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  1. Article: The impact of toxic bisphenols on model human erythrocyte membranes

    Wyżga, Beata / Połeć, Karolina / Olechowska, Karolina / Hąc-Wydro, Katarzyna

    Colloids and surfaces. 2020 Feb., v. 186

    2020  

    Abstract: Bisphenols are the environmental pollution of a highly harmful, but different in their magnitude, influence on the living organisms. Among various aspects of the toxicity of these compounds their effect on the red blood cells is intensively investigated. ...

    Abstract Bisphenols are the environmental pollution of a highly harmful, but different in their magnitude, influence on the living organisms. Among various aspects of the toxicity of these compounds their effect on the red blood cells is intensively investigated. The aim of this work was to compare the effect of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) on model erythrocyte membranes and to get insight into the origin of the differences in the harmful effect of these substances on cells. Thus, the influence of bisphenols on multicomponent Langmuir films imitating the outer leaflet of erythrocyte membrane was thoroughly analyzed. An important step of the experiments were the studies on the effect of bisphenols on the films composed from particular erythrocyte membrane lipids. It was confirmed that both BPA and BPF affect model lipid systems more strongly than BPS, by changing their condensation, ordering, stability and morphology. However, the most essential conclusion was that BPA acts on the erythrocyte lipids more selectively than BPS and BPF and the influence exerted by this molecule is more strongly determined by the membrane composition. It was also suggested that cholesterol may act as the molecule of a decisive role from the point of view of the magnitude of the incorporation and the effect of BPA and BPF on membrane. Thus, the level of bisphenols toxicity to erythrocytes may depend on the concentration of cholesterol in their membranes.
    Keywords bisphenol A ; bisphenol F ; bisphenol S ; cholesterol ; erythrocyte membrane ; erythrocytes ; humans ; models ; pollution ; toxicity
    Language English
    Dates of publication 2020-02
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2019.110670
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  2. Article: The influence of ergosterol on the action of the hop oil and its major terpenes on model fungi membranes. Towards understanding the mechanism of action of phytocompounds for food and plant protection

    Połeć, Karolina / Olechowska, Karolina / Klejdysz, Amanda / Dymek, Michał / Rachwalik, Rafał / Sikora, Elżbieta / Hąc-Wydro, Katarzyna

    Chemistry and physics of lipids. 2021 Aug., v. 238

    2021  

    Abstract: The aim of this work was to find the correlation between the content of ergosterol in fungi membrane and the action of the hop essential oil, myrcene and humulene on its properties. To reach this goal, the monolayers and bilayers composed of ... ...

    Abstract The aim of this work was to find the correlation between the content of ergosterol in fungi membrane and the action of the hop essential oil, myrcene and humulene on its properties. To reach this goal, the monolayers and bilayers composed of phosphatidylcholine, phosphatidyethanol amine and ergosterol, differing in the concentration of sterol, were used as model membrane systems. The impact of the essential oil and its major terpenes on one component ergosterol film was also investigated.It was found that pure isolated terpenes, in contrast to the hop oil being the mixture of them, do not incorporate into pure ergosterol membrane, however, they cause the loss of monolayer material from the interface. These results are in contrast to the effect of these terpenes on phospholipid films reported previously and they may suggest a strong effect of ergosterol on the behavior of terpenes in the mixed systems. Surprisingly, for model membranes, the effect of myrcene was qualitatively similar to the effect of the hop oil and ergosterol was found to regulate the incorporation of both these substances into the film. In contrast, very strong correlation between ergosterol content and the action of humulene was found. Namely, the ability of humulene to change model membrane properties was found to increase with ergosterol concentration. Additionally, the differentiating effect of ergosterol on humulene action in membranes was much more pronounced than for myrcene or the hop oil. Interestingly, at the highest ergosterol level the influence of humulene was even stronger than the effect of the hop oil. This is very important finding suggesting that ergosterol may regulate the sensitivity of particular membrane to the impact of humulene. Summarizing, ergosterol substantially differentiates the effect of the hop oil, myrcene and humulene on the lipid systems and it can be the molecule important for antifungal effect of the essential oil and terpenes.
    Keywords antifungal properties ; ergosterol ; essential oils ; humulene ; mechanism of action ; myrcene ; oils ; phosphatidylcholines ; physics ; plant protection
    Language English
    Dates of publication 2021-08
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 213869-4
    ISSN 1873-2941 ; 0009-3084
    ISSN (online) 1873-2941
    ISSN 0009-3084
    DOI 10.1016/j.chemphyslip.2021.105092
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 804: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The impact of toxic bisphenols on model human erythrocyte membranes.

