LIVIVO - Search results -

Search results

Result 1 - 10 of total 16

Search options

Article: Sclerosing encapsulating peritonitis presenting as acute-on-chronic small-bowel obstruction in a patient with history of peritoneal carcinomatosis.

Hajjar, Roy / Debroux, Éric / Richard, Carole / Plasse, Marylène / Loungnarath, Rasmy

Journal of surgical case reports

2018 Volume 2018, Issue 4, Page(s) rjy082

Abstract: Sclerosing encapsulating peritonitis (SEP) is a whitish fibrous envelope that encapsulates intra-abdominal peritonealized organs. Although it pathophysiology is not well understood, several possible causes have been reported in the literature, including ... ...

Abstract	Sclerosing encapsulating peritonitis (SEP) is a whitish fibrous envelope that encapsulates intra-abdominal peritonealized organs. Although it pathophysiology is not well understood, several possible causes have been reported in the literature, including peritoneal dialysis, past abdominal surgeries, peritonitis, beta-blockers and peritoneal carcinomatosis (PC). Some idiopathic cases, with no apparent causes, were described. We present a SEP case in a 43-year-old woman with a surgical history of pancreatic and liver resection for metastatic pseudopapillary pancreatic tumor, followed by several peritonectomies for PC. She was admitted for acute-on-chronic small-bowel obstruction that did not resolve with conservative management. Surgical exploration revealed a fibrous sheath covering the small-bowel. Extensive dissection, along with small-bowel segmental resection and anastomosis, was performed. The specimen was cancer-free. The mechanism through which SEP develops in certain surgical patients is still unknown. This report presents a case of successful surgical management and a review of the literature.
Language	English
Publishing date	2018-04-24
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjy082
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Homogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy.

Henault, David / Stephen, David / St-Hilaire, Pierre-Antoine / Messaoudi, Nouredin / Vandenbroucke-Menu, Franck / Simoneau, Eve / Rong, Zhixia / Plasse, Marylène / Létourneau, Richard / Roy, André / Dagenais, Michel / Lapointe, Réal / Nguyen, Bich / Mes-Masson, Anne-Marie / Soucy, G / Turcotte, Simon

Oncoimmunology

2023 Volume 12, Issue 1, Page(s) 2253642

Abstract: In colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex (MHC-I), and the pathological response to preoperative chemotherapy have been associated with ... ...

Abstract	In colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex (MHC-I), and the pathological response to preoperative chemotherapy have been associated with oncological outcomes after complete resection. However, the prognostic significance of the heterogeneity of these features in patients with multiple CRLMs remains under investigation. We used a tissue microarray of 220 mismatch repair-gene proficient CRLMs resected in 97 patients followed prospectively to quantify CD3
MeSH term(s)	Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Lymphocytes, Tumor-Infiltrating ; Colorectal Neoplasms
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-402X
ISSN (online)	2162-402X
ISSN	2162-402X
DOI	10.1080/2162402X.2023.2253642
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience.

Nassabein, Rami / Mansour, Laura / Richard, Corentin / Vandenbroucke-Menu, Franck / Aubin, Francine / Ayoub, Jean-Pierre / Dagenais, Michel / Lapointe, Real / Letourneau, Richard / Plasse, Marylène / Roy, André / Turcotte, Simon / Tehfe, Mustapha

Current oncology (Toronto, Ont.)

2021 Volume 28, Issue 3, Page(s) 1899–1908

Abstract: Surgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Herein, we report outcomes of older patients with ... ...

Abstract	Surgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Herein, we report outcomes of older patients with resectable CRLM in our center. We retrospectively analyzed characteristics and outcomes of older patients with CRLM operated at "Centre Hospitalier de l'Université de Montréal" (CHUM) between 2010 and 2019. We identified 210 patients aged ≥70 years with a median age of 76 (range: 70-85). CRLM were synchronous in 56% of patients. Median disease-free survival (DFS) was 41.3 months. Median overall survival (OS) was 62.2 months and estimated 5-year survival rate was 51.5% similar to those of younger counterparts. Patients with metachronous CRLM had a trend to a higher OS compared to those with synchronous disease (67.2 vs. 58.7 months;
MeSH term(s)	Aged ; Colorectal Neoplasms ; Disease-Free Survival ; Hepatectomy ; Humans ; Liver Neoplasms/surgery ; Retrospective Studies
Language	English
Publishing date	2021-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol28030176
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4305: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns.

