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Book ; Online: Chapter 7 It's okay not to like it

Pitts, Stephanie / Price, Sarah M.

2021

Abstract: Drawing on unique multi-arts, multi-city scholarly research, Understanding Audiences for the Contemporary Arts makes a timely and urgent contribution to debates about the place of arts and culture in contemporary society. 　 The authors critically ... ...

Abstract	Drawing on unique multi-arts, multi-city scholarly research, Understanding Audiences for the Contemporary Arts makes a timely and urgent contribution to debates about the place of arts and culture in contemporary society. 　 The authors critically interrogate the challenges of access, diversity, privilege and responsibility in contemporary art. Asking who benefits from, pays for and consumes the arts, the book highlights fresh, forward-thinking audience and organisational attitudes that show the potential of live arts engagement to contribute to engaged citizenship. Complemented by comparative global analysis, the cutting-edge insights in this book are relevant for interdisciplinary researchers across audience studies and beyond. Enhanced by a new framework for the understanding audience engagement, the book is relevant to scholars, policymakers and reflective practitioners across the spectrum of arts and cultural industries management
Keywords	Commerce ; History (General) ; Economic theory. Demography
Size	1 electronic resource (23 pages)
Publisher	Taylor and Francis
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020590142
ISBN	9780367358884 ; 0367358883
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Understanding Audience Engagement in the Contemporary Arts

Pitts, Stephanie / Price, Sarah M.

2021

Keywords	Business & management ; Museology & heritage studies ; Non-profitmaking organizations ; contemporary ; action ; alternative ; analysis ; approach
Size	1 electronic resource (246 pages)
Publisher	Taylor and Francis
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021029142
ISBN	9780367358884 ; 0367358883
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Regulation of RNA Polymerase I Stability and Function.

Pitts, Stephanie / Laiho, Marikki

Cancers

2022 Volume 14, Issue 23

Abstract: RNA polymerase I is a highly processive enzyme with fast initiation and elongation rates. The structure of Pol I, with its in-built RNA cleavage ability and incorporation of subunits homologous to transcription factors, enables it to quickly and ... ...

Abstract	RNA polymerase I is a highly processive enzyme with fast initiation and elongation rates. The structure of Pol I, with its in-built RNA cleavage ability and incorporation of subunits homologous to transcription factors, enables it to quickly and efficiently synthesize the enormous amount of rRNA required for ribosome biogenesis. Each step of Pol I transcription is carefully controlled. However, cancers have highjacked these control points to switch the enzyme, and its transcription, on permanently. While this provides an exceptional benefit to cancer cells, it also creates a potential cancer therapeutic vulnerability. We review the current research on the regulation of Pol I transcription, and we discuss chemical biology efforts to develop new targeted agents against this process. Lastly, we highlight challenges that have arisen from the introduction of agents with promiscuous mechanisms of action and provide examples of agents with specificity and selectivity against Pol I.
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14235776
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting pancreatic neuroendocrine tumors (PTHrP-PNETs): Case Report.

Pitts, Stephanie / Mahipal, Amit / Bajor, David / Mohamed, Amr

Frontiers in oncology

2023 Volume 13, Page(s) 1197288

Abstract: Parathyroid hormone-related protein (PTHrP) secretion is occasionally detected in various solid tumors such as renal cell carcinoma and lung cancers. It is considered quite rare for neuroendocrine tumors with only few published case reports. We reviewed ... ...

Abstract	Parathyroid hormone-related protein (PTHrP) secretion is occasionally detected in various solid tumors such as renal cell carcinoma and lung cancers. It is considered quite rare for neuroendocrine tumors with only few published case reports. We reviewed the current literature and summarized a case report of a patient with metastatic pancreatic neuroendocrine tumor (PNET) presenting with hypercalcemia due to elevation of PTHrP. The patient had histological confirmation of well-differentiated PNET and developed hypercalcemia years after his initial diagnosis. In our case report, evaluation showed intact parathyroid hormone (PTH) in the setting of concomitant elevation of PTHrP. The patient's hypercalcemia and PTHrP levels were improved by using a long-acting somatostatin analogue. In addition, we reviewed the current literature regarding the optimal management of malignant hypercalcemia due to PTHrP-producing PNETs.
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1197288
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evidence for Criterion-Related Validity of Pressure-Mediated Reflection Spectroscopy for Approximating Fruit and Vegetable Consumption among Preschool Children.