    Wyżga, Beata / Połeć, Karolina / Olechowska, Karolina / Hąc-Wydro, Katarzyna

    Colloids and surfaces. B, Biointerfaces

    2019  Volume 186, Page(s) 110670

    Abstract: Bisphenols are the environmental pollution of a highly harmful, but different in their magnitude, influence on the living organisms. Among various aspects of the toxicity of these compounds their effect on the red blood cells is intensively investigated. ...

    Abstract Bisphenols are the environmental pollution of a highly harmful, but different in their magnitude, influence on the living organisms. Among various aspects of the toxicity of these compounds their effect on the red blood cells is intensively investigated. The aim of this work was to compare the effect of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) on model erythrocyte membranes and to get insight into the origin of the differences in the harmful effect of these substances on cells. Thus, the influence of bisphenols on multicomponent Langmuir films imitating the outer leaflet of erythrocyte membrane was thoroughly analyzed. An important step of the experiments were the studies on the effect of bisphenols on the films composed from particular erythrocyte membrane lipids. It was confirmed that both BPA and BPF affect model lipid systems more strongly than BPS, by changing their condensation, ordering, stability and morphology. However, the most essential conclusion was that BPA acts on the erythrocyte lipids more selectively than BPS and BPF and the influence exerted by this molecule is more strongly determined by the membrane composition. It was also suggested that cholesterol may act as the molecule of a decisive role from the point of view of the magnitude of the incorporation and the effect of BPA and BPF on membrane. Thus, the level of bisphenols toxicity to erythrocytes may depend on the concentration of cholesterol in their membranes.
    MeSH term(s) Benzhydryl Compounds/pharmacology ; Cell Membrane/drug effects ; Erythrocytes/drug effects ; Humans ; Models, Biological ; Particle Size ; Phenols/pharmacology ; Sulfones/pharmacology ; Surface Properties
    Chemical Substances Benzhydryl Compounds ; Phenols ; Sulfones ; bisphenol F ; bis(4-hydroxyphenyl)sulfone (80-09-1) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2019-11-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2019.110670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The influence of ergosterol on the action of the hop oil and its major terpenes on model fungi membranes. Towards understanding the mechanism of action of phytocompounds for food and plant protection.

    Połeć, Karolina / Olechowska, Karolina / Klejdysz, Amanda / Dymek, Michał / Rachwalik, Rafał / Sikora, Elżbieta / Hąc-Wydro, Katarzyna

    Chemistry and physics of lipids

    2021  Volume 238, Page(s) 105092

    Abstract: The aim of this work was to find the correlation between the content of ergosterol in fungi membrane and the action of the hop essential oil, myrcene and humulene on its properties. To reach this goal, the monolayers and bilayers composed of ... ...

    Abstract The aim of this work was to find the correlation between the content of ergosterol in fungi membrane and the action of the hop essential oil, myrcene and humulene on its properties. To reach this goal, the monolayers and bilayers composed of phosphatidylcholine, phosphatidyethanol amine and ergosterol, differing in the concentration of sterol, were used as model membrane systems. The impact of the essential oil and its major terpenes on one component ergosterol film was also investigated. It was found that pure isolated terpenes, in contrast to the hop oil being the mixture of them, do not incorporate into pure ergosterol membrane, however, they cause the loss of monolayer material from the interface. These results are in contrast to the effect of these terpenes on phospholipid films reported previously and they may suggest a strong effect of ergosterol on the behavior of terpenes in the mixed systems. Surprisingly, for model membranes, the effect of myrcene was qualitatively similar to the effect of the hop oil and ergosterol was found to regulate the incorporation of both these substances into the film. In contrast, very strong correlation between ergosterol content and the action of humulene was found. Namely, the ability of humulene to change model membrane properties was found to increase with ergosterol concentration. Additionally, the differentiating effect of ergosterol on humulene action in membranes was much more pronounced than for myrcene or the hop oil. Interestingly, at the highest ergosterol level the influence of humulene was even stronger than the effect of the hop oil. This is very important finding suggesting that ergosterol may regulate the sensitivity of particular membrane to the impact of humulene. Summarizing, ergosterol substantially differentiates the effect of the hop oil, myrcene and humulene on the lipid systems and it can be the molecule important for antifungal effect of the essential oil and terpenes.
    MeSH term(s) Acyclic Monoterpenes/chemistry ; Alkenes/chemistry ; Cell Membrane/ultrastructure ; Ergosterol/chemistry ; Fungi ; Lipid Bilayers/chemistry ; Liposomes/chemistry ; Monocyclic Sesquiterpenes/chemistry ; Oils, Volatile/chemistry ; Phosphatidylcholines/chemistry ; Phospholipids/chemistry ; Phytochemicals/chemistry ; Sterols/chemistry ; Surface Tension ; Terpenes/chemistry
    Chemical Substances Acyclic Monoterpenes ; Alkenes ; Lipid Bilayers ; Liposomes ; Monocyclic Sesquiterpenes ; Oils, Volatile ; Phosphatidylcholines ; Phospholipids ; Phytochemicals ; Sterols ; Terpenes ; myrcene (3M39CZS25B) ; humulene (54W56MD2WD) ; Ergosterol (Z30RAY509F)
    Language English
    Publishing date 2021-05-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 213869-4
    ISSN 1873-2941 ; 0009-3084
    ISSN (online) 1873-2941
    ISSN 0009-3084
    DOI 10.1016/j.chemphyslip.2021.105092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 804: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The influence of terpinen-4-ol and eucalyptol - The essential oil components - on fungi and plant sterol monolayers.

