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  1. Article: Direct-Acting Antivirals and Host-Targeting Approaches against Enterovirus B Infections: Recent Advances.

    Tammaro, Chiara / Guida, Michela / Appetecchia, Federico / Biava, Mariangela / Consalvi, Sara / Poce, Giovanna

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Enterovirus B (EV-B)-related diseases, which can be life threatening in high-risk populations, have been recognized as a serious health problem, but their clinical treatment is largely supportive, and no selective antivirals are available on the market. ... ...

    Abstract Enterovirus B (EV-B)-related diseases, which can be life threatening in high-risk populations, have been recognized as a serious health problem, but their clinical treatment is largely supportive, and no selective antivirals are available on the market. As their clinical relevance has become more serious, efforts in the field of anti-EV-B inhibitors have greatly increased and many potential antivirals with very high selectivity indexes and promising in vitro activities have been discovered. The scope of this review encompasses recent advances in the discovery of new compounds with anti-viral activity against EV-B, as well as further progress in repurposing drugs to treat these infections. Current progress and future perspectives in drug discovery against EV-Bs are briefly discussed and existing gaps are spotlighted.
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020203
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  2. Article ; Online: Malaria transmission blocking compounds: a patent review.

    Consalvi, Sara / Tammaro, Chiara / Appetecchia, Federico / Biava, Mariangela / Poce, Giovanna

    Expert opinion on therapeutic patents

    2022  Volume 32, Issue 6, Page(s) 649–666

    Abstract: Introduction: Despite substantial progress in the field, malaria remains a global health issue and currently available control strategies are not sufficient to achieve eradication. Agents able to prevent transmission are likely to have a strong impact ... ...

    Abstract Introduction: Despite substantial progress in the field, malaria remains a global health issue and currently available control strategies are not sufficient to achieve eradication. Agents able to prevent transmission are likely to have a strong impact on malaria control and have been prioritized as a primary objective to reduce the number of secondary infections. Therefore, there is an increased interest in finding novel drugs targeting sexual stages of
    Areas covered: This review covers innovative transmission-blocking inventions patented between 2015 and October 2021. The focus is on chemical interventions, which could be used as 'chemical vaccines' to prevent transmission (small molecules, carbohydrates, and polypeptides).
    Expert opinion: Even though the development of novel strategies to block transmission still requires fundamental additional research and a deeper understanding of parasite sexual stages biology, the research in this field has significantly accelerated. Among innovative inventions patented over the last 6 years, the surface-delivery of antimalarial drugs to kill transmission-stages parasites in mosquitoes holds the highest promise for success in malaria control strategies, opening completely new scenarios in malaria transmission-blocking drug discovery.
    MeSH term(s) Animals ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Humans ; Malaria/drug therapy ; Malaria/prevention & control ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/prevention & control ; Patents as Topic ; Plasmodium falciparum
    Chemical Substances Antimalarials
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1186201-4
    ISSN 1744-7674 ; 0962-2594 ; 1354-3776
    ISSN (online) 1744-7674
    ISSN 0962-2594 ; 1354-3776
    DOI 10.1080/13543776.2022.2049239
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3962: Show issues Location:
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  3. Article ; Online: Overcoming drug resistance in TB: an update.

    Consalvi, Sara / Poce, Giovanna / Scarpecci, Cristina / Biava, Mariangela

    Future microbiology

    2020  Volume 15, Page(s) 1607–1609

    MeSH term(s) Antitubercular Agents/pharmacology ; Drug Resistance, Multiple, Bacterial ; Humans ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Mycobacterium tuberculosis/physiology ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2020-11-20
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb-2020-0089
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  4. Article: Antiviral Mechanisms of

    Laajala, Mira / Kalander, Kerttu / Consalvi, Sara / Amamuddy, Olivier Sheik / Bishop, Özlem Tastan / Biava, Mariangela / Poce, Giovanna / Marjomäki, Varpu

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: Enteroviruses are one of the most abundant groups of viruses infecting humans, and yet there are no approved antivirals against them. To find effective antiviral compounds against enterovirus B group viruses, an in-house chemical library was screened. ... ...

