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Article ; Online: Semen cryopreservation for an oncological reason: a retrospective study.

Santana-Plata, Ana / Rivera-Egea, Rocio / Garrido, Nicolás

2024 , Page(s) 103898

Abstract: Research question: How do cancer type and treatment affect semen quality before and after treatment, and what effect does it have in their clinical management of infertility? Also, what is the rate of patients using cryopreserved semen samples after ... ...

Abstract	Research question: How do cancer type and treatment affect semen quality before and after treatment, and what effect does it have in their clinical management of infertility? Also, what is the rate of patients using cryopreserved semen samples after treatment? Design: Patients who cryopreserved spermatozoa for oncological reasons between 2000 and 2022 in IVI clinics in Spain were retrospectively reviewed. Semen parameters were analysed before and after treatment, and utilization and destruction rates were calculated. Total motile sperm count (TMSC) was used for assisted reproductive technology (ART) counselling. Results: A total of 724 patients cryopreserved their semen during the study period. The semen parameters of the cancer patients' semen before and after treatment were heterogeneous, with significant differences between cancer type and semen parameters. The utilization rate was relatively low (0.4%), whereas the destruction rate was 23.1%. Conclusion: Cancer and antineoplastic treatment affect everyone differently. Therefore, sperm cryopreservation should be offered to all patients before starting treatment to ensure their reproductive future. Furthermore, in addition to considering the semen parameters defined by the World Health Organization, it is important to use TMSC in the diagnosis of men to choose appropriate ART according to type of cancer.
Language	English
Publishing date	2024-02-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2024.103898
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Article ; Online: Genotypic and Phenotypic Diversity of

Lappe-Oliveras, Patricia / Avitia, Morena / Sánchez-Robledo, Sara Darinka / Castillo-Plata, Ana Karina / Pedraza, Lorena / Baquerizo, Guillermo / Le Borgne, Sylvie

Journal of fungi (Basel, Switzerland)

2023 Volume 9, Issue 8

Abstract: ... ...

Abstract	Seven
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof9080795
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Article ; Online: Pérdida de respuesta a terapia anti-TNF en enfermedad inflamatoria intestinal: experiencia en un hospital de referencia en Lima - Perú.

Paredes Méndez, Juan Eloy / Alosilla Sandoval, Paulo Anibal / Vargas Marcacuzco, Henry Tomas / Mestanza Rivas Plata, Ana Lucía / Gonzá Les Yovera, Jhean Gabriel

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

2020 Volume 40, Issue 1, Page(s) 22–28

Abstract: Objective: To evaluate the response to treatment with anti-TNFs in patients with inflammatory bowel disease.: Materials and methods: Prospective observational study conducted in the Gastroenterology service of the Guillermo Almenara National Hospital, ...

Title translation	Loss of response to anti-TNF therapy in inflammatory bowel disease: experience in a reference hospital in Lima - Peru.
Abstract	Objective: To evaluate the response to treatment with anti-TNFs in patients with inflammatory bowel disease. Materials and methods: Prospective observational study conducted in the Gastroenterology service of the Guillermo Almenara National Hospital, from January 2015 to August 2018. Results: 31 patients with inflammatory bowel disease who received maintenance therapy with Infliximab were evaluated. Twelve (38.7%) patients (3 with ulcerative colitis and 9 with Crohn's disease) presented loss of response after 6 months of the beginning of the maintenance phase: 2 between 6-12 months, 4 between 12-18 months and 6 between 18- 24 months. As a first step, the dose was doubled (10 mg/kg) to the 12 patients, obtaining a response in 6 (50%) after 12 weeks. Of the remaining 6 patients, 4 switched to Adalimumab, 1 patient presented colon cancer and 1 patient presented anaphylaxis and sarcoidosis. Of the patients who received Adalimumab, 3 had endoscopic recurrence (75%) after 6 months and 1 did not respond to induction therapy and was subjected to colectomy (25%). Conclusions: Approximately one third of our patients presented loss of response to maintenance therapy with Infliximab. The dose escalation as a rescue therapy was successful in half of the patients. The change to Adalimumab in patients with loss of response to a first anti-TNF drug does not seem to be effective.
MeSH term(s)	Adalimumab/therapeutic use ; Adult ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Tolerance ; Female ; Gastrointestinal Agents/therapeutic use ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Infliximab/therapeutic use ; Maintenance Chemotherapy/methods ; Male ; Middle Aged ; Peru ; Prospective Studies ; Recurrence ; Treatment Failure
Chemical Substances	Gastrointestinal Agents ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
Language	Spanish
Publishing date	2020-05-05
Publishing country	Peru
Document type	Journal Article ; Observational Study
ZDB-ID	2058591-3
ISSN	1609-722X ; 1609-722X
ISSN (online)	1609-722X
ISSN	1609-722X
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Article ; Online: Epidemiología y fenotipo de la enfermedad de Crohn en un hospital de referencia en Lima - Perú.

