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  1. Article ; Online: Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval.

    Šimka, Jakub / Pudil, Radek / Fialová, Monika / Varhaník, Filip / Plíšek, Stanislav / Pařízek, Petr

    Acta medica (Hradec Kralove)

    2024  Volume 66, Issue 3, Page(s) 101–106

    Abstract: Aims: Antiviral drugs are considered as potentially cardiotoxic, due to prolongation of QT interval which may affect incidence of severe ventricular arrhythmias. The main aim of this retrospective study was to assess the influence of treatment by three ... ...

    Abstract Aims: Antiviral drugs are considered as potentially cardiotoxic, due to prolongation of QT interval which may affect incidence of severe ventricular arrhythmias. The main aim of this retrospective study was to assess the influence of treatment by three antiviral drugs on QT interval and to find patients who are at an increased risk of developing malignant ventricular arrhythmias.
    Methods: The study included 23 patients (14 men, 9 women) who were treated with a combination of interferon alpha, ribavirin, and an NS3/4A protease inhibitor. The parameters from the 12 leads electrocardiograms were evaluated before treatment, and then 3 ± 1 and 6 ± 1 months after treatment.
    Results: Heart rate (HR) 69 ± 12 / min and corrected QT interval (QTc) 412 ± 35 ms were obtained before the treatment and there was not observed a significant prolongation of intervals after 3 months (HR 72 ± 11 / min, QTc 412 ± 33 ms) and after 6 months (HR 64 ± 12 / min, QTc 405 ± 28 ms) respectively. In total QTc interval was prolonged from the baseline in 53% and in 43% of the patients 3 months respectively 6 months after treatment. A QTc prolongation over of 450 ms and new treatment-related repolarization change was noted in 1 (4%) patient.
    Conclusion: The study demonstrates that a combination therapy of 3 antiviral drugs does not significantly prolong the QTc interval and does not cause severe pathological changes on the ECG. Patients undergoing this treatment are not at risk of developing heart disease as an undesirable side effect.
    MeSH term(s) Male ; Humans ; Female ; Antiviral Agents/adverse effects ; Retrospective Studies ; Hepatitis C, Chronic/drug therapy ; Arrhythmias, Cardiac ; Electrocardiography ; Hepatitis C/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2024-03-21
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1360995-6
    ISSN 1805-9694 ; 1211-4286
    ISSN (online) 1805-9694
    ISSN 1211-4286
    DOI 10.14712/18059694.2024.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Úvodník

    Plíšek, Stanislav

    Klinicka mikrobiologie a infekcni lekarstvi

    2014  Volume 20, Issue 4, Page(s) 111

    Title translation Editorial.
    Language Czech
    Publishing date 2014-12
    Publishing country Czech Republic
    Document type Editorial
    ZDB-ID 2214815-2
    ISSN 1211-264X
    ISSN 1211-264X
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  3. Article ; Online: A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic - case report and review of the literature.

    Prasil, Petr / Ryskova, Lenka / Plisek, Stanislav / Bostik, Pavel

    BMC infectious diseases

    2020  Volume 20, Issue 1, Page(s) 100

    Abstract: Background: Invasive infections caused by Capnocytophaga canimorsus are rare. Immunocompromised patients, who report being bitten by or having a close contact with an animal, represent a high-risk group for this infection. There are only few dozens of ... ...

