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  1. Article ; Online: Epigenetic Therapeutics for Cardiovascular Disease: Writing, Erasing, Reading, and Maybe Forgetting.

    Plutzky, Jorge

    JAMA

    2020  Volume 323, Issue 16, Page(s) 1557–1558

    MeSH term(s) Acute Coronary Syndrome ; Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Epigenesis, Genetic ; Humans ; Quinazolinones
    Chemical Substances Quinazolinones ; apabetalone (8R4A7GDZ1D)
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.3298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: PPARs: altering clinical responses in type-2 diabetes and atherosclerosis

    Plutzky, Jorge

    based on a satellite symposium ... held on Nov. 10, 2003 during the scientific sessions 2003 of the American Heart Association, Nov. 9 - 12, 2003, Orlando, Florida

    (Clinical cardiology ; 27,7, Suppl. 4)

    2004  

    Title variant PPARs: altering clinical responses in type 2 diabetes and atherosclerosis
    Author's details guest ed.: Jorge Plutzky
    Series title Clinical cardiology ; 27,7, Suppl. 4
    Collection
    Language English
    Size IV-20 S. : Ill., graph. Darst.
    Publisher Foundation for Advances in Medicine and Science
    Publishing place Mahwah, N.J
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014336375
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: The Aging Aorta: Are We Only as Old as Our Endothelium?

    Gupta, Rajat M / Plutzky, Jorge

    Arteriosclerosis, thrombosis, and vascular biology

    2022  Volume 42, Issue 2, Page(s) 172–174

    MeSH term(s) Aorta ; Endothelium
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.121.317275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: The cardiovascular risk continuum from pre-diabetes to diabetes

    Davidson, Michael H. / Plutzky, Jorge

    the role of the cardiologist in therapeutic intervention to alter the disease process

    (The American journal of cardiology ; 108,3S = Suppl.)

    2011  

    Author's details guest ed.: Michael H. Davidson ; Jorge Plutzky
    Series title The American journal of cardiology ; 108,3S = Suppl.
    Collection
    Language English
    Size 67B S. : Ill., graph. Darst.
    Publisher Excerpta Medica
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016983737
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Conference proceedings: Second US Japanese dialogue on lipid disorders and coronary artery disease

    Plutzky, Jorge

    proceedings of a symposium held at the Brigham and Women's Hospital and Harvard Medical School, Boston, USA, on 11 November 1999

    (International congress and symposium series ; 243)

    2000  

    Title variant Second US-Japanese dialogue on lipid disorders and coronary artery disease
    Author's details ed. by J. Plutzky
    Series title International congress and symposium series ; 243
    International congress and symposium series / Royal Society of Medicine
    Collection International congress and symposium series / Royal Society of Medicine
    Keywords Arteriosklerose ; Ätiologie ; Pathogenese
    Subject Arterienverkalkung ; Atherosklerose ; Arteriosclerosis ; Krankheitsursache ; Krankheit
    Language English
    Size VI, 77 S. : Ill., graph. Darst.
    Publisher Royal Soc. of Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT012874147
    ISBN 1-85315-449-0 ; 978-1-85315-449-2
    Database Catalogue ZB MED Medicine, Health

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  6. Book ; Conference proceedings: First US Japanese dialogue on lipid disorders and coronary artery disease

    Plutzky, Jorge

    new issues for the next millennium ; proceedings of a symposium held at the Brigham and Women's Hospital and Harvard Medical School, Boston, USA, 12 November 1998

    (International congress and symposium series ; 238)

    1999  

    Title variant First US-Japanese dialogue on lipid disorders and coronary artery disease
    Author's details ed. by J. Plutzky
    Series title International congress and symposium series ; 238
    International congress and symposium series / Royal Society of Medicine
    Collection International congress and symposium series / Royal Society of Medicine
    Keywords Hyperlipidämie ; Koronare Herzkrankheit
    Subject Herzkranzgefäßleiden ; Koronararterie ; Herzkranzgefäßkrankheit ; Coronary artery disease ; Hyperlipoidämie ; Hyperproteinämie ; Blutfetterhöhung ; Hyperlipoproteinämie
    Language English
    Size VI, 83 S. : graph. Darst.
    Publisher Royal Soc. of Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    Note Includes bibliographical references
    HBZ-ID HT010911653
    ISBN 1-85315-445-8 ; 978-1-85315-445-4
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Feasibility of postprandial optical scattering of lipoproteins in blood as an optical marker of cardiovascular disease risk: modeling and experimental validation.

    Pilvar, Anahita / Smith, Declan W / Plutzky, Jorge / Roblyer, Darren

    Journal of biomedical optics

    2023  Volume 28, Issue 6, Page(s) 65002

    Abstract: Significance: Blood lipid levels (i.e., triglycerides (TGs) and cholesterol) are a strong predictor of cardiovascular disease (CVD) risk. Current methods for measuring blood lipids require invasive blood draws and traditional lab testing, limiting their ...

