LIVIVO - Search results -

Search results

Result 1 - 10 of total 43

Search options

Article ; Online: A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation.

Le Mentec, Hélène / Monniez, Emmanuelle / Legrand, Antoine / Monvoisin, Céline / Lagadic-Gossmann, Dominique / Podechard, Normand

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Non-alcoholic fatty liver disease (NAFLD), which starts with liver steatosis, is a growing worldwide epidemic responsible for chronic liver diseases. Among its risk factors, exposure to environmental contaminants, such as endocrine disrupting compounds ( ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD), which starts with liver steatosis, is a growing worldwide epidemic responsible for chronic liver diseases. Among its risk factors, exposure to environmental contaminants, such as endocrine disrupting compounds (EDC), has been recently emphasized. Given this important public health concern, regulation agencies need novel simple and fast biological tests to evaluate chemical risks. In this context, we developed a new in vivo bioassay called StAZ (Steatogenic Assay on Zebrafish) using an alternative model to animal experimentation, the zebrafish larva, to screen EDCs for their steatogenic properties. Taking advantage of the transparency of zebrafish larvae, we established a method based on fluorescent staining with Nile red to estimate liver lipid content. Following testing of known steatogenic molecules, 10 EDCs suspected to induce metabolic disorders were screened and DDE, the main metabolite of the insecticide DDT, was identified as a potent inducer of steatosis. To confirm this and optimize the assay, we used it in a transgenic zebrafish line expressing a blue fluorescent liver protein reporter. To obtain insight into DDE's effect, the expression of several genes related to steatosis was analyzed; an up-regulation of scd1 expression, probably relying on PXR activation, was found, partly responsible for both membrane remodeling and steatosis.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Endocrine Disruptors/toxicity ; Larva ; Liver/drug effects ; Non-alcoholic Fatty Liver Disease/chemically induced ; Zebrafish ; Biological Assay ; Dichlorodiphenyl Dichloroethylene/toxicity
Chemical Substances	Endocrine Disruptors ; Dichlorodiphenyl Dichloroethylene (4M7FS82U08)
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043942
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Effet des acides gras polyinsaturés à longue chaîne n-3 sur le remodelage membranaire induit par les toxiques chimiques : retentissement sur la mort cellulaire

Sergent, Odile / Podechard, Normand / Lagadic-Gossmann, Dominique

Société française de nutrition Cahiers de nutrition et de diététique. 2019 Apr., v. 54, no. 2

2019

Abstract: Homeostasis of plasma membrane is crucial for the regulation of many cell processes such as inflammation, cell proliferation, migration or death. This especially dynamic cell structure can undergo alteration when exposed to a wide range of chemical ... ...

Abstract	Homeostasis of plasma membrane is crucial for the regulation of many cell processes such as inflammation, cell proliferation, migration or death. This especially dynamic cell structure can undergo alteration when exposed to a wide range of chemical toxicants, thus triggering a membrane stress signal that can change the activation of intracellular signalling pathways, involved in such phenomena. Yet, long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) are described as capable of changing physicochemical properties of membranes. Thus, LC n-3 PUFA can possibly counteract or potentiate the effects of chemical toxicants with a membrane action. In this paper, we will mainly be interested in hepatotoxicants, notably benzo(a)pyrene, an environmental pollutant of the polycyclic aromatic hydrocarbon family, also found in cigarette smoke, and ethanol, the hepatoxicant prototype, whose human exposure is linked to lifestyle.
Keywords	benzo(a)pyrene ; cell proliferation ; death ; ethanol ; homeostasis ; inflammation ; lifestyle ; omega-3 fatty acids ; physicochemical properties ; plasma membrane ; pollutants ; polycyclic aromatic hydrocarbons ; polyunsaturated fatty acids ; prototypes ; signal transduction ; toxic substances
Language	English
Dates of publication	2019-04
Size	p. 116-127.
Publishing place	Elsevier Masson SAS
Document type	Article
ZDB-ID	840946-8
ISSN	0007-9960
ISSN	0007-9960
DOI	10.1016/j.cnd.2018.11.001
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4882: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors

Crouzet, Thibault / Grignard, Elise / Brion, François / Blanc, Etienne B. / Podechard, Normand / Langouet, Sophie / Alonso-Magdalena, Paloma / Hubert, Philippe / Kim, Min-ji / Audouze, Karine

Environment International. 2023 Apr., v. 174 p.107910-

2023

Abstract: Growing evidence shows that endocrine disruptors (EDs), known to affect the reproductive system, may also disturb other hormone-regulated functions leading to cancers, neurodevelopmental defects, metabolic and immune diseases. To reduce exposure to EDs ... ...