    Połeć, Karolina / Wójcik, Aneta / Flasiński, Michał / Wydro, Paweł / Broniatowski, Marcin / Hąc-Wydro, Katarzyna

    Biochimica et biophysica acta. Biomembranes

    2019  Volume 1861, Issue 6, Page(s) 1093–1102

    Abstract: Antifungal and herbicidal activity of terpenes, being the components of the essential oils, is directly related to the incorporation of these compounds into cellular membranes. Thus, the differences in the lipid composition of various pathogenic ... ...

    Abstract Antifungal and herbicidal activity of terpenes, being the components of the essential oils, is directly related to the incorporation of these compounds into cellular membranes. Thus, the differences in the lipid composition of various pathogenic membranes may be the factor determining the activity of these molecules. One of the class of lipids, which form the membrane environment are sterols. The aim of this work was to compare the effect of two terpenes: terpinen-4-ol and eucalyptol on the monolayers formed by ergosterol and β - sitosterol, which are the components of fungi and plant membranes, respectively. The modifications in the sterol monolayer properties were investigated in the surface pressure-area measurements and penetration studies as well as in a micrometer scale (Brewster angle microscopy experiments) and in nanoscale (GIXD technique). It was evidenced that although at higher surface pressure the terpene molecules are in part removed from the interface, they are able to substantially modify the condensation, morphology and molecular organization of the sterol film. It was also found that the incorporation of terpenes into sterol films is comparable for both sterols, however, β - sitosterol monolayers properties are affected more strongly than ergosterol films. Finally, the analysis of the results of the studies performed on model membrane systems and the results of antimicrobial studies reported in literature, enabled us to suggest that the activity of terpenes depends on the membrane composition and that the sterol concentration may be important from the point of view of antifungal effect of terpinen-4-ol and eucalyptol.
    MeSH term(s) Eucalyptol/chemistry ; Fungi/chemistry ; Microscopy/methods ; Oils, Volatile/chemistry ; Phytosterols/chemistry ; Sterols/chemistry ; Surface Properties ; Terpenes/chemistry ; X-Ray Diffraction/methods
    Chemical Substances Oils, Volatile ; Phytosterols ; Sterols ; Terpenes ; terpinenol-4 (562-74-3) ; Eucalyptol (RV6J6604TK)
    Language English
    Publishing date 2019-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2019.03.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The influence of the essential oil extracted from hops on monolayers and bilayers imitating plant pathogen bacteria membranes

    Połeć, Karolina / Artur Biela / Beata Barnaś / Elżbieta Sikora / Katarzyna Hąc-Wydro / Kinga Wójcik / Magdalena Kowalska / Michał Dymek / Michał Kobiałka / Rafał Rachwalik

    Colloids and surfaces. 2019 Jan. 01, v. 173

    2019  

    Abstract: Many plant-derived compounds possess antimicrobial, antioxidant and even anticancer activities. Therefore, they are considered as substances that can be used instead of synthetic compounds in various applications. In this work, the essential oil from hop ...

