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  1. Article ; Online: Effect of Exercise Training on Fitness in Multiple Sclerosis: A Meta-Analysis.

    Platta, Matthew E / Ensari, Ipek / Motl, Robert W / Pilutti, Lara A

    Archives of physical medicine and rehabilitation

    2016  Volume 97, Issue 9, Page(s) 1564–1572

    Abstract: Objective: To provide a quantitative synthesis of randomized controlled trials (RCTs) examining the effect of exercise training on muscular and cardiorespiratory fitness in persons with multiple sclerosis (MS).: Data sources: Three electronic ... ...

    Abstract Objective: To provide a quantitative synthesis of randomized controlled trials (RCTs) examining the effect of exercise training on muscular and cardiorespiratory fitness in persons with multiple sclerosis (MS).
    Data sources: Three electronic databases, PubMed, Google Scholar, and Web of Science, were searched for all relevant articles published up until October 2014.
    Study selection: Keywords included exercise or aerobic or strength or resistance training or cardiorespiratory and multiple sclerosis. Trials examining the effect of exercise training on muscular and/or cardiorespiratory fitness parameters were included.
    Data extraction: The initial search yielded 1501 articles; of these, 62 were reviewed in detail, and 20 RCTs met the inclusion criteria and provided enough data to compute effect sizes (ESs) (Cohen d). The meta-analyses was conducted using a random effects model to compute the overall or mean ES per fitness parameter.
    Data synthesis: The mean ES was .27 (SE=.05; 95% confidence interval [CI], .17-.38; z=5.05; P<.001) for muscular fitness outcomes and .47 (SE=.09; 95% CI, .30-.65; z=5.4; P<.001) for cardiorespiratory fitness outcomes. The weighted mean ES was not heterogeneous for muscular (Q13=11.09, P=.60, I(2)=.00) or cardiorespiratory (Q9=7.83, P=.55, I(2)=.00) fitness outcomes.
    Conclusions: The cumulative evidence supports that exercise training is associated with changes in muscular (small in magnitude) and cardiorespiratory (moderate in magnitude) fitness outcomes in persons with MS. Such an indication of magnitude is important for clinical research and practice by providing an evidence-based estimate of the actual benefit that exercise training confers on physiological fitness.
    MeSH term(s) Cardiorespiratory Fitness/physiology ; Clinical Trials as Topic ; Exercise Therapy/methods ; Humans ; Multiple Sclerosis/rehabilitation ; Physical Fitness/physiology ; Quality of Life
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 80057-0
    ISSN 1532-821X ; 0003-9993
    ISSN (online) 1532-821X
    ISSN 0003-9993
    DOI 10.1016/j.apmr.2016.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The safety of exercise training in multiple sclerosis: a systematic review.

    Pilutti, Lara A / Platta, Matthew E / Motl, Robert W / Latimer-Cheung, Amy E

    Journal of the neurological sciences

    2014  Volume 343, Issue 1-2, Page(s) 3–7

    Abstract: There are many reviews documenting the benefits of exercise training among persons with multiple sclerosis (MS). To date, we are unaware of a review that summarizes the risks of relapse and other adverse events (AEs) associated with exercise training, ... ...

    Abstract There are many reviews documenting the benefits of exercise training among persons with multiple sclerosis (MS). To date, we are unaware of a review that summarizes the risks of relapse and other adverse events (AEs) associated with exercise training, yet this is critical for informing decisions and recommendations regarding the safety of this behavior. We conducted a systematic review of relapse and other AEs reported in randomized controlled trials (RCTs) of exercise training in MS. We searched electronic databases for RCTs of exercise training in MS. We calculated the rate of relapse and AEs, and the relative risk of relapse and AEs for exercise training versus control. Twenty-six studies were reviewed that included 1295 participants. We determined that the rate of relapse was 6.3% and 4.6% for control and exercise, respectively. The rate of AEs was 1.2% and 2.0% for control and exercise, respectively. The relative risk of relapse for exercise training was 0.73, whereas the relative risk of AE for exercise training was 1.67. Exercise training was not associated with an increased risk of relapse, and risk of AEs was not higher than in healthy populations. This evidence should alleviate uncertainty regarding the safety of exercise training in MS.
    MeSH term(s) Exercise Therapy/methods ; Humans ; Multiple Sclerosis/rehabilitation
    Language English
    Publishing date 2014-08-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2014.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physical Fitness Assessment Across the Disability Spectrum in Persons With Multiple Sclerosis: A Comparison of Testing Modalities.