    Abstract Enteroviruses are one of the most abundant groups of viruses infecting humans, and yet there are no approved antivirals against them. To find effective antiviral compounds against enterovirus B group viruses, an in-house chemical library was screened. The most effective compounds against Coxsackieviruses B3 (CVB3) and A9 (CVA9) were CL212 and CL213, two
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15031028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mycobacterial tryptophan biosynthesis: A promising target for tuberculosis drug development?

    Consalvi, Sara / Scarpecci, Cristina / Biava, Mariangela / Poce, Giovanna

    Bioorganic & medicinal chemistry letters

    2019  Volume 29, Issue 23, Page(s) 126731

    Abstract: The biosynthetic pathways of amino acids are attractive targets for drug development against pathogens with an intracellular behavior like M. tuberculosis (Mtb). Indeed, while in the macrophages Mtb has restricted access to amino acids such as tryptophan ...

    Abstract The biosynthetic pathways of amino acids are attractive targets for drug development against pathogens with an intracellular behavior like M. tuberculosis (Mtb). Indeed, while in the macrophages Mtb has restricted access to amino acids such as tryptophan (Trp). Auxotrophic Mtb strains, with mutations in the Trp biosynthetic pathway, showed reduced intracellular survival in cultured human and murine macrophages and failed to cause the disease in immunocompetent and immunocompromised mice. Herein we present recent efforts in the discovery of Trp biosynthesis inhibitors.
    MeSH term(s) Animals ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Drug Development/methods ; Humans ; Mice ; Tryptophan/metabolism ; Tuberculosis/drug therapy
    Chemical Substances Antitubercular Agents ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2019-10-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2019.126731
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Novel therapies for glaucoma: a patent review (2013-2019).

    Guglielmi, Paolo / Carradori, Simone / Campestre, Cristina / Poce, Giovanna

    Expert opinion on therapeutic patents

    2019  Volume 29, Issue 10, Page(s) 769–780

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Animals ; Drug Development ; Glaucoma/drug therapy ; Glaucoma/physiopathology ; Humans ; Intraocular Pressure/drug effects ; Medication Adherence ; Patents as Topic ; Risk Factors ; Structure-Activity Relationship
    Language English
    Publishing date 2019-08-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1186201-4
    ISSN 1744-7674 ; 0962-2594 ; 1354-3776
    ISSN (online) 1744-7674
    ISSN 0962-2594 ; 1354-3776
    DOI 10.1080/13543776.2019.1653279
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3962: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: SAR Analysis of Small Molecules Interfering with Energy-Metabolism in

    Appetecchia, Federico / Consalvi, Sara / Scarpecci, Cristina / Biava, Mariangela / Poce, Giovanna

    Pharmaceuticals (Basel, Switzerland)

    2020  Volume 13, Issue 9

    Abstract: Tuberculosis remains the world's top infectious killer: it caused a total of 1.5 million deaths and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality has been falling in recent years, with an estimated 58 million ...

    Abstract Tuberculosis remains the world's top infectious killer: it caused a total of 1.5 million deaths and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality has been falling in recent years, with an estimated 58 million saved lives between 2000 and 2018. However, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR)
    Language English
    Publishing date 2020-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph13090227
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  8. Article: A Novel Class of Dual-Acting DCH-CORMs Counteracts Oxidative Stress-Induced Inflammation in Human Primary Tenocytes

    Appetecchia, Federico / Consalvi, Sara / Berrino, Emanuela / Gallorini, Marialucia / Granese, Arianna / Campestre, Cristina / Carradori, Simone / Biava, Mariangela / Poce, Giovanna

    Antioxidants. 2021 Nov. 18, v. 10, no. 11

    2021  

    Abstract: Carbon monoxide (CO) can prevent cell and tissue damage by restoring redox homeostasis and counteracting inflammation. CO-releasing molecules (CORMs) can release a controlled amount of CO to cells and are emerging as a safer therapeutic alternative to ... ...