Paredes Méndez, Juan Eloy / Alosilla Sandoval, Paulo Aníbal / Vargas Marcacuzco, Henry Tomas / Junes Pérez, Sonia Irene / Fernández Luque, Jorge Luis / Mestanza Rivas Plata, Ana Lucía / Gonzáles Yovera, Jhean Gabriel

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

2020 Volume 40, Issue 3, Page(s) 230–237

Abstract: Crohn's disease (CD) is a chronic inflammatory pathology of the digestive tract with great impact on the quality of life of patients. Global epidemiology is changing in recent years and its prevalence is increasing in Latin America.: Objective: To ... ...

Title translation	Epidemiology and phenotype of Crohn's disease in a reference hospital in Lima - Peru.
Abstract	Crohn's disease (CD) is a chronic inflammatory pathology of the digestive tract with great impact on the quality of life of patients. Global epidemiology is changing in recent years and its prevalence is increasing in Latin America. Objective: To evaluate the epidemiological characteristics, phenotype, clinical course, diagnosis and treatment of CD. Materials and methods: Retrospective, descriptive, observational study of patients diagnosed with CD from January 2004 to December 2019 in the gastroenterology service of the Guillermo Almenara Irigoyen National Hospital, Lima-Peru. Results: 55 patients with an average age of 56 ± 8.2 years were included. Male predominance (62%). The average diagnosis time was 18 ± 6.1 months. The most frequent symptoms were: abdominal pain 72.7% and weight loss 60%. Extraintestinal manifestations occurred in 20%. The ileal location (36.4%) was the most frequent, followed by colonic (32.7%). The inflammatory phenotype predominated in half of the patients, followed by stenosing in 25.5%. The most frequent activity clinical and endoscopic was moderate. For induction and maintenance treatment, systemic corticosteroids and biological therapy with anti-TNF were the most widely used, respectively. Approximately a third of patients required surgery during the evolution of the disease. Mortality was 5.4%. Conclusions: CD is an increasingly frequent disease in our country, with epidemiological and phenotypic characteristics that differ from other continents.
MeSH term(s)	Crohn Disease/diagnosis ; Crohn Disease/epidemiology ; Crohn Disease/genetics ; Crohn Disease/therapy ; Female ; Humans ; Male ; Middle Aged ; Peru ; Phenotype ; Referral and Consultation ; Retrospective Studies
Language	Spanish
Publishing date	2020-11-09
Publishing country	Peru
Document type	Journal Article ; Observational Study
ZDB-ID	2058591-3
ISSN	1609-722X ; 1609-722X
ISSN (online)	1609-722X
ISSN	1609-722X
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Article ; Online: Características clínico-patológicas y manejo endoscópico de lesiones serradas sésiles de colon en un hospital de referencia en Lima - Perú.

Paredes Méndez, Juan Eloy / Vargas Marcacuzco, Henry Tomas / Alosilla Sandoval, Paulo Anibal / Quiroga Purizaca, Wilmer Gustavo / Mestanza Rivas Plata, Ana Lucía / Gutiérrez Córdova, Isamar Benyi / Chotón Castañeda, Yesenia Vanessa / Arenas Gamio, José Luis

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

2020 Volume 40, Issue 2, Page(s) 142–148

Abstract: Colorectal cancer (CRC) is one of the most frequent worldwide. Approximately one third of cases originate from the serrated pathway of carcinogenesis, with colonic sessile serrated lesions (SSL) being the main cause of interval CRC.: Objective: To ... ...

