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Article: Advances in the Use of Deep Learning for the Analysis of Magnetic Resonance Image in Neuro-Oncology.

Pitarch, Carla / Ungan, Gulnur / Julià-Sapé, Margarida / Vellido, Alfredo

2024 Volume 16, Issue 2

Abstract: Machine Learning is entering a phase of maturity, but its medical applications still lag behind in terms of practical use. The field of oncological radiology (and neuro-oncology in particular) is at the forefront of these developments, now boosted by the ...

Abstract	Machine Learning is entering a phase of maturity, but its medical applications still lag behind in terms of practical use. The field of oncological radiology (and neuro-oncology in particular) is at the forefront of these developments, now boosted by the success of Deep-Learning methods for the analysis of medical images. This paper reviews in detail some of the most recent advances in the use of Deep Learning in this field, from the broader topic of the development of Machine-Learning-based analytical pipelines to specific instantiations of the use of Deep Learning in neuro-oncology; the latter including its use in the groundbreaking field of ultra-low field magnetic resonance imaging.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020300
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Article: AI-Based Glioma Grading for a Trustworthy Diagnosis: An Analytical Pipeline for Improved Reliability.

Pitarch, Carla / Ribas, Vicent / Vellido, Alfredo

Cancers

2023 Volume 15, Issue 13

Abstract: Glioma is the most common type of tumor in humans originating in the brain. According to the World Health Organization, gliomas can be graded on a four-stage scale, ranging from the most benign to the most malignant. The grading of these tumors from ... ...

Abstract	Glioma is the most common type of tumor in humans originating in the brain. According to the World Health Organization, gliomas can be graded on a four-stage scale, ranging from the most benign to the most malignant. The grading of these tumors from image information is a far from trivial task for radiologists and one in which they could be assisted by machine-learning-based decision support. However, the machine learning analytical pipeline is also fraught with perils stemming from different sources, such as inadvertent data leakage, adequacy of 2D image sampling, or classifier assessment biases. In this paper, we analyze a glioma database sourced from multiple datasets using a simple classifier, aiming to obtain a reliable tumor grading and, on the way, we provide a few guidelines to ensure such reliability. Our results reveal that by focusing on the tumor region of interest and using data augmentation techniques we significantly enhanced the accuracy and confidence in tumor classifications. Evaluation on an independent test set resulted in an AUC-ROC of 0.932 in the discrimination of low-grade gliomas from high-grade gliomas, and an AUC-ROC of 0.893 in the classification of grades 2, 3, and 4. The study also highlights the importance of providing, beyond generic classification performance, measures of how reliable and trustworthy the model's output is, thus assessing the model's certainty and robustness.
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15133369
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Article ; Online: HDL-related biomarkers are robust predictors of survival in patients with chronic liver failure.

Journal of hepatology

2020 Volume 73, Issue 1, Page(s) 113–120

Abstract: Background & aims: High-density lipoprotein cholesterol (HDL-C) levels are reduced in patients with chronic liver disease and inversely correlate with disease severity. During acute conditions such as sepsis, HDL-C levels decrease rapidly and HDL ... ...

