Article ; Online: Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity.
2016 Volume 23, Issue 5, Page(s) 1747–1756
Abstract: Silicon-containing nanoparticles (NPs) are considered promising drug carriers for targeted drug delivery. In this study, we investigated the physical and chemical properties of silicon-containing NPs, including silica and organomodified silica NPs ( ... ...
| Abstract | Silicon-containing nanoparticles (NPs) are considered promising drug carriers for targeted drug delivery. In this study, we investigated the physical and chemical properties of silicon-containing NPs, including silica and organomodified silica NPs (SiO2NPs and OrSiO2NPs, respectively), with different surface modifications, with the aim of increasing drug-loading efficiency. In addition, we described the original synthesis methods of different sizes of OrSiO2NPs, as well as new hybrid OrSiO2NPs with a silica core (SiO2 + OrSiO2NPs). Animal experiments revealed that the silicon-containing NPs investigated were non-toxic, as evidenced by a lack of hemodynamic response after intravenous administration. Bioelimination studies showed rapid renal excretion of OrSiO2NPs. In drug release kinetics studies, adenosine was immobilized on SiO2NPs using three different approaches: physical adsorption, ionic, and covalent bonding. We observed that the rate of adenosine desorption critically depended on the type of immobilization; therefore, adenosine release kinetics can be adjusted by SiO2NP surface modification technique. Adsorption of adenosine on SiO2 + OrSiO2NPs resulted in a significant attenuation of adenosine-induced hypotension and bradycardia. |
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| MeSH term(s) | Adsorption ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Drug Liberation ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Silicon/chemistry ; Silicon Dioxide/chemical synthesis ; Silicon Dioxide/chemistry ; Silicon Dioxide/metabolism ; Silicon Dioxide/toxicity | |||||
| Chemical Substances | Drug Carriers ; Silicon Dioxide (7631-86-9) ; Silicon (Z4152N8IUI) | |||||
| Language | English | |||||
| Publishing date | 2016-06 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1213261-5 | |||||
| ISSN | 1521-0464 ; 1071-7544 | |||||
| ISSN (online) | 1521-0464 | |||||
| ISSN | 1071-7544 | |||||
| DOI | 10.3109/10717544.2015.1069421 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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