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Article ; Online: BDNF CpG methylation and serum levels covary during alcohol withdrawal in patients with alcohol use disorder: A pilot study.

Lacroix, Aurélie / Ramoz, Nicolas / Girard, Murielle / Plansont, Brigitte / Poupon, Daphnée / Gorwood, Philip / Nubukpo, Philippe

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

2023 Volume 24, Issue 9, Page(s) 854–859

Abstract: Objectives: Brain-derived neurotrophic factor (BDNF) levels vary in various conditions including alcohol use disorder (AUD). We aimed to identify drivers of these variations.: Methods: Twelve patients with AUD were assessed at hospitalisation for ... ...

Abstract	Objectives: Brain-derived neurotrophic factor (BDNF) levels vary in various conditions including alcohol use disorder (AUD). We aimed to identify drivers of these variations. Methods: Twelve patients with AUD were assessed at hospitalisation for alcohol withdrawal and four months later. We looked for associations between the change in serum BDNF levels and (1) length of abstinence, (2) anxiety (Hamilton Anxiety Scale) and depression (Beck-Depression Inventory), (3) one functional BDNF genotype (rs6265) and (4) methylation levels of 12 CpG sites within the BDNF gene (located in exons I, IV and IX). Results: While abstinence remained, serum BDNF level increased. This increase correlated with the variation of methylation levels of the Conclusions: Epigenetic regulation of the
MeSH term(s)	Humans ; Alcoholism/genetics ; Substance Withdrawal Syndrome/genetics ; Brain-Derived Neurotrophic Factor/genetics ; Pilot Projects ; Epigenesis, Genetic ; DNA Methylation
Chemical Substances	Brain-Derived Neurotrophic Factor
Language	English
Publishing date	2023-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2051402-5
ISSN	1814-1412 ; 1562-2975
ISSN (online)	1814-1412
ISSN	1562-2975
DOI	10.1080/15622975.2023.2242924
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Article ; Online: Painful Life Events in Psychiatric Disorders: A Quantitative and Qualitative Analysis.

Paquet, Aude / Plansont, Brigitte / Girard, Murielle

Issues in mental health nursing

2019 Volume 40, Issue 9, Page(s) 781–789

Abstract: We reported in a previous study the painful events experienced in the past in subjects with schizophrenia or major depression, in comparison to controls, and related them to the experimental pain sensitivity, anxiety, and the diagnosis. We present here ... ...

Abstract	We reported in a previous study the painful events experienced in the past in subjects with schizophrenia or major depression, in comparison to controls, and related them to the experimental pain sensitivity, anxiety, and the diagnosis. We present here the detailed analysis of these past painful events, with the aim of determining whether schizophrenic, depressive and control groups are qualitatively (type of painful events experienced, emotional or sensory components associated with pain) and quantitatively (duration, severity, and intensity) comparable concerning their past painful experiences. The questionnaire used relies on memory and feelings and will provide an indication about the way pain is experienced and memorized in daily life. The reported history of pain was not the same in the three groups. Depressed subjects differed from the others by the number of reported painful events. Painful events of everyday life, such as trauma without fracture and wounds, were the most highly reported painful events for all groups. Surprisingly, the daily pain events are associated to affective component of pain perception. Other kinds of event were differently reported between the groups. Experience of pain appears to be memorized and reported differently depending on the psychiatric disorder and type of event. The characteristics of each individual, their previous experience, contribute to the expression of psychiatric disorders, including in the field of pain. Past pain experience should be taken into account when attending someone for pain.
MeSH term(s)	Depressive Disorder, Major/nursing ; Depressive Disorder, Major/psychology ; Evaluation Studies as Topic ; Humans ; Individuality ; Life Change Events ; Mental Recall ; Pain Measurement/nursing ; Pain Measurement/psychology ; Pain Perception ; Qualitative Research ; Schizophrenia/nursing ; Schizophrenic Psychology ; Surveys and Questionnaires
Language	English
Publishing date	2019-05-28
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	603180-8
ISSN	1096-4673 ; 0161-2840
ISSN (online)	1096-4673
ISSN	0161-2840
DOI	10.1080/01612840.2019.1591546
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Article ; Online: Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders.

