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  1. Article ; Online: Use of the alpha glucosidase inhibitor acarbose in patients with 'Middleton syndrome': normal gastric anatomy but with accelerated gastric emptying causing postprandial reactive hypoglycemia and diarrhea.

    Playford, Raymond J / Pither, Charlotte / Gao, Rui / Middleton, Stephen J

    Canadian journal of gastroenterology = Journal canadien de gastroenterologie

    2013  Volume 27, Issue 7, Page(s) 403–404

    Abstract: Postprandial reactive hypoglycemia, early satiety and diarrhea are well-recognized side effects following full or partial gastrectomy or gastric bypass. It has only recently been realized, however, that patients with normal gastric anatomy may experience ...

    Abstract Postprandial reactive hypoglycemia, early satiety and diarrhea are well-recognized side effects following full or partial gastrectomy or gastric bypass. It has only recently been realized, however, that patients with normal gastric anatomy may experience similar symptoms and signs due to primary accelerated gastric emptying (Middleton syndrome). In previous case studies, patients responded well to the use of dietary modification (frequent small-volume meals) alone. The authors describe two patients with this syndrome who continued to experience symptoms of reactive postprandial hypoglycemia despite dietary intervention but became asymptomatic following the addition of the alpha-glucosidase inhibitor acarbose.
    MeSH term(s) Acarbose/therapeutic use ; Adult ; Diarrhea/drug therapy ; Diarrhea/etiology ; Enzyme Inhibitors/therapeutic use ; Female ; Gastric Emptying ; Glycoside Hydrolase Inhibitors ; Humans ; Hypoglycemia/drug therapy ; Hypoglycemia/etiology ; Middle Aged ; Postprandial Period ; Treatment Outcome
    Chemical Substances Enzyme Inhibitors ; Glycoside Hydrolase Inhibitors ; Acarbose (T58MSI464G)
    Language English
    Publishing date 2013-06-03
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 639439-5
    ISSN 1916-7237 ; 0835-7900
    ISSN (online) 1916-7237
    ISSN 0835-7900
    DOI 10.1155/2013/791803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Preoperative comorbidity correlates inversely with survival after intestinal and multivisceral transplantation in adults.

    Sivaprakasam, Rajesh / Hidenori, Takahashi / Pither, Charlotte / Nishida, Seigo / Butler, Andrew J / Island, Eddie R / Moon, Jung / Dawwas, Muhammad / Gabe, Simon M / Jamieson, Neville V / Tzakis, Andreas G / Middleton, Stephen J

    Journal of transplantation

    2013  Volume 2013, Page(s) 202410

    Abstract: We investigated the relationship between preoperative comorbidity and postoperative survival after intestinal transplantation. Each patient received a score for preoperative comorbidity. Each comorbidity was given a score based on the degree it impaired ... ...

    Abstract We investigated the relationship between preoperative comorbidity and postoperative survival after intestinal transplantation. Each patient received a score for preoperative comorbidity. Each comorbidity was given a score based on the degree it impaired function (score range 0-3). A total score was derived from the summation of individual comorbidity scores. Patients (72 adults (M : F, 33 : 39)) received an isolated intestinal graft (27) or a cluster graft (45). Mean (standard deviation) survival was 1501 (1444) days. The Kaplan-Meier analysis revealed a significant inverse association between survival and comorbidity score (logrank test for trend, P < 0.0001). Patients grouped into comorbidity scores of 0 and 1, 2 and 3, 4 and 5, 6, and above had hazard ratios (95% confidence intervals) for death (compared to group 0 + 1), which increased with comorbidity scores: 1.945 (0.7622-5.816), 5.075 (3.314-36.17), and 13.77 (463.3-120100), respectively, (P < 0.0001). Receiver-operator curves at 1, 3, 5, and 10 years postoperative had "C" statistics of 0.88, 0.85, 0.88, and 0.92, respectively. When evaluating patients for transplantation, the degree of comorbidity should be considered as a major factor influencing postoperative survival.
    Language English
    Publishing date 2013-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2503421-2
    ISSN 2090-0015 ; 2090-0007
    ISSN (online) 2090-0015
    ISSN 2090-0007
    DOI 10.1155/2013/202410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management of acute mesenteric ischaemia: Results of a worldwide survey