Hasnin, Saima / Dev, Dipti A / Pitts, Stephanie Jilcott

The Journal of nutrition

2023 Volume 154, Issue 1, Page(s) 261–270

Abstract: Background: Skin carotenoids are a valid biomarker for approximating fruit and vegetable consumption (FVC). Veggie Meter® (VM®, Longevity Link Corp.) is a pressure-mediated reflection spectroscopy (RS)-based device that allows for noninvasive and rapid ... ...

Abstract	Background: Skin carotenoids are a valid biomarker for approximating fruit and vegetable consumption (FVC). Veggie Meter® (VM®, Longevity Link Corp.) is a pressure-mediated reflection spectroscopy (RS)-based device that allows for noninvasive and rapid assessment of skin-carotenoid score (SCS) in adults and children. Although VM® is established as a valid tool to measure FVC in adults, there is limited research supporting the validity evidence of the VM® to approximate FVC among preschool children. Objective: The current study aims to assess evidence supporting the criterion-related validity of RS-based SCS for approximating FVC among preschool children (3-5-y old). Methods: We collected cross-sectional data from typically developing preschool children (n = 136) attending the Child and Adult Care Food Program-participating family child care home settings (FCCHs) (n = 46) in Nebraska. Research team members collected children's height and weight to calculate body mass index; and measured children's SCS using the VM®. Children's FVC in FCCHs were collected using dietary observation. In addition, parents (n = 89) completed a shortened food frequency questionnaire to report children's FVC at home. Kendall's Tau (τ) correlation tests were conducted to measure the association between children's SCS with FVC in FCCHs and with parent-reported total fruit and vegetable (FV) frequency scores. Results: Children's SCS were significantly correlated with their mean FVC in FCCHs, τ = 0.14 (P = 0.02), total provitamin A carotenoids intake in FCCHs, τ = 0.19 (P < 0.001), and with parent-reported total FV frequency score, τ = 0.16 (P = 0.04). Conclusion: The correlation coefficients in this study are comparable with results from a meta-analysis examining associations between FVC and SCS in 7-10-y-old children (r = 0.20). Thus, evidence suggests that RS offers a potentially valid, objective, and feasible method to assess preschool children's total FVC in multiple settings, especially in conjunction with other dietary assessment tools.
MeSH term(s)	Adult ; Child, Preschool ; Humans ; Carotenoids/analysis ; Cross-Sectional Studies ; Diet ; Feeding Behavior ; Fruit/chemistry ; Spectrum Analysis ; Vegetables
Chemical Substances	Carotenoids (36-88-4)
Language	English
Publishing date	2023-11-25
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.11.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Systematic Literature Review of Nutrition Interventions Implemented to Address Food Insecurity as a Social Determinant of Health.

Norris, Kennedy / Jilcott Pitts, Stephanie / Reis, Heidi / Haynes-Maslow, Lindsey

Nutrients

2023 Volume 15, Issue 15

Abstract: Background: Policy initiatives have provided funding for non-acute nutrition interventions to address food insecurity as a social determinant of health, but more research is needed to understand the outcomes of these initiatives in order to determine ... ...

