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  1. Article: COVID-19 Compared to Other Pandemic Diseases.

    Pitlik, Silvio Daniel

    Rambam Maimonides medical journal

    2020  Volume 11, Issue 3

    Abstract: In December 2019, the first cases of a new contagious disease were diagnosed in the city of Wuhan, the capital of Hubei province in China. Within a short period of time the outbreak developed exponentially into a pandemic that infected millions of people, ...

    Abstract In December 2019, the first cases of a new contagious disease were diagnosed in the city of Wuhan, the capital of Hubei province in China. Within a short period of time the outbreak developed exponentially into a pandemic that infected millions of people, with a global death toll of more than 500,000 during its first 6 months. Eventually, the novel disease was named coronavirus disease 2019 (COVID-19), and the new virus was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Similar to all known pandemics throughout history, COVID-19 has been accompanied by a large degree of fear, anxiety, uncertainty, and economic disaster worldwide. Despite multiple publications and increasing knowledge regarding the biological secrets of SARS-CoV-2, as of the writing of this paper, there is neither an approved vaccine nor medication to prevent infection or cure for this highly infectious disease. Past pandemics were caused by a wide range of microbes, primarily viruses, but also bacteria. Characteristically, a significant proportion of them originated in different animal species (zoonoses). Since an understanding of the microbial cause of these diseases was unveiled relatively late in human history, past pandemics were often attributed to strange causes including punishment from God, demonic activity, or volatile unspecified substances. Although a high case fatality ratio was common to all pandemic diseases, some striking clinical characteristics of each disease allowed contemporaneous people to clinically diagnose the infection despite null microbiological information. In comparison to past pandemics, SARS-CoV-2 has tricky and complex mechanisms that have facilitated its rapid and catastrophic spread worldwide.
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 2573657-7
    ISSN 2076-9172
    ISSN 2076-9172
    DOI 10.5041/RMMJ.10418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID-19 Compared to Other Pandemic Diseases

    Pitlik, Silvio Daniel

    Rambam Maimonides medical journal

    Abstract: In December 2019, the first cases of a new contagious disease were diagnosed in the city of Wuhan, the capital of Hubei province in China Within a short period of time the outbreak developed exponentially into a pandemic that infected millions of people, ...

    Abstract In December 2019, the first cases of a new contagious disease were diagnosed in the city of Wuhan, the capital of Hubei province in China Within a short period of time the outbreak developed exponentially into a pandemic that infected millions of people, with a global death toll of more than 500,000 during its first 6 months Eventually, the novel disease was named coronavirus disease 2019 (COVID-19), and the new virus was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Similar to all known pandemics throughout history, COVID-19 has been accompanied by a large degree of fear, anxiety, uncertainty, and economic disaster worldwide Despite multiple publications and increasing knowledge regarding the biological secrets of SARS-CoV-2, as of the writing of this paper, there is neither an approved vaccine nor medication to prevent infection or cure for this highly infectious disease Past pandemics were caused by a wide range of microbes, primarily viruses, but also bacteria Characteristically, a significant proportion of them originated in different animal species (zoonoses) Since an understanding of the microbial cause of these diseases was unveiled relatively late in human history, past pandemics were often attributed to strange causes including punishment from God, demonic activity, or volatile unspecified substances Although a high case fatality ratio was common to all pandemic diseases, some striking clinical characteristics of each disease allowed contemporaneous people to clinically diagnose the infection despite null microbiological information In comparison to past pandemics, SARS-CoV-2 has tricky and complex mechanisms that have facilitated its rapid and catastrophic spread worldwide
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #721598
    Database COVID19

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  3. Article ; Online: How holobionts get sick-toward a unifying scheme of disease.

    Pitlik, Silvio D / Koren, Omry

    Microbiome

    2017  Volume 5, Issue 1, Page(s) 64

    Abstract: All humans, animals, and plants are holobionts. Holobionts comprise the host and a myriad of interacting microorganisms-the microbiota. The hologenome encompasses the genome of the host plus the composite of all microbial genomes (the microbiome). In ... ...

