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Article ; Online: Biologic drugs in the treatment of chronic inflammatory pulmonary diseases: recent developments and future perspectives.

Plichta, Jacek / Kuna, Piotr / Panek, Michał

2023 Volume 14, Page(s) 1207641

Abstract: Chronic inflammatory diseases of the lung are some of the leading causes of mortality and significant morbidity worldwide. Despite the tremendous burden these conditions put on global healthcare, treatment options for most of these diseases remain scarce. ...

Abstract	Chronic inflammatory diseases of the lung are some of the leading causes of mortality and significant morbidity worldwide. Despite the tremendous burden these conditions put on global healthcare, treatment options for most of these diseases remain scarce. Inhaled corticosteroids and beta-adrenergic agonists, while effective for symptom control and widely available, are linked to severe and progressive side effects, affecting long-term patient compliance. Biologic drugs, in particular peptide inhibitors and monoclonal antibodies show promise as therapeutics for chronic pulmonary diseases. Peptide inhibitor-based treatments have already been proposed for a range of diseases, including infectious disease, cancers and even Alzheimer disease, while monoclonal antibodies have already been implemented as therapeutics for a range of conditions. Several biologic agents are currently being developed for the treatment of asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and pulmonary sarcoidosis. This article is a review of the biologics already employed in the treatment of chronic inflammatory pulmonary diseases and recent progress in the development of the most promising of those treatments, with particular focus on randomised clinical trial outcomes.
MeSH term(s)	Humans ; Biological Products/therapeutic use ; Administration, Inhalation ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Chronic Disease ; Lung ; Antibodies, Monoclonal/therapeutic use
Chemical Substances	Biological Products ; Antibodies, Monoclonal
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1207641
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Article: Investigation of the Surface Treatment Process of AISI 304 Stainless Steel by Centrifugal Disc Finishing with the Use of an Active Workpiece Holder.

Juniewicz, Mateusz / Plichta, Jarosław / Sutowska, Marzena / Łukianowicz, Czesław / Kukiełka, Krzysztof / Zawadka, Wojciech

Materials (Basel, Switzerland)

2022 Volume 15, Issue 19

Abstract: This article presents the results of experimental studies of the centrifugal disc finishing (CDF) process of 304 steel elements with the use of an active workpieces holder, that allows workpieces for additional rotational and oscillation movements. The ... ...

Abstract	This article presents the results of experimental studies of the centrifugal disc finishing (CDF) process of 304 steel elements with the use of an active workpieces holder, that allows workpieces for additional rotational and oscillation movements. The main aim of the research was to evaluate the mechanism of formation of the surface texture and to assess the intensity and effectiveness of the machining process. It is shown that additional movements of the workpiece significantly affect the formation of the machining traces generated by the elementary phenomena of micro-cutting, scratching, grooving, etc. As a result, these combined and complex interactions lead to the formation of the surface topography of the workpieces. Based on the research results, it can be concluded that the use of an active workpiece holder in the CDF process allows changes in the intensity of the machining process. Moreover, the active holder allows modification of the surface smoothing process. The intensity of the treatment process depends primarily on the location of the workpiece holder in the appropriate energy area of the work charge. On the other hand, the efficiency of the workpiece surface smoothing depends on the parameters of the oscillation and rotational movements of the workpiece mounted in the active holder. The presented research results show that the use of an active holder, enabling rotation and oscillation of the workpiece, may lead to a more effective use of smoothing processes in CDF machines. The analysis of the results shows that the values of the
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15196762
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Article: The Role of Observation-Measurement Methods in the Surface Characterization of X39Cr13 Stainless-Steel Cutting Blades Used in the Fish Processing Industry.

Kapłonek, Wojciech / Nadolny, Krzysztof / Zieliński, Bartosz / Plichta, Jarosław / Pimenov, Danil Yurievich / Sharma, Shubham

Materials (Basel, Switzerland)

2020 Volume 13, Issue 24

Abstract: In the modern fish processing industry, flat fishes play an important role. They are processed into a final product in the form of a fillet during the skinning operation, which is carried out on machines operating in automated production lines. These ... ...

