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  1. Article ; Online: Response to Letter to the Editor From Chang Villacreses et al: "Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes".

    Rasouli, Neda / Pittas, Anastassios G

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 7, Page(s) e3095–e3096

    MeSH term(s) Dietary Supplements ; Humans ; Insulin Resistance/physiology ; Prediabetic State/drug therapy ; Vitamin D ; Vitamin D Deficiency/drug therapy
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac258
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  2. Article ; Online: Effect of vitamin D supplementation on circulating fibroblast growth factor-23 concentration in adults with prediabetes.

    Ceglia, Lisa / Pittas, Anastassios G / Dawson-Hughes, Bess

    Aging clinical and experimental research

    2023  Volume 35, Issue 3, Page(s) 525–530

    Abstract: Background: Recent meta-analyses report that vitamin D supplementation increases blood fibroblast growth factor-23 (FGF23) level.: Objectives: To determine the effect of 4000 IU/day of vitamin D: Methods: An ancillary analysis among adults 70 ... ...

    Abstract Background: Recent meta-analyses report that vitamin D supplementation increases blood fibroblast growth factor-23 (FGF23) level.
    Objectives: To determine the effect of 4000 IU/day of vitamin D
    Methods: An ancillary analysis among adults 70 years and older with prediabetes who participated in a trial comparing vitamin D
    Results: Characteristics of the 52 participants (vitamin D
    Conclusion: In obese older adults with sufficient vitamin D status and normal renal function, vitamin D
    Clinicaltrials: gov NCT 01,942,694, registered 9/16/2013.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Double-Blind Method ; Fibroblast Growth Factor-23 ; Prediabetic State/drug therapy ; Prediabetic State/complications ; Vitamin D ; Vitamin D Deficiency/complications
    Chemical Substances Cholecalciferol (1C6V77QF41) ; Fibroblast Growth Factor-23 (7Q7P4S7RRE) ; Vitamin D (1406-16-2) ; FGF23 protein, human
    Language English
    Publishing date 2023-01-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-022-02338-y
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  3. Article ; Online: Untangling the Gordian Knot of Vitamin D Supplementation and Type 2 Diabetes Prevention.

    Pittas, Anastassios G / Balk, Ethan M

    Diabetes care

    2021  Volume 43, Issue 7, Page(s) 1375–1377

    MeSH term(s) Diabetes Mellitus, Type 2/prevention & control ; Dietary Supplements ; Humans ; Insulin Resistance ; Vitamin D
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dci20-0011
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  4. Article ; Online: Integrating Nutrition Education into Clinical Practice.

    Delichatsios, Helen K / Pittas, Anastassios G

    Nestle Nutrition Institute workshop series

    2019  Volume 92, Page(s) 171–182

    Abstract: The power of physicians to educate patients about nutrition and provide the tools and motivation needed for patients to adopt healthy eating habits is under-utilized. To unleash that power, practicing physicians need to synthesize the latest in nutrition ...

    Abstract The power of physicians to educate patients about nutrition and provide the tools and motivation needed for patients to adopt healthy eating habits is under-utilized. To unleash that power, practicing physicians need to synthesize the latest in nutrition science, integrate it with the established body of evidence on healthy nutrition, and translate and communicate this knowledge to patients in a practical and effective way. Physicians and patients face similar barriers in discussing and incorporating healthy nutrition practices. Tactics and tools that are simple, effective, affordable, and scalable, can be incorporated in clinical practice, thereby making nutrition counseling feasible with only incremental burden to physicians' time and energy. These tactics include: (1) assessing body mass index at every visit, (2) adding obesity or overweight on the problem list, (3) assessing diet, (4) acknowledging risk, (5) being mindful of language, and (6) writing a prescription. Understanding the psychological aspects of food choices and behavioral change, use of technology, and engaging teams are also important. Group visits to address nutrition-related topics are a novel approach to discuss and taste (literally) healthy eating. Finally, physicians' own health and nutrition are powerful predictors of nutrition education to patients and can be a target of intervention as well.
    MeSH term(s) Body Mass Index ; Counseling ; Diet ; Diet, Healthy ; Exercise ; Feeding Behavior ; Food Preferences ; Health Education ; Health Promotion ; Humans ; Language ; Nutritional Sciences/education ; Nutritional Status ; Obesity/therapy ; Overweight/therapy ; Physician's Role ; Practice Patterns, Physicians' ; Risk Factors
    Language English
    Publishing date 2019-11-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1664-2155
    ISSN (online) 1664-2155
    DOI 10.1159/000499560
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  5. Article ; Online: Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study. Diabetes Care 2020;43:2916-2922.

    Dawson-Hughes, Bess / Nelson, Jason / Pittas, Anastassios G

    Diabetes care

    2021  Volume 44, Issue 5, Page(s) e106

    MeSH term(s) Adult ; Cholecalciferol ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Prediabetic State/epidemiology ; Vitamin D ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dci21-0006
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  6. Article ; Online: Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes.

    Pittas, Anastassios G / Kawahara, Tetsuya / Jorde, Rolf / Dawson-Hughes, Bess / Balk, Ethan M

    Annals of internal medicine

    2023  Volume 176, Issue 8, Page(s) eL230202

    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L23-0202
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  7. Article ; Online: The Role of Vitamin D in the Prevention of Type 2 Diabetes: To D or Not to D?

    Angellotti, Edith / Pittas, Anastassios G

    Endocrinology

    2017  Volume 158, Issue 7, Page(s) 2013–2021

    Abstract: Evidence on biological plausibility from mechanistic studies and highly consistent data from observational studies raise the possibility that optimizing vitamin D status may reduce the risk of type 2 diabetes. However, the observational nature of cohort ... ...