Abstract	Growing evidence shows that endocrine disruptors (EDs), known to affect the reproductive system, may also disturb other hormone-regulated functions leading to cancers, neurodevelopmental defects, metabolic and immune diseases. To reduce exposure to EDs and limit their health effects, development of screening and mechanism-based assays to identify EDs is encouraged. Nevertheless, the crucial validation step of test methods by regulatory bodies is a time- and resource-consuming process. One of the main raisons of this long duration process is that method developers, mainly researchers, are not fully aware of the regulatory needs to validate a test. We propose an online self-assessment questionnaire (SAQ) called ReadEDTest easy to be used by all researchers. The aim of ReadEDTest is to speed up the validation process by assessing readiness criteria of in vitro and fish embryo ED test methods under development. The SAQ is divided into 7 sections and 13 sub-sections containing essential information requested by the validating bodies. The readiness of the tests can be assessed by specific score limits for each sub-section. Results are displayed via a graphical representation to help identification of the sub-sections having sufficient or insufficient information. The relevance of the proposed innovative tool was supported using two test methods already validated by the OECD and four under development test methods.
Keywords	environment ; fish ; questionnaires ; reproductive system ; Endocrine disrupting chemicals ; Zebrafish embryo ; OBERON ; Pepper ; Validation process ; IATA ; OECD
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107910
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 3131: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Small RNA-sequencing reveals the involvement of microRNA-132 in benzo[a]pyrene-induced toxicity in primary human blood cells.

Souki, Rima / Amosse, Jérémy / Genêt, Valentine / Le Gall, Morgane / Saintpierre, Benjamin / Letourneur, Franck / Maître, Anne / Demeilliers, Christine / Le Ferrec, Eric / Lagadic-Gossmann, Dominique / Podechard, Normand / Sparfel, Lydie

Environmental pollution (Barking, Essex : 1987)

2023 Volume 328, Page(s) 121653

Abstract: Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental contaminants, triggering deleterious effects such as carcinogenicity and immunosuppression, and peripheral blood mononuclear cells (PBMCs) are among the main cell types targeted ...

Abstract	Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental contaminants, triggering deleterious effects such as carcinogenicity and immunosuppression, and peripheral blood mononuclear cells (PBMCs) are among the main cell types targeted by these pollutants. In the present study, we sought to identify the expression profiles and function of miRNAs, gene regulators involved in major cellular processes recently linked to environmental pollutants, in PBMC-exposed to the prototypical PAH, benzo[a]pyrene (B[a]P). Using small RNA deep sequencing, we identified several B[a]P-responsive miRNAs. Bioinformatics analyses showed that their predicted targets could modulate biological processes relevant to cell death and survival. Further studies of the most highly induced miRNA, miR-132, showed that its up-regulation by B[a]P was time- and dose-dependent and required aryl hydrocarbon receptor (AhR) activation. By evaluating the role of miR-132 in B[a]P-induced cell death, we propose a mechanism linking B[a]P-induced miR-132 expression and cytochromes P-450 (CYPs) 1A1 and 1B1 mRNA levels, which could contribute to the apoptotic response of PBMCs. Altogether, this study increases our understanding of the roles of miRNAs induced by B[a]P and provides the basis for further investigations into the mechanisms of gene expression regulation by PAHs.
MeSH term(s)	Humans ; Benzo(a)pyrene/toxicity ; Leukocytes, Mononuclear ; Cytochrome P-450 Enzyme System ; MicroRNAs/genetics ; Environmental Pollutants/toxicity ; Polycyclic Aromatic Hydrocarbons/toxicity ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism
Chemical Substances	Benzo(a)pyrene (3417WMA06D) ; Cytochrome P-450 Enzyme System (9035-51-2) ; MicroRNAs ; Environmental Pollutants ; Polycyclic Aromatic Hydrocarbons ; Receptors, Aryl Hydrocarbon ; MIRN132 microRNA, human
Language	English
Publishing date	2023-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121653
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors.