Abstract	Background & aims: High-density lipoprotein cholesterol (HDL-C) levels are reduced in patients with chronic liver disease and inversely correlate with disease severity. During acute conditions such as sepsis, HDL-C levels decrease rapidly and HDL particles undergo profound changes in their composition and function. We aimed to determine whether indices of HDL quantity and quality associate with progression and survival in patients with advanced liver disease. Methods: HDL-related biomarkers were studied in 508 patients with compensated or decompensated cirrhosis (including acute-on-chronic liver failure [ACLF]) and 40 age- and gender-matched controls. Specifically, we studied levels of HDL-C, its subclasses HDL2-C and HDL3-C, and apolipoprotein A1 (apoA-I), as well as HDL cholesterol efflux capacity as a metric of HDL functionality. Results: Baseline levels of HDL-C and apoA-I were significantly lower in patients with stable cirrhosis compared to controls and were further decreased in patients with acute decompensation (AD) and ACLF. In stable cirrhosis (n = 228), both HDL-C and apoA-I predicted the development of liver-related complications independently of model for end-stage liver disease (MELD) score. In patients with AD, with or without ACLF (n = 280), both HDL-C and apoA-I were MELD-independent predictors of 90-day mortality. On ROC analysis, both HDL-C and apoA-I had high diagnostic accuracy for 90-day mortality in patients with AD (AUROCs of 0.79 and 0.80, respectively, similar to that of MELD 0.81). On Kaplan-Meier analysis, HDL-C <17 mg/dl and apoA-I <50 mg/dl indicated poor short-term survival. The prognostic accuracy of HDL-C was validated in a large external validation cohort of 985 patients with portal hypertension due to advanced chronic liver disease (AUROCs HDL-C: 0.81 vs. MELD: 0.77). Conclusion: HDL-related biomarkers are robust predictors of disease progression and survival in chronic liver failure. Lay summary: People who suffer from cirrhosis (scarring of the liver) have low levels of cholesterol carried by high-density lipoproteins (HDL-C). These alterations are connected to inflammation, which is a problem in severe liver disease. Herein, we show that reduced levels of HDL-C and apolipoprotein A-I (apoA-I, the main protein carried by HDL) are closely linked to the severity of liver failure, its complications and survival. Both HDL-C and apoA-I can be easily measured in clinical laboratories and are as good as currently used prognostic scores calculated from several laboratory values by complex formulas.
MeSH term(s)	Acute-On-Chronic Liver Failure/blood ; Acute-On-Chronic Liver Failure/diagnosis ; Acute-On-Chronic Liver Failure/epidemiology ; Acute-On-Chronic Liver Failure/metabolism ; Apolipoprotein A-I/blood ; Apolipoprotein A-I/metabolism ; Biomarkers ; Cholesterol, HDL/blood ; Cholesterol, HDL/metabolism ; Cross-Sectional Studies ; Disease Progression ; Europe/epidemiology ; Female ; Humans ; Lipoproteins, HDL2/blood ; Lipoproteins, HDL2/metabolism ; Lipoproteins, HDL3/blood ; Lipoproteins, HDL3/metabolism ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/epidemiology ; Male ; Middle Aged ; Organ Dysfunction Scores ; Predictive Value of Tests ; Prognosis ; Severity of Illness Index
Chemical Substances	Apolipoprotein A-I ; Biomarkers ; Cholesterol, HDL ; Lipoproteins, HDL2 ; Lipoproteins, HDL3
Language	English
Publishing date	2020-02-14
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2020.01.026
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Article ; Online: Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis.

Trebicka, Jonel / Amoros, Alex / Pitarch, Carla / Titos, Esther / Alcaraz-Quiles, José / Schierwagen, Robert / Deulofeu, Carmen / Fernandez-Gomez, Javier / Piano, Salvatore / Caraceni, Paolo / Oettl, Karl / Sola, Elsa / Laleman, Wim / McNaughtan, Jane / Mookerjee, Rajeshwar P / Coenraad, Minneke J / Welzel, Tania / Steib, Christian / Garcia, Rita /

Frontiers in immunology

2019 Volume 10, Page(s) 476

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Acute-On-Chronic Liver Failure/blood ; Acute-On-Chronic Liver Failure/pathology ; Aged ; Biomarkers/blood ; Creatinine/blood ; Cytokines/blood ; Female ; Humans ; Inflammation/blood ; Inflammation/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/pathology ; Male ; Middle Aged ; Phenotype ; Prognosis ; Severity of Illness Index
Chemical Substances	Biomarkers ; Cytokines ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2019-03-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.00476
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Article ; Online: The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.

Trebicka, Jonel / Fernandez, Javier / Papp, Maria / Caraceni, Paolo / Laleman, Wim / Gambino, Carmine / Giovo, Ilaria / Uschner, Frank Erhard / Jimenez, Cesar / Mookerjee, Rajeshwar / Gustot, Thierry / Albillos, Agustin / Bañares, Rafael / Janicko, Martin / Steib, Christian / Reiberger, Thomas / Acevedo, Juan / Gatti, Pietro / Bernal, William /

