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Article ; Online: Interferon Gamma and Contact-dependent Cytotoxicity Are Each Rate Limiting for Natural Killer Cell-Mediated Antibody-dependent Chronic Rejection.

Lin, C M / Plenter, R J / Coulombe, M / Gill, R G

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2016 Volume 16, Issue 11, Page(s) 3121–3130

Abstract: Natural killer (NK) cells are key components of the innate immune system. In murine cardiac transplant models, donor-specific antibodies (DSA), in concert with NK cells, are sufficient to inflict chronic allograft vasculopathy independently of T and B ... ...

Abstract	Natural killer (NK) cells are key components of the innate immune system. In murine cardiac transplant models, donor-specific antibodies (DSA), in concert with NK cells, are sufficient to inflict chronic allograft vasculopathy independently of T and B cells. In this study, we aimed to determine the effector mechanism(s) required by NK cells to trigger chronic allograft vasculopathy during antibody-mediated rejection. Specifically, we tested the relative contribution of the proinflammatory cytokine interferon gamma (IFN-γ) versus the contact-dependent cytotoxic mediators of perforin and the CD95/CD95L (Fas/Fas ligand [FasL]) pathway for triggering these lesions. C3H/HeJ cardiac allografts were transplanted into immune-deficient C57BL/6 rag
MeSH term(s)	Animals ; Antibodies, Monoclonal/immunology ; Cytokines/metabolism ; Fas Ligand Protein/immunology ; Female ; Graft Rejection/immunology ; Heart Transplantation ; Histocompatibility Antigens Class I/metabolism ; Interferon-gamma/metabolism ; Killer Cells, Natural/immunology ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Perforin/immunology ; T-Lymphocytes, Cytotoxic/immunology ; Transplantation, Homologous ; fas Receptor/immunology
Chemical Substances	Antibodies, Monoclonal ; Cytokines ; Fas Ligand Protein ; Fas protein, mouse ; Histocompatibility Antigens Class I ; fas Receptor ; Perforin (126465-35-8) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2016-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.13865
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Article ; Online: C-kit-derived CD11b

Plenter, R J / Coulombe, M G / Roybal, H M / Lin, C M / Gill, R G / Zamora, M R / Grazia, T J

Cellular immunology

2019 Volume 347, Page(s) 104023

Abstract: Autologous C- ... ...

Abstract	Autologous C-kit
MeSH term(s)	Abatacept/pharmacology ; Allografts ; Animals ; CD11b Antigen/metabolism ; Calcineurin Inhibitors ; Cardiomyopathies/mortality ; Cardiomyopathies/surgery ; Cyclosporine/pharmacology ; Female ; Graft Rejection/immunology ; Graft Survival/immunology ; Heart Transplantation/methods ; Immunosuppressive Agents/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myeloid Cells/immunology ; Proto-Oncogene Proteins c-kit/metabolism ; Stem Cell Transplantation ; Stem Cells/physiology ; Transplantation, Homologous
Chemical Substances	CD11b Antigen ; Calcineurin Inhibitors ; Immunosuppressive Agents ; Itgam protein, mouse ; Abatacept (7D0YB67S97) ; Cyclosporine (83HN0GTJ6D) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2019-12-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2019.104023
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Article ; Online: Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory.

Nelsen, M K / Beard, K S / Plenter, R J / Kedl, R M / Clambey, E T / Gill, R G

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2017 Volume 17, Issue 7, Page(s) 1742–1753

Abstract: Several approaches successfully achieve allograft tolerance in preclinical models but are challenging to translate into clinical practice. Many clinically relevant factors can attenuate allograft tolerance induction, including intrinsic genetic ... ...

Abstract	Several approaches successfully achieve allograft tolerance in preclinical models but are challenging to translate into clinical practice. Many clinically relevant factors can attenuate allograft tolerance induction, including intrinsic genetic resistance, peritransplant infection, inflammation, and preexisting antidonor immunity. The prevailing view for immune memory as a tolerance barrier is that the host harbors memory cells that spontaneously cross-react to donor MHC antigens. Such preexisting "heterologous" memory cells have direct reactivity to donor cells and resist most tolerance regimens. In this study, we developed a model system to determine if an alternative form of immune memory could also block tolerance. We posited that host memory T cells could potentially respond to donor-derived non-MHC antigens, such as latent viral antigens or autoantigens, to which the host is immune. Results show that immunity to a model nonself antigen, ovalbumin (OVA), can dramatically disrupt tolerance despite undetectable initial reactivity to donor MHC antigens. Importantly, this blockade of tolerance was CD8
MeSH term(s)	Animals ; Antigen Presentation/immunology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Graft Rejection/immunology ; Immunologic Memory/immunology ; Islets of Langerhans Transplantation/methods ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Ovalbumin/administration & dosage ; Transplantation Tolerance/immunology ; Transplantation, Homologous
Chemical Substances	Ovalbumin (9006-59-1)
Language	English
Publishing date	2017-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.14194
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Article ; Online: Prolongation of cardiac allograft survival by a novel population of autologous CD117+ bone marrow-derived progenitor cells.