Messaoudi, Nouredin / Henault, David / Stephen, David / Cousineau, Isabelle / Simoneau, Eve / Rong, Zhixia / Létourneau, Richard / Plasse, Marylène / Dagenais, Michel / Roy, André / Lapointe, Réal / Vandenbroucke-Menu, Franck / Kunda, Rastislav / Ysebaert, Dirk / Soucy, Geneviève / Stagg, John / Vermeulen, Peter / Turcotte, Simon

British journal of cancer

2022 Volume 126, Issue 9, Page(s) 1329–1338

Abstract: Background: After resection, colorectal cancer liver metastases (CRLM) surrounded by a desmoplastic rim carry a better prognosis than the metastases replacing the adjacent liver. However, these histopathological growth patterns (HGPs) are insufficient ... ...

Abstract	Background: After resection, colorectal cancer liver metastases (CRLM) surrounded by a desmoplastic rim carry a better prognosis than the metastases replacing the adjacent liver. However, these histopathological growth patterns (HGPs) are insufficient to guide clinical decision-making. We explored whether the adaptive immune features of HGPs could refine prognostication. Methods: From 276 metastases resected in 176 patients classified by HGPs, tissue microarrays were used to assess intratumoral T cells (CD3), antigen presentation capacity (MHC class I) and CD73 expression producing immunosuppressive adenosine. We tested correlations between these variables and patient outcomes. Results: The 101 (57.4%) patients with dominant desmoplastic HGP had a median recurrence-free survival (RFS) of 17.1 months compared to 13.3 months in the 75 patients (42.6%) with dominant replacement HGP (p = 0.037). In desmoplastic CRLM, high vs. low CD73 was the only prognostically informative immune parameter and was associated with a median RFS of 12.3 months compared to 26.3, respectively (p = 0.010). Only in dominant replacement CRLM, we found a subgroup (n = 23) with high intratumoral MHC-I expression but poor CD3 Conclusions: Combining the assessments of HGP and adaptive immune features in resected CRLM could help identify patients at risk of early recurrence.
MeSH term(s)	Colorectal Neoplasms/pathology ; Hepatectomy ; Humans ; Liver Neoplasms/pathology ; Prognosis
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-021-01667-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.142: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Effect of intraoperative hypovolemic phlebotomy on transfusion and clinical outcomes in patients undergoing hepatectomy: a retrospective cohort study.

Al Khaldi, Maher / Gryspeerdt, Filip / Carrier, François Martin / Bouchard, Claudia / Simoneau, Ève / Rong, Zhixia / Plasse, Marylène / Létourneau, Richard / Dagenais, Michel / Roy, André / Lapointe, Réal / Massicotte, Luc / Vandenbroucke-Menu, Franck / Rioux-Massé, Benjamin / Turcotte, Simon

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2021 Volume 68, Issue 7, Page(s) 980–990

Abstract: Background: There is no consensus on how to best achieve a low central venous pressure during hepatectomy for the purpose of reducing blood loss and red blood cell (RBC) transfusions. We analyzed the associations between intraoperative hypovolemic ... ...

Title translation	Effet de la phlébotomie hypovolémique peropératoire sur la transfusion et les résultats cliniques des patients subissant une hépatectomie : une étude de cohorte rétrospective.
Abstract	Background: There is no consensus on how to best achieve a low central venous pressure during hepatectomy for the purpose of reducing blood loss and red blood cell (RBC) transfusions. We analyzed the associations between intraoperative hypovolemic phlebotomy (IOHP), transfusions, and postoperative outcomes in cancer patients undergoing hepatectomy. Methods: Using surgical and transfusion databases of patients who underwent hepatectomy for cancer at one institution (11 January 2011 to 22 June 2017), we retrospectively analyzed associations between IOHP and RBC transfusion on the day of surgery (primary outcome), and with total perioperative transfusions, intraoperative blood loss, and postoperative complications (secondary outcomes). We fitted logistic regression models by inverse probability of treatment weighting to adjust for confounders and reported adjusted odds ratio (aOR). Results: There were 522 instances of IOHP performed during 683 hepatectomies, with a mean (standard deviation) volume of 396 (119) mL. The IOHP patients had a 6.9% transfusion risk on the day of surgery compared with 12.4% in non-IOHP patients (aOR, 0.53; 95% confidence interval [CI], 0.29 to 0.98; P = 0.04). Total perioperative RBC transfusion tended to be lower in IOHP patients compared with non-IOHP patients (14.9% vs 22.4%, respectively; aOR, 0.72; 95% CI, 0.44 to 1.16; P = 0.18). In patients with a predicted risk of ≥ 47.5% perioperative RBC transfusion, 24.6% were transfused when IOHP was used compared with 56.5% without IOHP. The incidence of severe postoperative complications (Clavien-Dindo scores ≥ 3) was similar in patients whether or not IOHP was performed (15% vs 16% respectively; aOR, 0.97; 95% CI, 0.53 to 1.54; P = 0.71). Conclusions: The use of IOHP during hepatectomy was associated with less RBCs transfused on the same day of surgery. Trials comparing IOHP with other techniques to reduce blood loss and transfusion are needed in liver surgery.
MeSH term(s)	Blood Transfusion ; Hepatectomy ; Humans ; Hypovolemia/epidemiology ; Phlebotomy ; Retrospective Studies
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-021-01958-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 109: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Prognostic value of CD73 expression in resected colorectal cancer liver metastasis.