Title translation	Clinical-pathological characteristics and endoscopic management of colonic sessile serrated lesions in a reference hospital in Lima - Peru.
Abstract	Colorectal cancer (CRC) is one of the most frequent worldwide. Approximately one third of cases originate from the serrated pathway of carcinogenesis, with colonic sessile serrated lesions (SSL) being the main cause of interval CRC. Objective: To evaluate the clinical, endoscopic, histological characteristics and endoscopic management of colonic LSS. Materials and methods: Observational, descriptive, retrospective study from July 2017 to June 2019 in the gastroenterology service of the Guillermo Almenara Irigoyen National Hospital, Lima - Peru. The characteristics of 79 LSS were evaluated, the chi-square statistic was used to analyze the association of clinical and endoscopic variables with the presence of dysplasia; and the size of the lesion with the type of endoscopic resection. Results: In 74 patients, 79 SSL were found, 67 (84.8%) with dysplasia (44 high-grade and 23 low-grade). Average age of 52 years and 44 (59.4%) were males. The location in the right colon (OR=5.09, 95% CI 1.38â€"18.7, p=0.009), the size >10 mm (OR=6.13, 95% CI 1.50â€"24,94, p=0.014) and the â€œblurred edgesâ€ (OR=5.08, 95% CI 1.17-21.98, p=0.019), are significantly related to the presence of dysplasia. SSL smaller than 20 mm showed statistical association with bloc resection (OR=69.3, 95% CI 7.35-653.9, p <0.001) with respect to the piecemeal resection. Conclusions: The finding of SSL during colonoscopies is frequent. The location, size and finding of blurred edges are related to the presence of dysplasia. Mucosal endoscopic resection was a safe and effective technique.
MeSH term(s)	Colonic Polyps/pathology ; Colonic Polyps/surgery ; Colonoscopy ; Female ; Humans ; Male ; Middle Aged ; Peru ; Retrospective Studies
Language	Spanish
Publishing date	2020-09-01
Publishing country	Peru
Document type	Journal Article ; Observational Study
ZDB-ID	2058591-3
ISSN	1609-722X ; 1609-722X
ISSN (online)	1609-722X
ISSN	1609-722X
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Article ; Online: Exercise during pregnancy on maternal lipids: a secondary analysis of randomized controlled trial.

Ramírez-Vélez, Robinson / Lobelo, Felipe / Aguilar-de Plata, Ana C / Izquierdo, Mikel / García-Hermoso, Antonio

BMC pregnancy and childbirth

2017 Volume 17, Issue 1, Page(s) 396

MeSH term(s)	Adult ; Cholesterol, LDL/blood ; Exercise/physiology ; Exercise Therapy/methods ; Female ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/etiology ; Obstetric Labor Complications/etiology ; Postpartum Hemorrhage/etiology ; Pregnancy ; Pregnancy Trimesters/blood ; Prenatal Care/methods ; Triglycerides/blood ; Young Adult
Chemical Substances	Cholesterol, LDL ; Triglycerides
Language	English
Publishing date	2017-11-28
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1471-2393
ISSN (online)	1471-2393
DOI	10.1186/s12884-017-1571-6
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Article: Long-Term Experience with Hyperthermic Chemotherapy (HIVEC) Using Mitomycin-C in Patients with Non-Muscle Invasive Bladder Cancer in Spain.

Journal of clinical medicine

2021 Volume 10, Issue 21

Abstract: 1) Background: Intravesical mitomycin-C (MMC) combined with hyperthermia is increasingly used in non-muscle invasive bladder cancer (NMIBC), especially in the context of a relative BCG shortage. We aim to determine real-world data on the long-term ... ...

