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  1. Book: Management of pancreatic neuroendocrine tumors

    Pisegna, Joseph R.

    2015  

    Author's details Joseph R. Pisegna ed
    Language English
    Size X, 167 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018465294
    ISBN 978-1-4939-1797-6 ; 1-4939-1797-8 ; 9781493917983 ; 1493917986
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 4417 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Diagnosis and Treatment Design Strategy for Gastric Neoplasia.

    Pisegna, Joseph R

    The American journal of gastroenterology

    2023  Volume 118, Issue 12, Page(s) 2144–2145

    MeSH term(s) Humans ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/therapy ; Gastroscopy ; Gastric Mucosa
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002390
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Conference proceedings: 5th International Meeting VIP, PACAP, Secretin, Glucagon and Related Peptides

    Pisegna, Joseph R.

    Santa Barbara, California, November 4 - 8, 2001

    (Regulatory peptides ; 109,1/3 = Special issue)

    2002  

    Event/congress International Symposium on VIP, PACAP, Secretin, Glucagon and Related Peptides (5, 2001, SantaBarbaraCalif.)
    Author's details guest eds.: J. R. Pisegna
    Series title Regulatory peptides ; 109,1/3 = Special issue
    Collection
    Language English
    Size S. 1 - 216 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT013520360
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1593 -109- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Editorial: tegoprazan-the newest advance in the management of acid-related diseases.

    Marcus, Elizabeth A / Pisegna, Joseph R

    Alimentary pharmacology & therapeutics

    2020  Volume 52, Issue 6, Page(s) 1074–1075

    MeSH term(s) Benzene Derivatives ; Humans ; Imidazoles ; Lansoprazole ; Potassium ; Stomach Ulcer
    Chemical Substances Benzene Derivatives ; Imidazoles ; Lansoprazole (0K5C5T2QPG) ; Potassium (RWP5GA015D) ; tegoprazan (W017G7IF4S)
    Language English
    Publishing date 2020-10-29
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Isolation of Nuclei from Human Snap-frozen Liver Tissue for Single-nucleus RNA Sequencing.

    Alvarez, Marcus / Benhammou, Jihane N / Rao, Shuyun / Mishra, Lopa / Pisegna, Joseph R / Pajukanta, Päivi

    Bio-protocol

    2023  Volume 13, Issue 3, Page(s) e4601

    Abstract: Single-nucleus RNA sequencing (snRNA-seq) provides a powerful tool for studying cell type composition in heterogenous tissues. The liver is a vital organ composed of a diverse set of cell types; thus, single-cell technologies could greatly facilitate the ...

    Abstract Single-nucleus RNA sequencing (snRNA-seq) provides a powerful tool for studying cell type composition in heterogenous tissues. The liver is a vital organ composed of a diverse set of cell types; thus, single-cell technologies could greatly facilitate the deconvolution of liver tissue composition and various downstream omics analyses at the cell-type level. Applying single-cell technologies to fresh liver biopsies can, however, be very challenging, and snRNA-seq of snap-frozen liver biopsies requires some optimization given the high nucleic acid content of the solid liver tissue. Therefore, an optimized protocol for snRNA-seq specifically targeted for the use of frozen liver samples is needed to improve our understanding of human liver gene expression at the cell-type resolution. We present a protocol for performing nuclei isolation from snap-frozen liver tissues, as well as guidance on the application of snRNA-seq. We also provide guidance on optimizing the protocol to different tissue and sample types.
    Language English
    Publishing date 2023-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton.

    Benhammou, Jihane N / Qiao, Bo / Ko, Arthur / Sinnett-Smith, James / Pisegna, Joseph R / Rozengurt, Enrique

    American journal of physiology. Gastrointestinal and liver physiology

    2023  Volume 325, Issue 3, Page(s) G239–G250

    Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of liver-related death. Lipophilic statins have been associated with a decrease in HCC incidence, raising the possibility of their use as chemoprevention agents. The Yes-associated protein (YAP) ... ...

    Abstract Hepatocellular carcinoma (HCC) is the third leading cause of liver-related death. Lipophilic statins have been associated with a decrease in HCC incidence, raising the possibility of their use as chemoprevention agents. The Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) have emerged as an important pro-oncogenic mechanism in HCC. Statins modulate YAP/TAZ in other solid tumors, but few studies have assessed their mechanisms in HCC. We aimed to delineate how lipophilic statins regulate YAP protein localization by interrogating the mevalonate pathway in a stepwise manner using pharmacological and genetical approaches in HCC cells. Huh7 and Hep3B HCC cells were treated with the lipophilic statins cerivastatin and atorvastatin. YAP protein localization was determined using quantitative immunofluorescence (IF) imaging. The gene expression of
    MeSH term(s) Humans ; Actin Cytoskeleton/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Carcinoma, Hepatocellular/drug therapy ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Liver Neoplasms/drug therapy ; Mevalonic Acid/metabolism ; rho GTP-Binding Proteins/metabolism ; YAP-Signaling Proteins/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Mevalonic Acid (S5UOB36OCZ) ; rho GTP-Binding Proteins (EC 3.6.5.2) ; YAP-Signaling Proteins ; YAP1 protein, human
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00089.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Management of pancreatic neuroendocrine tumors

    Pisegna, Joseph R

    2015  

    Author's details Joseph R. Pisegna, editor
    MeSH term(s) Pancreatic Neoplasms/diagnosis ; Neuroendocrine Tumors/diagnosis ; Pancreatic Neoplasms/therapy ; Neuroendocrine Tumors/therapy
    Language English
    Size x, 167 pages :, illustrations
    Document type Book
    ISBN 9781493917976 ; 9781493917983 ; 1493917978 ; 1493917986
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Familial Duodenal Somatostatinomatosis Not Associated With a Known Genetic Syndrome.