Grazia, T J / Plenter, R J / Lepper, H M / Victorino, F / Miyamoto, S D / Crossno, J T / Pietra, B A / Gill, R G / Zamora, M R

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2010 Volume 11, Issue 1, Page(s) 34–44

Abstract: Autologous CD117(+) progenitor cells (PC) have been successfully utilized in myocardial infarction and ischemic injury, potentially through the replacement/repair of damaged vascular endothelium. To date, such cells have not been used to enhance solid ... ...

Abstract	Autologous CD117(+) progenitor cells (PC) have been successfully utilized in myocardial infarction and ischemic injury, potentially through the replacement/repair of damaged vascular endothelium. To date, such cells have not been used to enhance solid organ transplant outcome. In this study, we determined whether autologous bone marrow-derived CD117(+) PC could benefit cardiac allograft survival, possibly by replacing donor vascular cells. Autologous, positively selected CD117(+) PC were administered posttransplantation and allografts were assessed for acute rejection. Although significant generation of recipient vascular cell chimerism was not observed, transferred PC disseminated both to the allograft and to peripheral lymphoid tissues and facilitated a significant, dose-dependent prolongation of allograft survival. While CD117(+) PC dramatically inhibited alloreactive T cell proliferation in vitro, this property did not differ from nonprotective CD117(-) bone marrow populations. In vivo, CD117(+) PC did not significantly inhibit T cell alloreactivity or increase peripheral regulatory T cell numbers. Thus, rather than inhibiting adaptive immunity to the allograft, CD117(+) PC may play a cytoprotective role in prolonging graft survival. Importantly, autologous CD117(+) PC appear to be distinct from bone marrow-derived mesenchymal stem cells (MSC) previously used to prolong allograft survival. As such, autologous CD117(+) PC represent a novel cellular therapy for promoting allograft survival.
MeSH term(s)	Animals ; Bone Marrow Cells/immunology ; Bone Marrow Transplantation/immunology ; Graft Survival/immunology ; Heart Transplantation/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Proto-Oncogene Proteins c-kit/immunology ; Stem Cells/immunology ; T-Lymphocytes/immunology ; Transplantation, Homologous
Chemical Substances	Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2010-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/j.1600-6143.2010.03335.x
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Article: The suspensory ligament of the clitoris: connective tissue supports of the erectile tissues of the female urogenital region.

Rees, M A / O'Connell, H E / Plenter, R J / Hutson, J M

Clinical anatomy (New York, N.Y.)

2000 Volume 13, Issue 6, Page(s) 397–403

Abstract: We aimed to define the gross anatomy of the supporting structures of the clitoris. We performed a dissection of the perineum of a series of 22 female and four male cadavers. Specific dissection of the clitoral and penile suspensory ligament complex was ... ...

Abstract	We aimed to define the gross anatomy of the supporting structures of the clitoris. We performed a dissection of the perineum of a series of 22 female and four male cadavers. Specific dissection of the clitoral and penile suspensory ligament complex was performed in four female and two male cadavers. Serial written observations and photography were used to document the findings. Our findings were then compared with the anatomical description of these structures in the historical and current anatomical literature. The suspensory ligament of clitoris consistently displayed two components: a superficial fibro-fatty structure extending from a broad base within the mons pubis to converge on the body of the clitoris and extending into the labia majora: in addition there is a deep component with a narrow origin on the symphysis pubis extending to the body and the bulbs of the clitoris. The supporting structures of the clitoris are more substantial and complex than previously described. Their shape, extent, and orientation are different from analogous structures of the penis, the suspensory ligament of which was found as described in the literature.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Clitoris/anatomy & histology ; Female ; Humans ; Infant ; Ligaments/anatomy & histology ; Male ; Middle Aged ; Penis/anatomy & histology
Language	English
Publishing date	2000
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1025505-9
ISSN	1098-2353 ; 0897-3806
ISSN (online)	1098-2353
ISSN	0897-3806
DOI	10.1002/1098-2353(2000)13:6<397::AID-CA1>3.0.CO;2-2
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Zs.A 2592: Show issues

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Article: Anatomical relationship between urethra and clitoris.

