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  1. AU="Pitha, Paula M"
  2. AU="Carmen Ruiz de Almodóvar"
  3. AU="Qiu, Xudong"
  4. AU="Groh, M"
  5. AU="Defres, S"
  6. AU="Khurana, Navneet"
  7. AU="Yanshan Yang"
  8. AU=Brouillet Emmanuel AU=Brouillet Emmanuel
  9. AU="Rajput, Sandeep"
  10. AU="Mansfield, Shawn D"
  11. AU="Isolan, Cecilia"
  12. AU="Li, Yiran"
  13. AU="Kang, Weechang"
  14. AU="Landoni, Elisa"
  15. AU=McCubbin Keith I AU=McCubbin Keith I
  16. AU="Jessica Bijsterbosch"
  17. AU="Dela Cruz, Charles S."
  18. AU="Yoo, Jennifer"
  19. AU="Berger, Miriam B"
  20. AU="Carlson, Jeffrey R"

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  1. Buch: Interferon: the 50th anniversary

    Pitha, Paula M.

    with 8 tables

    (Current topics in microbiology and immunology ; 316)

    2007  

    Verfasserangabe Paula M. Pitha (ed.)
    Serientitel Current topics in microbiology and immunology ; 316
    Überordnung
    Schlagwörter Interferon
    Sprache Englisch
    Umfang VI, 391 S. : Ill., graph. Darst.
    Verlag Springer
    Erscheinungsort Berlin u.a.
    Erscheinungsland Deutschland
    Dokumenttyp Buch
    HBZ-ID HT015291793
    ISBN 978-3-540-71328-9 ; 3-540-71328-X
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Innate antiviral response: role in HIV-1 infection.

    Pitha, Paula M

    Viruses

    2011  Band 3, Heft 7, Seite(n) 1179–1203

    Abstract: As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early ... ...

    Abstract As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early inflammatory genes: The well-characterized family of NFkB factors and the family of interferon regulatory factors (IRF). The IRFs play a critical role in the induction of type I interferon (IFN) and chemokine genes, as well as genes mediating antiviral, antibacterial, and inflammatory responses. Type I IFNs represent critical components of innate antiviral immunity. These proteins not only exert direct antiviral effects, but also induce maturation of dendritic cells (DC), and enhance functions of NK, T and B cells, and macrophages. This review will summarize the current knowledge of the mechanisms leading to the innate antiviral response with a focus on its role in the regulation of HIV-1 infection and pathogenicity. We would like this review to be both historical and a future perspective.
    Mesh-Begriff(e) Animals ; Cytokines/immunology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/immunology ; Humans ; Immunity, Innate/immunology
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2011-07-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v3071179
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: My interferon years.

    Pitha, Paula M

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2008  Band 28, Heft 12, Seite(n) 699–702

    Mesh-Begriff(e) History, 20th Century ; History, 21st Century ; Interferons/history
    Chemische Substanzen Interferons (9008-11-1)
    Sprache Englisch
    Erscheinungsdatum 2008-12
    Erscheinungsland United States
    Dokumenttyp Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2008.2812.hp
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch: Interferon

    Pitha, Paula M

    the 50th anniversary

    (Current topics in microbiology and immunology, ; 316)

    2007  

    Verfasserangabe Paula M. Pitha, ed
    Serientitel Current topics in microbiology and immunology, ; 316
    Schlagwörter Interferon.
    Sprache Englisch
    Umfang vi, 391 p. :, ill. ;, 24 cm.
    Verlag Springer
    Erscheinungsort Berlin ; New York
    Dokumenttyp Buch
    ISBN 9783540713289 ; 354071328X
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Buch: Interferon

    Pitha, Paula M

    the 50th anniversary

    (Current topics in microbiology and immunology, ; 316)

    2007  

    Verfasserangabe Paula M. Pitha, ed
    Serientitel Current topics in microbiology and immunology, ; 316
    Mesh-Begriff(e) Interferon Type I
    Sprache Englisch
    Umfang vi, 391 p. :, ill.
    Verlag Springer
    Erscheinungsort Berlin ; New York
    Dokumenttyp Buch
    ISBN 9783540713289 ; 354071328X
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  6. Buch: Interferon

    Pitha, Paula M

    the 50th anniversary

    (Current topics in microbiology and immunology ; 316)

    2007  

    Verfasserangabe Paula M. Pitha (ed.)
    Serientitel Current topics in microbiology and immunology ; 316
    Schlagwörter Interferon
    Sprache Englisch
    Umfang VI, 391 S, graph. Darst, 235 mm x 155 mm
    Verlag Springer
    Erscheinungsort Berlin u.a.
    Dokumenttyp Buch
    ISBN 354071328X ; 9783540713289
    Datenquelle Bibliothek der Tierärztlichen Hochschule Hannover

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  7. Buch: Interferon

    Pitha, Paula M

    the 50th anniversary

    (Current topics in microbiology and immunology ; 316)

    2007  

    Verfasserangabe Paula M. Pitha (ed.)
    Serientitel Current topics in microbiology and immunology ; 316
    Schlagwörter Interferon
    Sprache Englisch
    Umfang VI, 391 S, graph. Darst, 235 mm x 155 mm
    Dokumenttyp Buch
    ISBN 354071328X ; 9783540713289
    Datenquelle Friedrich Loeffler-Institut, Bundesforschungsinstitut für Tiergesundheit

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  8. Artikel ; Online: Role of hsp90 in systemic lupus erythematosus and its clinical relevance.

