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Book ; Online: Il Parlagioco Uno strumento per comunicare attraverso il gioco

Pizzamiglio, Maria Rosa / Mattioli, Marina / Piccardi, Laura

2005

Author's details	by Maria Rosa Pizzamiglio, Laura Piccardi, Marina Mattioli
Keywords	Rehabilitation ; Speech pathology
Publisher	Springer-Verlag Italia, Milano
Publishing place	Milano
Document type	Book ; Online
HBZ-ID	TT050387905
ISBN	978-88-470-0323-1 ; 978-88-470-0368-2 ; 88-470-0323-7 ; 88-470-0368-7
DOI	10.1007/88-470-0368-7
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Evolving paradigms in breast cancer screening: Balancing efficacy, personalization, and equity.

Pesapane, Filippo / Rotili, Anna / Raimondi, Sara / Aurilio, Gaetano / Lazzeroni, Matteo / Nicosia, Luca / Latronico, Antuono / Pizzamiglio, Maria / Cassano, Enrico / Gandini, Sara

European journal of radiology

2024 Volume 172, Page(s) 111321

Abstract: Breast cancer remains a significant global health challenge, with projections indicating a troubling increase in incidence. Breast cancer screening programs have long been hailed as life-saving initiatives, yet their true impact on mortality rates is a ... ...

Abstract	Breast cancer remains a significant global health challenge, with projections indicating a troubling increase in incidence. Breast cancer screening programs have long been hailed as life-saving initiatives, yet their true impact on mortality rates is a subject of ongoing debate. Screening poses the risk of false positives and the detection of indolent tumors, potentially leading to overtreatment. Bias factors, including lead time, length time, and selection biases, further complicate the assessment of screening efficacy. Recent studies suggest that AI-driven image analysis may revolutionize breast cancer screening, maintaining diagnostic accuracy while reducing radiologists' workload. However, the generalizability of these findings to diverse populations is a critical consideration. Personalized screening approaches and equitable access to advanced technologies are essential to mitigate disparities. In conclusion, the breast cancer screening landscape is evolving, emphasizing the need for risk stratification, appropriate imaging modalities, and a personalized approach to reduce overdiagnosis and focus on cancers with the potential to impact lives while prioritizing patient-centered care.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/epidemiology ; Early Detection of Cancer/methods ; Radiologists ; Incidence ; Mammography/methods ; Mass Screening/methods
Language	English
Publishing date	2024-01-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2024.111321
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Contrast-enhanced mammography BI-RADS: a case-based approach to radiology reporting.

Nicosia, Luca / Battaglia, Ottavia / Venturini, Massimo / Fontana, Federico / Minenna, Manuela / Pesenti, Aurora / Budascu, Diana / Pesapane, Filippo / Bozzini, Anna Carla / Pizzamiglio, Maria / Meneghetti, Lorenza / Latronico, Antuono / Signorelli, Giulia / Mariano, Luciano / Cassano, Enrico

Insights into imaging

2024 Volume 15, Issue 1, Page(s) 37

Abstract: Contrast-enhanced mammography (CEM) is a relatively recent diagnostic technique increasingly being utilized in clinical practice. Until recently, there was a lack of standardized reporting for CEM findings. However, this has changed with the publication ... ...

Abstract	Contrast-enhanced mammography (CEM) is a relatively recent diagnostic technique increasingly being utilized in clinical practice. Until recently, there was a lack of standardized reporting for CEM findings. However, this has changed with the publication of a supplement in the Breast Imaging Reporting and Data System (BI-RADS). A comprehensive understanding of CEM is essential for further enhancing its role in both screening and managing patients with breast malignancies. CEM can also be beneficial for problem-solving, improving the management of uncertain breast findings. Practitioners in this field should become more cognizant of how and when to employ this technique and interpret the various CEM findings. This paper aims to outline the key findings in the updated version of the BI-RADS specifically dedicated to CEM. Additionally, it will present some clinical cases commonly encountered in clinical practice.Critical relevance statement Standardized reporting and a thorough understanding of CEM findings are pivotal for advancing the role of CEM in screening and managing breast cancer patients. This standardization contributes significantly to integrating CEM as an essential component of daily clinical practice.Key points • A complete knowledge and understanding of the findings outlined in the new BI-RADS CEM are necessary for accurate reporting.• BI-RADS CEM supplement is intuitive and practical to use.• Standardization of the CEM findings enables more accurate patient management.
Language	English
Publishing date	2024-02-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-024-01612-z
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Article: Atypical Ductal Hyperplasia and Lobular In Situ Neoplasm: High-Risk Lesions Challenging Breast Cancer Prevention.