Abstract	In the modern fish processing industry, flat fishes play an important role. They are processed into a final product in the form of a fillet during the skinning operation, which is carried out on machines operating in automated production lines. These machines are usually equipped with a single planar cutting blade or a few of such blades. The high-efficiency skinning and industrial conditions cause rapid wear of the cutting edge of the blade, which is detrimental to the quality of the final product. One of the forms of renewing the cutting ability of these types of tools is the regeneration carried out with the use of precise traverse surface grinding. The results of this process must be carefully verified for determining its correctness and possible optimization of its parameters. The main goal of this article was to characterize the usefulness of a number of observational and measuring methods to evaluate the results of the technical blade regeneration process. In this work, a number of contemporary observation-measurement methods such as optical microscopy (OM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), optical profilometry (OP), and angle-resolved scattering (ARS), supported by image processing and analysis techniques, were analyzed. The authors focused on presenting the role of the abovementioned methods in the surface characterization of planar cutting blades made of X39Cr13 chromium martensitic stainless steel before and after the technological operation of flat-fish skinning. Additionally, the surface condition after the regeneration process carried out using the five-axis CNC (computerized numerical control) grinding machine was also assessed. Numerous results of surface observations, elemental composition microanalysis, high-accuracy surface microgeometry measurements, and quantitative and qualitative analysis confirming the possibility of using the proposed methods in the presented applications are presented.
Language	English
Publishing date	2020-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13245796
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Article ; Online: Survival Benefit of Chemotherapy According to 21-Gene Recurrence Score in Young Women with Breast Cancer.

Nash, A L / Ren, Y / Plichta, J K / Rosenberger, L H / van den Bruele, A M B / DiNome, M L / Westbrook, K / Hwang, E Shelley

Annals of surgical oncology

2023 Volume 30, Issue 4, Page(s) 2130–2139

Abstract: Background: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of ... ...

Abstract	Background: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of chemotherapy according to RS among younger women eligible for oncotype testing. Methods: Women aged 40-50, diagnosed with HR-positive, HER2-negative breast cancer between 2010 and 2017 were selected from the National Cancer Database (NCBD). Patients were grouped by age, RS, nodal status, and chemotherapy receipt. Kaplan-Meier curves were used to compare unadjusted overall survival (OS) between the groups, and log-rank tests were used to test for a difference between groups. Cox proportional hazards models were used to examine the association between select factors and OS. Results: A total of 15,422 patients met inclusion criteria, 45.3% of whom received chemotherapy. Median follow-up time was 66.4 (50.6-86.6) months. Patients who received chemotherapy were more likely to have higher-stage and higher-grade tumors, tumors that were PR-negative, and have higher RS (p < 0.001 for all). RS was prognostic for OS regardless of nodal status. After adjustment, chemotherapy was associated with a significant improvement in OS only in the pN1 RS 31-50 subgroup (p = 0.02). Conclusions: RS retains its prognostic value in younger patients with early stage HR-positive, HER2-negative breast cancer. Chemotherapy survival benefit was limited to patients aged 40-50 with pN1 disease and RS of 31-50. Therefore, chemotherapy decision-making should be especially preference-sensitive in women aged 40-50 with intermediate RS, where it may not provide a survival benefit for many women.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Biomarkers, Tumor/genetics ; Receptors, Estrogen ; Prognosis ; Proportional Hazards Models ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Chemotherapy, Adjuvant
Chemical Substances	Biomarkers, Tumor ; Receptors, Estrogen
Language	English
Publishing date	2023-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-12699-3
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Article ; Online: Risk factors for persistent pain after breast cancer surgery: a multicentre prospective cohort study.

Tan, H S / Plichta, J K / Kong, A / Tan, C W / Hwang, S / Sultana, R / Wright, M C / Sia, A T H / Sng, B L / Habib, A S

Anaesthesia

2023 Volume 78, Issue 4, Page(s) 432–441

Abstract: Identifying factors associated with persistent pain after breast cancer surgery may facilitate risk stratification and individualised management. Single-population studies have limited generalisability as socio-economic and genetic factors contribute to ... ...