Crouzet, Thibault / Grignard, Elise / Brion, François / Blanc, Etienne B / Podechard, Normand / Langouet, Sophie / Alonso-Magdalena, Paloma / Hubert, Philippe / Kim, Min Ji / Audouze, Karine

Environment international

2023 Volume 174, Page(s) 107910

Abstract	Growing evidence shows that endocrine disruptors (EDs), known to affect the reproductive system, may also disturb other hormone-regulated functions leading to cancers, neurodevelopmental defects, metabolic and immune diseases. To reduce exposure to EDs and limit their health effects, development of screening and mechanism-based assays to identify EDs is encouraged. Nevertheless, the crucial validation step of test methods by regulatory bodies is a time- and resource-consuming process. One of the main raisons of this long duration process is that method developers, mainly researchers, are not fully aware of the regulatory needs to validate a test. We propose an online self-assessment questionnaire (SAQ) called ReadEDTest easy to be used by all researchers. The aim of ReadEDTest is to speed up the validation process by assessing readiness criteria of in vitro and fish embryo ED test methods under development. The SAQ is divided into 7 sections and 13 sub-sections containing essential information requested by the validating bodies. The readiness of the tests can be assessed by specific score limits for each sub-section. Results are displayed via a graphical representation to help identification of the sub-sections having sufficient or insufficient information. The relevance of the proposed innovative tool was supported using two test methods already validated by the OECD and four under development test methods.
MeSH term(s)	Animals ; Endocrine Disruptors/toxicity ; Endocrine Disruptors/metabolism ; In Vitro Techniques
Chemical Substances	Endocrine Disruptors
Language	English
Publishing date	2023-03-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107910
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3131: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Small RNA-sequencing reveals the involvement of microRNA-132 in benzo[a]pyrene-induced toxicity in primary human blood cells

Environmental Pollution. 2023 July, v. 328 p.121653-

2023

Abstract	Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental contaminants, triggering deleterious effects such as carcinogenicity and immunosuppression, and peripheral blood mononuclear cells (PBMCs) are among the main cell types targeted by these pollutants. In the present study, we sought to identify the expression profiles and function of miRNAs, gene regulators involved in major cellular processes recently linked to environmental pollutants, in PBMC-exposed to the prototypical PAH, benzo[a]pyrene (B[a]P). Using small RNA deep sequencing, we identified several B[a]P-responsive miRNAs. Bioinformatics analyses showed that their predicted targets could modulate biological processes relevant to cell death and survival. Further studies of the most highly induced miRNA, miR-132, showed that its up-regulation by B[a]P was time- and dose-dependent and required aryl hydrocarbon receptor (AhR) activation. By evaluating the role of miR-132 in B[a]P-induced cell death, we propose a mechanism linking B[a]P-induced miR-132 expression and cytochromes P-450 (CYPs) 1A1 and 1B1 mRNA levels, which could contribute to the apoptotic response of PBMCs. Altogether, this study increases our understanding of the roles of miRNAs induced by B[a]P and provides the basis for further investigations into the mechanisms of gene expression regulation by PAHs.
Keywords	apoptosis ; aryl hydrocarbon receptors ; bioinformatics ; blood ; carcinogenicity ; cytochromes ; dose response ; gene expression regulation ; genes ; humans ; immunosuppression ; microRNA ; pollution ; sequence analysis ; Polycyclic aromatic hydrocarbons ; Peripheral blood mononuclear cells ; microRNAs ; Benzo[a]pyrene ; miR-132–3p ; Aryl hydrocarbon receptor ; Cytochromes P-450 1A1 and 1B1 ; AhR ; AhRR ; anti-miR-CTR ; anti-miR-132 ; B[a]P ; CYPs ; CTP-I ; CTP-S ; DMSO ; FDR ; IPA ; miRNAs ; PAHs ; PBMCs ; PYR ; RNA-seq ; TIPARP ; UTR ; Z-VAD
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121653
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4136: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure.