Abstract	(1) Background: Intravesical mitomycin-C (MMC) combined with hyperthermia is increasingly used in non-muscle invasive bladder cancer (NMIBC), especially in the context of a relative BCG shortage. We aim to determine real-world data on the long-term treatment outcomes of adjunct hyperthermic intravesical chemotherapy (HIVEC) with MMC and a COMBAT® bladder recirculation system (BRS); (2) Methods: A prospective observational trial was performed on patients with NMIBC treated with HIVEC using BRS in nine academic institutions in Spain between 2012-2020 (HIVEC-E). Treatment effectiveness (recurrence, progression and overall mortality) was evaluated in patients treated with HIVEC MMC 40mg in the adjuvant setting, with baseline data and a clinical follow-up, that comprise the Full Analysis Set (FAS). Safety, according to the number and severity of adverse effects (AEs), was evaluated in the safety (SAF) population, composed by patients with at least one adjunct HIVEC MMC instillation; (3) Results: The FAS population (
Language	English
Publishing date	2021-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10215105
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Article ; Online: Asociación entre adiposidad y factores de riesgo cardiovascular en infantes pre-púberes.

Ramírez-Vélez, Robinson / Suaréz-Ortegón, Milton Fabian / Aguilar de Plata, Ana Cecilia

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion

2011 Volume 58, Issue 9, Page(s) 457–463

Abstract: Introduction and objectives: To examine the relationships between of four measures of adiposity, namely waist circumference (WC), body mass index (BMI), and subscapular and abdominal skinfolds, with different cardiovascular risk factors in prepubertal ... ...

Title translation	Association between adiposity and cardiovascular risk factors in prepubertal children.
Abstract	Introduction and objectives: To examine the relationships between of four measures of adiposity, namely waist circumference (WC), body mass index (BMI), and subscapular and abdominal skinfolds, with different cardiovascular risk factors in prepubertal children. Methods: Four hundred and ninety-four prepubertal children aged 6-10 years participated in this cross-sectional study. The subscapular and abdominal skinfolds, WC, and BMI were measured to assess adiposity, and cardiovascular risk factors (CVRFs) were assessed by measuring systolic (SBP) and diastolic blood pressures (DBP), glucose, triglycerides (TG), and high density (HDL-C) and low density lipoprotein cholesterol (LDL-C). Dichotomous variables were created based on whether or not the subjects were in the upper quartile (Q4) for the WC, BMI, and skinfold variables. Results: No CVRF was found in 52.8% of children, 33.4% had one factor, and 10.9% and 2.8% had 2 and 3 factors respectively. An adjusted logistic regression analysis showed that being in Q4 of anthropometric variables and CVRFs was associated to TG levels ≥ 100 mg/dL. Glucose levels ≥ 96 mg/dL were associated to Q4 and abdominal fold. Presence of 2 or more CVRFs was significantly associated to Q4 in all anthropometric variables despite adjustment for age, gender, and calorie intake. The subscapular skinfold was the adiposity marker associated to the highest risk. Conclusions: Children with a more unfavorable adiposity profile tend to have a greater cardiovascular risk in the prepubertal stage.
MeSH term(s)	Adiposity ; Adolescent ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Child ; Female ; Humans ; Male ; Risk Factors
Language	Spanish
Publishing date	2011-11
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1469349-5
ISSN	1579-2021 ; 0211-2299 ; 1575-0922
ISSN (online)	1579-2021
ISSN	0211-2299 ; 1575-0922
DOI	10.1016/j.endonu.2011.06.008
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Article ; Online: Centiles de lípidos séricos en adolescentes de Colombia.

Ramírez-Vélez, Robinson / Guillermo Ortega, José / Mosquera Escudero, Mildrey / Aguilar de Plata, Ana Cecilia

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion

2011 Volume 58, Issue 8, Page(s) 395–400

Abstract: Objective: To assess age- and sex-specific percentile baseline data for total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) in Colombian children and adolescents aged 10 to 17 years.: Patients and methods: A ... ...