    Abstract Background: Invasive infections caused by Capnocytophaga canimorsus are rare. Immunocompromised patients, who report being bitten by or having a close contact with an animal, represent a high-risk group for this infection. There are only few dozens of infections by this bacteria manifesting as purulent meningitis reported worldwide. The reported case is a first reported case of purulent meningitis caused by by Capnocytophaga canimorsus in Czech Republic with only a limited risk factor history.
    Case presentation: The patient, a 74 years old man, was referred to the infectious diseases department of a teaching hospital with clear signs of developing purulent meningitis. His anamnestic data did not show any unusual findings. He was treated for compensated diabetes mellitus type II. The blood cultures were negative and the etiological agent did not grow from the cerebrospinal fluid (CSF) on common media. Eventually, it was identified by detecting pan-bacterial DNA and DNA sequencing. Subsequently, the pathogen was confirmed by anaerobic cultivation from CSF. Only after then the patient recalled being bitten by his German shepherd puppy during play. The patient was successfully treated intravenously by ceftriaxone.
    Conclusions: Purulent meningitis caused by Capnocytophaga spp. is a rare disease, but it needs to be considered in patients at risk with pre-existing conditions, who report close contact with or being bitten by an animal. It is important to test for this microbe in cases with negative microbiological results for the more common agents.
    MeSH term(s) Aged ; Animals ; Bites and Stings/complications ; Blood Culture ; Capnocytophaga/genetics ; Capnocytophaga/pathogenicity ; Ceftriaxone/therapeutic use ; Czech Republic ; Dogs ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/etiology ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Immunocompromised Host ; Male ; Meningitis, Bacterial/drug therapy ; Meningitis, Bacterial/etiology ; Meningitis, Bacterial/microbiology
    Chemical Substances Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-020-4760-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Long-Term Antibody Response and Vaccination Efficacy in Patients with COVID-19: A Single Center One-Year Prospective Study from the Czech Republic

    Fajfr, Miroslav / Sleha, Radek / Janovska, Sylva / Koblizek, Vladimir / Skala, Mikulas / Plisek, Stanislav / Prasil, Petr / Smahel, Petr / Bostik, Pavel

    Viruses. 2022 Mar. 04, v. 14, no. 3

    2022  

    Abstract: Background: The diagnosis of SARS-CoV-2 is almost exclusively performed by PCR or antigen detection. The detection of specific antibodies has not yet been considered in official diagnostic guidelines as major laboratory evidence for a case definition. ... ...

    Abstract Background: The diagnosis of SARS-CoV-2 is almost exclusively performed by PCR or antigen detection. The detection of specific antibodies has not yet been considered in official diagnostic guidelines as major laboratory evidence for a case definition. The aim the present study is to analyze antibody responses in outpatient and inpatient cohorts of COVID-19 patients in the Czech Republic over a 12-month period, and assess the potential of antibodies as a diagnostic tool. Methods: A total of 644 patients was enrolled in the prospective study. IgA, IgM and IgG antibody levels, as well as virus neutralization titers, were analyzed over a 12-month period. Results: Our study showed low antibody positivity levels at the admission. However, at 2 weeks after infection, 98.75% and 95.00% of hospitalized patients were IgA and IgG positive, respectively. Even in the outpatient cohort characterized by milder disease courses, the IgG antibody response was still sustained at 9 and 12 months. The data show a high correlation between the IgG levels and virus neutralization titers (VNTs). Samples from later time-points showed positive antibody responses after vaccination in both cohorts characterized by high IgG levels and VNT over 1:640. The samples from unvaccinated persons indicated a relatively high level of reinfection at 6.87%. Conclusions: Our results show that the detection of antibodies against the SARS-CoV-2 shows an increasing sensitivity from week 2 after infection and remains highly positive over the 12-month period. The levels of IgG antibodies correlate significantly with the VNTs. This suggests that the serological data may be a valuable tool in the diagnosis of SARS-CoV-2 infection.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; antibody formation ; antigen detection ; diagnostic techniques ; neutralization tests ; prospective studies ; vaccination ; Czech Republic
    Language English
    Dates of publication 2022-0304
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030526
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: [Caring for women planning pregnancy or who are already pregnant: an infectious disease doctor's view].

    Pellantová, Věra / Kosina, Pavel / Rumlarová, Šárka / Kračmarová, Renata / Plíšek, Stanislav

    Klinicka mikrobiologie a infekcni lekarstvi

    2020  Volume 25, Issue 4, Page(s) 125–131

    Abstract: The article discusses possible prevention and prophylaxis of infectious diseases affecting the course of pregnancy with respect to the mother, fetus and newborn. Also mentioned are diseases for which there is no vaccination. The options for prevention ... ...

