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Article ; Online: Virology: a scientific discipline facing new challenges.

Antonelli, G / Pistello, M

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2018 Volume 25, Issue 2, Page(s) 133–135

MeSH term(s)	Humans ; Research ; Virology/trends ; Virus Diseases
Language	English
Publishing date	2018-12-21
Publishing country	England
Document type	Editorial
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2018.12.003
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Calendar of international meetings.

Pistello, Mauro

Reviews in medical virology

2015 Volume 25, Issue 3, Page(s) 202

Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1086043-5
ISSN	1099-1654 ; 1052-9276
ISSN (online)	1099-1654
ISSN	1052-9276
DOI	10.1002/rmv.1838
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Article ; Online: Integration of the viral genome into the host cell genome: a double-edged sword.

Pistello, M / Antonelli, G

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2016 Volume 22, Issue 4, Page(s) 296–298

MeSH term(s)	Gene Rearrangement ; Host-Pathogen Interactions ; Humans ; Virus Integration ; Virus Physiological Phenomena
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Editorial
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2016.01.022
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Future management of viral diseases: role of new technologies and new approaches in microbial interactions.

Maggi, F / Pistello, M / Antonelli, G

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2018 Volume 25, Issue 2, Page(s) 136–141

Abstract: Background: New technologies allow rapid detecting and counting of virus genomes in clinical specimens, defining susceptibility to specific antivirals, pinpointing molecular sequences correlated to virulence traits, and identifying viral and host ... ...

Abstract	Background: New technologies allow rapid detecting and counting of virus genomes in clinical specimens, defining susceptibility to specific antivirals, pinpointing molecular sequences correlated to virulence traits, and identifying viral and host factors driving resolution or chronicity of infections. As a result, during the past three decades the diagnostic virology laboratory has become crucial for patient care and an integral component of the multifarious armamentarium for patient management. This change in paradigm has caused obsolescence of methods once considered the reference standard of infectious disease diagnosis that were used to detect whole or specific components of virions in the specimen. Objectives: This review provides an overview of standard and novel technologies applied to molecular diagnosis of viral infections and illustrates some crucial points for correcting interpretation of the laboratory data. Sources: Peer-reviewed literature of topics pertinent to this review. Content and implications: New technologies are reinventing the way virologic diagnoses are made, with a conversion to new, simpler-to-use platforms. Although indicated for the same purpose, not all methods are equal and can yield different results. Further, tests identifying multiple analytes at once can detect microorganisms present or activated as a result of pathologic processes triggered by other pathogens or noninfectious causes. Thus, new directions will have to be taken in the way in which the diagnoses of viral diseases are performed. This represents a breakthrough in the clinical virology laboratory.
MeSH term(s)	High-Throughput Nucleotide Sequencing ; Humans ; Microbial Interactions ; Molecular Diagnostic Techniques ; Virus Diseases/diagnosis ; Virus Diseases/virology ; Viruses/classification ; Viruses/isolation & purification
Language	English
Publishing date	2018-11-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2018.11.015
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Kinetics of anti-SARS-COV2 spike protein IgG and IgA antibodies at 4°C: Implications for convalescent plasma stability.

Focosi, Daniele / Moscato, Giovanna / Pistello, Mauro / Maggi, Fabrizio

Transfusion medicine (Oxford, England)

2021 Volume 31, Issue 3, Page(s) 221–222

MeSH term(s)	Antibodies, Viral ; COVID-19/therapy ; Humans ; Immunization, Passive ; Immunoglobulin A ; Immunoglobulin G ; Kinetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Chemical Substances	Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-04-25
Publishing country	England
Document type	Letter
ZDB-ID	1067989-3
ISSN	1365-3148 ; 0958-7578
ISSN (online)	1365-3148
ISSN	0958-7578
DOI	10.1111/tme.12776
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Zs.A 3177: Show issues

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Article ; Online: Human neural progenitor cell models to study the antiviral effects and neuroprotective potential of approved and investigational human cytomegalovirus inhibitors.

Trevisan, Marta / Pianezzola, Anna / Onorati, Marco / Apolloni, Lorenzo / Pistello, Mauro / Arav-Boger, Ravit / Palù, Giorgio / Mercorelli, Beatrice / Loregian, Arianna

Antiviral research

2024 Volume 223, Page(s) 105816

Abstract: Human cytomegalovirus (HCMV) is the viral leading cause of congenital defects in newborns worldwide. Many aspects of congenital CMV (cCMV) infection, which currently lacks a specific treatment, as well as the main determinants of neuropathogenesis in the ...