Zeuzem, Stefan / Zipprich, Alexander / Piano, Salvatore / Berg, Thomas / Bruns, Tony / Bendtsen, Flemming / Coenraad, Minneke / Merli, Manuela / Stauber, Rudolf / Zoller, Heinz / Ramos, José Presa / Solè, Cristina / Soriano, Germán / de Gottardi, Andrea / Gronbaek, Henning / Saliba, Faouzi / Trautwein, Christian / Özdogan, Osman Cavit / Francque, Sven / Ryder, Stephen / Nahon, Pierre / Romero-Gomez, Manuel / Van Vlierberghe, Hans / Francoz, Claire / Manns, Michael / Garcia, Elisabet / Tufoni, Manuel / Amoros, Alex / Pavesi, Marco / Sanchez, Cristina / Curto, Anna / Pitarch, Carla / Putignano, Antonella / Moreno, Esau / Shawcross, Debbie / Aguilar, Ferran / Clària, Joan / Ponzo, Paola / Jansen, Christian / Vitalis, Zsuzsanna / Zaccherini, Giacomo / Balogh, Boglarka / Vargas, Victor / Montagnese, Sara / Alessandria, Carlo / Bernardi, Mauro / Ginès, Pere / Jalan, Rajiv / Moreau, Richard / Angeli, Paolo / Arroyo, Vicente

Journal of hepatology

2020 Volume 73, Issue 4, Page(s) 842–854

Abstract: Background & aims: Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof, requiring hospitalization. The presence of organ failure( ...

Abstract	Background & aims: Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF). The PREDICT study is a European, prospective, observational study, designed to characterize the clinical course of AD and to identify predictors of ACLF. Methods: A total of 1,071 patients with AD were enrolled. We collected detailed pre-specified information on the 3-month period prior to enrollment, and clinical and laboratory data at enrollment. Patients were then closely followed up for 3 months. Outcomes (liver transplantation and death) at 1 year were also recorded. Results: Three groups of patients were identified. Pre-ACLF patients (n = 218) developed ACLF and had 3-month and 1-year mortality rates of 53.7% and 67.4%, respectively. Unstable decompensated cirrhosis (UDC) patients (n = 233) required ≥1 readmission but did not develop ACLF and had mortality rates of 21.0% and 35.6%, respectively. Stable decompensated cirrhosis (SDC) patients (n = 620) were not readmitted, did not develop ACLF and had a 1-year mortality rate of only 9.5%. The 3 groups differed significantly regarding the grade and course of systemic inflammation (high-grade at enrollment with aggravation during follow-up in pre-ACLF; low-grade at enrollment with subsequent steady-course in UDC; and low-grade at enrollment with subsequent improvement in SDC) and the prevalence of surrogates of severe portal hypertension throughout the study (high in UDC vs. low in pre-ACLF and SDC). Conclusions: Acute decompensation without ACLF is a heterogeneous condition with 3 different clinical courses and 2 major pathophysiological mechanisms: systemic inflammation and portal hypertension. Predicting the development of ACLF remains a major future challenge. CLINICALTRIALS. Gov number: NCT03056612. Lay summary: Herein, we describe, for the first time, 3 different clinical courses of acute decompensation (AD) of cirrhosis after hospital admission. The first clinical course includes patients who develop acute-on-chronic liver failure (ACLF) and have a high short-term risk of death - termed pre-ACLF. The second clinical course (unstable decompensated cirrhosis) includes patients requiring frequent hospitalizations unrelated to ACLF and is associated with a lower mortality risk than pre-ACLF. Finally, the third clinical course (stable decompensated cirrhosis), includes two-thirds of all patients admitted to hospital with AD - patients in this group rarely require hospital admission and have a much lower 1-year mortality risk.
MeSH term(s)	Acute-On-Chronic Liver Failure/complications ; Acute-On-Chronic Liver Failure/mortality ; Acute-On-Chronic Liver Failure/physiopathology ; Europe/epidemiology ; Female ; Follow-Up Studies ; Humans ; Hypertension, Portal/etiology ; Hypertension, Portal/physiopathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/physiopathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Severity of Illness Index ; Survival Rate/trends
Language	English
Publishing date	2020-07-13
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2020.06.013
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Article ; Online: PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

Trebicka, Jonel / Fernandez, Javier / Papp, Maria / Caraceni, Paolo / Laleman, Wim / Gambino, Carmine / Giovo, Ilaria / Uschner, Frank Erhard / Jansen, Christian / Jimenez, Cesar / Mookerjee, Rajeshwar / Gustot, Thierry / Albillos, Agustin / Bañares, Rafael / Jarcuska, Peter / Steib, Christian / Reiberger, Thomas / Acevedo, Juan / Gatti, Pietro /