    Abstract The article discusses possible prevention and prophylaxis of infectious diseases affecting the course of pregnancy with respect to the mother, fetus and newborn. Also mentioned are diseases for which there is no vaccination. The options for prevention targeted at the periods before and during pregnancy and after delivery are explained. Finally, practical procedures related to vaccination and diagnosis of infectious diseases in women of childbearing age are presented.
    MeSH term(s) Communicable Diseases/diagnosis ; Female ; Humans ; Infant, Newborn ; Infectious Disease Medicine/methods ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/prevention & control ; Vaccination
    Language Czech
    Publishing date 2020-04-28
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 2214815-2
    ISSN 1211-264X
    ISSN 1211-264X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Long-Term Antibody Response and Vaccination Efficacy in Patients with COVID-19: A Single Center One-Year Prospective Study from the Czech Republic.

    Fajfr, Miroslav / Sleha, Radek / Janovska, Sylva / Koblizek, Vladimir / Skala, Mikulas / Plisek, Stanislav / Prasil, Petr / Smahel, Petr / Bostik, Pavel

    Viruses

    2022  Volume 14, Issue 3

    Abstract: Background: The diagnosis of SARS-CoV-2 is almost exclusively performed by PCR or antigen detection. The detection of specific antibodies has not yet been considered in official diagnostic guidelines as major laboratory evidence for a case definition. ... ...

    Abstract Background: The diagnosis of SARS-CoV-2 is almost exclusively performed by PCR or antigen detection. The detection of specific antibodies has not yet been considered in official diagnostic guidelines as major laboratory evidence for a case definition. The aim the present study is to analyze antibody responses in outpatient and inpatient cohorts of COVID-19 patients in the Czech Republic over a 12-month period, and assess the potential of antibodies as a diagnostic tool.
    Methods: A total of 644 patients was enrolled in the prospective study. IgA, IgM and IgG antibody levels, as well as virus neutralization titers, were analyzed over a 12-month period.
    Results: Our study showed low antibody positivity levels at the admission. However, at 2 weeks after infection, 98.75% and 95.00% of hospitalized patients were IgA and IgG positive, respectively. Even in the outpatient cohort characterized by milder disease courses, the IgG antibody response was still sustained at 9 and 12 months. The data show a high correlation between the IgG levels and virus neutralization titers (VNTs). Samples from later time-points showed positive antibody responses after vaccination in both cohorts characterized by high IgG levels and VNT over 1:640. The samples from unvaccinated persons indicated a relatively high level of reinfection at 6.87%.
    Conclusions: Our results show that the detection of antibodies against the SARS-CoV-2 shows an increasing sensitivity from week 2 after infection and remains highly positive over the 12-month period. The levels of IgG antibodies correlate significantly with the VNTs. This suggests that the serological data may be a valuable tool in the diagnosis of SARS-CoV-2 infection.
    MeSH term(s) Antibodies, Viral ; Antibody Formation ; COVID-19/diagnosis ; COVID-19/epidemiology ; Czech Republic/epidemiology ; Humans ; Prospective Studies ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4

    Holub, Michal / Stráníková, Alžběta / Beran, Ondřej / Arientová, Simona / Bartoš, Oldřich / Kondelková, Kateřina / Plíšek, Stanislav / Chalupa, Pavel

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2021  Volume 2021, Page(s) 6689834

    Abstract: Background: Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response.: Objective: The aim of the study was to characterize functional alterations in CD4: Result: The patients with CHC had significantly lower percentages ... ...

    Abstract Background: Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response.
    Objective: The aim of the study was to characterize functional alterations in CD4
    Result: The patients with CHC had significantly lower percentages of CD4
    Conclusion: Chronic HCV infection is associated with downregulation of TFs Gata3 and Ror
    Language English
    Publishing date 2021-03-12
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2021/6689834
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  8. Article: [Standard diagnostic and therapeutic approach to chronic hepatitis C virus (HCV) infection 22 - guidelines].

    Urbánek, Petr / Husa, Petr / Plíšek, Stanislav / RoŽnovský, Luděk

    Klinicka mikrobiologie a infekcni lekarstvi

    2017  Volume 23, Issue 1, Page(s) 22–40

    Language Czech
    Publishing date 2017-03
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 2214815-2
    ISSN 1211-264X
    ISSN 1211-264X
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  9. Article: Oční forma toxoplazmózy - hledání strategie léčby.