Nicosia, Luca / Mariano, Luciano / Pellegrino, Giuseppe / Ferrari, Federica / Pesapane, Filippo / Bozzini, Anna Carla / Frassoni, Samuele / Bagnardi, Vincenzo / Pupo, Davide / Mazzarol, Giovanni / De Camilli, Elisa / Sangalli, Claudia / Venturini, Massimo / Pizzamiglio, Maria / Cassano, Enrico

Cancers

2024 Volume 16, Issue 4

Abstract: This retrospective study investigates the histopathological outcomes, upgrade rates, and disease-free survival (DFS) of high-risk breast lesions, including atypical ductal hyperplasia (ADH or DIN1b) and lobular in situ neoplasms (LIN), following Vacuum- ... ...

Abstract	This retrospective study investigates the histopathological outcomes, upgrade rates, and disease-free survival (DFS) of high-risk breast lesions, including atypical ductal hyperplasia (ADH or DIN1b) and lobular in situ neoplasms (LIN), following Vacuum-Assisted Breast Biopsy (VABB) and surgical excision. The study addresses the challenge posed by these lesions due to their association with synchronous or adjacent Breast Cancer (BC) and increased future BC risk. The research, comprising 320 patients who underwent stereotactic VABB, focuses on 246 individuals with a diagnosis of ADH (120) or LIN (126) observed at follow-up. Pathological assessments, categorized by the UK B-coding system, were conducted, and biopsy samples were compared with corresponding excision specimens to determine upgrade rates for in situ or invasive carcinoma. Surgical excision was consistently performed for diagnosed ADH or LIN. Finally, patient follow-ups were assessed and compared between LIN and ADH groups to identify recurrence signs, defined as histologically confirmed breast lesions on either the same or opposite side. The results reveal that 176 (71.5%) patients showed no upgrade post-surgery, with ADH exhibiting a higher upgrade rate to in situ pathology than LIN1 (Atypical Lobular Hyperplasia, ALH)/LIN2 (Low-Grade Lobular in situ Carcinoma, LCIS) (38% vs. 20%, respectively,
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16040837
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Article: History of Mammography: Analysis of Breast Imaging Diagnostic Achievements over the Last Century.

Nicosia, Luca / Gnocchi, Giulia / Gorini, Ilaria / Venturini, Massimo / Fontana, Federico / Pesapane, Filippo / Abiuso, Ida / Bozzini, Anna Carla / Pizzamiglio, Maria / Latronico, Antuono / Abbate, Francesca / Meneghetti, Lorenza / Battaglia, Ottavia / Pellegrino, Giuseppe / Cassano, Enrico

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 11

Abstract: Breast cancer is the most common forms of cancer and a leading cause of mortality in women. Early and correct diagnosis is, therefore, essential to save lives. The development of diagnostic imaging applied to the breast has been impressive in recent ... ...

Abstract	Breast cancer is the most common forms of cancer and a leading cause of mortality in women. Early and correct diagnosis is, therefore, essential to save lives. The development of diagnostic imaging applied to the breast has been impressive in recent years and the most used diagnostic test in the world is mammography, a low-dose X-ray technique used for imaging the breast. In the first half of the 20th century, the diagnosis was in practice only clinical, with consequent diagnostic delay and an unfavorable prognosis in the short term. The rise of organized mammography screening has led to a remarkable reduction in mortality through the early detection of breast malignancies. This historical review aims to offer a complete panorama of the development of mammography and breast imaging during the last century. Through this study, we want to understand the foundations of the pillar of radiology applied to the breast through to the most modern applications such as contrast-enhanced mammography (CEM), artificial intelligence, and radiomics. Understanding the history of the development of diagnostic imaging applied to the breast can help us understand how to better direct our efforts toward an increasingly personalized and effective diagnostic approach. The ultimate goal of imaging applied to the detection of breast malignancies should be to reduce mortality from this type of disease as much as possible. With this paper, we want to provide detailed documentation of the main steps in the evolution of breast imaging for the diagnosis of breast neoplasms; we also want to open up new scenarios where the possible current and future applications of imaging are aimed at being more precise and personalized.
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11111596
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Article: Contrast-Enhanced Spectral Mammography in the Evaluation of Breast Microcalcifications: Controversies and Diagnostic Management.

