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  1. Article: Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil.

    Barbosa, Alzira Maria de Castro / Ribeiro, Rosangela Albuquerque / Silva, Cícero Ígor Simões Moura / Cruz, Francisco Will Saraiva / Azevedo, Orleancio Gomes Ripardo de / Pitombeira, Maria Helena da Silva / Braga, Lucia Libanez Campelo

    Revista brasileira de hematologia e hemoterapia

    2017  Volume 40, Issue 1, Page(s) 12–17

    Abstract: Background: Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the ... ...

    Abstract Background: Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent.
    Objective: The purpose of this study was to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil.
    Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment.
    Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.
    Conclusions: H. pylori eradication therapy showed relatively low platelet recovery rates, comparable with previous studies from southeastern Brazil. The effect of H. pylori eradication on platelet counts remained after one year of follow-up suggesting that treating H. pylori infection might be worthwhile in a subset of chronic idiopathic thrombocytopenic purpura patients.
    Language English
    Publishing date 2017-11-24
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.1016/j.bjhh.2017.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dengue: profile of hematological and biochemical dynamics.

    Azin, Francisca Raimunda F Guerreiro / Gonçalves, Romelia Pinheiro / Pitombeira, Maria Helena da Silva / Lima, Danielle Malta / Branco, Ivo Castelo

    Revista brasileira de hematologia e hemoterapia

    2012  Volume 34, Issue 1, Page(s) 36–41

    Abstract: Aim: The objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease.: Methods: This is ...

    Abstract Aim: The objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease.
    Methods: This is an observational, descriptive and retrospective study of 154 patients with clinical and serological diagnoses of dengue fever who, in the period from January to May 2008, were admitted in a tertiary state hospital in the city of Fortaleza that is a referral center for infectious diseases. The patients were allocated to two groups according to age: under 15 years old (n = 66) and 15 years or older (n = 88). The tests analyzed were blood count, platelet count, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations.
    Results: Thrombocytopenia and elevated transaminases were observed in patients with classic dengue fever. The main laboratory abnormalities found in dengue hemorrhagic fever were thrombocytopenia, hemoconcentration and elevated transaminases, similar to severe dengue with the exception of hemoconcentration. Most laboratory abnormalities started on the 3rd day but were more evident on the 5th day with restoration of values by the 11(th) day; this was more prominent in under 15-year-olds and with the more severe clinical forms.
    Conclusion: These results are relevant in assessing the disease because they can be used as markers for more severe forms and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.
    Language English
    Publishing date 2012-09-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20120012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hodgkin's Lymphoma - evaluation of patients submitted to Autologous transplantation of hematopoietic cells in the Hematology Service of the Hospital Walter Cantídio - Fortaleza, Brazil.

    Duarte, Fernando Barroso / Fernandes, Mabel Gomes de Brito / Kaufmann, Jacques / Barroso, Karine Sampaio Nunes / Leitão, João Paulo de Vasconcelos / Araujo, Beatriz Stela Gomes de Souza Pitombeira / Costa, Clara Maria Bastos Eloy da / Quixadá-Medica, Acy Teles / Holanda, Jacqueline de Souza / Landim, Samuel Vasconcelos / Pitombeira, Maria Helena

    Revista da Associacao Medica Brasileira (1992)

    2016  Volume 62 Suppl 1, Page(s) 34–38

    Abstract: The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the HUWC/ ... ...

    Abstract The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the HUWC/ HEMOCE (Fortaleza - CE, Brazil). Fifty-two transplanted patients were studied from January 2009 to October 2015, among them, 30 men and 22 women, mean age of 28.2 years. All of them received GCS-F during the mobilization, in some cases associated with Vinorelbine or Plerixafor, with CD34 collection averaging 4.8 CD34/kg. The conditioning was performed with BEAC, NEAM or BEAM and the grafting with an average of 10 days. The evaluation on D + 100 showed: CR - 42 (82.7%), PR - 08 (13.5%) and 02 (3.8%) deaths, three and six days after cell infusion. After the D+100, 08 patients in CR showed HL recurrence from 06 to 36 months; 03 died and 05 are being treated with brentuximab; among the 08 patients in PR, 01 died due to HL activity, 04 months after BMT and 07 patients are undergoing treatment. The final evaluation of HL transplant patients showed an OS of 88.5% and a DFS of 61.5% in 6 years, with OS of the chemosensitive patients of 81% and of the chemoresistant ones, of 72.6%. It is possible to conclude that the Autologous HSCT has shown to be an excellent rescue therapy regarding tolerance, as well as the overall survival.
    MeSH term(s) Adolescent ; Adult ; Brazil ; Disease-Free Survival ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/mortality ; Hodgkin Disease/mortality ; Hodgkin Disease/surgery ; Humans ; Male ; Middle Aged ; Time Factors ; Transplantation Conditioning/methods ; Transplantation, Autologous/methods ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2016-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.62.suppl1.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Serum concentrations of nitrite and malondialdehyde as markers of oxidative stress in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.

    Petrola, Maria Juracy / de Castro, Alana Joselina Montenegro / Pitombeira, Maria Helena da Silva / Barbosa, Maritza Cavalcante / Quixadá, Acy Telles de Souza / Duarte, Fernando Barroso / Gonçalves, Romelia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2011  Volume 34, Issue 5, Page(s) 352–355

    Abstract: Background: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation. The tyrosine kinase abl fusion protein,the initial leukemogenic event in chronic ... ...

    Abstract Background: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation. The tyrosine kinase abl fusion protein,the initial leukemogenic event in chronic myeloid leukemia, is constitutively activated thus inducing the production of reactive oxygen species. Of particular relevance is the fact that an increase in reactive oxygen species can facilitate genomic instability and may contribute to disease progression.
    Objective: To evaluate oxidative stress by determining the levels of malondialdehyde and nitrite in chronic myeloid leukemia patients under treatment with 1st and 2nd generation tyrosine kinase inhibitors monitored at a referral hospital in Fortaleza, Ceará.
    Methods: A cross-sectional study was performed of 64 male and female adults. Patients were stratified according to treatment. The levels of malondialdehyde and nitrite were determined by spectrophotometry. Statistical differences between groups were observed using the Student t-test and Fisher's exact test. The results are expressed as mean ± standard error of mean. The significance level was set for a p-value < 0.05 in all analyses.
    Results: The results show significantly higher mean concentrations of nitrite and malondialdehyde in chronic myeloid leukemia patients using second-generation tyrosine kinase inhibitors compared to patients on imatinib.
    Conclusion: It follows that chronic myeloid leukemia patients present higher oxidative activity and that the increases in oxidative damage markers can indicate resistance to 1st generation tyrosine kinase inhibitors.
    Language English
    Publishing date 2011-01-14
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20120091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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