O'Connell, H E / Hutson, J M / Anderson, C R / Plenter, R J

The Journal of urology

1998 Volume 159, Issue 6, Page(s) 1892–1897

Abstract: Purpose: We investigated the anatomical relationship between the urethra and the surrounding erectile tissue, and reviewed the appropriateness of the current nomenclature used to describe this anatomy.: Materials and methods: A detailed dissection ... ...

Abstract	Purpose: We investigated the anatomical relationship between the urethra and the surrounding erectile tissue, and reviewed the appropriateness of the current nomenclature used to describe this anatomy. Materials and methods: A detailed dissection was performed on 2 fresh and 8 fixed human female adult cadavers (age range 22 to 88 years). The relationship of the urethra to the surrounding erectile tissue was ascertained in each specimen, and the erectile tissue arrangement was determined and compared to standard anatomical descriptions. Nerves supplying the erectile tissue were carefully preserved and their relationship to the soft tissues and bony pelvis was noted. Results: The female urethra, distal vaginal wall and erectile tissue are packed into the perineum caudal (superficial) to the pubic arch, which is bounded laterally by the ischiopubic rami, and superficially by the labia minora and majora. This complex is not flat against the rami as is commonly depicted but projects from the bony landmarks for 3 to 6 cm. The perineal urethra is embedded in the anterior vaginal wall and is surrounded by erectile tissue in all directions except posteriorly where it relates to the vaginal wall. The bulbs of the vestibule are inappropriately named as they directly relate to the other clitoral components and the urethra. Their association with the vestibule is inconsistent and, thus, we recommend that these structures be renamed the bulbs of the clitoris. Conclusions: A series of detailed dissections suggest that current anatomical descriptions of female human urethral and genital anatomy are inaccurate.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cadaver ; Clitoris/anatomy & histology ; Female ; Humans ; Middle Aged ; Urethra/anatomy & histology
Language	English
Publishing date	1998-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/S0022-5347(01)63188-4
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Infiltrating cells in mouse cardiac allografts after anti-CD4 monoclonal antibody treatment.

Han, W R / Mottram, P L / Purcell, L J / Plenter, R J / McKenzie, I F

Transplantation proceedings

1995 Volume 27, Issue 3, Page(s) 2163

MeSH term(s)	Animals ; Antibodies, Monoclonal/therapeutic use ; CD4-Positive T-Lymphocytes/immunology ; Cytotoxicity, Immunologic ; Heart Transplantation/immunology ; Immunity, Cellular ; Immunosuppression/methods ; Mice ; Mice, Inbred BALB C ; Mice, Inbred CBA
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	1995-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
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Article: Enhancement of rabbit cardiac allografts by third-party hepatocytes.

Mitchell, S V / Dumble, L J / Plenter, R J / Millar, R J / Clunie, G J

Transplantation proceedings

1991 Volume 23, Issue 1 Pt 1, Page(s) 737–738

MeSH term(s)	Animals ; Graft Survival ; Heart Transplantation/immunology ; Immunosuppression ; Liver Transplantation/immunology ; Rabbits ; Tissue Transplantation ; Transplantation, Homologous
Language	English
Publishing date	1991-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
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Article: Enhancement of rabbit skin allograft survival by pretransplant and peroperative hepatic antigen treatments.

Mitchell, S V / Dumble, L J / Plenter, R J / Millar, R J / Clunie, G J

Transplantation proceedings

1990 Volume 22, Issue 5, Page(s) 2097–2098

MeSH term(s)	Animals ; Antigens/administration & dosage ; Blood Transfusion ; Female ; Graft Survival ; Immunosuppression ; Liver/immunology ; Necrosis ; Rabbits ; Skin Transplantation/immunology ; Skin Transplantation/pathology ; Transplantation, Autologous ; Transplantation, Homologous
Chemical Substances	Antigens
Language	English
Publishing date	1990-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
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Article: Cyclosporine-sparing influence of the synthetic PGE1 analogue enisoprost in rabbit cardiac allograft recipients.

Mitchell, S V / Dumble, L J / Plenter, R J / Millar, R J / Moran, M / Clunie, G J

Transplantation proceedings

1992 Volume 24, Issue 1, Page(s) 229–230

MeSH term(s)	Alprostadil/analogs & derivatives ; Alprostadil/therapeutic use ; Animals ; Cyclosporine/therapeutic use ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Graft Survival ; Heart Transplantation/immunology ; Rabbits ; Transplantation, Homologous
Chemical Substances	Cyclosporine (83HN0GTJ6D) ; Alprostadil (F5TD010360) ; enisoprost (J85F4K48Q1)
Language	English
Publishing date	1992-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
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