Abstract	Human cytomegalovirus (HCMV) is the viral leading cause of congenital defects in newborns worldwide. Many aspects of congenital CMV (cCMV) infection, which currently lacks a specific treatment, as well as the main determinants of neuropathogenesis in the developing brain during HCMV infection are unclear. In this study, we modeled HCMV infection at different stages of neural development. Moreover, we evaluated the effects of both approved and investigational anti-HCMV drugs on viral replication and gene expression in two different neural progenitor cell lines, i.e., human embryonic stem cells-derived neural stem cells (NSCs) and fetus-derived neuroepithelial stem (NES) cells. Ganciclovir, letermovir, nitazoxanide, and the ozonide OZ418 reduced viral DNA synthesis and the production of infectious virus in both lines of neural progenitors. HCMV infection dysregulated the expression of genes that either are markers of neural progenitors, such as SOX2, NESTIN, PAX-6, or play a role in neurogenesis, such as Doublecortin. Treatment with antiviral drugs had different effects on HCMV-induced dysregulation of the genes under investigation. This study contributes to the understanding of the molecular mechanisms of cCMV neuropathogenesis and paves the way for further consideration of anti-HCMV drugs as candidate therapeutic agents for the amelioration of cCMV-associated neurological manifestations.
MeSH term(s)	Infant, Newborn ; Humans ; Cytomegalovirus ; Cytomegalovirus Infections/drug therapy ; Brain ; Drugs, Investigational ; Stem Cells ; Antiviral Agents/pharmacology
Chemical Substances	Drugs, Investigational ; Antiviral Agents
Language	English
Publishing date	2024-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2024.105816
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Zs.A 1627: Show issues

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Article: Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis.

Parisi, Francesca / Fonti, Niccolò / Millanta, Francesca / Freer, Giulia / Pistello, Mauro / Poli, Alessandro

Infectious agents and cancer

2023 Volume 18, Issue 1, Page(s) 40

Abstract: Currently, it is estimated that 15% of human neoplasms globally are caused by infectious agents, with new evidence emerging continuously. Multiple agents have been implicated in various forms of neoplasia, with viruses as the most frequent. In recent ... ...

Abstract	Currently, it is estimated that 15% of human neoplasms globally are caused by infectious agents, with new evidence emerging continuously. Multiple agents have been implicated in various forms of neoplasia, with viruses as the most frequent. In recent years, investigation on viral mechanisms underlying tumoral transformation in cancer development and progression are in the spotlight, both in human and veterinary oncology. Oncogenic viruses in veterinary medicine are of primary importance not only as original pathogens of pets, but also in the view of pets as models of human malignancies. Hence, this work will provide an overview of the main oncogenic viruses of companion animals, with brief notes of comparative medicine.
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2251117-9
ISSN	1750-9378
ISSN	1750-9378
DOI	10.1186/s13027-023-00518-7
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Article ; Online: Canonical fibroblast growth factors in viral infection.

Lottini, Giulia / Plicanti, Erika / Lai, Michele / Quaranta, Paola / Pistello, Mauro / Freer, Giulia

Reviews in medical virology

2023 Volume 33, Issue 4, Page(s) e2452

Abstract: Fibroblast growth factors (FGFs) are a family of proteins that play a crucial role in the development and maintenance of various tissues in the body. There are three function-al groups of FGFs: canonical FGFs (cFGFs), intracellularly retained FGFs, and ... ...

Abstract	Fibroblast growth factors (FGFs) are a family of proteins that play a crucial role in the development and maintenance of various tissues in the body. There are three function-al groups of FGFs: canonical FGFs (cFGFs), intracellularly retained FGFs, and metabolic (also called endocrine) FGFs. cFGFs are secreted and act in an autocrine/paracrine fashion to regulate differentiation during foetal development, as well as tissue repair in adults. Recent studies have also begun to unravel the role of cFGFs during viral infections, suggesting that FGF-2 and other canonical FGFs may have an important virus-specific role, also by the regulation of the immune response. Because dysregulation in the FGF pathways is pivotal in cancer development, FGFs are the target of many anticancer drugs. These drugs may be repurposed to treat viral infection, since dysregulation of FGF signalling has been implicated in the pathogenesis of viral infections, such as hepatitis C. Overall, the role of cFGFs during viral infection is an underrepresented area of current research. This review focuses on overviewing the effects of canonical FGFs during infection by different viruses. Many studies highlight that the effects of FGFs during viral infection may be complex and context-dependent. While there is evidence to suggest that FGFs may have a beneficial impact on the immune response and tissue repair during viral infection, further studies are needed to fully understand the mechanisms underlying these effects and to determine in what cases FGFs could be targeted as a therapeutic approach for viral infection.
MeSH term(s)	Humans ; Fibroblast Growth Factors/metabolism ; Antineoplastic Agents ; Neoplasms/metabolism ; Virus Diseases
Chemical Substances	Fibroblast Growth Factors (62031-54-3) ; Antineoplastic Agents
Language	English
Publishing date	2023-04-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1086043-5
ISSN	1099-1654 ; 1052-9276
ISSN (online)	1099-1654
ISSN	1052-9276
DOI	10.1002/rmv.2452
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Article ; Online: Trends in hospital acquired New Delhi metallo-beta-lactamase-producing Enterobacterales in Tuscany (Italy) from 2019 to 2021: impact of the COVID-19 pandemic.