Messaoudi, Nouredin / Cousineau, Isabelle / Arslanian, Elizabeth / Henault, David / Stephen, David / Vandenbroucke-Menu, Franck / Dagenais, Michel / Létourneau, Richard / Plasse, Marylène / Roy, André / Lapointe, Réal / Ysebaert, Dirk / Trudel, Dominique / Soucy, Geneviève / Stagg, John / Turcotte, Simon

Oncoimmunology

2020 Volume 9, Issue 1, Page(s) 1746138

Abstract: Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive metabolic pathways is being explored as a new immunotherapeutic approach. We assessed whether CD73, ...

Abstract	Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive metabolic pathways is being explored as a new immunotherapeutic approach. We assessed whether CD73, the rate limiting enzyme that catalyzes the degradation of extracellular AMP into immunosuppressive adenosine, could be an immunological determinant of colorectal liver metastases (CRLMs). By immunofluorescence on tissue microarrays, intratumoral CD73 expression (tCD73) was analyzed in 391 CRLMs resected in 215 patients, and soluble CD73 (sCD73) was measured by ELISA in the pre-operative serum of 193 patients. High tCD73 was associated with worse pathological features, such as multiple and larger CRLMs, and poorer pathologic response to pre-operative chemotherapy. The median time to recurrence and disease-specific survival after CRLM resection was significantly shorter in patients with high tCD73 (11.0 and 46.4 months, respectively) compared with low tCD73 (19.0 and 61.5 months, respectively). tCD73 was strongly associated with patient outcomes independently of clinicopathological variables. sCD73 did not correlate with tCD73. Patients with high levels of sCD73 also had shorter disease-specific survival. Our results suggested that CD73 in CRLMs may be prognostically informative and may help select patients more likely to respond to adenosine pathway blocking agents.
MeSH term(s)	Humans ; Liver Neoplasms/surgery ; Neoplasm Recurrence, Local ; Prognosis ; Rectal Neoplasms
Language	English
Publishing date	2020-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-4011
ISSN (online)	2162-402X
ISSN	2162-4011
DOI	10.1080/2162402X.2020.1746138
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Answer to case of the month #162. Emphysematous infection of the liver parenchyma.

Létourneau-Guillon, Laurent / Audet, Pascale / Plasse, Marylène / Lepanto, Luigi

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

2010 Volume 61, Issue 2, Page(s) 117–119

MeSH term(s)	Contrast Media ; Diagnosis, Differential ; Emphysema/diagnostic imaging ; Emphysema/microbiology ; Fatal Outcome ; Hepatitis/diagnostic imaging ; Hepatitis/microbiology ; Humans ; Liver Function Tests ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/microbiology ; Tomography, X-Ray Computed
Chemical Substances	Contrast Media
Language	English
Publishing date	2010-03-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	418190-6
ISSN	0846-5371 ; 0008-2902
ISSN	0846-5371 ; 0008-2902
DOI	10.1016/j.carj.2009.10.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 299: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Portal vein embolization does not affect the long-term survival and risk of cancer recurrence among colorectal liver metastases patients: A prospective cohort study.

