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  1. AU="Piton, Yasmin Vendruscolo"
  2. AU="Thadani, Nicole N"
  3. AU="Allison E. Norlander" AU="Allison E. Norlander"
  4. AU="Wei, Peifa"
  5. AU="Colak, Errol"
  6. AU="Hassan, Hosni M"
  7. AU="Becker, D T"
  8. AU="Lewis-Lloyd, Christopher A"
  9. AU=Doshi Rupali Kotwal AU=Doshi Rupali Kotwal
  10. AU="Kore Schlottau"
  11. AU="Jamjoom, Mona"
  12. AU="Bergmann, P."
  13. AU="Li, Congju"
  14. AU="Christenson, Robert"
  15. AU="O'Neill, Hugh M"
  16. AU="Vaccaro, Daniel H."
  17. AU=Panchin Yuri V
  18. AU=McIlvennan Colleen K
  19. AU="Khan, Mohammad Afsar"
  20. AU="Zhuang, Hua-Lu"
  21. AU="Lopez, Omar M"
  22. AU=Asfaw Abay
  23. AU="Santana, Ricardo Costa de"
  24. AU="Ortega, Johis"
  25. AU="Sogaolu, Moyosore"
  26. AU="Duchesne, Gabriela"
  27. AU="Sander, Klaus"
  28. AU="Wiegersma, Aline Marileen"
  29. AU=Mehta Yatin
  30. AU="Ki Hwan Kim"
  31. AU="Gulati, Rajiv"
  32. AU="Sullivan, Christopher"
  33. AU="Meier-Stephenson, Vanessa C"
  34. AU=Kim Joo Seop
  35. AU="Mortensen, Jennifer L"
  36. AU="Manthey, Helga D"
  37. AU="Baker, Susan"
  38. AU="Gunasegaram, James R"
  39. AU="Jung, Steffen"
  40. AU="Cairns, Anita"
  41. AU="Fox, Lindsay"

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  1. Artikel ; Online: Immunomodulatory effect of imidacloprid on macrophage RAW 264.7 cells.

    Cestonaro, Larissa Vivan / Crestani, Riciéli Pacheco / Conte, Fernanda Mocelin / Piton, Yasmin Vendruscolo / Schmitz, Felipe / Ferreira, Fernanda Silva / Wyse, Angela T S / Garcia, Solange Cristina / Arbo, Marcelo Dutra

    Environmental toxicology and pharmacology

    2023  Band 101, Seite(n) 104190

    Abstract: The neonicotinoid imidacloprid was promoted in the market because of widespread resistance to other insecticides, plus its low mammalian impact and higher specific toxicity towards insects. This study aimed to evaluate the immunomodulatory effect of ... ...

    Abstract The neonicotinoid imidacloprid was promoted in the market because of widespread resistance to other insecticides, plus its low mammalian impact and higher specific toxicity towards insects. This study aimed to evaluate the immunomodulatory effect of imidacloprid on macrophages. RAW 264.7 cells were incubated to 0-4000 mg/L of imidacloprid for 24 and 96 h. Imidacloprid presented a concentration-dependent cytotoxicity after 24 h and 96 h incubation for MTT reduction (3-(4,5-dimethyl-thiazol-2-yl)- 2,5-diphenyltetrazolium bromide) (EC
    Mesh-Begriff(e) Animals ; Mice ; RAW 264.7 Cells ; Neonicotinoids/toxicity ; Nitro Compounds/toxicity ; Insecticides/toxicity ; Macrophages ; Mammals
    Chemische Substanzen imidacloprid (3BN7M937V8) ; Neonicotinoids ; Nitro Compounds ; Insecticides
    Sprache Englisch
    Erscheinungsdatum 2023-06-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2023.104190
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: L-cysteine improves boar semen motility at 5 ºC but does not affect the oxidative status.

    Dos Santos, Guilherme / Tamanini, Mayara de Souza Costa / Leal, Leonardo Abreu / Wolf, Lucas Michel / Christ, Thaís Spohr / Piton, Yasmin Vendruscolo / Arbo, Marcelo Dutra / Bernardi, Mari Lourdes / Ulguim, Rafael da Rosa / Bortolozzo, Fernando Pandolfo / Mellagi, Ana Paula Gonçalves

    Animal reproduction science

    2023  Band 260, Seite(n) 107384

    Abstract: Hypothermic storage has been proposed as a method to reduce bacterial loads and promoting prudent use of antibiotics. Reducing temperature, however, can lead to cold shock damage and oxidative stress in boar semen. This study verified the effect of L- ... ...