Abstract	Background: Policy initiatives have provided funding for non-acute nutrition interventions to address food insecurity as a social determinant of health, but more research is needed to understand the outcomes of these initiatives in order to determine the areas of highest impact. Therefore, the purpose of this systematic review was to evaluate the outcomes that were assessed in three nutrition interventions (produce prescription programs, medically tailored meals, and community supported agriculture) that aim to address food insecurity as a social determinant of health, and this was undertaken in order to identify future areas of study that can heighten impact. Methods: This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria. A list of search terms and keywords were compiled by the research team. A Boolean search was conducted from 1 January 2000 to 1 January 2023 in the PubMed advanced search database. Results: A total of 1015 articles were initially pulled from the PubMed database, and, after a screening process, 21 articles were included in our review. Nineteen of the articles focused on adult populations or families and two focused on children. The main outcomes assessed were changes in self-reported dietary intake, while a few of the articles addressed feasibility and cost-related outcomes. Conclusions: More research is needed to assess whether nutritional interventions to address food insecurity as a social determinant of health are feasible and more cost effective in the long term. Additionally, more work should be conducted in pediatric populations, which could have a robust return on investment in terms of both healthcare utilization and healthcare expenditure.
MeSH term(s)	Child ; Adult ; Humans ; Social Determinants of Health ; Social Factors ; Food Insecurity
Language	English
Publishing date	2023-08-05
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15153464
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Thesis ; Online: Modeling and Simulation of Microstructure Evolution and Deformation in an Irradiated Environment

Pitts, Stephanie Anne

2019

Abstract: The ability to predict the behavior of structural components in a nuclear power plant is critical to the nuclear industry. Structural metals in the primary loop of nuclear power plants must endure challenges such as irradiation and mechanical and thermal ...

Abstract	The ability to predict the behavior of structural components in a nuclear power plant is critical to the nuclear industry. Structural metals in the primary loop of nuclear power plants must endure challenges such as irradiation and mechanical and thermal loading, and these structural metal components must continue to function in potential transient and accident conditions throughout the operational lifetime of the power plant. This extreme operational environment changes the metal microstructure by creating additional defects. The physical interactions of dislocations with these defects govern how the metal will respond to future conditions. Therefore predicting the mechanical response of these metals requires a set of physically based and reliable models of dislocation and defect interactions. These microstructure elements include glide mobile and immobile dislocations, geometrically necessary dislocations, twinning dislocations, irradiation defects, and thermal aging defects. We present here a continuum dislocation dynamics crystal plasticity framework to capture the interaction mechanisms of these dislocations and defects, verified with a combination of benchmark problems and comparisons with experimental data for two different types of structural metals: α iron and nickel-based alloys. In our simulations of α iron we highlight the advantages of applying a Monte Carlo stochastic model of cross slip dislocation motion and show the importance of capturing the 3D nature of glide dislocation and self-interstitial atom loop radiation defect interactions. We demonstrate coupling of glide dislocations with geometrically necessary dislocations to capture the influence of lattice bending, including the sensitivity of the geometrically necessary dislocations to changes in the grain boundary angle. We further examine the interaction of glide dislocations with the twin dislocations and thermally aged defects which have been observed in a nickel-based alloy with additional models. Finally we assess the reliability of this crystal plasticity framework by comparing two dislocation glide velocity models across the range of normal operation temperatures. In successfully applying our crystal plasticity framework to multiple metals, we provide further evidence of the reliability of our approach. The results of this mechanism-based continuum dislocation dynamics crystal plasticity framework can be used to inform engineering scale models throughout the nuclear industry.
Keywords	Mechanics\|Materials science\|Mechanical engineering
Subject code	669
Language	ENG
Publishing date	2019-01-01 00:00:01.0
Publisher	Washington State University
Publishing country	us
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Need for Evidence-Based Interventions to Reduce Food Insecurity Among College Students.

Pitts, Stephanie Jilcott / Brothers, Sarah

Journal of Appalachian health

2020 Volume 2, Issue 2, Page(s) 1–6

Abstract: Food insecurity is defined as insufficient resources to meet food needs. This is a global problem but is not confined to those countries identified as poor. One group of Americans who are particularly affected, and for whom the effects are particularly ... ...

Abstract	Food insecurity is defined as insufficient resources to meet food needs. This is a global problem but is not confined to those countries identified as poor. One group of Americans who are particularly affected, and for whom the effects are particularly severe, is college students.
Language	English
Publishing date	2020-04-15
Publishing country	United States
Document type	Journal Article
ISSN	2641-7804
ISSN (online)	2641-7804
DOI	10.13023/jah.0202.01
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Produce Prescription Program in Eastern North Carolina Results in Increased Voucher Redemption Rates and Increased Fruit and Vegetable Intake among Participants.