    Yu, Run / Rao, Jianyu / Zhai, Jing / Hecht, J Randolph / Pisegna, Joseph R

    Pancreas

    2022  Volume 51, Issue 8, Page(s) 1056–1060

    Abstract: Abstract: We report a father and his daughter who both had multiple somatostatinomas in the duodenal bulb without a known syndrome. The father, at age 68 years, was incidentally found to harbor 4 approximately 1.5-cm well-differentiated neuroendocrine ... ...

    Abstract Abstract: We report a father and his daughter who both had multiple somatostatinomas in the duodenal bulb without a known syndrome. The father, at age 68 years, was incidentally found to harbor 4 approximately 1.5-cm well-differentiated neuroendocrine tumors in the duodenal bulb. His preoperative somatostatin level was elevated. He underwent partial duodenectomy and regional lymph node dissection; one lymph node was positive for metastasis. One year postoperatively, a recurrence was found in the surgical bed; he was treated with octreotide for 2 years, which stabilized the recurrent tumor. Ten years postoperatively, the mucosa of his remaining duodenum was normal. His daughter, at age 53 years, was found to harbor multiple small neuroendocrine tumors in the duodenal bulb. Immunostaining of available specimens showed that the neuroendocrine tumors from the father and daughter both were strongly positive for somatostatin. Micronodules of somatostatin-expressing neuroendocrine cells were found in the parts of the specimens uninvolved with the tumors. Both patients exhibited no evidence of known syndromes associated with somatostatinoma. The daughter did not harbor mutations in 93 genes commonly found in genetic tumor syndromes. The 2 cases thus suggest a novel, autosomal dominant, genetic syndrome of familial duodenal somatostatinomatosis.
    MeSH term(s) Male ; Humans ; Aged ; Middle Aged ; Duodenal Neoplasms/genetics ; Duodenal Neoplasms/complications ; Neoplasm Recurrence, Local ; Duodenum/pathology ; Somatostatinoma/diagnosis ; Somatostatinoma/genetics ; Somatostatinoma/complications ; Neuroendocrine Tumors/pathology ; Somatostatin/therapeutic use ; Pancreatic Neoplasms/pathology
    Chemical Substances Somatostatin (51110-01-1)
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000002126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: PACAP and VIP Neuropeptides' and Receptors' Effects on Appetite, Satiety and Metabolism.

    Vu, John P / Luong, Leon / Sanford, Daniel / Oh, Suwan / Kuc, Alma / Pisegna, Rita / Lewis, Michael / Pisegna, Joseph R / Germano, Patrizia M

    Biology

    2023  Volume 12, Issue 7

    Abstract: The overwhelming increase in the prevalence of obesity and related disorders in recent years is one of the greatest threats to the global healthcare system since it generates immense healthcare costs. As the prevalence of obesity approaches epidemic ... ...

    Abstract The overwhelming increase in the prevalence of obesity and related disorders in recent years is one of the greatest threats to the global healthcare system since it generates immense healthcare costs. As the prevalence of obesity approaches epidemic proportions, the importance of elucidating the mechanisms regulating appetite, satiety, body metabolism, energy balance and adiposity has garnered significant attention. Currently, gastrointestinal (GI) bariatric surgery remains the only approach capable of achieving successful weight loss. Appetite, satiety, feeding behavior, energy intake and expenditure are regulated by central and peripheral neurohormonal mechanisms that have not been fully elucidated yet. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Vasoactive Intestinal Polypeptide (VIP) are members of a family of regulatory peptides that are widely distributed in parallel with their specific receptors, VPAC1R, VPAC2R and PAC1R, in the central nervous system (CNS) and in the periphery, such as in the gastrointestinal tract and its associated organs and immune cells. PACAP and VIP have been reported to play an important role in the regulation of body phenotype, metabolism and homeostatic functions. The purpose of this review is to present recent data on the effects of PACAP, VIP, VPAC1R, VPAC2R and PAC1R on the modulation of appetite, satiety, metabolism, calorie intake and fat accumulation, to evaluate their potential use as therapeutic targets for the treatment of obesity and metabolic syndrome.
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12071013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Management of Pancreatic Neuroendocrine Tumors

    Pisegna, Joseph R

    2015  

    Abstract: This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the ... ...

    Author's details edited by Joseph R. Pisegna
    Abstract This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists
    Keywords Endocrinology ; Gastroenterology ; Medicine ; Oncology ; Radiology, Medical
    Language English
    Size Online-Ressource (X, 167 p. 28 illus., 20 illus. in color), online resource
    Publisher Springer New York
    Publishing place New York, NY ;s.l
    Document type Book ; Online
    Note Includes index
    ISBN 9781493917976 ; 9781493917983 ; 1493917978 ; 1493917986
    DOI 10.1007/978-1-4939-1798-3
    Database Former special subject collection: coastal and deep sea fishing

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