    Pilutti, Lara A / Sandroff, Brian M / Klaren, Rachel E / Learmonth, Yvonne C / Platta, Matthew E / Hubbard, Elizabeth A / Stratton, Michelle / Motl, Robert W

    Journal of neurologic physical therapy : JNPT

    2015  Volume 39, Issue 4, Page(s) 241–249

    Abstract: Background and purpose: Appropriate assessment of physical fitness (ie, aerobic capacity and muscular strength) is necessary for the design and evaluation of exercise training in multiple sclerosis (MS). However, this is challenging in persons with ... ...

    Abstract Background and purpose: Appropriate assessment of physical fitness (ie, aerobic capacity and muscular strength) is necessary for the design and evaluation of exercise training in multiple sclerosis (MS). However, this is challenging in persons with substantial disability, because of physical inaccessibility and insensitivity of certain exercise testing modalities. This study compared different methods of measuring cardiorespiratory (arm ergometer vs recumbent stepper) and muscular (hand-held dynamometry vs computerized dynamometry) fitness across the MS disability spectrum. Associations between physical fitness and other measures that represented all domains of the International Classification of Functioning, Disability and Health (ICF) were also examined.
    Methods: Sixty-four participants with MS completed 2 symptom-limited cardiorespiratory fitness and muscular strength tests. We also assessed disability, cognition, fatigue, walking speed and endurance, health-related quality of life, and activities of daily living.
    Results: Across all levels of disability, peak aerobic capacity assessed by recumbent stepping was higher compared with arm ergometry (P < 0.001). Peak torque of the knee extensors and knee flexors was significantly higher assessed by computerized dynamometry compared with hand-held dynamometry (P < 0.001). Aerobic capacity and peak torque decreased as a function of increasing disability (P < 0.001). Significant, moderate to strong correlations were observed between the physical fitness measures and measures representing all domains of the ICF, irrespective of the fitness testing mode.
    Discussion and conclusions: Overall, peak physical capacity was higher when assessed by recumbent stepping and computerized dynamometry. The assessment and prescription of exercise in MS should be based on these modalities to provide the most appropriate stimulus for exercise training adaptations. There continues to be an important association between physical fitness and other measures that represent all domains of the ICF, regardless of fitness assessment mode.Video Abstract available for additional insights from the authors (see Video Abstract, Supplemental Digital Content 1, http://links.lww.com/JNPT/A109).
    MeSH term(s) Adult ; Disabled Persons ; Exercise/physiology ; Exercise Test/methods ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/physiopathology ; Muscle Strength/physiology ; Physical Fitness/physiology
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2276921-3
    ISSN 1557-0584 ; 1557-0576 ; 1085-049X
    ISSN (online) 1557-0584
    ISSN 1557-0576 ; 1085-049X
    DOI 10.1097/NPT.0000000000000099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetic mapping and phenotypic analysis of

    Talley, Elyse M / Watts, Charlie T / Aboyer, Sonia / Adamson, Madeline G / Akoto, Harriet Ab / Altemus, Haley / Avella, Philip J / Bailey, Rebecca / Bell, Elizabeth R / Bell, Katheryn L / Breneman, Kelsey / Burkhart, Jessica S / Chanley, Logan J / Cook, Savannah S / DesLaurier, Mackenzie T / Dorsey, Timothy R / Doyle, Cassandra J / Egloff, Merris E / Fasawe, Ayoola S /
    Garcia, Katy K / Graves, Nathaniel P / Gray, Tyler K / Gustafson, Evan M / Hall, Makayla J / Hayes, Jaden D / Holic, Lindsay J / Jarvis, Brice A / Klos, Piotr S / Kritzmire, Sidney / Kuzovko, Lera / Lainez, Edwyna / McCoy, Shamerra / Mierendorf, James C / Neri, Nicole A / Neville, Caley R / Osborn, Kelley / Parker, Kaitlyn / Parks, Megan E / Peck, Kylee / Pitt, Robyn / Platta, Matthew E / Powell, Brianna / Rodriguez, Katalina / Ruiz, Clara / Schaefer, Mariah N / Shields, Amanda B / Smiley, Jasmine B / Stauffer, Briona / Straub, Devan / Sweeney, John L / Termine, Kaitlyn M / Thomas, Brett / Toth, Sophia D / Veile, Taylor R / Walker, Kayla S / Webster, Paige N / Woodard, Brian J / Yoder, Quentin L / Young, McKenzie K / Zeedyk, McKenzie L / Ziegler, Logan N / Bieser, Kayla L / Puthoff, David P / Stamm, Joyce / Vrailas-Mortimer, Alysia D / Kagey, Jacob D / Merkle, Julie A

    microPublication biology

    2021  Volume 2021

    Abstract: Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen ... ...

    Abstract Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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