    Abstract Many plant-derived compounds possess antimicrobial, antioxidant and even anticancer activities. Therefore, they are considered as substances that can be used instead of synthetic compounds in various applications. In this work, the essential oil from hop cones was extracted and analyzed, and then its effects on model bacteria membranes were studied to verify whether the hop essential oils could be used as ecological pesticides. The experiments involved surface pressure-area measurements, penetration studies and Brewster angle microscopy (BAM) imaging of lipid monolayers as well as hydrodynamic diameter, zeta potential, steady-state fluorescence anisotropy and Cryo-Transmission Electron Microscopy (cryo-TEM) measurements of liposomes. Finally the bactericidal tests on plant pathogen bacteria Pseudomonas syringae pv. lachrymans PCM 1410 were performed. The obtained results showed that the components of the essential oils from hop cones incorporate into lipid monolayers and bilayers and alter their fluidity. However, the observed effect is determined by the system composition, its condensation and the oil concentration. Interestingly, at a given dose, the effect of the essential oil on membranes was found to stabilize. Moreover, BAM images proved that hop oil prevents the formation of a large fraction of a condensed phase at the interface. Both the studies on model membranes as well as the in vitro tests allow one to conclude that the hop essential oil could likely be considered as the candidate to be used in agriculture as a natural pesticide.
    Keywords anisotropy ; antineoplastic activity ; antioxidants ; bacteria ; colloids ; cryo-electron microscopy ; essential oils ; fluorescence ; hops ; hydrodynamics ; image analysis ; in vitro studies ; lipids ; models ; oils ; pesticides ; plant pathogens ; Pseudomonas syringae pv. lachrymans ; transmission electron microscopy ; zeta potential
    Language English
    Dates of publication 2019-0101
    Size p. 672-680.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2018.10.047
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  7. Article ; Online: The influence of the essential oil extracted from hops on monolayers and bilayers imitating plant pathogen bacteria membranes.

    Połeć, Karolina / Barnaś, Beata / Kowalska, Magdalena / Dymek, Michał / Rachwalik, Rafał / Sikora, Elżbieta / Biela, Artur / Kobiałka, Michał / Wójcik, Kinga / Hąc-Wydro, Katarzyna

    Colloids and surfaces. B, Biointerfaces

    2018  Volume 173, Page(s) 672–680

    Abstract: Many plant-derived compounds possess antimicrobial, antioxidant and even anticancer activities. Therefore, they are considered as substances that can be used instead of synthetic compounds in various applications. In this work, the essential oil from hop ...

    Abstract Many plant-derived compounds possess antimicrobial, antioxidant and even anticancer activities. Therefore, they are considered as substances that can be used instead of synthetic compounds in various applications. In this work, the essential oil from hop cones was extracted and analyzed, and then its effects on model bacteria membranes were studied to verify whether the hop essential oils could be used as ecological pesticides. The experiments involved surface pressure-area measurements, penetration studies and Brewster angle microscopy (BAM) imaging of lipid monolayers as well as hydrodynamic diameter, zeta potential, steady-state fluorescence anisotropy and Cryo-Transmission Electron Microscopy (cryo-TEM) measurements of liposomes. Finally the bactericidal tests on plant pathogen bacteria Pseudomonas syringae pv. lachrymans PCM 1410 were performed. The obtained results showed that the components of the essential oils from hop cones incorporate into lipid monolayers and bilayers and alter their fluidity. However, the observed effect is determined by the system composition, its condensation and the oil concentration. Interestingly, at a given dose, the effect of the essential oil on membranes was found to stabilize. Moreover, BAM images proved that hop oil prevents the formation of a large fraction of a condensed phase at the interface. Both the studies on model membranes as well as the in vitro tests allow one to conclude that the hop essential oil could likely be considered as the candidate to be used in agriculture as a natural pesticide.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Cardiolipins/chemistry ; Humulus/chemistry ; Lipid Bilayers/chemistry ; Membrane Fluidity/drug effects ; Microbial Sensitivity Tests ; Oils, Volatile/chemistry ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology ; Phosphatidylethanolamines/chemistry ; Phosphatidylglycerols/chemistry ; Pseudomonas syringae/chemistry ; Pseudomonas syringae/drug effects ; Pseudomonas syringae/growth & development ; Unilamellar Liposomes/chemistry
    Chemical Substances 1,1',2,2'-tetraoleoylcardiolipin ; Anti-Bacterial Agents ; Cardiolipins ; Lipid Bilayers ; Oils, Volatile ; Phosphatidylethanolamines ; Phosphatidylglycerols ; Unilamellar Liposomes ; 1-palmitoyl-2-oleoylphosphatidylethanolamine (10015-88-0) ; 1-palmitoyl-2-oleoylglycero-3-phosphoglycerol (81490-05-3)
    Language English
    Publishing date 2018-10-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2018.10.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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