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  1. Article: Multiomics Picture of Obesity in Young Adults.

    Kiseleva, Olga I / Pyatnitskiy, Mikhail A / Arzumanian, Viktoriia A / Kurbatov, Ilya Y / Ilinsky, Valery V / Ilgisonis, Ekaterina V / Plotnikova, Oksana A / Sharafetdinov, Khaider K / Tutelyan, Victor A / Nikityuk, Dmitry B / Ponomarenko, Elena A / Poverennaya, Ekaterina V

    Biology

    2024  Volume 13, Issue 4

    Abstract: Obesity is a socially significant disease that is characterized by a disproportionate accumulation of fat. It is also associated with chronic inflammation, cancer, diabetes, and other comorbidities. Investigating biomarkers and pathological processes ... ...

    Abstract Obesity is a socially significant disease that is characterized by a disproportionate accumulation of fat. It is also associated with chronic inflammation, cancer, diabetes, and other comorbidities. Investigating biomarkers and pathological processes linked to obesity is especially vital for young individuals, given their increased potential for lifestyle modifications. By comparing the genetic, proteomic, and metabolomic profiles of individuals categorized as underweight, normal, overweight, and obese, we aimed to determine which omics layer most accurately reflects the phenotypic changes in an organism that result from obesity. We profiled blood plasma samples by employing three omics methodologies. The untargeted GC×GC-MS metabolomics approach identified 313 metabolites. To augment the metabolomic dataset, we integrated a label-free HPLC-MS/MS proteomics method, leading to the identification of 708 proteins. The genomic layer encompassed the genotyping of 647,250 SNPs. Utilizing omics data, we trained sparse Partial Least Squares models to predict body mass index. Molecular features exhibiting frequently non-zero coefficients were selected as potential biomarkers, and we further explored enriched biological pathways. Proteomics was the most effective in single-omics analyses, with a median absolute error (MAE) of 5.44 ± 0.31 kg/m
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13040272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Clinical Blood Metabogram: Application to Overweight and Obese Patients.

    Lokhov, Petr G / Balashova, Elena E / Trifonova, Oxana P / Maslov, Dmitry L / Plotnikova, Oksana A / Sharafetdinov, Khaider K / Nikityuk, Dmitry B / Tutelyan, Victor A / Ponomarenko, Elena A / Archakov, Alexander I

    Metabolites

    2023  Volume 13, Issue 7

    Abstract: Recently, the concept of a mass spectrometric blood metabogram was introduced, which allows the analysis of the blood metabolome in terms of the time, cost, and reproducibility of clinical laboratory tests. It was demonstrated that the components of the ... ...

    Abstract Recently, the concept of a mass spectrometric blood metabogram was introduced, which allows the analysis of the blood metabolome in terms of the time, cost, and reproducibility of clinical laboratory tests. It was demonstrated that the components of the metabogram are related groups of the blood metabolites associated with humoral regulation; the metabolism of lipids, carbohydrates, and amines; lipid intake into the organism; and liver function, thereby providing clinically relevant information. The purpose of this work was to evaluate the relevance of using the metabogram in a disease. To do this, the metabogram was used to analyze patients with various degrees of metabolic alterations associated with obesity. The study involved 20 healthy individuals, 20 overweight individuals, and 60 individuals with class 1, 2, or 3 obesity. The results showed that the metabogram revealed obesity-associated metabolic alterations, including changes in the blood levels of steroids, amino acids, fatty acids, and phospholipids, which are consistent with the available scientific data to date. Therefore, the metabogram allows testing of metabolically unhealthy overweight or obese patients, providing both a general overview of their metabolic alterations and detailing their individual characteristics. It was concluded that the metabogram is an accurate and clinically applicable test for assessing an individual's metabolic status in disease.
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13070798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Does Proteomic Mirror Reflect Clinical Characteristics of Obesity?