Lacroix, Aurélie / Paquet, Aude / Okassa, Mireille / Vinais, Théodore / Lannaud, Marilyne / Plansont, Brigitte / Buisson, Alexandre / Guignandon, Sandrine / Malauzat, Dominique / Girard, Murielle / Calvet, Benjamin

International journal of environmental research and public health

2023 Volume 20, Issue 7

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Transcranial Magnetic Stimulation/methods ; Bipolar Disorder/therapy ; Anxiety Disorders ; Treatment Outcome ; Prefrontal Cortex
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20075276
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Article ; Online: Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression.

Lacroix, Aurélie / Calvet, Benjamin / Laplace, Benjamin / Lannaud, Marilyne / Plansont, Brigitte / Guignandon, Sandrine / Balestrat, Patrice / Girard, Murielle

Translational psychiatry

2021 Volume 11, Issue 1, Page(s) 587

Abstract: Repeated transcranial magnetic stimulation (rTMS) is a therapeutic brain-stimulation technique that is particularly used for drug-resistant depressive disorders. European recommendations mention the effectiveness of 30 to 64%. The failure rate of ... ...

Abstract	Repeated transcranial magnetic stimulation (rTMS) is a therapeutic brain-stimulation technique that is particularly used for drug-resistant depressive disorders. European recommendations mention the effectiveness of 30 to 64%. The failure rate of treatment is high and clinical improvement is visible only after a certain period of time. It would thus be useful to have indicators that could anticipate the success of treatment and more effectively guide therapeutic choices. We aimed to find predictive indicators of clinical improvement at 1 month after the start of rTMS treatment among the data collected during the care of patients with drug-resistant depression included in the Neuromodulation Unit of the Esquirol Hospital in Limoges since 2007. In total, 290 patients with a pharmaco-resistant depressive episode, according to the Hamilton Depression Rating Scale (HDRS) (score ≥8), before treatment who underwent a complete course of rTMS treatment and did not object to the use of their collected data were included. The clinical response in routine practice, corresponding to a decrease in the HDRS score of at least 50% from inclusion, was determined and complemented by interquartile analysis. A combination of factors predictive of clinical response during care, such as a short duration of the current depressive episode associated with a higher HDRS agitation item value (or a lower perceived sleepiness value) and a higher number of previous rTMS treatments, were identified as being useful in predicting the efficacy of rTMS treatment in routine clinical practice, thus facilitating the therapeutic choice for patients with drug-resistant depression.
MeSH term(s)	Depression ; Depressive Disorder, Major/therapy ; Humans ; Pharmaceutical Preparations ; Prefrontal Cortex ; Transcranial Magnetic Stimulation ; Treatment Outcome
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-021-01555-9
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Article ; Online: Past Pain Experience and Experimentally induced Pain Perception.

Paquet, Aude / Plansont, Brigitte / Labrunie, Anaïs / Malauzat, Dominique / Girard, Murielle

Issues in mental health nursing

2017 Volume 38, Issue 12, Page(s) 1013–1021

Abstract: Many intercurrent factors may be involved in the modulation of the pain message and its expression, such as the previous experience of pain built along the life. In this study, we aimed to determine whether susceptibility to experimentally induced pain ... ...

Abstract	Many intercurrent factors may be involved in the modulation of the pain message and its expression, such as the previous experience of pain built along the life. In this study, we aimed to determine whether susceptibility to experimentally induced pain is differentially influenced by the individual previous painful experience in subjects with schizophrenia (SC) major depression (MD), and controls (C). Methods: The SC (30), MD (32) and C (30) groups participated in experimental pain tests (application of pressure and induction of ischemia) after a semi-structured interview to make an inventory of the previous painful experiences, and the evaluation of anxiety either with autonomic (heart rate, blood pressure) or psychological (Hospital Anxiety Depression scale HAD) measures, and catastrophism. Results: The reported pain intensities, severities, duration, of the previous pain events, and the number of previous painful events were equivalent in the three groups, except for the number of painful events experimented before the last six months which was lower in the MD group. Experimental pain sensitivity was influenced by the diagnosis, the HAD scores or the number and intensities of previous lived painful events. Conclusion: The lack of a past experience of pain was comparable for the different groups, suggesting that psychiatric disorders do not affect the experience of pain associated with daily life or past events. For each subject, the reported previous experience of pain influences the present feeling of pain.
MeSH term(s)	Adult ; Case-Control Studies ; Depressive Disorder, Major/psychology ; Female ; Humans ; Male ; Middle Aged ; Pain/psychology ; Pain Perception/physiology ; Prospective Studies ; Schizophrenia/complications ; Schizophrenic Psychology
Language	English
Publishing date	2017-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	603180-8
ISSN	1096-4673 ; 0161-2840
ISSN (online)	1096-4673
ISSN	0161-2840
DOI	10.1080/01612840.2017.1354103
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Article ; Online: BDNF and pro-BDNF in serum and exosomes in major depression: Evolution after antidepressant treatment.