Lyonnais, Mary Jane / Rafferty, Ann P / Spratt, Susannah / Jilcott Pitts, Stephanie

Nutrients

2022 Volume 14, Issue 12

Abstract: Few produce prescription programs have taken place in rural areas, in the context of existing public health programs. Thus, the purpose of this mixed-methods study was to examine voucher redemption rates, change in fruit and vegetable intake, and ... ...

Abstract	Few produce prescription programs have taken place in rural areas, in the context of existing public health programs. Thus, the purpose of this mixed-methods study was to examine voucher redemption rates, change in fruit and vegetable intake, and suggestions for improvement among participants enrolled in a produce prescription program occurring in existing public health programs throughout rural eastern North Carolina. We examined voucher redemption rates and conducted pre- (
MeSH term(s)	Fruit ; Health Promotion/methods ; Humans ; North Carolina ; Prescriptions ; Rural Population ; Vegetables
Language	English
Publishing date	2022-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14122431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Examining Potential Modifiers of Human Skin and Plasma Carotenoid Responses in a Randomized Trial of a Carotenoid-Containing Juice Intervention.

Jilcott Pitts, Stephanie B / Wu, Qiang / Moran, Nancy E / Laska, Melissa N / Harnack, Lisa

The Journal of nutrition

2023 Volume 153, Issue 11, Page(s) 3287–3294

Abstract: Background: Skin carotenoid measurements are emerging as a valid and reliable indicator of fruit and vegetable intake and carotenoid intake. However, little is known about the extent to which skin carotenoid responsivity to dietary changes differs based ...

Abstract	Background: Skin carotenoid measurements are emerging as a valid and reliable indicator of fruit and vegetable intake and carotenoid intake. However, little is known about the extent to which skin carotenoid responsivity to dietary changes differs based on demographic and physiologic characteristics. Objectives: This study examined potential effect modifiers of skin carotenoid and plasma carotenoid responses to a carotenoid-rich juice intervention. Methods: We leveraged data from 2 arms of a 3-site randomized controlled trial of a carotenoid-containing juice intervention (moderate dose = 6 ounces juice, 4 mg total carotenoids/d, high dose = 12 ounces juice, 8 mg total carotenoids/d) (n = 106) to examine effect modification by age, self-categorized race/ethnicity, biological sex, baseline body fat, body mass index, skin melanin, skin hemoglobin, skin hemoglobin saturation, skin coloration, sun exposure, and baseline intake of carotenoids from foods. Skin carotenoid concentrations were assessed using pressure-mediated reflection spectroscopy (Veggie Meter), and plasma carotenoid concentrations were measured using high-performance liquid chromatography. Results: In bivariate analyses, among the high-dose group (8 mg/d), those of older age had lower skin carotenoid responsiveness than their younger counterparts, and those with greater hemoglobin saturation and lighter skin had higher skin carotenoid score responsiveness. In the moderate-dose group (4 mg/d), participants from one site had greater plasma carotenoid responsiveness than those from other sites. In multivariate analyses, participants with higher baseline skin carotenoids had smaller skin carotenoid responses to both moderate and high doses. Conclusions: Changes in skin carotenoid scores in response to interventions to increase fruit and vegetable intake should be interpreted in the context of baseline skin carotenoid scores, but other variables (e.g., self-categorized race/ethnicity, biological sex, baseline body fat, body mass index, skin melanin, and sun exposure) do not significantly modify the effect of carotenoid intake on changes in skin carotenoid scores. This trial was registered at clinicaltrials.gov as NCT04056624.
MeSH term(s)	Humans ; Carotenoids ; Diet ; Fruit/chemistry ; Hemoglobins/analysis ; Melanins/analysis ; Skin ; Vegetables
Chemical Substances	Carotenoids (36-88-4) ; Hemoglobins ; Melanins
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.09.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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