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  1. Book: Transcriptional switches during development

    Plaza, Serge

    (Current topics in developmental biology ; 98)

    2012  

    Author's details ed. by Serge Plaza
    Series title Current topics in developmental biology ; 98
    Collection
    Keywords Entwicklungsbiologie ; Transkription ; Genetik
    Subject Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre
    Language English
    Size XVI, 348, [22] S. : Ill.
    Edition 1. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017176699
    ISBN 978-0-12-386499-4 ; 0-12-386499-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 175 -98- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Functions of animal microRNA-encoded peptides: the race is on!

    Dozier, Christine / Plaza, Serge

    EMBO reports

    2022  Volume 23, Issue 5, Page(s) e54789

    Abstract: Short open reading frame (sORF)-encoded peptides (SEPs) recently emerged as new key players in biology. Pioneering work first established that sORFs encoded by long non-coding RNAs (lncRNAs) are efficiently translated and produce functional peptides. In ... ...

    Abstract Short open reading frame (sORF)-encoded peptides (SEPs) recently emerged as new key players in biology. Pioneering work first established that sORFs encoded by long non-coding RNAs (lncRNAs) are efficiently translated and produce functional peptides. In plants, primary transcripts of microRNAs (pri-miRNAs) also produce sORF-encoded peptides called miPEPs, which are involved in specific transcriptional autoregulatory feedback loops (Lauressergues et al, 2015). To what extend are such mechanisms conserved in other species, especially in animals? In this issue of EMBO reports, Zhou et al show that pri-miR-31 encodes a miPEP promoting Treg differentiation and downregulating pri-miR-31 expression (Zhou et al, 2022).
    MeSH term(s) Animals ; Gene Expression Regulation, Plant ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Open Reading Frames ; Peptides/genetics ; Peptides/metabolism ; RNA, Long Noncoding
    Chemical Substances MicroRNAs ; Peptides ; RNA, Long Noncoding
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202254789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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  3. Article ; Online: The Essentials on microRNA-Encoded Peptides from Plants to Animals.

    Ormancey, Mélanie / Thuleau, Patrice / Combier, Jean-Philippe / Plaza, Serge

    Biomolecules

    2023  Volume 13, Issue 2

    Abstract: Primary transcripts of microRNAs (pri-miRNAs) were initially defined as long non-coding RNAs that host miRNAs further processed by the microRNA processor complex. A few years ago, however, it was discovered in plants that pri-miRNAs actually contain ... ...

    Abstract Primary transcripts of microRNAs (pri-miRNAs) were initially defined as long non-coding RNAs that host miRNAs further processed by the microRNA processor complex. A few years ago, however, it was discovered in plants that pri-miRNAs actually contain functional open reading frames (sORFs) that translate into small peptides called miPEPs, for microRNA-encoded peptides. Initially detected in
    MeSH term(s) Humans ; Animals ; MicroRNAs/genetics ; Peptides/genetics ; Plants/genetics ; Arabidopsis/genetics ; RNA, Long Noncoding ; Gene Expression Regulation, Plant
    Chemical Substances MicroRNAs ; Peptides ; RNA, Long Noncoding
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13020206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pri peptides temporally coordinate transcriptional programs during epidermal differentiation.

    Gallois, Maylis / Menoret, Delphine / Marques-Prieto, Simon / Montigny, Audrey / Valenti, Philippe / Moussian, Bernard / Plaza, Serge / Payre, François / Chanut-Delalande, Hélène

    Science advances

    2024  Volume 10, Issue 6, Page(s) eadg8816

    Abstract: To achieve a highly differentiated state, cells undergo multiple transcriptional processes whose coordination and timing are not well understood. ... ...

    Abstract To achieve a highly differentiated state, cells undergo multiple transcriptional processes whose coordination and timing are not well understood. In
    MeSH term(s) Animals ; Ecdysone/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; Cell Differentiation/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Peptides/metabolism ; Larva/genetics ; Insecta/genetics ; Gene Expression Regulation, Developmental ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism
    Chemical Substances Ecdysone (3604-87-3) ; Transcription Factors ; Peptides ; Drosophila Proteins
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adg8816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recent advances in mass spectrometry-based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions.

    Fabre, Bertrand / Combier, Jean-Philippe / Plaza, Serge

    Current opinion in chemical biology

    2021  Volume 60, Page(s) 122–130

    Abstract: Short open reading frame (sORF)-encoded polypeptides (SEPs) have recently emerged as key regulators of major cellular processes. Computational methods for the annotation of sORFs combined with transcriptomics and ribosome profiling approaches predicted ... ...

    Abstract Short open reading frame (sORF)-encoded polypeptides (SEPs) have recently emerged as key regulators of major cellular processes. Computational methods for the annotation of sORFs combined with transcriptomics and ribosome profiling approaches predicted the existence of tens of thousands of SEPs across the kingdom of life. Although, we still lack unambiguous evidence for most of them. The method of choice to validate the expression of SEPs is mass spectrometry (MS)-based peptidomics. Peptides are less abundant than proteins, which tends to hinder their detection. Therefore, optimization and enrichment methods are necessary to validate the existence of SEPs. In this article, we discuss the challenges for the detection of SEPs by MS and recent developments of biochemical approaches applied to the study of these peptides. We detail the advances made in the different key steps of a typical peptidomics workflow and highlight possible alternatives that have not been explored yet.
    MeSH term(s) Mass Spectrometry ; Open Reading Frames/genetics ; Peptides/genetics ; Peptides/metabolism ; Proteomics/methods ; Workflow
    Chemical Substances Peptides
    Language English
    Publishing date 2021-01-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2020.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4986: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Transcriptional switches during development