    Abstract All humans, animals, and plants are holobionts. Holobionts comprise the host and a myriad of interacting microorganisms-the microbiota. The hologenome encompasses the genome of the host plus the composite of all microbial genomes (the microbiome). In health, there is a fine-tuned and resilient equilibrium within the members of the microbiota and between them and the host. This relative stability is maintained by a high level of microbial diversity, a delicate bio-geographic distribution of microorganisms, and a sophisticated and intricate molecular crosstalk among the multiple components of the holobiont. Pathobionts are temporarily benign microbes with the potential, under modified ecosystem conditions, to become key players in disease. Pathobionts may be endogenous, living for prolonged periods of time inside or on the host, or exogenous, invading the host during opportunistic situations. In both cases, the end result is the transformation of the beneficial microbiome into a health-perturbing pathobiome. We hypothesize that probably all diseases of holobionts, acute or chronic, infectious or non-infectious, and regional or systemic, are characterized by a perturbation of the healthy microbiome into a diseased pathobiome.
    Language English
    Publishing date 2017-06-24
    Publishing country England
    Document type Letter
    ZDB-ID 2697425-3
    ISSN 2049-2618 ; 2049-2618
    ISSN (online) 2049-2618
    ISSN 2049-2618
    DOI 10.1186/s40168-017-0281-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Oscar the cat, carbapenem-resistant Klebsiella pneumoniae, and attributable mortality.

    Pitlik, Silvio Daniel

    Infection control and hospital epidemiology

    2009  Volume 30, Issue 5, Page(s) 500–501

    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Cats ; Drug Resistance, Bacterial ; Humans ; Klebsiella Infections/microbiology ; Klebsiella Infections/mortality ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/pathogenicity ; Nursing Homes ; Predictive Value of Tests ; Rhode Island ; Virulence
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2009-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1086/596733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Vets, meds, and zoonotic threats.

    Pitlik, Silvio

    Emerging infectious diseases

    2004  Volume 10, Issue 4, Page(s) 760–761

    MeSH term(s) Animals ; Bioterrorism ; Humans ; Zoonoses/transmission
    Keywords covid19
    Language English
    Publishing date 2004-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6040
    ISSN 1080-6040
    DOI 10.3201/eid1004.030805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Old drugs for new bugs.

    Pitlik, Silvio

    BMJ (Clinical research ed.)

    2001  Volume 326, Issue 7383, Page(s) 235–236

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Drug Resistance, Bacterial ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2001-02-06
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.326.7383.235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Appropriateness of antibiotic therapy on weekends versus weekdays.

    Bishara, Jihad / Hershkovitz, Dov / Paul, Mical / Rotenberg, Zvi / Pitlik, Silvio

    The Journal of antimicrobial chemotherapy

    2007  Volume 60, Issue 3, Page(s) 625–628

    Abstract: Objectives: To compare the appropriateness of antibiotic treatment prescribed in an emergency department (ED) of a tertiary medical centre on weekdays and weekends.: Methods: During a 1 month period, medical charts of 1029 ED visits for patients who ... ...

    Abstract Objectives: To compare the appropriateness of antibiotic treatment prescribed in an emergency department (ED) of a tertiary medical centre on weekdays and weekends.
    Methods: During a 1 month period, medical charts of 1029 ED visits for patients who were discharged from the ED were reviewed. Data of patients who were discharged with antibiotics were blind evaluated by two infectious disease specialists, and an 'appropriateness score' was given to the antibiotic prescription.
    Results: Antibiotics were prescribed at discharge for 182 (17.7%) patients. Appropriate antibiotic treatment was administered significantly less frequently on weekends when compared with weekdays (P = 0.004). Appropriateness scores were higher for the surgical and urological wings (P = 0.011) and for diagnoses of pneumonia and urinary tract infection (P = 0.005). Time of the day and patient's age and sex did not have a significant effect on the appropriateness score. Adjusting for all variables, only weekends remained significantly associated with less appropriate antibiotic treatment, odds ratio 0.35 and 95% confidence intervals 0.16-0.78.
    Conclusions: This study shows less appropriate antibiotic prescription in an ED on weekends than weekdays. More studies are required to clarify measures to improve appropriate antibiotic therapy at weekends.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Communicable Diseases/drug therapy ; Drug Utilization ; Female ; Hospital Departments ; Hospitals, University ; Humans ; Infant ; Israel ; Male ; Middle Aged ; Time Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkm233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Travel-related leptospirosis in Israel: a nationwide study.