    Kiseleva, Olga I / Arzumanian, Viktoriia A / Poverennaya, Ekaterina V / Pyatnitskiy, Mikhail A / Ilgisonis, Ekaterina V / Zgoda, Victor G / Plotnikova, Oksana A / Sharafetdinov, Khaider K / Lisitsa, Andrey V / Tutelyan, Victor A / Nikityuk, Dmitry B / Archakov, Alexander I / Ponomarenko, Elena A

    Journal of personalized medicine

    2021  Volume 11, Issue 2

    Abstract: Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive ...

    Abstract Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive intake of "cheap calories" are major contributors to obesity, triggering type 2 diabetes, cardiovascular diseases, and other comorbidities. Understanding the molecular mechanisms responsible for development of obesity is essential as it might result in the introducing of anti-obesity targets and early-stage obesity biomarkers, allowing the distinction between metabolic syndromes. The complex nature of this disease, coupled with the phenomenon of metabolically healthy obesity, inspired us to perform data-centric, hypothesis-generating pilot research, aimed to find correlations between parameters of classic clinical blood tests and proteomic profiles of 104 lean and obese subjects. As the result, we assembled patterns of proteins, which presence or absence allows predicting the weight of the patient fairly well. We believe that such proteomic patterns with high prediction power should facilitate the translation of potential candidates into biomarkers of clinical use for early-stage stratification of obesity therapy.
    Language English
    Publishing date 2021-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11020064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients--a randomized double-blind placebo-controlled pilot study.

    Sharafedtinov, Khaider K / Plotnikova, Oksana A / Alexeeva, Ravilay I / Sentsova, Tatjana B / Songisepp, Epp / Stsepetova, Jelena / Smidt, Imbi / Mikelsaar, Marika

    Nutrition journal

    2013  Volume 12, Page(s) 138

    Abstract: Background: Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche Sammlung für Mikroorganismen, DSM 21380) ... ...

    Abstract Background: Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche Sammlung für Mikroorganismen, DSM 21380) could reduce some symptoms of metabolic syndrome in Russian adults with obesity and hypertension.
    Methods: In this 3-week, randomized, double-blind, placebo-controlled, parallel pilot study, 25 subjects ingested probiotic cheese and 15 ingested control cheese. Fifty grams of each cheese provided 175 kcal of energy. Blood pressure (BP), anthropometric characteristics, markers of liver and kidney function, metabolic indices (plasma glucose, lipids, and cholesterol), and urine polyamines were measured. Counts of fecal lactobacilli and L. plantarum TENSIA were evaluated using molecular methods. The data were analyzed by t-test for independent samples and Spearman's partial correlation analysis.
    Results: The probiotic L. plantarum TENSIA was present in variable amounts (529.6 ± 232.5 gene copies) in 16/25 (64%) study subjects. Body mass index (BMI) was significantly reduced (p = 0.031) in the probiotic cheese group versus the control cheese group. The changes in BMI were closely associated with the water content of the body (r = 0.570, p = 0.0007) when adjusted for sex and age. Higher values of intestinal lactobacilli after probiotic cheese consumption were associated with higher BMI (r = 0.383, p = 0.0305) and urinary putrescine content (r = 0.475, p = 0.006). In patients simultaneously treated with BP-lowering drugs, similar reductions of BP were observed in both groups. A positive association was detected between TENSIA colonization and the extent of change of morning diastolic BP (r = 0.617, p = 0.0248) and a trend toward lower values of morning systolic BP (r = -0.527, p = 0.0640) at the end of the study after adjusting for BMI, age, and sex.
    Conclusion: In a pilot study of obese hypertensive patients, a hypocaloric diet supplemented with a probiotic cheese helps to reduce BMI and arterial BP values, recognized symptoms of metabolic syndrome.
    MeSH term(s) Adult ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Body Mass Index ; Cheese/adverse effects ; Cheese/analysis ; Cheese/microbiology ; Combined Modality Therapy/adverse effects ; Diet, Reducing/adverse effects ; Double-Blind Method ; Estonia ; Feces/microbiology ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/etiology ; Hypertension/prevention & control ; Lactobacillaceae/growth & development ; Lactobacillaceae/isolation & purification ; Lactobacillaceae/metabolism ; Lactobacillus plantarum/growth & development ; Lactobacillus plantarum/isolation & purification ; Lactobacillus plantarum/metabolism ; Male ; Metabolic Syndrome/diet therapy ; Metabolic Syndrome/microbiology ; Metabolic Syndrome/physiopathology ; Metabolic Syndrome/urine ; Middle Aged ; Obesity/etiology ; Obesity/prevention & control ; Pilot Projects ; Probiotics/adverse effects ; Probiotics/metabolism ; Probiotics/therapeutic use ; Putrescine/analysis ; Putrescine/metabolism ; Putrescine/urine ; Weight Loss
    Chemical Substances Antihypertensive Agents ; Putrescine (V10TVZ52E4)
    Language English
    Publishing date 2013-10-12
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1475-2891
    ISSN (online) 1475-2891
    DOI 10.1186/1475-2891-12-138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - a randomized double-blind placebo-controlled pilot study