    Plaza, Serge / Payre, François

    (Current topics in developmental biology, ; v. 98)

    2012  

    Author's details edited by Serge Plaza and François Payre
    Series title Current topics in developmental biology, ; v. 98
    MeSH term(s) Transcription, Genetic/physiology ; Genes, Switch/physiology ; Embryonic Development/genetics ; Gene Expression Regulation, Developmental/genetics
    Language English
    Size xvi, 348 p., [22] p. of plates :, ill.
    Edition 1st ed.
    Publisher Elsevier ; Academic Press
    Publishing place Amsterdam
    Document type Book
    ISBN 9780123864994 ; 0123864992
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article ; Online: Evidence That Regulation of Pri-miRNA/miRNA Expression Is Not a General Rule of miPEPs Function in Humans.

    Prel, Anne / Dozier, Christine / Combier, Jean-Philippe / Plaza, Serge / Besson, Arnaud

    International journal of molecular sciences

    2021  Volume 22, Issue 7

    Abstract: Some miRNAs are located in RNA precursors (pri-miRNAs) annotated as long non-coding (lncRNAs) due to absence of long open reading frames (ORFs). However, recent studies have shown that some lnc pri-miRNAs encode peptides called miPEPs (miRNA-encoded ... ...

    Abstract Some miRNAs are located in RNA precursors (pri-miRNAs) annotated as long non-coding (lncRNAs) due to absence of long open reading frames (ORFs). However, recent studies have shown that some lnc pri-miRNAs encode peptides called miPEPs (miRNA-encoded peptides). Initially discovered in plants, three miPEPs have also been identified in humans. Herein, we found that a dozen human pri-miRNAs potentially encode miPEPs, as revealed by ribosome profiling and proteomic databases survey. So far, the only known function of plant miPEPs is to enhance the transcription of their own pri-miRNAs, thereby increasing the level and activity of their associated miRNAs and downregulating the expression of their target genes. To date, in humans, only miPEP133 was shown to promote a positive autoregulatory loop. We investigated whether other human miPEPs are also involved in regulating the expression of their miRNAs by studying miPEP155, encoded by the lnc MIR155HG, miPEP497, a sORF-encoded peptide within lnc MIR497HG, and miPEP200a, encoded by the pri-miRNA of miR-200a/miR-200b. We show that overexpression of these miPEPs is unable to impact the expression/activity of their own pri-miRNA/miRNAs in humans, indicating that the positive feedback regulation observed with plant miPEPs and human miPEP133 is not a general rule of human miPEP function.
    MeSH term(s) Gene Expression Regulation ; Gene Expression Regulation, Neoplastic ; Gene Expression Regulation, Plant ; HeLa Cells ; Humans ; MicroRNAs/chemistry ; MicroRNAs/genetics ; Open Reading Frames ; PC-3 Cells ; Peptides/chemistry ; Proteomics ; RNA Precursors/genetics ; RNA Processing, Post-Transcriptional
    Chemical Substances MicroRNAs ; Peptides ; RNA Precursors
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22073432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Use of microRNA-encoded peptides to improve agronomic traits.

    Ormancey, Mélanie / Guillotin, Bruno / San Clemente, Hélène / Thuleau, Patrice / Plaza, Serge / Combier, Jean-Philippe

    Plant biotechnology journal

    2021  Volume 19, Issue 9, Page(s) 1687–1689

    MeSH term(s) Gene Expression Regulation, Plant ; MicroRNAs/genetics ; Peptides/genetics ; Peptides/metabolism ; Phenotype
    Chemical Substances MicroRNAs ; Peptides
    Language English
    Publishing date 2021-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2136367-5
    ISSN 1467-7652 ; 1467-7644
    ISSN (online) 1467-7652
    ISSN 1467-7644
    DOI 10.1111/pbi.13654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in

    Dozier, Christine / Montigny, Audrey / Viladrich, Mireia / Culerrier, Raphael / Combier, Jean-Philippe / Besson, Arnaud / Plaza, Serge

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and ... ...

    Abstract MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). However, several lnc pri-miRNAs contain translatable small open reading frames (smORFs). If smORFs present within lncRNAs can encode functional small peptides, they can also constitute
    MeSH term(s) Animals ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Open Reading Frames/genetics ; RNA, Long Noncoding ; RNA, Small Untranslated
    Chemical Substances MIRN14 microRNA, Drosophila ; MIRN497 microRNA, human ; MicroRNAs ; RNA, Long Noncoding ; RNA, Small Untranslated
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage.

    Mancheno-Ferris, Alexandra / Immarigeon, Clément / Rivero, Alexia / Depierre, David / Schickele, Naomi / Fosseprez, Olivier / Chanard, Nicolas / Aughey, Gabriel / Lhoumaud, Priscilla / Anglade, Julien / Southall, Tony / Plaza, Serge / Payre, François / Cuvier, Olivier / Polesello, Cédric

    iScience

    2023  Volume 27, Issue 1, Page(s) 108624

    Abstract: The transcription factor Shavenbaby (Svb), the only member of the OvoL family ... ...

    Abstract The transcription factor Shavenbaby (Svb), the only member of the OvoL family in
    Language English
    Publishing date 2023-12-03
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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