    Shukla, Hem D / Pitha, Paula M

    Autoimmune diseases

    2012  Band 2012, Seite(n) 728605

    Abstract: Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved proteins which play an essential role as molecular chaperones in protein folding and transport. Heat Shock Protein 90 (Hsp90) is not mandatory for the biogenesis of ... ...

    Abstract Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved proteins which play an essential role as molecular chaperones in protein folding and transport. Heat Shock Protein 90 (Hsp90) is not mandatory for the biogenesis of most proteins, rather it participate in structural maturation and conformational regulation of a number of signaling molecules and transcription factors. Hsp90 has been shown to play an important role in antigen presentation, activation of lymphocytes, macrophages, maturation of dendritic cells, and in the enhanceosome mediated induction of inflammation. Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Dysregulated expression of Type I interferon α, activation of B cells and production of autoantibodies are hallmarks of SLE. The enhanced levels of Hsp90 were detected in the serum of SLE patients. The elevated level of Hsp90 in SLE has also been correlated with increased levels of IL-6 and presence of autoantibodies to Hsp90. This suggests that Hsp90 may contribute to the inflammation and disease progression and that targeting of Hsp 90 expression may be a potential treatment of SLE. The pharmacologic inhibition of Hsp90 was successfully applied in mouse models of autoimmune encephalomyelitis and SLE-like autoimmune diseases. Thus targeting Hsp90 may be an effective treatment for SLE, especially if combined with other targeted therapeutic approaches.
    Sprache Englisch
    Erscheinungsdatum 2012-10-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2573894-X
    ISSN 2090-0430 ; 2090-0430
    ISSN (online) 2090-0430
    ISSN 2090-0430
    DOI 10.1155/2012/728605
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Unexpected similarities in cellular responses to bacterial and viral invasion.

    Pitha, Paula M

    Proceedings of the National Academy of Sciences of the United States of America

    2004  Band 101, Heft 3, Seite(n) 695–696

    Mesh-Begriff(e) Animals ; Bacterial Infections/immunology ; Bacterial Infections/metabolism ; DNA-Binding Proteins/metabolism ; Humans ; I-kappa B Kinase ; Immunity, Cellular ; Immunity, Innate ; Interferon Regulatory Factor-3 ; Membrane Glycoproteins/metabolism ; Models, Immunological ; Protein-Serine-Threonine Kinases/metabolism ; Receptors, Cell Surface/metabolism ; Signal Transduction ; Toll-Like Receptors ; Transcription Factors/metabolism ; Virus Diseases/immunology ; Virus Diseases/metabolism
    Chemische Substanzen DNA-Binding Proteins ; IRF3 protein, human ; Interferon Regulatory Factor-3 ; Membrane Glycoproteins ; Receptors, Cell Surface ; Toll-Like Receptors ; Transcription Factors ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1) ; CHUK protein, human (EC 2.7.11.10) ; I-kappa B Kinase (EC 2.7.11.10) ; IKBKB protein, human (EC 2.7.11.10) ; IKBKE protein, human (EC 2.7.11.10)
    Sprache Englisch
    Erscheinungsdatum 2004-01-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0307303101
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer.

    Baresova, Petra / Pitha, Paula M / Lubyova, Barbora

    Journal of virology

    2013  Band 87, Heft 17, Seite(n) 9398–9410

    Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency and ... ...

    Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency and lytic replication. In latency, the KSHV genome persists as a circular episome in the nucleus of the host cell and only a few viral genes are expressed. In this review, we focus on oncogenic, antiapoptotic, and immunomodulating properties of KSHV-encoded homologues of cellular interferon regulatory factors (IRFs)--viral IRF1 (vIRF1) to vIRF4--and their possible role in the KSHV-mediated antiviral response, apoptosis, and oncogenicity.
    Mesh-Begriff(e) Apoptosis ; Carcinogenesis ; Genes, Viral ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/immunology ; Herpesvirus 8, Human/pathogenicity ; Humans ; Inflammation/etiology ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/immunology ; Interferons/metabolism ; Models, Biological ; Multigene Family ; Signal Transduction ; Viral Proteins/genetics ; Viral Proteins/immunology
    Chemische Substanzen Interferon Regulatory Factors ; Viral Proteins ; viral interferon regulatory factors ; Interferons (9008-11-1)
    Sprache Englisch
    Erscheinungsdatum 2013-06-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.03315-12
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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