    Abstract Carbon monoxide (CO) can prevent cell and tissue damage by restoring redox homeostasis and counteracting inflammation. CO-releasing molecules (CORMs) can release a controlled amount of CO to cells and are emerging as a safer therapeutic alternative to delivery of CO in vivo. Sustained oxidative stress and inflammation can cause chronic pain and disability in tendon-related diseases, whose therapeutic management is still a challenge. In this light, we developed three small subsets of 1,5-diarylpyrrole and pyrazole dicobalt(0)hexacarbonyl (DCH)-CORMs to assess their potential use in musculoskeletal diseases. A myoglobin-based spectrophotometric assay showed that these CORMs act as slow and efficient CO-releasers. Five selected compounds were then tested on human primary-derived tenocytes before and after hydrogen peroxide stimulation to assess their efficacy in restoring cell redox homeostasis and counteracting inflammation in terms of PGE₂ secretion. The obtained results showed an improvement in tendon homeostasis and a cytoprotective effect, reflecting their activity as CO-releasers, and a reduction of PGE₂ secretion. As these compounds contain structural fragments of COX-2 selective inhibitors, we hypothesized that such a composite mechanism of action results from the combination of CO-release and COX-2 inhibition and that these compounds might have a potential role as dual-acting therapeutic agents in tendon-derived diseases.
    Keywords carbon monoxide ; homeostasis ; humans ; hydrogen peroxide ; inflammation ; mechanism of action ; musculoskeletal system ; oxidative stress ; pain ; secretion ; tenocytes ; therapeutics
    Language English
    Dates of publication 2021-1118
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111828
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Overcoming drug resistance for tuberculosis.

    Poce, Giovanna / Biava, Mariangela

    Future microbiology

    2015  Volume 10, Issue 11, Page(s) 1735–1741

    Abstract: Despite enormous progress, tuberculosis (TB) is still a major global health problem. Poor patients' adherence to the current treatment leads to the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) strains. While increased ... ...

    Abstract Despite enormous progress, tuberculosis (TB) is still a major global health problem. Poor patients' adherence to the current treatment leads to the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) strains. While increased numbers of MDR-TB cases can be ascribed to difficulties in treating TB-HIV coinfected patients, many studies demonstrated that the emergence of drug-resistant TB is clearly linked to misdiagnosis and mismanagement of drug-susceptible TB. Therefore, rapid detection and proper treatment are needed globally to both cure TB patients and prevent wide spreading of the disease. This paper provides a survey of the major strategies that have been explored for overcoming drug resistance in TB.
    MeSH term(s) Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Diagnostic Tests, Routine/methods ; Diagnostic Tests, Routine/standards ; Drug Resistance, Bacterial ; Drug Therapy/methods ; Drug Therapy/standards ; Humans ; Medication Adherence ; Mycobacterium/drug effects ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/microbiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb.15.76
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Chocolate Consumers and Lymphocyte-to-Monocyte Ratio: A Working Hypothesis from a Preliminary Report of a Pilot Study in Celiac Subjects

    Raguzzini, Anna / Poce, Giovanna / Consalvi, Sara / Toti, Elisabetta / Palmacci, Francesca / Biava, Mariangela / Peluso, Ilaria

    Antioxidants. 2019 Oct. 01, v. 8, no. 10

    2019  

    Abstract: Background and aim: The aim of this work was to evaluate the relationship between platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) with habitual consumption of dark chocolate in a group of celiac subjects in which chocolate ... ...

    Abstract Background and aim: The aim of this work was to evaluate the relationship between platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) with habitual consumption of dark chocolate in a group of celiac subjects in which chocolate consumption and lower neutrophil-to-lymphocyte ratio (NLR) association had already been observed. Additionally, due to the known anti-nutrient effect on iron absorption, we evaluated red blood cell count (RBC), mean corpuscular volume (MCV) and hemoglobin (Hb) values. Methods: Chocolate consumers and non-consumers were matched for sex, menopausal status, NLR values over the previously suggested cut off (2.32) for celiac patients, and co-morbidities. Results: Chocolate consumers had high LMR compared to non-consumers, whereas no differences were observed between chocolate consumers and non-consumers in RBC, MCV, Hb and PLR. However, similar number of subjects had PLR higher than the previously suggested cut off (143.7) for celiac disease. Conclusions: This preliminary report suggests a working hypothesis for larger studies aimed at establishing cut off values for LMR in celiac patients and the modulation of this marker by dietary antioxidants.
    Keywords antinutritional factors ; antioxidants ; celiac disease ; chocolate ; erythrocyte count ; erythrocytes ; hemoglobin ; iron absorption ; menopause ; patients
    Language English
    Dates of publication 2019-1001
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox8100440
    Database NAL-Catalogue (AGRICOLA)

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