LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: An introduction to causal inference for pharmacometricians.

    Rogers, James A / Maas, Hugo / Pitarch, Alejandro Pérez

    CPT: pharmacometrics & systems pharmacology

    2022  Volume 12, Issue 1, Page(s) 27–40

    Abstract: As formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and artificial intelligence/machine learning, pharmacometricians may increasingly benefit from a basic ... ...

    Abstract As formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and artificial intelligence/machine learning, pharmacometricians may increasingly benefit from a basic fluency in foundational causal inference concepts. This tutorial seeks to orient pharmacometricians to three such fundamental concepts: potential outcomes, g-formula, and directed acyclic graphs (DAGs).
    MeSH term(s) Humans ; Artificial Intelligence ; Confounding Factors, Epidemiologic ; Data Interpretation, Statistical ; Biometry ; Causality
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12894
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: 89

    Miedema, Iris H C / Huisman, Marc C / Zwezerijnen, Gerben J C / Grempler, Rolf / Pitarch, Alejandro Perez / Thiele, Andrea / Hesse, Raphael / Elgadi, Mabrouk / Peltzer, Alexander / Vugts, Danielle J / van Dongen, Guus A M S / de Gruijl, Tanja D / Menke-van der Houven van Oordt, C Willemien / Bahce, Idris

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 7, Page(s) 2068–2080

    Abstract: Purpose: Although lymphocyte activation gene-3 (LAG-3) directed therapies demonstrate promising clinical anti-cancer activity, only a subset of patients seems to benefit and predictive biomarkers are lacking. Here, we explored the potential use of the ... ...

    Abstract Purpose: Although lymphocyte activation gene-3 (LAG-3) directed therapies demonstrate promising clinical anti-cancer activity, only a subset of patients seems to benefit and predictive biomarkers are lacking. Here, we explored the potential use of the anti-LAG-3 antibody tracer [
    Methods: Patients with head and neck (N = 2) or lung cancer (N = 4) were included in an imaging substudy of a phase 1 trial with BI 754091 (anti-PD-1) and BI 754111 (anti-LAG-3). After baseline tumor biopsy and [
    Results: Tracer uptake in tumors was clearly visible at the 4-mg mass dose (tumor-to-plasma ratio 1.63 [IQR 0.37-2.89]) and could be saturated by increasing mass doses (44 mg: 0.67 [IQR 0.50-0.85]; 604 mg: 0.56 [IQR 0.42-0.75]), demonstrating target specificity. Tumor uptake correlated to immune cell-derived RNA signatures.
    Conclusions: [
    Trial registration: ClinicalTrials.gov , NCT03780725. Registered 19 December 2018.
    MeSH term(s) Humans ; Radioisotopes ; Squamous Cell Carcinoma of Head and Neck ; Positron-Emission Tomography/methods ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/diagnostic imaging ; Zirconium ; Cell Line, Tumor
    Chemical Substances Radioisotopes ; Zirconium (C6V6S92N3C)
    Language English
    Publishing date 2023-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06164-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top