Article ; Online: A TLR4 agonist liposome formulation effectively stimulates innate immunity and enhances protection from bacterial infection.
2023 Volume 29, Issue 3-4, Page(s) 45–57
Abstract: Stimulation of innate immunity can protect against infectious insult and could be used in combination with other therapies. Since antibiotic resistance is an increasing concern, strategies to reduce the dose or eliminate the need for these drugs are ... ...
| Abstract | Stimulation of innate immunity can protect against infectious insult and could be used in combination with other therapies. Since antibiotic resistance is an increasing concern, strategies to reduce the dose or eliminate the need for these drugs are warranted. Lipo-CRX is a formulation in which the TLR4 agonist CRX-527 is incorporated into lipid membranes in liposomes. Lipo-CRX is less inflammatory than either CRX-527 or LPS, but retains unique capacity to enhance host defense responses. We compared lipo-CRX to other agonists |
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| MeSH term(s) | Animals ; Cattle ; Mice ; Brucella abortus ; Liposomes ; Toll-Like Receptor 4 ; Lipopolysaccharides/pharmacology ; Escherichia coli ; Immunity, Innate ; Brucellosis ; Mammals |
| Chemical Substances | AGP 527 ; Liposomes ; Toll-Like Receptor 4 ; Lipopolysaccharides ; Tlr4 protein, mouse |
| Language | English |
| Publishing date | 2023-04-21 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2381250-3 |
| ISSN | 1753-4267 ; 1753-4259 |
| ISSN (online) | 1753-4267 |
| ISSN | 1753-4259 |
| DOI | 10.1177/17534259231168725 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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