Imran, Muhammad / Chalmel, Frédéric / Sergent, Odile / Evrard, Bertrand / Le Mentec, Hélène / Legrand, Antoine / Dupont, Aurélien / Bescher, Maëlle / Bucher, Simon / Fromenty, Bernard / Huc, Laurence / Sparfel, Lydie / Lagadic-Gossmann, Dominique / Podechard, Normand

Cell biology and toxicology

2022 Volume 39, Issue 2, Page(s) 371–390

Abstract: Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic for which environmental contaminants are increasingly recognized as important etiological factors. Among them, the combination of benzo[a]pyrene (B[a]P), a potent environmental carcinogen, ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic for which environmental contaminants are increasingly recognized as important etiological factors. Among them, the combination of benzo[a]pyrene (B[a]P), a potent environmental carcinogen, with ethanol, was shown to induce the transition of steatosis toward steatohepatitis. However, the underlying mechanisms involved remain to be deciphered. In this context, we used high-fat diet fed zebrafish model, in which we previously observed progression of steatosis to a steatohepatitis-like state following a 7-day-co-exposure to 43 mM ethanol and 25 nM B[a]P. Transcriptomic analysis highlighted the potent role of mitochondrial dysfunction, alterations in heme and iron homeostasis, involvement of aryl hydrocarbon receptor (AhR) signaling, and oxidative stress. Most of these mRNA dysregulations were validated by RT-qPCR. Moreover, similar changes were observed using a human in vitro hepatocyte model, HepaRG cells. The mitochondria structural and functional alterations were confirmed by transmission electronic microscopy and Seahorse technology, respectively. Involvement of AhR signaling was evidenced by using in vivo an AhR antagonist, CH223191, and in vitro in AhR-knock-out HepaRG cells. Furthermore, as co-exposure was found to increase the levels of both heme and hemin, we investigated if mitochondrial iron could induce oxidative stress. We found that mitochondrial labile iron content was raised in toxicant-exposed larvae. This increase was prevented by the iron chelator, deferoxamine, which also inhibited liver co-exposure toxicity. Overall, these results suggest that the increase in mitochondrial iron content induced by B[a]P/ethanol co-exposure causes mitochondrial dysfunction that contributes to the pathological progression of NAFLD.
MeSH term(s)	Animals ; Humans ; Non-alcoholic Fatty Liver Disease/chemically induced ; Non-alcoholic Fatty Liver Disease/genetics ; Ethanol/toxicity ; Zebrafish ; Benzo(a)pyrene/toxicity ; Larva ; Transcriptome ; Mitochondria ; Heme
Chemical Substances	Ethanol (3K9958V90M) ; Benzo(a)pyrene (3417WMA06D) ; Heme (42VZT0U6YR)
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	48824-0
ISSN	1573-6822 ; 0742-2091
ISSN (online)	1573-6822
ISSN	0742-2091
DOI	10.1007/s10565-022-09706-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 3024: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Membrane Remodeling as a Key Player of the Hepatotoxicity Induced by Co-Exposure to Benzo[a]pyrene and Ethanol of Obese Zebrafish Larvae.

Imran, Muhammad / Sergent, Odile / Tête, Arnaud / Gallais, Isabelle / Chevanne, Martine / Lagadic-Gossmann, Dominique / Podechard, Normand

Biomolecules

2018 Volume 8, Issue 2

Abstract: The rise in prevalence of non-alcoholic fatty liver disease (NAFLD) constitutes an important public health concern worldwide. Including obesity, numerous risk factors of NAFLD such as benzo[a]pyrene (B[a]P) and ethanol have been identified as modifying ... ...