Collin, Yves / Paré, Alex / Belblidia, Assia / Létourneau, Richard / Plasse, Marylène / Dagenais, Michel / Turcotte, Simon / Martel, Guillaume / Roy, André / Lapointe, Real / Vandenbroucke-Menu, Frank

International journal of surgery (London, England)

2018 Volume 61, Page(s) 42–47

Abstract: Background: Previous studies comparing the survival outcomes of liver resections with and without preoperative portal vein embolization (PVE) for colorectal liver metastases (CLM) have linked PVE to higher rate of tumor progression, lower overall ... ...

Abstract	Background: Previous studies comparing the survival outcomes of liver resections with and without preoperative portal vein embolization (PVE) for colorectal liver metastases (CLM) have linked PVE to higher rate of tumor progression, lower overall survival (OS) and lower disease-free survival (DFS). The lack of adjusted models to compare these outcomes is a limitation of these studies since patients requiring PVE may differ significantly from the ones receiving upfront surgery. Materials and methods: Prospective cohort study of 128 patients undergoing CLM resection. The OS analysis followed an intent-to-treat (ITT) approach. The adjusted impact of PVE on OS and DFS was evaluated using multivariate Cox regression models. Results: Seventy-one patients underwent PVE before attempting a liver resection while 57 received upfront surgery (NoPVE). All NoPVE patients were resected while 14 PVE participants (19.7%) were not operated (tumor progression = 9/14). PVE patients had a significantly higher preoperative lesions count (3 [1.75-4] vs 1 [1-2.5]; p < 0.001), a higher prevalence of bilateral metastases (23.5% vs 8.8, p = 0.028) and a higher count of neo-adjuvant chemotherapy cycles compared to NoPVE patients. The OS of PVE patients was similar to NoPVE participants (44.7 months [26.9-69.5] vs 49.0 [24.9-64.8], p = 0.761). The DFS of resected PVE patients was higher than NoPVE patients (33.2 months [10.7-54.6] vs 23.4 months [14.1-58.1], p = 0.991). In the adjusted models, preoperative lesions count was the only significant predictor of overall mortality (HR+IC Conclusion: In the context of CLM, patients requiring PVE differ significantly from patients receiving upfront surgery. This confirms the need for adjusted models when comparing the clinical outcomes of both groups. Our adjusted analysis suggests that PVE is not a significant predictor of a lower OS or DFS. PVE allowed the resection of 80% of participants with initially unresectable CLM. Institutional protocol number: 12.106 STUDY REGISTRATION NUMBER: NCT03168230.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cohort Studies ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Female ; Hepatectomy/adverse effects ; Hepatectomy/methods ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/etiology ; Portal Vein/surgery ; Postoperative Complications ; Preoperative Care/methods ; Prospective Studies ; Risk Factors ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2018-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2018.11.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6502: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact of localized congestion related to venous deprivation after hepatectomy.

Scatton, Olivier / Plasse, Marylène / Dondero, Fédérica / Vilgrain, Valérie / Sauvanet, Alain / Belghiti, Jacques

Surgery

2008 Volume 143, Issue 4, Page(s) 483–489

Abstract: Objective: We sought to assess the impact of localized venous congestion related to venous deprivation on liver function recovery and regeneration after hepatectomy, using the living donation model. Harvesting the middle hepatic vein (MHV) optimizes the ...

Abstract	Objective: We sought to assess the impact of localized venous congestion related to venous deprivation on liver function recovery and regeneration after hepatectomy, using the living donation model. Harvesting the middle hepatic vein (MHV) optimizes the venous drainage of right grafts but could lead to donor segment IV congestion. Methods: In a series of 44 donors, 25 underwent right liver harvesting without the MHV and 19 with the MHV. The venous drainage anatomy of segment IV was defined as type I if exclusive through the MHV and type II if shared through the left hepatic vein. We prospectively studied the occurrence, magnitude (global or partial), and regeneration impacts of segment IV congestion on computed tomography (CT) performed 1 week and 1 month after surgery. Results: Early postoperative CT showed that segment IV congestion was never observed in the group without MHV harvesting, and it was present in 16 (84%) of 19 donors with MHV harvesting. Segment IV congestion was global in 9 donors, including 7 with type I anatomy. Postoperative data comparing data of the 9 donors with global congestion (GC) with other donors showed that the prothrombin time was significantly (P < .05) lower on day 1 and 5 (53% vs 63% and 76% vs 86%, respectively), and segment IV regeneration rate was lower (3.6% vs 11%) in the former group. However, a higher regeneration rate of segments II and III in the GC group (11.8% vs 3.6%) resulted in a similar regeneration rate of the remnant liver 1 month after hepatectomy (59.4 +/- 12% vs 57.8 +/- 12.4%). Conclusions: Postoperative localized venous congestion is highly related to venous anatomy and affects both early postoperative liver function and regeneration rate. Based on this living donor model, we suggest that venous anatomy evaluation of the future remnant liver parenchyma be performed systematically before extended resection of living small or diseased remnants.
MeSH term(s)	Adolescent ; Adult ; Hepatectomy ; Hepatic Veins/surgery ; Hepatic Veins/transplantation ; Humans ; Liver/blood supply ; Liver Regeneration/physiology ; Liver Transplantation/adverse effects ; Living Donors ; Middle Aged ; Tomography, X-Ray Computed ; Venous Insufficiency/diagnostic imaging ; Venous Insufficiency/etiology
Language	English
Publishing date	2008-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2007.11.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uk I Zs.129: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharide-induced obstructive jaundice.