Gelle, Thibaut / Samey, Rayhanatou Altine / Plansont, Brigitte / Bessette, Barbara / Jauberteau-Marchan, Marie-Odile / Lalloué, Fabrice / Girard, Murielle

Progress in neuro-psychopharmacology & biological psychiatry

2020 Volume 109, Page(s) 110229

Abstract: Background: The study of clinically related biological indicators in Major Depression (MD) is important. The Brain Derived Neurotrophic Factor (BDNF) appears to play an important role in MD, through its neurotrophic effect, and its levels are ... ...

Abstract	Background: The study of clinically related biological indicators in Major Depression (MD) is important. The Brain Derived Neurotrophic Factor (BDNF) appears to play an important role in MD, through its neurotrophic effect, and its levels are significantly decreased. The variation in the serum levels of its precursor proBDNF, which has opposite effects, is not known. Their distribution between serum and exosomes and their evolution during antidepressant treatment is also not known, and may be important in modulating their effects. The aim of this study is to evaluate whether serum and exosome mBDNF and proBDNF levels are altered in patients with MD during antidepressant treatment compared to controls, and their association with clinical improvement and clinical variables. Materials and methods: 42 MD subjects and 40 controls were included. Questionnaires to assess the severity of depression and cognitive impairment and blood samples were collected during the three visits at D0 (inclusion) and 3 and 7 weeks after the start of antidepressant treatment. Assays for mBDNF and proBDNF levels were performed in serum and exosomes by ELISA. Results: MD subjects had decreased serum and exosomal BDNF levels and increased proBDNF levels at D0 compared to controls. BDNF and pro-BDNF vary in an inverse manner in both serum and exosomes during antidepressant treatment. No relationship of BDNF and proBDNF levels to clinical improvement and depression scales was found. Conclusion: We demonstrated an evolution of those molecules either in serum or in exosomes after MD treatment. These transport vesicles could have a role in the regulation of BDNF.
MeSH term(s)	Adult ; Antidepressive Agents/therapeutic use ; Brain-Derived Neurotrophic Factor/blood ; Brain-Derived Neurotrophic Factor/metabolism ; Depressive Disorder, Major/blood ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Major/therapy ; Exosomes/metabolism ; Female ; Humans ; Male ; Middle Aged ; Protein Precursors/blood ; Protein Precursors/metabolism ; Transcranial Magnetic Stimulation ; Treatment Outcome
Chemical Substances	Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Protein Precursors ; brain-derived neurotrophic factor precursor
Language	English
Publishing date	2020-12-31
Publishing country	England
Document type	Journal Article
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2020.110229
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Article ; Online: Experimental pain hypersensitivity in schizophrenic patients.

Girard, Murielle / Plansont, Brigitte / Bonnabau, Henri / Malauzat, Dominique

The Clinical journal of pain

2011 Volume 27, Issue 9, Page(s) 790–795

Abstract: Objective: Whether schizophrenic patients are hypoalgesic or feel pain in the same manner as unaffected individuals can affect the primary care of schizophrenic patients, which often involves an assessment of pain severity made by a medical provider. ... ...