    Abstract Evidence on biological plausibility from mechanistic studies and highly consistent data from observational studies raise the possibility that optimizing vitamin D status may reduce the risk of type 2 diabetes. However, the observational nature of cohort studies precludes a definitive assessment of cause and effect because residual confounding or reverse causation cannot be excluded. Confounding is especially problematic with studies of vitamin D because blood 25-hydoxyvitamin D concentration is not only an excellent biomarker of vitamin D status, reflecting intake or biosynthesis, but also an excellent marker of good overall health. Results from underpowered trials and post hoc analyses of trials designed for nondiabetic outcomes do not support a role of vitamin D supplementation for prevention of type 2 diabetes among people with normal glucose tolerance. Whether vitamin D supplementation may have a role in the prevention of diabetes in high-risk populations remains to be seen. Adequately powered, randomized trials in well-defined populations (e.g., prediabetes) are ongoing and expected to establish whether vitamin D supplementation lowers risk of diabetes.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/prevention & control ; Humans ; Insulin/metabolism ; Insulin Resistance/physiology ; Insulin Secretion ; Insulin-Secreting Cells/physiology ; Prediabetic State/blood ; Prediabetic State/drug therapy ; Vitamin D/blood ; Vitamin D/therapeutic use ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy
    Chemical Substances Insulin ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2017-05-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2017-00265
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  8. Article ; Online: New-Onset Diabetes After COVID-19.

    Kim, Sun H / Arora, Ipsa / Hsia, Daniel S / Knowler, William C / LeBlanc, Erin / Mylonakis, Eleftherios / Pratley, Richard / Pittas, Anastassios G

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 11, Page(s) e1164–e1174

    Abstract: There is evidence suggesting that infection with SARS-CoV-2 can lead to several long-term sequelae including diabetes. This mini-review examines the rapidly evolving and conflicting literature on new-onset diabetes after COVID-19, which we term NODAC. We ...

    Abstract There is evidence suggesting that infection with SARS-CoV-2 can lead to several long-term sequelae including diabetes. This mini-review examines the rapidly evolving and conflicting literature on new-onset diabetes after COVID-19, which we term NODAC. We searched PubMed, MEDLINE, and medRxiv from inception until December 1, 2022, using Medical Subject Headings (MeSH) terms and free text words including "COVID-19," "SARS-CoV-2," "diabetes," "hyperglycemia," "insulin resistance," and "pancreatic β-cell." We also supplemented searches by examining reference lists from retrieved articles. Current evidence suggests that COVID-19 increases the risk of developing diabetes, but the attributable risk is uncertain because of limitations of study designs and the evolving nature of the pandemic, including new variants, widespread population exposure to the virus, diagnostic options for COVID-19, and vaccination status. The etiology of diabetes after COVID-19 is likely multifactorial and includes factors associated with host characteristics (eg, age), social determinants of health (eg, deprivation index), and pandemic-related effects both at the personal (eg, psychosocial stress) and the societal-community level (eg, containment measures). COVID-19 may have direct and indirect effects on pancreatic β-cell function and insulin sensitivity related to the acute infection and its treatment (eg, glucocorticoids); autoimmunity; persistent viral residency in multiple organs including adipose tissue; endothelial dysfunction; and hyperinflammatory state. While our understanding of NODAC continues to evolve, consideration should be given for diabetes to be classified as a post-COVID syndrome, in addition to traditional classifications of diabetes (eg, type 1 or type 2), so that the pathophysiology, natural history, and optimal management can be studied.
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Hyperglycemia ; Risk Factors ; Insulin Resistance
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad284
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  9. Article ; Online: Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial.

    LeBlanc, Erin S / Pittas, Anastassios G / Nelson, Jason / Chatterjee, Ranee / Rasouli, Neda / Rhee, Mary K / Pratley, Richard E / Desouza, Cyrus V / Neff, Lisa M / Peters, Anne M / Dagogo-Jack, Samuel / Hsia, Daniel S

    BMJ open diabetes research & care

    2024  Volume 12, Issue 1

    Abstract: Introduction: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by ... ...

    Abstract Introduction: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race.
    Research design and methods: From data collected at 22 US clinical sites, we conducted a cross-sectional study of concurrently measured A1c and OGTT and observational longitudinal follow-up of the subset with high-risk pre-diabetes. Numerical integration methods were used to calculate area under the glycemic curve (AUC
    Results: 1016 black, 2658 white, and 193 Asian persons at risk of diabetes were included in cross-sectional analysis. Of these, 2154 with high-risk pre-diabetes were followed for 2.5 years. For a given A1c level, AUC
    Conclusions: Use of additional testing beyond A1c to screen for diabetes may better stratify diabetes risk in the diverse US population.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Prediabetic State/epidemiology ; Prediabetic State/diagnosis ; Vitamin D ; Cross-Sectional Studies ; Glycated Hemoglobin ; Blood Glucose/analysis ; Race Factors ; Vitamins ; White
    Chemical Substances Vitamin D (1406-16-2) ; Glycated Hemoglobin ; Blood Glucose ; Vitamins
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2732918-5
    ISSN 2052-4897 ; 2052-4897
    ISSN (online) 2052-4897
    ISSN 2052-4897
    DOI 10.1136/bmjdrc-2023-003613
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  10. Article ; Online: Response to Letter to the Editor from Dalan: "Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?"

    Pittas, Anastassios G / Jorde, Rolf / Kawahara, Tetsuya / Dawson-Hughes, Bess

    The Journal of clinical endocrinology and metabolism

    2020  Volume 106, Issue 4, Page(s) e1928–e1929

    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; Dietary Supplements ; Humans ; Vitamin D ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/prevention & control
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa971
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