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  1. Article ; Online: Cerebral Lactate Uptake After Half-Molar Sodium Lactate Therapy in Traumatic Brain Injury: A Brief Report.

    Plourde, Guillaume / Ichai, Carole / Quintard, Hervé

    Journal of neurotrauma

    2024  

    Abstract: Exogenous sodium lactate has many advantages after traumatic brain injury, including intracranial pressure control and alternative energetic supply. It remains unclear, however, whether half-molar sodium lactate (HSL) is effectively incorporated in brain ...

    Abstract Exogenous sodium lactate has many advantages after traumatic brain injury, including intracranial pressure control and alternative energetic supply. It remains unclear, however, whether half-molar sodium lactate (HSL) is effectively incorporated in brain metabolism, which we can verify using the arteriovenous difference in lactate (AVD
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2023.0508
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    Zs.A 2016: Show issues Location:
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  2. Article ; Online: Variations in Autoregulation-Based Optimal Cerebral Perfusion Pressure Determination Using Two Integrated Neuromonitoring Platforms in a Trauma Patient.

    Plourde, Guillaume / Carrier, François Martin / Bijlenga, Philippe / Quintard, Hervé

    Neurocritical care

    2024  

    Abstract: Background: Neuromonitoring devices are often used in traumatic brain injury. The objective of this report is to raise awareness concerning variations in optimal cerebral perfusion pressure (CPPopt) determination using exploratory information provided ... ...

    Abstract Background: Neuromonitoring devices are often used in traumatic brain injury. The objective of this report is to raise awareness concerning variations in optimal cerebral perfusion pressure (CPPopt) determination using exploratory information provided by two neuromonitoring monitors that are part of research programs (Moberg CNS Monitor and RAUMED NeuroSmart LogO).
    Methods: We connected both monitors simultaneously to a parenchymal intracranial pressure catheter and recorded the pressure reactivity index (PRx) and the derived CPPopt estimates for a patient with a severe traumatic brain injury. These estimates were available at the bedside and were updated at each minute.
    Results: Using the Bland and Altman method, we found a mean variation of - 3.8 (95% confidence internal from - 8.5 to 0.9) mm Hg between the CPPopt estimates provided by the two monitors (limits of agreement from - 26.6 to 19.1 mm Hg). The PRx and CPPopt trends provided by the two monitors were similar over time, but CPPopt trends differed when PRx values were around zero. Also, almost half of the CPPopt estimates differed by more than 10 mm Hg.
    Conclusions: These wide variations recorded in the same patient are worrisome and reiterate the importance of understanding and standardizing the methodology and algorithms behind commercial neuromonitoring devices prior to incorporating them in clinical use.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-024-01949-9
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  3. Article ; Online: Neuroprotective effects of lactate and ketone bodies in acute brain injury.

    Plourde, Guillaume / Roumes, Hélène / Suissa, Laurent / Hirt, Lorenz / Doche, Émilie / Pellerin, Luc / Bouzier-Sore, Anne-Karine / Quintard, Hervé

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2024  , Page(s) 271678X241245486

    Abstract: The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we ... ...

    Abstract The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X241245486
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    Zs.A 1663: Show issues Location:
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  4. Article ; Online: Preoperative fibrinogen level and blood transfusions in liver transplantation: A systematic review.

    Thibeault, Félix / Plourde, Guillaume / Fellouah, Massine / Ziegler, Daniela / Carrier, François Martin

    Transplantation reviews (Orlando, Fla.)

    2023  Volume 37, Issue 4, Page(s) 100797

    Abstract: Background: Orthotopic liver transplantation (OLT) is a major surgery often associated with significant bleeding. We conducted a systematic review to explore the association between preoperative fibrinogen level and intraoperative blood products ... ...

    Abstract Background: Orthotopic liver transplantation (OLT) is a major surgery often associated with significant bleeding. We conducted a systematic review to explore the association between preoperative fibrinogen level and intraoperative blood products transfusion, blood loss and clinical outcomes in patients undergoing OLT.
    Methods: We included observational studies conducted in patients undergoing an OLT mostly for end-stage liver disease that reported an association between the preoperative fibrinogen level and our outcomes of interest. Our primary outcome was the intraoperative red blood cell (RBC) transfusion requirements. Our secondary outcomes were intraoperative blood loss, intraoperative transfusion of any blood product, postoperative RBC transfusion, postoperative thrombotic or hemorrhagic complications, and mortality. We used a standardized search strategy. We reported our results mostly descriptively but conducted meta-analyses using random-effect models when judged feasible.
    Results: We selected 24 cohort studies reporting at least one of our outcomes. We found that a high preoperative fibrinogen level was associated with fewer intraoperative RBC and other blood products transfusions, and lower blood loss. We also found a lower overall survival in patients with a higher fibrinogen level (pooled hazard ratio [95% CI] of 1.50 [1.23 to 1.84]; 5 studies, n = 1012, I
    Conclusion: A higher preoperative fibrinogen level was associated with fewer intraoperative RBC and other blood products transfusions, lower blood loss, and higher mortality. Further studies may help clarify observed associations and inform guidelines.
    MeSH term(s) Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Blood Transfusion ; Erythrocyte Transfusion/adverse effects ; Fibrinogen ; End Stage Liver Disease
    Chemical Substances Fibrinogen (9001-32-5)
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 639400-0
    ISSN 1557-9816 ; 0955-470X
    ISSN (online) 1557-9816
    ISSN 0955-470X
    DOI 10.1016/j.trre.2023.100797
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  5. Article ; Online: Radial Access in Women for Percutaneous Coronary Intervention: Toward the End of the Sex Paradox?