Abstract	Identifying factors associated with persistent pain after breast cancer surgery may facilitate risk stratification and individualised management. Single-population studies have limited generalisability as socio-economic and genetic factors contribute to persistent pain development. Therefore, this prospective multicentre cohort study aimed to develop a predictive model from a sample of Asian and American women. We enrolled women undergoing elective breast cancer surgery at KK Women's and Children's Hospital and Duke University Medical Center. Pre-operative patient and clinical characteristics and EQ-5D-3L health status were recorded. Pain catastrophising scale; central sensitisation inventory; coping strategies questionnaire-revised; brief symptom inventory-18; perceived stress scale; mechanical temporal summation; and pressure-pain threshold assessments were performed. Persistent pain was defined as pain score ≥ 3 or pain affecting activities of daily living 4 months after surgery. Univariate associations were generated using generalised estimating equations. Enrolment site was forced into the multivariable model, and risk factors with p < 0.2 in univariate analyses were considered for backwards selection. Of 210 patients, 135 (64.3%) developed persistent pain. The multivariable model attained AUC = 0.807, with five independent associations: age (OR 0.85 95%CI 0.74-0.98 per 5 years); diabetes (OR 4.68, 95%CI 1.03-21.22); pre-operative pain score at sites other than the breast (OR 1.48, 95%CI 1.11-1.96); previous mastitis (OR 4.90, 95%CI 1.31-18.34); and perceived stress scale (OR 1.35, 95%CI 1.01-1.80 per 5 points), after adjusting for: enrolment site; pre-operative pain score at the breast; pre-operative overall pain score at rest; postoperative non-steroidal anti-inflammatory drug use; and pain catastrophising scale. Future research should validate this model and evaluate pre-emptive interventions to reduce persistent pain risk.
MeSH term(s)	Child ; Humans ; Female ; Child, Preschool ; Breast Neoplasms/surgery ; Prospective Studies ; Cohort Studies ; Activities of Daily Living ; Pain ; Risk Factors ; Pain, Postoperative/epidemiology ; Pain, Postoperative/etiology ; Pain, Postoperative/diagnosis
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1111/anae.15958
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Article ; Online: Call for action: expanding global access to hereditary cancer genetic testing.

Bychkovsky, Brittany / Rana, Huma Q / Ademuyiwa, Foluso / Plichta, Jennifer / Anderson, Karen / Nogueira-Rodrigues, Angélica / Santa-Maria, Cesar A / Coffman, Lan G / Marquez, Carol / Das, Arunangshu / Taghian, Alphonse / Koeller, Diane R / Sandoval, Renata L / Park, Ben Ho / Dizon, Don S

The Lancet. Oncology

2022 Volume 23, Issue 9, Page(s) 1124–1126

MeSH term(s)	Genetic Counseling ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(22)00378-3
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Genetic Counseling and Testing in African American Patients With Breast Cancer: A Nationwide Survey of US Breast Oncologists.

Ademuyiwa, Foluso O / Salyer, Patricia / Tao, Yu / Luo, Jingqin / Hensing, Whitney L / Afolalu, Abisola / Peterson, Lindsay L / Weilbaecher, Katherine / Housten, Ashley J / Baumann, Ana A / Desai, Monica / Jones, Susan / Linnenbringer, Erin / Plichta, Jennifer / Bierut, Laura

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2021 Volume 39, Issue 36, Page(s) 4020–4028

Abstract: Purpose: To determine if physicians' self-reported knowledge, attitudes, and practices regarding genetic counseling and testing (GCT) vary by patients' race.: Methods: We conducted a nationwide 49-item survey among breast oncology physicians in the ... ...

Abstract	Purpose: To determine if physicians' self-reported knowledge, attitudes, and practices regarding genetic counseling and testing (GCT) vary by patients' race. Methods: We conducted a nationwide 49-item survey among breast oncology physicians in the United States. We queried respondents about their own demographics, clinical characteristics, knowledge, attitudes, practices, and perceived barriers in providing GCT to patients with breast cancer. Results: Our survey included responses from 277 physicians (females, 58.8%; medical oncologists, 75.1%; academic physicians, 61.7%; and Whites, 67.1%). Only 1.8% indicated that they were more likely to refer a White patient than refer an African American patient for GCT, and 66.9% believed that African American women with breast cancer have lower rates of GCT than White women. Regarding perceived barriers to GCT, 63.4% of respondents indicated that African American women face more barriers than White women do and 21% felt that African American women require more information and guidance during the GCT decision-making process than White women. Although 32% of respondents indicated that lack of trust was a barrier to GCT in all patients, 58.1% felt that this was a greater barrier for African American women ( Conclusion: We demonstrated that racial differences exist in oncology physicians' perceived barriers to GCT for patients with breast cancer. This nationwide survey will serve as a basis for understanding physicians' determinants of GCT for African American women and highlights the necessity of education and interventions to address bias among physicians. Awareness of such physician biases can enable further work to address inequities, ultimately leading to improved GCT equity for African American women with breast cancer.
MeSH term(s)	Adult ; African Americans ; Aged ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Female ; Genetic Counseling/methods ; Genetic Testing/methods ; Humans ; Middle Aged ; Oncologists/standards ; Self Report ; Surveys and Questionnaires ; United States
Language	English
Publishing date	2021-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.21.01426
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Neoadjuvant Endocrine Therapy Versus Neoadjuvant Chemotherapy in Node-Positive Invasive Lobular Carcinoma.