Nicosia, Luca / Bozzini, Anna Carla / Signorelli, Giulia / Palma, Simone / Pesapane, Filippo / Frassoni, Samuele / Bagnardi, Vincenzo / Pizzamiglio, Maria / Farina, Mariagiorgia / Trentin, Chiara / Penco, Silvia / Meneghetti, Lorenza / Sangalli, Claudia / Cassano, Enrico

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 4

Abstract: The aim of this study was to evaluate the diagnostic performance of contrast-enhanced spectral mammography (CESM) in predicting breast lesion malignancy due to microcalcifications compared to lesions that present with other radiological findings. Three ... ...

Abstract	The aim of this study was to evaluate the diagnostic performance of contrast-enhanced spectral mammography (CESM) in predicting breast lesion malignancy due to microcalcifications compared to lesions that present with other radiological findings. Three hundred and twenty-one patients with 377 breast lesions that underwent CESM and histological assessment were included. All the lesions were scored using a 4-point qualitative scale according to the degree of contrast enhancement at the CESM examination. The histological results were considered the gold standard. In the first analysis, enhancement degree scores of 2 and 3 were considered predictive of malignity. The sensitivity (SE) and positive predictive value (PPV) were significative lower for patients with lesions with microcalcifications without other radiological findings (SE = 53.3% vs. 82.2%,
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11040511
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Article ; Online: Future Directions in the Assessment of Axillary Lymph Nodes in Patients with Breast Cancer.

Pesapane, Filippo / Mariano, Luciano / Magnoni, Francesca / Rotili, Anna / Pupo, Davide / Nicosia, Luca / Bozzini, Anna Carla / Penco, Silvia / Latronico, Antuono / Pizzamiglio, Maria / Corso, Giovanni / Cassano, Enrico

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 9

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Lymphatic Metastasis/pathology ; Artificial Intelligence ; Lymph Nodes/pathology ; Sentinel Lymph Node Biopsy/methods ; Lymph Node Excision ; Axilla
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59091544
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Article ; Online: Breast Imaging Reporting and Data System and Contrast Enhancement Mammography: Lesion Conspicuity Likelihood of Malignancy and Relationship With Breast Tumor Receptor Status.

Nicosia, Luca / Bozzini, Anna Carla / Palma, Simone / Pesapane, Filippo / Meneghetti, Lorenza / Pizzamiglio, Maria / Abbate, Francesca / Latronico, Antuono / Bagnardi, Vincenzo / Frassoni, Samuele / Sangalli, Claudia / Cassano, Enrico

Academic radiology

2023 Volume 30, Issue 10, Page(s) 2243–2251

Abstract: Rationale and objectives: The new version of the Contrast Enhanced Mammography (CEM) Breast imaging Reporting and Data System (BIRADs) encourages investigations of a new enhancement descriptor: "Lesion Conspicuity" (LC). The study aims to assess the ... ...

Abstract	Rationale and objectives: The new version of the Contrast Enhanced Mammography (CEM) Breast imaging Reporting and Data System (BIRADs) encourages investigations of a new enhancement descriptor: "Lesion Conspicuity" (LC). The study aims to assess the diagnostic performance and the relationship with the receptor profile of this new enhancement descriptor. Materials and methods: Three hundred twenty-five patients with 381 breast lesions who underwent CEM before histological assessmentwere selected. Four radiologists, blinded to each other, categorized LC into the following levels: absent, low, moderate, and high. Considering moderate and high evaluations as predictive of malignancy, the diagnostic performance of CEM was calculated using histological results of the biopsy as the gold standard. The association between LC values and the receptor profile of the neoplasms was also evaluated. Results: The median age at the CEM examination was 50 years (IQR: 45-59). Considering the value of LC of the most experienced radiologist with the interpretation of Low Energy images (LE), we obtained a sensitivity (SE) of 91.9% (95% CI: 88.6%-95.2%) and a specificity (SP) of 67.2% (95% CI: 58.9%-75.5%). An association between "high" lesion conspicuity with ER/PgR not expressed (p = 0.025), with Ki-67>20% (p = 0.033), and with Grading G3 (p = 0.020) was observed. Conclusion: The new feature of enhancement, "Lesion Conspicuity", demonstrated satisfactory performance in predicting the malignancy of lesions and significant correlation with the receptor profile of malignant breast neoplasms.
MeSH term(s)	Humans ; Middle Aged ; Female ; Contrast Media ; Mammography/methods ; Breast Neoplasms/pathology ; Biopsy ; Radiologists
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2023.02.008
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Article ; Online: Inter-reader agreement of breast magnetic resonance imaging and contrast-enhanced mammography in breast cancer diagnosis: a multi-reader retrospective study.