    Prášil, Petr / Plíšek, Stanislav / Boštík, Pavel

    Klinicka mikrobiologie a infekcni lekarstvi

    2014  Volume 20, Issue 4, Page(s) 112–115

    Abstract: Aim: To compare the effectiveness of treatment for ocular toxoplasmosis with pyrimethamine + clindamycin (or sulfadiazine) + a corticoid (Group 1), or azithromycin or a combination of azithromycin with a corticoid or a corticoid alone (Group 2). To ... ...

    Title translation Ocular toxoplasmosis - seeking a strategy for treatment.
    Abstract Aim: To compare the effectiveness of treatment for ocular toxoplasmosis with pyrimethamine + clindamycin (or sulfadiazine) + a corticoid (Group 1), or azithromycin or a combination of azithromycin with a corticoid or a corticoid alone (Group 2). To determine the relapse rate depending on the treatment approach.
    Material and methods: A total of 25 patients treated for ocular toxoplasmosis over the last five years (2008-2013) were analyzed. Group 1 comprised 16 patients (3 were excluded) and Group 2 consisted of 6 patients.
    Results: Visual improvement was more rapid in Group 1 (day 10.7) than in Group 2 (significant improvement on day 29.6). There were 5 cases of relapse in Group 1; in 13 cases, no relapse was noted; all patients in Group 2 relapsed (a total of 13 relapses). Twenty-three patients were positive for specific IgG antibodies.
    Conclusion: According to our experiences, pyrimethamine + clindamycin (or sulfadiazine) + a corticoid should be the treatment of choice in patients with ocular toxoplasmosis.
    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Male ; Recurrence ; Retrospective Studies ; Toxoplasmosis, Ocular/drug therapy
    Chemical Substances Adrenal Cortex Hormones ; Anti-Bacterial Agents
    Language Czech
    Publishing date 2014-12
    Publishing country Czech Republic
    Document type English Abstract ; Journal Article
    ZDB-ID 2214815-2
    ISSN 1211-264X
    ISSN 1211-264X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Vyšetření přilrozene variant Q80K v genu pro proteázu NS3 HCV.

    Kutová, Radka / Plíšková, Lenka / Štěpánová, Vlasta / Plíšek, Stanislav / Machač, Jan

    Klinicka mikrobiologie a infekcni lekarstvi

    2015  Volume 21, Issue 4, Page(s) 126–129

    Abstract: Objectives: The aim was to introduce a diagnostic method for detecting variants of hepatitis C virus (HCV) with protease NS3 resistance primarily to simeprevir (Q80K mutation in HCV genotype 1a) and its subsequent use in routine practice.: Material ... ...

    Title translation Determination of the naturally occurring Q80K mutation in the HCV NS3 protease gene.
    Abstract Objectives: The aim was to introduce a diagnostic method for detecting variants of hepatitis C virus (HCV) with protease NS3 resistance primarily to simeprevir (Q80K mutation in HCV genotype 1a) and its subsequent use in routine practice.
    Material and methods: The detection of HCV resistance-associated variants in the NS3 protease gene by sequence analysis was introduced in the molecular biology laboratory of University Hospital Hradec Kralove in 2015. The primers were designed by sequence analysis software Custom Primers - OligoPerfect™ Designer. The method was optimized for HCV genotype 1a. The search for variants was performed using two programs.
    Results: A total of 16 patients with genotype 1a chronic hepatitis C have been examined since 2015. In five of them, the Q80K variant was detected.
    Conclusion: The development of resistance to antiviral therapy for chronic hepatitis C gained importance after the introduction of direct-acting antivirals. Given the relatively high prevalence of the Q80K mutation in HCV genotype 1a, it is crucial to confirm its presence or absence before the therapy is initiated. The reported method enables clear and early detection of the Q80K mutation.
    MeSH term(s) Drug Resistance, Viral/genetics ; Hepacivirus/genetics ; Hepatitis C/diagnosis ; Hepatitis C/virology ; Humans ; Mutation/genetics ; Viral Nonstructural Proteins/genetics ; Virology/methods
    Chemical Substances NS3 protein, hepatitis C virus ; Viral Nonstructural Proteins
    Language Czech
    Publishing date 2015-12
    Publishing country Czech Republic
    Document type English Abstract ; Journal Article
    ZDB-ID 2214815-2
    ISSN 1211-264X
    ISSN 1211-264X
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