    Abstract Hypothermic storage has been proposed as a method to reduce bacterial loads and promoting prudent use of antibiotics. Reducing temperature, however, can lead to cold shock damage and oxidative stress in boar semen. This study verified the effect of L-cysteine on the quality of semen stored at 5 °C for 120 h. Twenty-one normospermic ejaculates were diluted in Beltsville Thawing Solution into five treatments: Positive control (Pos_Cont, storage at 17 °C without L-cysteine) and groups with 0, 0.5, 1, and 2 mmol/L of L-cysteine supplementation stored at 5 °C. Variables were analyzed as repeated measures, considering treatment, storage time, and interaction as main factors. The effects of different L-cysteine concentrations were also evaluated using polynomial orthogonal contrasts. Sperm motility and pH were higher in the Pos_Cont compared to the groups stored at 5 °C (P < 0.05). In polynomial orthogonal contrast models, total motility was affected by the interaction between L-cysteine and storage time (P = 0.04), with a linear increase in motility when increasing the amount of L-cysteine at 72 and 120 h. Progressive motility increased quadratically as the L-cysteine reached 1 mmol/L (P < 0.01). In the thermoresistance test at 120 h, sperm motility increased quadratically up to an L-cysteine dose of 1 mmol/L (P < 0.05). Sulfhydryl content linearly increased with L-cysteine supplementation (P = 0.01), with no effect on intracellular ROS and sperm lipid peroxidation (P ≥ 0.06) in 5ºC-stored doses. In conclusion, L-cysteine supplementation has a positive effect on sperm motility up to 120 h of storage at 5 °C.
    Mesh-Begriff(e) Swine ; Male ; Animals ; Sperm Motility ; Semen ; Cysteine/pharmacology ; Semen Preservation/veterinary ; Semen Preservation/methods ; Spermatozoa ; Oxidative Stress
    Chemische Substanzen Cysteine (K848JZ4886)
    Sprache Englisch
    Erscheinungsdatum 2023-11-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 429674-6
    ISSN 1873-2232 ; 0378-4320
    ISSN (online) 1873-2232
    ISSN 0378-4320
    DOI 10.1016/j.anireprosci.2023.107384
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Levamisole, a cocaine cutting agent, induces acute and subchronic systemic alterations in Wistar rats.

    Laurentino, Ana Olívia Martins / Solómon, Janaína / Tonietto, Bruna Ducatti / Cestonaro, Larissa Vivan / Dos Santos, Nícolas Guimarães / Piton, Yasmin Vendruscolo / Izolan, Lucas / Marques, Douglas / Costa-Valle, Marina Tuerlinckx / Garcia, Solange Cristina / Sebben, Viviane / Dallegrave, Eliane / Schaefer, Pedro Guilherme / Barros, Elvino José / Arbo, Marcelo Dutra / Leal, Mirna Bainy

    Toxicology and applied pharmacology

    2021  Band 426, Seite(n) 115649

    Abstract: The use of the anthelmintic levamisole as a cocaine adulterant has been increasing worldwide. Complications caused by this association include systemic vasculitis, agranulocytosis, neutropenia, tissue necrosis, pulmonary hemorrhage, and renal injury. ... ...

    Abstract The use of the anthelmintic levamisole as a cocaine adulterant has been increasing worldwide. Complications caused by this association include systemic vasculitis, agranulocytosis, neutropenia, tissue necrosis, pulmonary hemorrhage, and renal injury. Data about toxicity of levamisole are scarce, therefore the aim of this study was to evaluate the acute and subchronic toxic effects of levamisole in rats. Male Wistar rats received saline or levamisole by intraperitoneal route at the doses of 12, 24 and 36 mg/kg in the acute toxicity test; and at 3, 6 and 12 mg/kg in the subchronic toxicity test. Toxicity was evaluated using behavioral, cognitive, renal, hematological, biochemical and histopathological parameters. Acute administration of levamisole caused behavioral and histopathological alterations. Subchronic administration caused behavioral, cognitive and hematological alterations (p < 0.0001 and p < 0.05, respectively), impairment of liver and kidney functions (p < 0.05), and changes of antioxidant defenses (p ≤ 0.0001). Both administrations produced toxic effects of clinical relevance, which make levamisole a dangerous cutting agent. Furthermore, the knowledge of these effects can contribute to the correct diagnosis and treatment of cocaine dependents with unusual systemic alterations.
    Mesh-Begriff(e) Animals ; Antinematodal Agents/toxicity ; Behavior, Animal/drug effects ; Cocaine ; Leukocyte Count ; Levamisole/toxicity ; Liver/drug effects ; Liver/pathology ; Male ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/immunology ; Neurotoxicity Syndromes/metabolism ; Neurotoxicity Syndromes/pathology ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Rats, Wistar ; Toxicity Tests, Acute ; Rats
    Chemische Substanzen Antinematodal Agents ; Levamisole (2880D3468G) ; Cocaine (I5Y540LHVR)
    Sprache Englisch
    Erscheinungsdatum 2021-07-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2021.115649
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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