    Hess, Benjamin / Cahenzli, Martin / Forbes, Alastair / Rosa Burgos / Coccolini, Federico / Corcos, Olivier / Holst, Mette / Irtun, Øivind / Klek, Stanislaw / Pironi, Loris / Rasmussen, Henrik Højgaard / Serlie, Mireille J. / Thibault, Ronan / Gabe, Simon / Reintam Blaser, Annika / Akin, Emrah / Ali, Syed Muhammad / Argenio, Giulio / Atici, Semra Demirli /
    Augustin, Goran / Baili, Efstratia / Bains, Lovenish / Bala, Miklosh / Baldini, Edoardo / Baraket, Oussama / Barone, Mirko / Biloslavo, Alan / Roberto Bini / Bombardini, Cristina / Brisinda, Giuseppe / Buonomo, Luis / Catena, F. / Ceresoli, Marco / Chiarello, Maria Michela / Chouliaras, Christos / D'Acapito, Fabrizio / Damaskos, Dimitrios / De Simone, Belinda / Delogu, Daniele / Demetrashvili, Zaza / Di Carlo, Isidoro / D'Oria, Mario / Durán-Muñoz-Cruzado, Virginia María / Forget, Patrice / Fortuna, Laura / Fransvea, Pietro / Frey, Christian / Gapejeva, Olga / Garcon, Pierre / Gass, Jörn-Markus / Teixeira Gonsaga, Ricardo Alessandro / Griffiths, Ewen / Gundogan, Kursat / Gurjar, Mohan / Hamid, Hytham K.S. / Silesky Jiménez, Juan Ignacio / Kase, Karri / Hussain Kazmi, Syed Sajid / Kechagias, Aristotelis / Khokha, Vladimir / Kobe, Yoshiro / Korkolis, Dimitrios P. / Litvin, Andrey / Lostoridis, Eftychios / Mahendran, Hans Alexander / Marino, Fabio / Martinuzzi, Andres / Mesina, Cristian / Neri, Vincenzo / Panisic, Marina / Paolillo, Ciro / Pararas, Nikolaos / Perrone, Gennaro / Pesce, Antonio / Picardi, Biagio / Pither, Charlotte / Podda, Mauro / Poskus, Tomas / Poullenot, Florian / Przemyslaw, Matras / Sartelli, Massimo / Sasia, Diego / Scheiterle, Maximilian / Seretis, Fotios / Søreide, Kjetil / Sydorchuk, Ruslan / Szczepanek, Kinga / Bodnar, Zsolt / Tamion, Fabienne / Tarasconi, Antonio / Teraa, Martin / Tolonen, Matti / Vanuytsel, Tim / Veroux, Massimiliano / Vinter-Jensen, Lars / Visconti, Diego / Widmer, Lukas / Zakaria, Andee Dzulkarnaen / Zubareva, Nadezhda / Endorsing International Societies / ESICM (European Society of Intensive Care Medicine) / WSES (World Society of Emergency Surgery) / WSACS (The Abdominal Compartment Society) / In-principle support / WFICC (World Federation of Intensive and Critical Care)

    Clinical Nutrition ESPEN. 2023 Apr., v. 54 p.194-205

    2023  

    Abstract: Acute mesenteric ischaemia (AMI) is a condition with high mortality. This survey assesses current attitudes and practices to manage AMI worldwide. A questionnaire survey about the practices of diagnosing and managing AMI, endorsed by several specialist ... ...

    Institution ESPEN Special Interest Group on Acute Intestinal Failure ESPEN (European Society for Clinical Nutrition and Metabolism)
    Abstract Acute mesenteric ischaemia (AMI) is a condition with high mortality. This survey assesses current attitudes and practices to manage AMI worldwide. A questionnaire survey about the practices of diagnosing and managing AMI, endorsed by several specialist societies, was sent to different medical specialists and hospitals worldwide. Data from individual health care professionals and from medical teams were collected. We collected 493 individual forms from 71 countries and 94 team forms from 34 countries. Almost half of respondents were surgeons, and most of the responding teams (70%) were led by surgeons. Most of the respondents indicated that diagnosis of AMI is often delayed but rarely missed. Emergency revascularisation is often considered for patients with AMI but rarely in cases of transmural ischaemia (intestinal infarction). Responses from team hospitals with a dedicated special unit (14 team forms) indicated more aggressive revascularisation. Abdominopelvic CT-scan with intravenous contrast was suggested as the most useful diagnostic test, indicated by approximately 90% of respondents. Medical history and risk factors were thought to be more important in diagnosis of AMI without transmural ischaemia, whereas for intestinal infarction, plasma lactate concentrations and surgical exploration were considered more useful. In elderly patients, a palliative approach is often chosen over extensive bowel resection. There was a large variability in anticoagulant treatment, as well as in timing of surgery to restore bowel continuity. Delayed diagnosis of AMI is common despite wide availability of an adequate imaging modality, i.e. CT-scan. Large variability in treatment approaches exists, indicating the need for updated guidelines. Increased awareness and knowledge of AMI may improve current practice until more robust evidence becomes available. Adherence to the existing guidelines may help in improving differences in treatment and outcomes.
    Keywords anticoagulants ; clinical nutrition ; elderly ; health services ; infarction ; intestines ; intravenous injection ; ischemia ; lactic acid ; medical history ; mortality ; questionnaires ; resection ; risk ; surveys ; Acute mesenteric ischaemia ; Acute mesenteric infarction ; NOMI (Non-occlusive mesenteric ischaemia) ; Occlusive intestinal ischaemia ; Intestinal failure ; Survey ; Treatment
    Language English
    Dates of publication 2023-04
    Size p. 194-205.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2022.12.022
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