Pesapane, Filippo / Nicosia, Luca / Tantrige, Priyan / Schiaffino, Simone / Liguori, Alessandro / Montesano, Marta / Bozzini, Anna / Rotili, Anna / Cellina, Michaela / Orsi, Marcello / Penco, Silvia / Pizzamiglio, Maria / Carrafiello, Gianpaolo / Cassano, Enrico

Breast cancer research and treatment

2023 Volume 202, Issue 3, Page(s) 451–459

Abstract: Objective: Breast magnetic resonance imaging (MRI) and contrast-enhanced mammography (CEM) are nowadays used in breast imaging but studies about their inter-reader agreement are lacking. Therefore, we compared the inter-reader agreement of CEM and MRI ... ...

Abstract	Objective: Breast magnetic resonance imaging (MRI) and contrast-enhanced mammography (CEM) are nowadays used in breast imaging but studies about their inter-reader agreement are lacking. Therefore, we compared the inter-reader agreement of CEM and MRI in breast cancer diagnosis in the same patients. Methods: Breast MRI and CEM exams performed in a single center (09/2020-09/2021) for an IRB-approved study were retrospectively and independently evaluated by four radiologists of two different centers with different levels of experience who were blinded to the clinical and other imaging data. The reference standard was the histological diagnosis or at least 1-year negative imaging follow-up. Inter-reader agreement was examined using Cohen's and Fleiss' kappa (κ) statistics and compared with the Wald test. Results: Of the 750 patients, 395 met inclusion criteria (44.5 ± 14 years old), with 752 breasts available for CEM and MRI. Overall agreement was moderate (κ = 0.60) for MRI and substantial (κ = 0.74) for CEM. For expert readers, the agreement was substantial (κ = 0.77) for MRI and almost perfect (κ = 0.82) for CEM; for non-expert readers was fair (κ = 0.39); and for MRI and moderate (κ = 0.57) for CEM. Pairwise agreement between expert readers and non-expert readers was moderate (κ = 0.50) for breast MRI and substantial (κ = 0.74) for CEM and it showed a statistically superior agreement of the expert over the non-expert readers only for MRI (p = 0.011) and not for CEM (p = 0.062). Conclusions: The agreement of CEM was superior to that of MRI (p = 0.012), including for both expert (p = 0.031) and non-expert readers (p = 0.005).
Language	English
Publishing date	2023-09-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-023-07093-w
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Article: Inter-Reader Agreement of Diffusion-Weighted Magnetic Resonance Imaging for Breast Cancer Detection: A Multi-Reader Retrospective Study.

Pesapane, Filippo / Rotili, Anna / Penco, Silvia / Montesano, Marta / Agazzi, Giorgio Maria / Dominelli, Valeria / Trentin, Chiara / Pizzamiglio, Maria / Cassano, Enrico

Cancers

2021 Volume 13, Issue 8

Abstract: Purpose: In order to evaluate the use of un-enhanced magnetic resonance imaging (MRI) for detecting breast cancer, we evaluated the accuracy and the agreement of diffusion-weighted imaging (DWI) through the inter-reader reproducibility between expert ... ...

Abstract	Purpose: In order to evaluate the use of un-enhanced magnetic resonance imaging (MRI) for detecting breast cancer, we evaluated the accuracy and the agreement of diffusion-weighted imaging (DWI) through the inter-reader reproducibility between expert and non-expert readers. Material and methods: Consecutive breast MRI performed in a single centre were retrospectively evaluated by four radiologists with different levels of experience. The per-breast standard of reference was the histological diagnosis from needle biopsy or surgical excision, or at least one-year negative follow-up on imaging. The agreement across readers (by inter-reader reproducibility) was examined for each breast examined using Cohen's and Fleiss' kappa (κ) statistics. The Wald test was used to test the difference in inter-reader agreement between expert and non-expert readers. Results: Of 1131 examinations, according to our inclusion and exclusion criteria, 382 women were included (49.5 ± 12 years old), 40 of them with unilateral mastectomy, totaling 724 breasts. Overall inter-reader reproducibility was substantial (κ = 0.74) for expert readers and poor (κ = 0.37) for non- expert readers. Pairwise agreement between expert readers and non-expert readers was moderate (κ = 0.60) and showed a statistically superior agreement of the expert readers over the non-expert readers ( Conclusions: DWI showed substantial inter-reader reproducibility among expert-level readers. Pairwise comparison showed superior agreement of the expert readers over the non-expert readers, with the expert readers having higher inter-reader reproducibility than the non-expert readers. These findings open new perspectives for prospective studies investigating the actual role of DWI as a stand-alone method for un-enhanced breast MRI.
Language	English
Publishing date	2021-04-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13081978
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