    Leshem, Eyal / Segal, Gadi / Barnea, Ada / Yitzhaki, Shmuel / Ostfeld, Iris / Pitlik, Silvio / Schwartz, Eli

    The American journal of tropical medicine and hygiene

    2010  Volume 82, Issue 3, Page(s) 459–463

    Abstract: Leptospirosis is re-emerging in developed countries as a travel-related infection. In this nationwide study of travel-related leptospirosis in Israel, all cases diagnosed at the Central Reference Laboratory for Leptospirosis, during 2002-2008 were ... ...

    Abstract Leptospirosis is re-emerging in developed countries as a travel-related infection. In this nationwide study of travel-related leptospirosis in Israel, all cases diagnosed at the Central Reference Laboratory for Leptospirosis, during 2002-2008 were retrospectively reviewed and only travel-related cases were included. During the study years, 20 (42%) of 48 leptospirosis cases in Israel were travel-related. Exposure occurred in Southeast Asia in 15 (75%) of 20 cases. The estimated yearly incidence of travel-related leptospirosis was 1.78/100,000 travelers compared with an incidence of endemic cases of 0.06/100,000 inhabitants (risk ratio = 29.6, 95% confidence interval = 16.7-52.4). Most patients (89%) were infected during water-related activities. Severe disease was present in 10 (55%) of 18 patients; 7 of them were presumptively infected with the Icterohaemorrhagiae serogroup. Thus, travel-related leptospirosis is becoming increasingly important in the epidemiology of leptospirosis in Israel. Leptospirosis should be suspected in any traveler with undifferentiated febrile illness, especially when water exposure is reported.
    MeSH term(s) Adult ; Female ; Humans ; Incidence ; Israel/epidemiology ; Leptospirosis/epidemiology ; Male ; Middle Aged ; Time Factors ; Travel ; Young Adult
    Language English
    Publishing date 2010-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.2010.09-0239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Ill from eel?

    Zeeli, Tal / Samra, Zmira / Pitlik, Silvio

    The Lancet. Infectious diseases

    2003  Volume 3, Issue 3, Page(s) 168

    MeSH term(s) Adult ; Animals ; Eels/microbiology ; Fresh Water/microbiology ; Humans ; Male ; Mycobacterium Infections/diagnosis ; Mycobacterium Infections/drug therapy ; Mycobacterium Infections/microbiology ; Mycobacterium Infections/transmission ; Mycobacterium marinum/isolation & purification
    Language English
    Publishing date 2003-03-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/s1473-3099(03)00548-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Successful organ transplantation from donors with Acinetobacter baumannii septic shock.

    Cohen, Jonathan / Michowiz, Rachael / Ashkenazi, Tamar / Pitlik, Silvio / Singer, Pierre

    Transplantation

    2006  Volume 81, Issue 6, Page(s) 853–855

    Abstract: Donor bacteremia with severe sepsis, especially due to gram-negative organisms, has been considered a contraindication to transplantation. Over a 6-month period we prospectively collected standardized data on all brain-dead, heart-beating organ donors ... ...

    Abstract Donor bacteremia with severe sepsis, especially due to gram-negative organisms, has been considered a contraindication to transplantation. Over a 6-month period we prospectively collected standardized data on all brain-dead, heart-beating organ donors with gram negative bacteremia and septic shock and the recipients of their organs in hospitals throughout Israel. Donors were treated with appropriate antibiotics for at least 48 hr prior to organ retrieval while recipients received 7 days of culture-specific antibiotics following transplantation. In total, 12 organs were transplanted (5 kidneys, 2 livers, 3 lungs and 2 hearts) from 3 donors with Acinetobacter baumannii bacteremia and septic shock. All patients were alive with good graft function 60 days following transplantation, apart from one of the heart recipients who died of primary nonfunction on the second postoperative day. Two recipients developed postoperative infections, none with Acinetobacter sp. (one Pseudomonas sp. urinary tract infection, one Klebsiella sp. central venous catheter sepsis).
    MeSH term(s) Acinetobacter Infections ; Acinetobacter baumannii ; Adult ; Anti-Bacterial Agents/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Organ Transplantation ; Prospective Studies ; Shock, Septic ; Tissue Donors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2006-03-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/01.tp.0000203804.95180.6e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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