    Pironi, Loris / Steiger, Ezra / Joly, Francisca / Jeppesen, Palle B. / Wanten, Geert / Sasdelli, Anna S. / Chambrier, Cecile / Aimasso, Umberto / Mundi, Manpreet S. / Szczepanek, Kinga / Jukes, Amelia / Theilla, Miriam / Kunecki, Marek / Daniels, Joanne / Serlie, Mireille / Poullenot, Florian / Cooper, Sheldon C. / Rasmussen, Henrik H. / Compher, Charlene /
    Seguy, David / Crivelli, Adriana / Santarpia, Lidia / Guglielmi, Francesco W. / Kozjek, Nada Rotovnik / Schneider, Stéphane M. / Ellegard, Lars / Thibault, Ronan / Matras, Przemysław / Matysiak, Konrad / Van Gossum, Andrè / Forbes, Alastair / Wyer, Nicola / Taus, Marina / Virgili, Nuria M. / O'Callaghan, Margie / Chapman, Brooke / Osland, Emma / Cuerda, Cristina / Udvarhelyi, Gábor / Jones, Lynn / Won Lee, Andre D. / Masconale, Luisa / Orlandoni, Paolo / Spaggiari, Corrado / Díez, Marta Bueno / Doitchinova-Simeonova, Maryana / Serralde-Zúñiga, Aurora E. / Olveira, Gabriel / Krznaric, Zeljko / Czako, Laszlo / Kekstas, Gintautas / Sanz-Paris, Alejandro / Jáuregui, Mª Estrella Petrina / Murillo, Ana Zugasti / Schafer, Eszter / Arends, Jann / Suárez-Llanos, José P. / Youssef, Nader N. / Brillanti, Giorgia / Nardi, Elena / Lal, Simon / Crivelli, Adriana N. / Muñiz, Hector Solar / Chapman, Brooke R. / Hodgson, Ruth / Wallin, Siobhan / Lasenby, Kay / Van Gossum, Andre / Won Lee, Andre Dong / Rasmussen, Henrik Højgaard / Brandt, Chrisoffer / Boehm, Vanessa / Bataille, Julie / Billiauws, Lore / Molnar, Tomas / Zsilak-Urban, Mihaly / Izbéki, Ferenc / Sahin, Peter / Sasdelli, Anna Simona / Dario, Merlo F. / Bertasi, Valentino / Regano, Nunzia / Lidia, Santarpia / Alfonsi, Lucia / Busni, Debora / Gillanders, Lyn / Zmarzly, Anna / Bueno, Marta / Garde, Carmen / Jáuregui, Ma Estrella Petrina / Jonker, Cora / Di Caro, Simona / Keane, Niamh / Patel, Pinal / Nelson Hughes, Sarah-Jane / Lloyd, Rachel / Abraham, Arun / Garside, Gerda / Taylor, Michael / Wu, Jian / Smith, Trevor / Pither, Charlotte / Stroud, Michael / Parmar, Reena / Burch, Nicola / Zeraschi, Sarah / Mundi, Manpreet / Jezerski, Denise

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2021 Oct., v. 45

    2021  

    Abstract: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was ... ...

    Institution The Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN
    The European Society for Clinical Nutrition and Metabolism
    Abstract The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries.The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1–2, 2–3 and >3 L/day.In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn’ disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused ≥5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland.SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.
    Keywords adults ; clinical nutrition ; colon ; cross-sectional studies ; data collection ; electrolytes ; intravenous injection ; ischemia ; parenteral feeding ; surveys ; Denmark ; France ; Italy ; Netherlands ; Poland
    Language English
    Dates of publication 2021-10
    Size p. 433-441.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2021.07.004
    Database NAL-Catalogue (AGRICOLA)

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