Arzilli, G / Forni, S / Righi, L / Barnini, S / Petricci, P / Parisio, E M / Pistello, M / Vivani, P / Gemignani, G / Baggiani, A / Bellandi, T / Privitera, G / Gemmi, F / Tavoschi, L / Porretta, A

The Journal of hospital infection

2023 Volume 137, Page(s) 44–53

Abstract: Objectives: In Tuscany, Italy, New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacterales (NDM-CRE) in hospitalized patients has increasingly been observed since 2018, leading in 2019 to the implementation of enhanced control ... ...

Abstract	Objectives: In Tuscany, Italy, New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacterales (NDM-CRE) in hospitalized patients has increasingly been observed since 2018, leading in 2019 to the implementation of enhanced control measures successfully reducing transmission. We describe the NDM-CRE epidemiology during the COVID-19 pandemic in Tuscany. Methods: Data on NDM-CRE patients hospitalized in five Tuscan hospitals were collected from January 2019 to December 2021. Weekly rates of NDM-CRE cases on hospital days in medical and critical-care wards were calculated. In March-December 2020, NDM-CRE rates were stratified by COVID-19 diagnosis. Multi-variate regression analysis was performed to assess outcomes' differences among two periods analysed and between COVID-19 populations. Results: Since March 2020, an increase in NDM-CRE cases was observed, associated with COVID-19 admissions. COVID-19 patients differed significantly from non-COVID-19 ones by several variables, including patient features (age, Charlson index) and clinical history and outcomes (NDM-CRE infection/colonization, intensive care unit stay, length of stay, mortality). During the pandemic, we observed a higher rate of NDM-CRE cases per hospital day in both non-COVID-19 patients (273/100,000) and COVID-19 patients (370/100,00) when compared with pre-pandemic period cases (187/100,00). Conclusions: Our data suggest a resurgence in NDM-CRE spread among hospitalized patients in Tuscany during the COVID-19 pandemic, as well as a change in patients' case-mix. The observed increase in hospital transmission of NDM-CRE could be related to changes in infection prevention and control procedures, aimed mainly at COVID-19 management, leading to new challenges in hospital preparedness and crisis management planning.
MeSH term(s)	Humans ; Pandemics ; COVID-19 Testing ; COVID-19/epidemiology ; beta-Lactamases ; Hospitals ; Gammaproteobacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests
Chemical Substances	beta-lactamase NDM-1 (EC 3.5.2.6) ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2023.04.016
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Zs.A 1586: Show issues

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Article: Varicella-zoster virus infection: natural history, clinical manifestations, immunity and current and future vaccination strategies.

Freer, Giulia / Pistello, Mauro

The new microbiologica

2018 Volume 41, Issue 2, Page(s) 95–105

Abstract: Varicella-zoster virus (VZV) is the etiologic agent of varicella (chicken pox), a childhood exanthematic disease that develops as a result of primary infection, and zoster (shingles), caused by reactivation of the virus persisting in a latent form in the ...

Abstract	Varicella-zoster virus (VZV) is the etiologic agent of varicella (chicken pox), a childhood exanthematic disease that develops as a result of primary infection, and zoster (shingles), caused by reactivation of the virus persisting in a latent form in the dorsal sensory ganglia. Although varicella is generally a mild self-limiting illness, in immunocompromised subjects and adults it can have a serious clinical course that can lead to permanent damage of the central nervous system. In these and in most zoster cases, treatment with anti-herpetic drugs and/or immunotherapy is necessary. Because it is highly contagious, varicella is one of the most common exanthematic diseases. It is preventable by vaccination with an attenuated vaccine administered around the first year of age, and with a boost vaccination in school age. This article briefly describes the natural history and pathophysiology of VZV infection and its current epidemiology and provides an overview of current and future vaccine options to protect against varicella and/or zoster.
MeSH term(s)	Chickenpox/prevention & control ; Chickenpox/virology ; Chickenpox Vaccine/immunology ; Herpes Zoster/prevention & control ; Herpes Zoster/virology ; Humans ; Vaccination ; Vaccines, Attenuated
Chemical Substances	Chickenpox Vaccine ; Vaccines, Attenuated
Language	English
Publishing date	2018-04
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	756168-4
ISSN	1121-7138 ; 0391-5352
ISSN	1121-7138 ; 0391-5352
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