Shawcross, Debbie L / Zeuzem, Stefan / Zipprich, Alexander / Piano, Salvatore / Berg, Thomas / Bruns, Tony / Danielsen, Karen Vagner / Coenraad, Minneke / Merli, Manuela / Stauber, Rudolf / Zoller, Heinz / Ramos, José Presa / Solé, Cristina / Soriano, Germán / de Gottardi, Andrea / Gronbaek, Henning / Saliba, Faouzi / Trautwein, Christian / Kani, Haluk Tarik / Francque, Sven / Ryder, Stephen / Nahon, Pierre / Romero-Gomez, Manuel / Van Vlierberghe, Hans / Francoz, Claire / Manns, Michael / Garcia-Lopez, Elisabet / Tufoni, Manuel / Amoros, Alex / Pavesi, Marco / Sanchez, Cristina / Praktiknjo, Michael / Curto, Anna / Pitarch, Carla / Putignano, Antonella / Moreno, Esau / Bernal, William / Aguilar, Ferran / Clària, Joan / Ponzo, Paola / Vitalis, Zsuzsanna / Zaccherini, Giacomo / Balogh, Boglarka / Gerbes, Alexander / Vargas, Victor / Alessandria, Carlo / Bernardi, Mauro / Ginès, Pere / Moreau, Richard / Angeli, Paolo / Jalan, Rajiv / Arroyo, Vicente

Journal of hepatology

2020 Volume 74, Issue 5, Page(s) 1097–1108

Abstract: Background & aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading ... ...

Abstract	Background & aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients with AD (No ACLF = 1,071; ACLF = 202). Medical history, clinical data and laboratory data were collected at enrolment and during 90-day follow-up, with particular attention given to the following characteristics of precipitants: induction of organ dysfunction or failure, systemic inflammation, chronology, intensity, and relationship to outcome. Results: Among various clinical events, 4 distinct events were precipitants consistently related to AD: proven bacterial infections, severe alcoholic hepatitis, gastrointestinal bleeding with shock and toxic encephalopathy. Among patients with precipitants in the AD-No ACLF cohort and the AD-ACLF cohort (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Survival was similar in patients with proven bacterial infections or severe alcoholic hepatitis in both AD phenotypes. The number of precipitants was associated with significantly increased 90-day mortality and was paralleled by increasing levels of surrogates for systemic inflammation. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with a lower ACLF development rate and lower 90-day mortality. Conclusions: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis in patients with AD. Specific preventive and therapeutic strategies targeting these events may improve outcomes in patients with decompensated cirrhosis. Lay summary: Acute decompensation (AD) of cirrhosis is characterized by a rapid deterioration in patient health. Herein, we aimed to analyze the precipitating events that cause AD in patients with cirrhosis. Proven bacterial infections and severe alcoholic hepatitis, either alone or in combination, accounted for almost all (96-97%) cases of AD and acute-on-chronic liver failure. Whilst the type of precipitant was not associated with mortality, the number of precipitant(s) was. This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD. Specific preventive and therapeutic strategies targeting these events may improve patient outcomes.
MeSH term(s)	Acute-On-Chronic Liver Failure/blood ; Acute-On-Chronic Liver Failure/diagnosis ; Acute-On-Chronic Liver Failure/etiology ; Acute-On-Chronic Liver Failure/prevention & control ; Bacterial Infections/complications ; Bacterial Infections/diagnosis ; Bacterial Infections/drug therapy ; Disease Progression ; Europe/epidemiology ; Female ; Hepatitis, Alcoholic/complications ; Hepatitis, Alcoholic/diagnosis ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/physiopathology ; Male ; Medical History Taking/statistics & numerical data ; Middle Aged ; Needs Assessment ; Organ Dysfunction Scores ; Precipitating Factors ; Preventive Health Services/methods ; Prognosis
Language	English
Publishing date	2020-11-20
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2020.11.019
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Article ; Online: Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS.

Trebicka, Jonel / Gu, Wenyi / Ibáñez-Samaniego, Luis / Hernández-Gea, Virginia / Pitarch, Carla / Garcia, Elisabet / Procopet, Bogdan / Giráldez, Álvaro / Amitrano, Lucio / Villanueva, Candid / Thabut, Dominique / Silva-Junior, Gilberto / Martinez, Javier / Genescà, Joan / Bureau, Cristophe / Llop, Elba / Laleman, Wim / Palazon, Jose Maria / Castellote, Jose /