    Sharafedtinov, Khaider K / Plotnikova, Oksana A / Alexeeva, Ravilay I / Sentsova, Tatjana B / Songisepp, Epp / Stsepetova, Jelena / Smidt, Imbi / Mikelsaar, Marika

    Nutrition journal. 2013 Dec., v. 12, no. 1

    2013  

    Abstract: BACKGROUND: Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche Sammlung für Mikroorganismen, DSM 21380) ... ...

    Abstract BACKGROUND: Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche Sammlung für Mikroorganismen, DSM 21380) could reduce some symptoms of metabolic syndrome in Russian adults with obesity and hypertension. METHODS: In this 3-week, randomized, double-blind, placebo-controlled, parallel pilot study, 25 subjects ingested probiotic cheese and 15 ingested control cheese. Fifty grams of each cheese provided 175 kcal of energy. Blood pressure (BP), anthropometric characteristics, markers of liver and kidney function, metabolic indices (plasma glucose, lipids, and cholesterol), and urine polyamines were measured. Counts of fecal lactobacilli and L. plantarum TENSIA were evaluated using molecular methods. The data were analyzed by t-test for independent samples and Spearman’s partial correlation analysis. RESULTS: The probiotic L. plantarum TENSIA was present in variable amounts (529.6 ± 232.5 gene copies) in 16/25 (64%) study subjects. Body mass index (BMI) was significantly reduced (p = 0.031) in the probiotic cheese group versus the control cheese group. The changes in BMI were closely associated with the water content of the body (r = 0.570, p = 0.0007) when adjusted for sex and age. Higher values of intestinal lactobacilli after probiotic cheese consumption were associated with higher BMI (r = 0.383, p = 0.0305) and urinary putrescine content (r = 0.475, p = 0.006). In patients simultaneously treated with BP-lowering drugs, similar reductions of BP were observed in both groups. A positive association was detected between TENSIA colonization and the extent of change of morning diastolic BP (r = 0.617, p = 0.0248) and a trend toward lower values of morning systolic BP (r = −0.527, p = 0.0640) at the end of the study after adjusting for BMI, age, and sex. CONCLUSION: In a pilot study of obese hypertensive patients, a hypocaloric diet supplemented with a probiotic cheese helps to reduce BMI and arterial BP values, recognized symptoms of metabolic syndrome. TRIAL REGISTRATION: Current Controlled Trials ISRCTN76271778
    Keywords Lactobacillus plantarum ; adults ; blood glucose ; blood pressure ; body mass index ; cheeses ; cholesterol ; dairy consumption ; drugs ; energy ; genes ; humans ; hypertension ; liver ; metabolic syndrome ; obesity ; patients ; polyamines ; probiotics ; putrescine ; renal function ; t-test ; urine ; water content
    Language English
    Dates of publication 2013-12
    Size p. 714.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2091602-4
    ISSN 1475-2891
    ISSN 1475-2891
    DOI 10.1186/1475-2891-12-138
    Database NAL-Catalogue (AGRICOLA)

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