    Abstract Significance: Blood lipid levels (i.e., triglycerides (TGs) and cholesterol) are a strong predictor of cardiovascular disease (CVD) risk. Current methods for measuring blood lipids require invasive blood draws and traditional lab testing, limiting their practicality for frequent monitoring. Optical measurements of lipoproteins, which carry TG and cholesterol in blood, may lead to simpler invasive or non-invasive methods for more frequent and rapid blood lipid measurements.
    Aim: To investigate the effect of lipoproteins on optical properties of blood before and after a high-fat meal (i.e., the pre- and post-prandial state).
    Approach: Simulations were performed using Mie theory to estimate lipoprotein scattering properties. A literature review was conducted to identify key simulation parameters including lipoprotein size distributions and number density. Experimental validation of
    Results: Our results indicated that lipoproteins in blood, particularly very low-density lipoproteins and chylomicrons, are highly scattering in the visible and near-infrared wavelength region. Estimates of the increase in the reduced scattering coefficient (
    Conclusion: These findings lay the foundation for future research in the development of optical methods for invasive and non-invasive optical measure of blood lipoproteins, which could improve early detection and management of CVD risk.
    MeSH term(s) Humans ; Cardiovascular Diseases/diagnostic imaging ; Diabetes Mellitus, Type 2 ; Feasibility Studies ; Lipoproteins ; Anisotropy
    Chemical Substances Lipoproteins
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.28.6.065002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties.

    Pilvar, Anahita / Plutzky, Jorge / Pierce, Mark / Roblyer, Darren

    Journal of biomedical optics

    2022  Volume 27, Issue 6

    Abstract: Significance: The shortwave infrared (SWIR) optical window (∼900 to 2000 nm) has attracted interest for deep tissue imaging due to the lower scattering of light. SWIR spatial frequency domain imaging (SWIR SFDI) provides wide-field tissue optical ... ...

    Abstract Significance: The shortwave infrared (SWIR) optical window (∼900 to 2000 nm) has attracted interest for deep tissue imaging due to the lower scattering of light. SWIR spatial frequency domain imaging (SWIR SFDI) provides wide-field tissue optical property measurements in this wavelength band. Key design and performance characteristics, such as portability, wavelength selection, measurement resolution, and the effect of skin have not yet been addressed for SWIR SFDI.
    Aim: To fabricate and characterize a SWIR SFDI system for clinical use.
    Approach: The optimal choice of wavelengths was identified based on optical property uncertainty estimates and imaging depth. A compact light-emitting diode-based dual wavelength SWIR SFDI system was fabricated. A two-layer inverse model was developed to account for the layered structure of skin. Performance was validated using tissue-simulating phantoms and in-vivo measurements from three healthy subjects.
    Results: The SWIR SFDI system had a μs' resolution of at least 0.03  mm  -  1 at 880 nm and 0.02  mm  -  1 at 1100 nm. The two-layer inverse model reduced the error in deeper layer μs' extractions by at least 24% in the phantom study. The two-layer model also increased the contrast between superficial vessels and the surrounding tissue for in-vivo measurements.
    Conclusion: The clinic-ready SWIR SFDI device is sensitive to small optical property alterations in diffuse media, provides enhanced accuracy in quantifying optical properties in the deeper layers in phantoms, and provided enhanced contrast of subcutaneous blood vessels.
    MeSH term(s) Diagnostic Imaging/methods ; Humans ; Optical Imaging/methods ; Phantoms, Imaging ; Skin/diagnostic imaging
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.27.6.066003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Emerging epigenetic maps in atherosclerosis.

    Plutzky, Jorge

    Circulation. Cardiovascular genetics

    2014  Volume 7, Issue 5, Page(s) 573–575

    MeSH term(s) Aorta/metabolism ; Atherosclerosis/genetics ; Chromosome Mapping/methods ; DNA Methylation ; Female ; Humans
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2477394-3
    ISSN 1942-3268 ; 1942-325X
    ISSN (online) 1942-3268
    ISSN 1942-325X
    DOI 10.1161/CIRCGENETICS.114.000829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sodium/Glucose Cotransporter 2 Inhibitors in Patients With Diabetes Mellitus and Chronic Kidney Disease: Turning the Page.

    Plutzky, Jorge / Bakris, George

    Circulation

    2018  Volume 137, Issue 2, Page(s) 130–133

    MeSH term(s) Benzhydryl Compounds ; Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Glucose ; Glucosides ; Humans ; Renal Insufficiency, Chronic ; Sodium
    Chemical Substances Benzhydryl Compounds ; Glucosides ; Sodium (9NEZ333N27) ; empagliflozin (HDC1R2M35U) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-01-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.031422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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