Rodrigues, Susanag / Gluud, Liselotte / Ferreira, Carlos Noronha / Barcelo, Rafael / Cañete, Nuria / Rodríguez, Manuel / Ferlitsch, Arnulf / Mundi, Jose Luis / Gronbaek, Henning / Hernández-Guerra, Manuel / Sassatelli, Romano / Dell'Era, Alessandra / Senzolo, Marco / Abraldes, Juan G / Romero-Gómez, Manuel / Zipprich, Alexander / Casas, Meritxell / Masnou, Helena / Primignani, Massimo / Weiss, Emmanuel / Catalina, Maria-Vega / Erasmus, Hans-Peter / Uschner, Frank Erhard / Schulz, Martin / Brol, Maximilian J / Praktiknjo, Michael / Chang, Johannes / Krag, Aleksander / Nevens, Frederik / Calleja, Jose Luis / Robic, Marie Angèle / Conejo, Irene / Albillos, Agustin / Rudler, Marika / Alvarado, Edilmar / Guardascione, Maria Anna / Tantau, Marcel / Bosch, Jaime / Torres, Ferran / Pavesi, Marco / Garcia-Pagán, Juan Carlos / Jansen, Christian / Bañares, Rafael

Journal of hepatology

2020 Volume 73, Issue 5, Page(s) 1082–1091

Abstract: Background & aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and prognosis of ACLF in the context of AVB is unclear, while the role of transjugular ...

Abstract	Background & aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and prognosis of ACLF in the context of AVB is unclear, while the role of transjugular intrahepatic portosystemic shunt (TIPS) in the management in patients with ACLF has not been described to date. Methods: A multicenter, international, observational study was conducted in 2,138 patients from 34 centers between 2011 and 2015. ACLF was defined and graded according to the EASL-CLIF consortium definition. Placement of pre-emptive TIPS (pTIPS) was based on individual center policy. Patients were followed-up for 1 year, until death or liver transplantation. Cox regression and competing risk models (Gray's test) were used to identify independent predictors of rebleeding or mortality. Results: At admission, 380/2,138 (17.8%) patients had ACLF according to EASL-CLIF criteria (grade 1: 38.7%; grade 2: 39.2%; grade 3: 22.1%). The 42-day rebleeding (19% vs. 10%; p <0.001) and mortality (47% vs. 10%; p <0.001) rates were higher in patients with ACLF and increased with ACLF grades. Of note, the presence of ACLF was independently associated with rebleeding and mortality. pTIPS placement improved survival in patients with ACLF at 42 days and 1 year. This effect was also observed in propensity score matching analysis of 66 patients with ACLF, of whom 44 received pTIPs and 22 did not. Conclusions: This large multicenter international real-life study identified ACLF at admission as an independent predictor of rebleeding and mortality in patients with AVB. Moreover, pTIPS was associated with improved survival in patients with ACLF and AVB. Lay summary: Acute variceal bleeding is a deadly complication of liver cirrhosis that results from severe portal hypertension. This study demonstrates that the presence of acute-on-chronic liver failure (ACLF) is the strongest predictor of mortality in patients with acute variceal bleeding. Importantly, patients with ACLF and acute variceal (re)bleeding benefit from pre-emptive (early) placement of a transjugular intrahepatic portosystemic shunt.
MeSH term(s)	Acute-On-Chronic Liver Failure/etiology ; Acute-On-Chronic Liver Failure/mortality ; Acute-On-Chronic Liver Failure/surgery ; Early Medical Intervention/methods ; Early Medical Intervention/statistics & numerical data ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/physiopathology ; Europe/epidemiology ; Female ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/mortality ; Gastrointestinal Hemorrhage/prevention & control ; Humans ; Hypertension, Portal/etiology ; Hypertension, Portal/surgery ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Male ; Middle Aged ; Portasystemic Shunt, Transjugular Intrahepatic/methods ; Portasystemic Shunt, Transjugular Intrahepatic/statistics & numerical data ; Prevalence ; Prognosis ; Recurrence ; Risk Adjustment/methods ; Risk Assessment
Language	English
Publishing date	2020-04-24
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2020.04.024
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Article: Advances in the Use of Deep Learning for the Analysis of Magnetic Resonance Image in Neuro-Oncology.

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Article: AI-Based Glioma Grading for a Trustworthy Diagnosis: An Analytical Pipeline for Improved Reliability.

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Article ; Online: HDL-related biomarkers are robust predictors of survival in patients with chronic liver failure.

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Article ; Online: Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis.

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Article ; Online: The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.

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Article ; Online: PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

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Article ; Online: Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS.

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