Abstract	Objective: Whether schizophrenic patients are hypoalgesic or feel pain in the same manner as unaffected individuals can affect the primary care of schizophrenic patients, which often involves an assessment of pain severity made by a medical provider. This study was developed to explore the pain sensitivity of schizophrenics under conditions similar to those of a medical examination that included investigating for sites of pain. Methods: We developed 2 experimental models of pain induction using either pressure or ischemia and used them with 35 schizophrenic patients and 35 controls to record: (1) the stimulus intensity required to induce moderate pain; and (2) the pain intensity induced by a predetermined level of pressure. Clinical data were also collected for the schizophrenic group. Results: Schizophrenic patients needed less pressure (P=0.006) and a shorter duration of ischemia (P<0.001) than controls to record moderate pain, and they felt more pain from a fixed pressure stimulus (P<0.001). Pain histories for the previous 6 months and the heart rate variations that occurred during the tests did not differ between the groups. Pain responses were unrelated to the clinical characteristics of the schizophrenic patients, although hallucination production correlated with the pain felt during the fixed pressure test. Discussion: Under these conditions, schizophrenic patients were hypersensitive to pain induction compared with normal individuals. The hypoalgesia typically associated with schizophrenic patients may correspond to fewer than normal reports of pain, rather than to impaired sensations of pain. This should be taken into account during routine medical practice.
MeSH term(s)	Adult ; Chi-Square Distribution ; Female ; Humans ; Hyperalgesia/physiopathology ; Ischemia/complications ; Male ; Middle Aged ; Pain Measurement ; Pain Threshold/physiology ; Pressure/adverse effects ; Psychophysics ; Schizophrenia/diagnosis ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Sensitivity and Specificity
Language	English
Publishing date	2011-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	632582-8
ISSN	1536-5409 ; 0749-8047
ISSN (online)	1536-5409
ISSN	0749-8047
DOI	10.1097/AJP.0b013e31821d904c
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Article: A serum analysis before and after antidepressant treatment in major depression: A pilot study

Girard, Murielle / Vuillier-Devilers, Karine / Pinault, Emilie / Bessette, Barbara / Malauzat, Dominique / Plansont, Brigitte

Clinical Medicine Insights: Psychiatry (6), 1-12. (2015)

Abstract: We investigated the serum protein profiles of subjects with major depressive disorder (MDD), with (n = 4) and without clinicalimprovement (n = 4), at the initiation of antidepressant treatment (venlafaxine) (T0) and 4 weeks later (T28), by difference gel ...

Abstract	We investigated the serum protein profiles of subjects with major depressive disorder (MDD), with (n = 4) and without clinicalimprovement (n = 4), at the initiation of antidepressant treatment (venlafaxine) (T0) and 4 weeks later (T28), by difference gel electrophoresis intwo dimensions (2D-DIGE) and mass spectrometry. The nine proteins displaying differences in composition between the two time points in thegroup with clinical improvement between T0 and T28 included gelsolin, clusterin, and the activated fragment of complement C3 (C3a). We thenanalyzed serum samples from MDD subjects receiving different antidepressants between T0 and T28. Subjects were classified into two groups,with (n = 17) or without (n = 14) clinical improvement ( 50% decrease in baseline Hamilton Depression Rating Scale score), at T28. Clusterinlevels did not differ between groups at either time point. Gelsolin and C3a levels differed between T0 and T28 only in the group presenting clinicalimprovement. A comparison with serum samples from controls suggested that the levels of these two proteins changed during MDD and werepotentially modified after successful antidepressant treatment. Despite the small sample size, the results of this pilot study suggest that severalchanges in the expression of some serum proteins occur in association with the clinical relevance of the treatment, and indicate changes to generalpathways requiring further study.
Language	English
Document type	Article
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article: A serum analysis before and after antidepressant treatment in major depression: A pilot study

Girard, Murielle / Vuillier-Devilers, Karine / Pinault, Emilie / Bessette, Barbara / Malauzat, Dominique / Plansont, Brigitte

Clinical Medicine Insights: Psychiatry (6), 1-12. (2015)

Abstract	We investigated the serum protein profiles of subjects with major depressive disorder (MDD), with (n = 4) and without clinicalimprovement (n = 4), at the initiation of antidepressant treatment (venlafaxine) (T0) and 4 weeks later (T28), by difference gel electrophoresis intwo dimensions (2D-DIGE) and mass spectrometry. The nine proteins displaying differences in composition between the two time points in thegroup with clinical improvement between T0 and T28 included gelsolin, clusterin, and the activated fragment of complement C3 (C3a). We thenanalyzed serum samples from MDD subjects receiving different antidepressants between T0 and T28. Subjects were classified into two groups,with (n = 17) or without (n = 14) clinical improvement ( 50% decrease in baseline Hamilton Depression Rating Scale score), at T28. Clusterinlevels did not differ between groups at either time point. Gelsolin and C3a levels differed between T0 and T28 only in the group presenting clinicalimprovement. A comparison with serum samples from controls suggested that the levels of these two proteins changed during MDD and werepotentially modified after successful antidepressant treatment. Despite the small sample size, the results of this pilot study suggest that severalchanges in the expression of some serum proteins occur in association with the clinical relevance of the treatment, and indicate changes to generalpathways requiring further study.
Language	English
Document type	Article
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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