    Plourde, Guillaume / Bertrand, Olivier F

    JACC. Cardiovascular interventions

    2018  Volume 11, Issue 1, Page(s) 51–52

    MeSH term(s) Acute Coronary Syndrome ; Female ; Humans ; Percutaneous Coronary Intervention ; Radial Artery
    Language English
    Publishing date 2018-01-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2017.10.025
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    Zs.A 6669: Show issues Location:
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  6. Article ; Online: Low rate fluoroscopy in cardiac catheterization: Toward a new standard?

    Plourde, Guillaume / Bertrand, Olivier F

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2017  Volume 89, Issue 4, Page(s) 670–671

    MeSH term(s) Cardiac Catheterization ; Catheterization ; Fluoroscopy ; Humans ; Radiation Dosage ; Treatment Outcome
    Language English
    Publishing date 2017--01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.27009
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    Zs.A 1226: Show issues Location:
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  7. Article ; Online: Flow is not perfusion, and perfusion is not function: ancillary testing for the diagnosis of brain death.

    Plourde, Guillaume / Briard, Joel Neves / Shemie, Sam D / Shankar, Jai Jai Shiva / Chassé, Michaël

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2021  Volume 68, Issue 7, Page(s) 953–961

    Title translation Circulation ne veut pas dire perfusion, et perfusion ne signifie pas fonction : les tests complémentaires pour le diagnostic de la mort cérébrale.
    MeSH term(s) Brain ; Brain Death/diagnosis ; Cerebrovascular Circulation ; Humans ; Perfusion
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-021-01988-2
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    Zs.A 109: Show issues Location:
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  8. Article ; Online: In reply: The capacity for consciousness and the clinical diagnosis of brain death: are we using the correct gold standard?

    Plourde, Guillaume / Neves Briard, Joel / Shemie, Sam D / Shankar, Jai Jai Shiva / Chassé, Michaël

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2021  Volume 68, Issue 10, Page(s) 1578–1579

    MeSH term(s) Brain Death/diagnosis ; Consciousness ; Humans
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-021-02047-6
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    Zs.A 109: Show issues Location:
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  9. Article ; Online: In reply: Mistaken concepts on the use of ancillary testing in brain death diagnosis.

    Plourde, Guillaume / Briard, Joel Neves / Shemie, Sam D / Shankar, Jai Jai Shiva / Chassé, Michaël

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2021  Volume 69, Issue 3, Page(s) 407–408

    MeSH term(s) Brain ; Brain Death/diagnosis ; Head ; Humans ; Tissue and Organ Procurement
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-021-02186-w
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  10. Article ; Online: Association between obesity and hospital mortality in critical COVID-19: a retrospective cohort study.

    Plourde, Guillaume / Fournier-Ross, Emanuel / Tessier-Grenier, Hubert / Mullie, Louis-Antoine / Chassé, Michaël / Carrier, François Martin

    International journal of obesity (2005)

    2021  Volume 45, Issue 12, Page(s) 2617–2622

    Abstract: Background: The impact of obesity on outcomes in acute respiratory distress syndrome (ARDS) is not well understood and remains controversial. Recent studies suggest that obesity might be associated with higher morbidity and mortality in respiratory ... ...

    Abstract Background: The impact of obesity on outcomes in acute respiratory distress syndrome (ARDS) is not well understood and remains controversial. Recent studies suggest that obesity might be associated with higher morbidity and mortality in respiratory disease caused by SARS-CoV-2 (COVID-19 disease). Our objective was to evaluate the association between obesity and hospital mortality in critical COVID-19 patients.
    Methods: We conducted a retrospective cohort study in a tertiary academic center located in Montréal between March and August 2020. We included all consecutive adult patients admitted to the ICU for COVID-19-confirmed respiratory disease. Our main outcome was hospital mortality. We estimated the association between obesity, using the body mass index as a continuous variable, and hospital survival by fitting a multivariable Cox proportional hazards model.
    Results: We included 94 patients. Median [q1, q3] body mass index (BMI) was 29 [26-32] kg/m
    Conclusions: Obesity was prevalent in hospitalized patients with critical illness secondary to COVID-19 disease and a higher BMI was associated with higher hospital mortality. Further studies are needed to validate this association and to better understand its underlying mechanisms.
    MeSH term(s) Adult ; Aged ; Body Mass Index ; COVID-19/mortality ; Comorbidity ; Critical Illness ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Obesity/epidemiology ; Quebec ; Retrospective Studies ; Survival Analysis
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-021-00938-8
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