Thornton, M J / Williamson, H V / Westbrook, K E / Greenup, R A / Plichta, J K / Rosenberger, L H / Gupta, A M / Hyslop, T / Hwang, E S / Fayanju, O M

Annals of surgical oncology

2019 Volume 26, Issue 10, Page(s) 3166–3177

Abstract: Background: Neoadjuvant chemotherapy (NACT) is often recommended for patients with node-positive invasive lobular carcinoma (ILC) despite unclear benefit in this largely hormone receptor-positive (HR+) group. We sought to compare overall survival (OS) ... ...

Abstract	Background: Neoadjuvant chemotherapy (NACT) is often recommended for patients with node-positive invasive lobular carcinoma (ILC) despite unclear benefit in this largely hormone receptor-positive (HR+) group. We sought to compare overall survival (OS) between patients with node-positive ILC who received neoadjuvant endocrine therapy (NET) and those who received NACT. Methods: Women with cT1-4c, cN1-3 HR+ ILC in the National Cancer Data Base (2004-2014) who underwent surgery following neoadjuvant therapy were identified. Kaplan-Meier curves and Cox proportional hazards modeling were used to estimate unadjusted and adjusted overall survival (OS), respectively. Results: Of the 5942 patients in the cohort, 855 received NET and 5087 received NACT. NET recipients were older (70 vs. 54 years) and had more comorbidities (Charlson-Deyo score ≥ 1: 21.1% vs. 11.5%), lower cT classification (cT3-4: 44.2% vs. 51.0%), lower rates of mastectomy (72.5% vs. 82.2%), lower rates of pathologic complete response (0% vs. 2.5%), and lower rates of postlumpectomy (73.2% vs. 91.0%) and postmastectomy (60.0% vs. 80.8%) radiation versus NACT recipients (all p < 0.001). NACT recipients had higher unadjusted 10-year OS versus NET recipients (57.9% vs. 36.0%), but after adjustment, there was no significant difference in OS between the two groups (p = 0.10). Conclusions: Patients with node-positive ILC who received NET presented with smaller tumors, older age, and greater burden of comorbidities versus NACT recipients but had similar adjusted OS. While there is evidence from clinical trials supporting efficacy of NET in HR+ breast cancer, our findings suggest the need for further, histology-specific investigation regarding the optimal inclusion and sequence of endocrine therapy and chemotherapy in ILC.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Aromatase Inhibitors/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Carcinoma, Lobular/drug therapy ; Carcinoma, Lobular/pathology ; Chemotherapy, Adjuvant/mortality ; Female ; Follow-Up Studies ; Humans ; Lymph Nodes/pathology ; Middle Aged ; Neoadjuvant Therapy/mortality ; Neoplasm Invasiveness ; Prognosis ; Survival Rate
Chemical Substances	Aromatase Inhibitors
Language	English
Publishing date	2019-07-24
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-019-07564-9
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Book ; Thesis: Prallstrahlströmung in der Gasfeuchtigkeitsmeßtechnik

Plichta, J

1984

Author's details	J Plichta
Language	German
Size	VI, 113 S
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Techn. Hochsch, Fak. für Maschineningenieurwesen, Diss.--Karl-Marx-Stadt, 1984
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Dosahovanie projektovanych parametrov na stavbach SM vo Vychodoslovenskom kraji

Plichta, J

Statni statky 1978. v. 21 (8)

1978

Title translation	Attainment of projected parameters on state farm constructions in the East Slovakian region.
Keywords	Czechoslovakia
Language	Slovak
Size	p. 179-181., ill.
Document type	Article
ZDB-ID	406860-9
ISSN	0039-0704
ISSN	0039-0704
Database	NAL-Catalogue (AGRICOLA)

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