Abstract	The rise in prevalence of non-alcoholic fatty liver disease (NAFLD) constitutes an important public health concern worldwide. Including obesity, numerous risk factors of NAFLD such as benzo[a]pyrene (B[a]P) and ethanol have been identified as modifying the physicochemical properties of the plasma membrane in vitro thus causing membrane remodeling-changes in membrane fluidity and lipid-raft characteristics. In this study, the possible involvement of membrane remodeling in the in vivo progression of steatosis to a steatohepatitis-like state upon co-exposure to B[a]P and ethanol was tested in obese zebrafish larvae. Larvae bearing steatosis as the result of a high-fat diet were exposed to ethanol and/or B[a]P for seven days at low concentrations coherent with human exposure in order to elicit hepatotoxicity. In this condition, the toxicant co-exposure raised global membrane order with higher lipid-raft clustering in the plasma membrane of liver cells, as evaluated by staining with the fluoroprobe di-4-ANEPPDHQ. Involvement of this membrane's remodeling was finally explored by using the lipid-raft disruptor pravastatin that counteracted the effects of toxicant co-exposure both on membrane remodeling and toxicity. Overall, it can be concluded that B[a]P/ethanol co-exposure can induce in vivo hepatotoxicity via membrane remodeling which could be considered as a good target mechanism for developing combination therapy to deal with steatohepatitis.
MeSH term(s)	Animals ; Benzo(a)pyrene/toxicity ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Ethanol/toxicity ; Fatty Liver/etiology ; Fatty Liver/metabolism ; Fatty Liver/pathology ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Membrane Microdomains/drug effects ; Zebrafish
Chemical Substances	Benzo(a)pyrene (3417WMA06D) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2018-05-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom8020026
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Organic chemicals from diesel exhaust particles affects intracellular calcium, inflammation and β-adrenoceptors in endothelial cells.

Brinchmann, Bendik C / Le Ferrec, Eric / Podechard, Normand / Lagadic-Gossmann, Dominique / Holme, Jørn A / Øvrevik, Johan

Toxicology letters

2018 Volume 302, Page(s) 18–27

Abstract: Exposure to diesel exhaust particles (DEP) may contribute to endothelial dysfunction and cardiovascular disease. DEP, extractable organic material from DEP (DEP-EOM) and certain PAHs seem to trigger [ ... ...

Abstract	Exposure to diesel exhaust particles (DEP) may contribute to endothelial dysfunction and cardiovascular disease. DEP, extractable organic material from DEP (DEP-EOM) and certain PAHs seem to trigger [Ca
MeSH term(s)	Calcium/metabolism ; Calcium Signaling/drug effects ; Cell Line ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Gene Expression Regulation ; Humans ; Inflammation Mediators/metabolism ; Organic Chemicals/toxicity ; Receptor, PAR-2/drug effects ; Receptor, PAR-2/metabolism ; Receptors, Adrenergic, beta/drug effects ; Receptors, Adrenergic, beta/genetics ; Receptors, Adrenergic, beta/metabolism ; Receptors, G-Protein-Coupled/drug effects ; Receptors, G-Protein-Coupled/metabolism ; Vehicle Emissions/toxicity
Chemical Substances	F2RL1 protein, human ; Inflammation Mediators ; Organic Chemicals ; Receptor, PAR-2 ; Receptors, Adrenergic, beta ; Receptors, G-Protein-Coupled ; Vehicle Emissions ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-11-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2018.11.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1367: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

Bernal, Kévin / Touma, Charbel / Erradhouani, Chedi / Boronat‐Belda, Talía / Gaillard, Lucas / Al Kassir, Sara / Le Mentec, Hélène / Martin‐Chouly, Corinne / Podechard, Normand / Lagadic‐Gossmann, Dominique / Langouet, Sophie / Brion, François / Knoll‐Gellida, Anja / Babin, Patrick J. / Sovadinova, Iva / Babica, Pavel / Andreau, Karine / Barouki, Robert / Vondráček, Jan /

Alonso‐Magdalena, Paloma / Blanc, Etienne / Kim, Min-ji / Coumoul, Xavier

FEBS Letters. 2022 Dec., v. 596, no. 24 p.3107-3123

2022

Abstract: The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently ... ...

Abstract	The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs. With regard to these pathomechanisms, we will discuss the needs, and the stakes of evolving the testing and assessment of endocrine disruptors to improve the prevention and management of metabolic diseases that have become a global epidemic since the end of last century.
Keywords	computer simulation ; diabetes ; epidemiology ; liver ; metabolic syndrome ; obesity ; pathogenesis ; toxicology ; vision
Language	English
Dates of publication	2022-12
Size	p. 3107-3123.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14465
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2005/702: Show issues
Z 5.4: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED