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  1. AU="Pocorni, Noëlle"
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  1. Article ; Online: Immune Cell Infiltrate in Chronic-Active Antibody-Mediated Rejection.

    Sablik, Kasia A / Jordanova, Ekaterina S / Pocorni, Noelle / Clahsen-van Groningen, Marian C / Betjes, Michiel G H

    Frontiers in immunology

    2020  Volume 10, Page(s) 3106

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Antibody-Dependent Cell Cytotoxicity ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Biomarkers ; Biopsy ; Chronic Disease ; Female ; Graft Rejection/immunology ; Graft Rejection/metabolism ; Graft Rejection/pathology ; Graft Survival/immunology ; Humans ; Immunophenotyping ; Kidney Function Tests ; Kidney Transplantation/adverse effects ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Lymphocyte Subsets/pathology ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Middle Aged ; Transplantation, Homologous
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.03106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neoadjuvant cisplatin and paclitaxel modulate tumor-infiltrating T cells in patients with cervical cancer.

    Heeren, A Marijne / van Luijk, Iske F / Lakeman, Joost / Pocorni, Noëlle / Kole, Jeroen / de Menezes, Renée X / Kenter, Gemma G / Bosse, Tjalling / de Kroon, Cornelis D / Jordanova, Ekaterina S

    Cancer immunology, immunotherapy : CII

    2019  Volume 68, Issue 11, Page(s) 1759–1767

    Abstract: Resistance to chemotherapy is widely recognized as one of the major factors limiting therapeutic efficacy and influences clinical outcomes in patients with cancer. Many studies on various tumor types have focused on combining standard-of-care ... ...

    Abstract Resistance to chemotherapy is widely recognized as one of the major factors limiting therapeutic efficacy and influences clinical outcomes in patients with cancer. Many studies on various tumor types have focused on combining standard-of-care chemotherapy with immunotherapy. However, for cervical cancer, the role of neoadjuvant chemotherapy (NACT) on the local immune microenvironment is largely unexplored. We performed a pilot study on 13 primary cervical tumor samples, before and after NACT, to phenotype and enumerate tumor-infiltrating T-cell subpopulations using multiplex immunohistochemistry (CD3, CD8, FoxP3, Ki67, and Tbet) and automated co-expression analysis software. A significant decrease in proliferating (Ki67
    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Cisplatin/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Middle Aged ; Neoadjuvant Therapy/methods ; Paclitaxel/administration & dosage ; Pilot Projects ; Prognosis ; Retrospective Studies ; T-Lymphocytes, Regulatory/immunology ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/pathology ; Young Adult
    Chemical Substances Paclitaxel (P88XT4IS4D) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-10-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-019-02412-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8

    Rotman, Jossie / Heeren, A Marijne / Gassama, Awa A / Lougheed, Sinead M / Pocorni, Noëlle / Stam, Anita G M / Bleeker, Maaike C G / Zijlmans, Henry J M A A / Mom, Constantijne H / Kenter, Gemma G / Jordanova, Ekaterina S / de Gruijl, Tanja D

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 26, Issue 14, Page(s) 3791–3802

    Abstract: Purpose: Adenocarcinoma of the uterine cervix is the second most common type of cervical cancer after squamous cell carcinoma (SCC). Although both subtypes are treated similarly, patients with adenocarcinoma have a worse prognosis. In this study, ... ...

    Abstract Purpose: Adenocarcinoma of the uterine cervix is the second most common type of cervical cancer after squamous cell carcinoma (SCC). Although both subtypes are treated similarly, patients with adenocarcinoma have a worse prognosis. In this study, immunologic features of the tumor microenvironment in these two subsets were pursued with potential therapeutic implications.
    Experimental design: The immune microenvironment of primary tumors and nonmetastatic tumor-draining lymph nodes (TDLN) was compared between patients with cervical adenocarcinoma (
    Results: Flow cytometric analyses revealed intact T-cell differentiation in TDLNs, but hampered effector T-cell trafficking to the primary tumors in adenocarcinoma, as compared with SCC. TCGA analysis demonstrated higher expression of chemokines involved in effector T-cell homing (CXCL9/10/11) in SCC primary tumors as compared with adenocarcinoma primary tumors, which was highly correlated to a transcriptional signature for type I conventional dendritic cells (cDC1). This was consistent with elevated frequencies of CD141/BDCA3
    Conclusions: Our data have identified an opportunity for the investigation of potentially novel therapeutic interventions in adenocarcinoma of the cervix, that is, β-catenin inhibition and cDC1 mobilization.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/immunology ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adult ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/immunology ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Cervix Uteri/immunology ; Cervix Uteri/pathology ; Datasets as Topic ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/immunology ; Female ; Gene Expression Profiling ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Lymphocyte Activation ; Lymphocytes, Tumor-Infiltrating/immunology ; Middle Aged ; Tumor Microenvironment/immunology ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/pathology ; beta Catenin/antagonists & inhibitors ; beta Catenin/metabolism
    Chemical Substances CTNNB1 protein, human ; Immune Checkpoint Inhibitors ; beta Catenin
    Language English
    Publishing date 2020-03-27
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-3826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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