Caglikulekci, Mehmet / Dirlik, Musa / Pata, Cengiz / Plasse, Marylene / Tamer, Lulufer / Ogetman, Zekai / Ercan, Bahadir

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2006 Volume 19, Issue 3, Page(s) 175–184

Abstract: In obstructive jaundice, free radical production is increased and antioxidative activity is reduced. N-Acetylcysteine (NAC) has a beneficial effect with anti-inflammatory and antioxidant activity, acting as a free radical scavenger. NAC inhibits ... ...

Abstract	In obstructive jaundice, free radical production is increased and antioxidative activity is reduced. N-Acetylcysteine (NAC) has a beneficial effect with anti-inflammatory and antioxidant activity, acting as a free radical scavenger. NAC inhibits inducible nitric oxide synthase, suppresses cytokine expression/release, and inhibits adhesion molecule expression and nuclear factor kappa B. The aim of this study was to investigate the effects of NAC on liver/renal tissue and serum lipid peroxidation in lipopolysaccharide (LPS)-induced obstructive jaundice. We randomized 60 rats into 6 groups: group 1, Sham; group 2, obstructive jaundice (OJ) induced after bile-duct ligation; group 3, OJ + NAC (100 mg kg- 1 subcutaneously); group 4, OJ + LPS (10 mg kg-1); group 5, OJ + NAC + LPS; and group 6, OJ + LPS + NAC. For each group, the biochemical markers of lipid peroxidation and the antioxidant products were measured in serum and liver/renal tissue after sacrifice. Almost all lipid peroxidation products levels were increased and antioxidant products levels were decreased in groups who received LPS (groups 4, 5, and 6), but the effect was less remarkable when NAC was administered before LPS (group 5). The same trend was seen for groups with OJ +/- LPS who did not received NAC or received it after induced toxemia (groups 2, 4, and 6) as compared to groups 1 and 3. Moreover, in the case of OJ + LPS, rats treated with NAC before LPS (group 5) had lower lipid peroxidation products levels and higher antioxidant products levels as compared to those who did not received NAC (group 4). This phenomenon was not reproducible with NAC administered after LPS (group 6). Thus, results of this study showed that NAC prevents the deleterious effects of LPS in obstructive jaundice by reducing lipid peroxidation in serum and liver/renal tissue if administered before LPS. Nonetheless, NAC failed to prevent the lipid peroxidation in the case of established endotoxemia in obstructive jaundice.
MeSH term(s)	Acetylcysteine/pharmacology ; Animals ; Ascorbic Acid/blood ; Bile Ducts ; Erythrocytes/metabolism ; Free Radical Scavengers/pharmacology ; Glutathione/metabolism ; Jaundice, Obstructive/chemically induced ; Jaundice, Obstructive/drug therapy ; Jaundice, Obstructive/metabolism ; Kidney/metabolism ; Ligation ; Lipid Peroxidation/drug effects ; Lipopolysaccharides/pharmacology ; Liver/metabolism ; Male ; Malondialdehyde/blood ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Sodium-Potassium-Exchanging ATPase/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism
Chemical Substances	Free Radical Scavengers ; Lipopolysaccharides ; Thiobarbituric Acid Reactive Substances ; Malondialdehyde (4Y8F71G49Q) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Glutathione (GAN16C9B8O) ; Ascorbic Acid (PQ6CK8PD0R) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2006-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941930600674702
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2364: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito