical history, performance status, and tumor characteristics. Conversely, local excision can be implemented when balancing frailty, oncological outcomes, functional outcomes, and life expectancy. A watch and wait strategy can be considered in selected frail elderly patients with low-rectal tumors in case of complete clinical response after neoadjuvant chemoradiotherapy, with a stringent surveillance protocol, at least in the first three years.
    Conclusions: In elderly patients with rectal cancer, the adoption of strategies for patient involvement in healthcare decision-making is essential, as well as the evaluation of the social background and a discussion with the patient about therapeutic modalities.
    MeSH term(s) Aged ; Humans ; Treatment Outcome ; Rectal Neoplasms/surgery ; Neoadjuvant Therapy ; Chemoradiotherapy ; Digestive System Surgical Procedures
    Language English
    Publishing date 2023-02-01
    Publishing country Italy
    Document type Review ; Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.09845-3
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  8. Article ; Online: Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score-matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial).

    Podda, Mauro / Poillucci, Gaetano / Pacella, Daniela / Mortola, Lorenzo / Canfora, Alfonso / Aresu, Simona / Pisano, Marcello / Erdas, Enrico / Pisanu, Adolfo / Cillara, Nicola

    International journal of colorectal disease

    2021  Volume 36, Issue 3, Page(s) 589–598

    Abstract: Purpose: The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy as treatment for patients with uncomplicated appendicitis confirmed by ultrasound and/or computed tomography.: Methods: The study was conducted ... ...

    Abstract Purpose: The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy as treatment for patients with uncomplicated appendicitis confirmed by ultrasound and/or computed tomography.
    Methods: The study was conducted from January 2017 to January 2018. Data regarding all patients discharged from the participating centers with a diagnosis of uncomplicated appendicitis were collected prospectively.
    Results: Of the 318 patients enrolled in the study, 27.4% underwent antibiotic-first therapy, and 72.6% underwent appendectomy. The matched group was composed of 87 patients in both study arms. Of the 87 patients available of 1-year follow-up in the antibiotic-first group, 64 (73.6%) did not require appendectomy. The complication-free treatment success in the antibiotic-first group was 64.4%. A statistically significant higher complication-free treatment success was found in the appendectomy group: 81.8% in the pre-matching sample and 83.9% in the post-matching sample. Patients in the antibiotic-first group reported lower VAS scores compared to those treated with an appendectomy, both at discharge (2.0 ± 1.7 vs 3.6 ± 2.3) and at 30-day follow-up (0.3 ± 0.6 vs 2.1 ± 1.7). The mean of the days of absence from work was higher in the appendectomy group (β 0.63; 95% CI 0.08-1.18).
    Conclusion: Although laparoscopic appendectomy remains the gold standard of treatment for uncomplicated appendicitis, conservative treatment with antibiotics is a safe option in most cases. Approximately 65% of patients treated with antibiotics are symptom-free at 1 year, without increased risk of adverse events should symptoms recur, and better outcomes in terms of less pain and shorter period of absence from work compared to patients undergoing an appendectomy.
    Trial registration: Clinicaltrials.gov identifier (NCT number): NCT03080103.
    MeSH term(s) Acute Disease ; Anti-Bacterial Agents/therapeutic use ; Appendectomy ; Appendicitis/drug therapy ; Appendicitis/surgery ; Conservative Treatment ; Humans ; Patient-Centered Care ; Propensity Score ; Prospective Studies ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-01-17
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-021-03843-8
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    Zs.A 2121: Show issues Location:
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  9. Article ; Online: Systematic review with meta-analysis of studies comparing single-incision laparoscopic colectomy and multiport laparoscopic colectomy.

    Podda, Mauro / Saba, Alessandra / Porru, Federica / Pisanu, Adolfo

    Surgical endoscopy

    2016  Volume 30, Issue 11, Page(s) 4697–4720

    Abstract: Background: There is currently a paucity of research comparing the clinical outcomes of single-incision laparoscopic colectomy (SILC) with those obtained with multiport laparoscopic colectomy (MLC). This meta-analysis aimed to examine whether SILC shows ...

    Abstract Background: There is currently a paucity of research comparing the clinical outcomes of single-incision laparoscopic colectomy (SILC) with those obtained with multiport laparoscopic colectomy (MLC). This meta-analysis aimed to examine whether SILC shows real benefits over MLC, especially in terms of feasibility, safety, and oncological adequacy.
    Methods: A literature review of studies comparing SILC and MLC has been performed which looked at the following outcomes: mortality, morbidity, and oncological parameters of adequacy, as well as other potential benefits and drawbacks. Standardized mean difference for continuous variables and odds ratios for qualitative variables were calculated.
    Results: Thirty studies comparing SILC and MLC were reviewed: two prospective randomized clinical trials (RCTs), eight prospective studies, and 20 retrospective comparative observational studies. Overall, in a cohort of 3502 patients who underwent surgery, SILC was used in 1068 cases (30.5 %) and MLC was used in 2434 cases (69.5 %). Mean intraoperative blood loss was significantly lower when the SILC procedure had been used (75.06 vs. 91.45 ml, P = 0.03); bowel function recovered significantly earlier in the SILC patients (1.96 vs. 2.15 days, P = 0.03); mean postoperative hospital stay was significantly shorter in the SILC group (5.55 vs. 6.60 days, P = 0.0005); and length of skin incision was significantly shorter in SILC patients (3.98 vs. 5.28 cm, P = 0.01). However, in the latter four outcomes, evidence of heterogeneity was found. In contrast, MLC showed significantly better results when compared to SILC in terms of distal free margins (12.26 vs. 10.98 cm, P = 0.01).
    Conclusions: SILC could be considered as a safe and feasible alternative to MLC in experienced hands. Further evidence for this surgical procedure should be assessed in the form of high-quality RCTs, with additional focus on its use in low rectal cancer resection.
    MeSH term(s) Blood Loss, Surgical ; Colectomy/methods ; Colonic Diseases/surgery ; Hand ; Humans ; Laparoscopy/methods ; Length of Stay ; Postoperative Complications/epidemiology ; Safety ; Treatment Outcome
    Language English
    Publishing date 2016-11
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-016-4812-2
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  10. Article ; Online: Olanzapine-Associated Portal and Superior Mesenteric Vein Thrombosis.

    Mameli, Antonella / Natale, Luca / Musu, Mario / Finco, Gabriele / Pisanu, Adolfo / Marongiu, Francesco / Barcellona, Doris

    American journal of therapeutics

    2019  Volume 27, Issue 4, Page(s) e419–e420

    MeSH term(s) Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Female ; Humans ; Mesenteric Veins/pathology ; Middle Aged ; Olanzapine/adverse effects ; Olanzapine/therapeutic use ; Portal Vein/pathology ; Schizophrenia/drug therapy ; Venous Thrombosis/chemically induced
    Chemical Substances Antipsychotic Agents ; Olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2019-06-27
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1280786-2
    ISSN 1536-3686 ; 1075-2765
    ISSN (online) 1536-3686
    ISSN 1075-2765
    DOI 10.1097/MJT.0000000000000994
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