Title translation	Centile values for serum lipids in Colombian adolescents.
Abstract	Objective: To assess age- and sex-specific percentile baseline data for total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) in Colombian children and adolescents aged 10 to 17 years. Patients and methods: A cross-sectional, descriptive study was conducted on 1,773 children and adolescents. Each participant underwent a fasting measurement to quantify TC, HDL-C, and TG levels using enzymatic-colorimetric methods. Smoothed age- and sex-specific 5(th), 25(th), 50(th), 75(th), 90(th) and 95(th) percentile values where derived using LMS regression (Least Mean Square) using the statistical package Growth Analyzer. Results: Overall, males had lower serum TC and TG levels as compared to females. P95 of TG and TC was higher in males aged 10 to 14 years as compared to females, while HDL-C levels were similar in both sexes. Conclusions: Percentile values will help classify children and adolescents as compared to other populations based on this health indicator.
MeSH term(s)	Adolescent/physiology ; Child ; Cholesterol/blood ; Cholesterol, HDL/blood ; Colombia ; Colorimetry ; Cross-Sectional Studies ; Fasting/blood ; Female ; Humans ; Lipids/blood ; Male ; Reference Values ; Triglycerides/blood
Chemical Substances	Cholesterol, HDL ; Lipids ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	Spanish
Publishing date	2011-10
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1469349-5
ISSN	1579-2021 ; 0211-2299 ; 1575-0922
ISSN (online)	1579-2021
ISSN	0211-2299 ; 1575-0922
DOI	10.1016/j.endonu.2011.07.003
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Article ; Online: Effect of exercise training on eNOS expression, NO production and oxygen metabolism in human placenta.

Ramírez-Vélez, Robinson / Bustamante, Juanita / Czerniczyniec, Analia / Aguilar de Plata, Ana C / Lores-Arnaiz, Silvia

PloS one

2013 Volume 8, Issue 11, Page(s) e80225

Abstract: Objective: To determine the effects of combined aerobic and resistance exercise training during the second half of pregnancy on endothelial NOS expression (eNOS), nitric oxide (NO) production and oxygen metabolism in human placenta.: Methods: The ... ...

Abstract	Objective: To determine the effects of combined aerobic and resistance exercise training during the second half of pregnancy on endothelial NOS expression (eNOS), nitric oxide (NO) production and oxygen metabolism in human placenta. Methods: The study included 20 nulliparous in gestational week 16-20, attending prenatal care at three tertiary hospitals in Colombia who were randomly assigned into one of two groups: The exercise group (n = 10) took part in an exercise session three times a week for 12 weeks which consisted of: aerobic exercise at an intensity of 55-75% of their maximum heart rate for 60 min and 25 mins. Resistance exercise included 5 exercise groups circuit training (50 repetitions of each) using barbells (1-3 kg/exercise) and low-to-medium resistance bands. The control group (n = 10) undertook their usual physical activity. Mitochondrial and cytosol fractions were isolated from human placental tissue by differential centrifugation. A spectrophotometric assay was used to measure NO production in cytosolic samples from placental tissue and Western Blot technique to determine eNOS expression. Mitochondrial superoxide levels and hydrogen peroxide were measured to determine oxygen metabolism. Results: Combined aerobic and resistance exercise training during pregnancy leads to a 2-fold increase in eNOS expression and 4-fold increase in NO production in placental cytosol (p = 0.05). Mitochondrial superoxide levels and hydrogen peroxide production rate were decreased by 8% and 37% respectively in the placental mitochondria of exercising women (p = 0.05). Conclusion: Regular exercise training during the second half of pregnancy increases eNOS expression and NO production and decreases reactive oxygen species generation in human placenta. Collectively, these data demonstrate that chronic exercise increases eNOS/NO production, presumably by increasing endothelial shear stress. This adaptation may contribute to the beneficial effects of exercise on the vascular and antioxidant system and in turn reduce the risk of preeclampsia, diabetes or hypertension during pregnancy.
MeSH term(s)	Adolescent ; Exercise/physiology ; Female ; Gene Expression ; Humans ; Hydrogen Peroxide/metabolism ; Mitochondria/metabolism ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Oxygen/metabolism ; Placenta/chemistry ; Placenta/metabolism ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Superoxides/metabolism ; Young Adult
Chemical Substances	Superoxides (11062-77-4) ; Nitric Oxide (31C4KY9ESH) ; Hydrogen Peroxide (BBX060AN9V) ; NOS3 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Oxygen (S88TT14065)
Language	English
Publishing date	2013-11-14
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0080225
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