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  1. AU="Poenisch, Falk"
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  1. Book ; Online ; Thesis: Optimierung der Positronen-Emissions-Tomographie bei der Schwerionentherapie auf der Basis von Röntgentomogrammen

    Pönisch, Falk

    2003  

    Author's details Falk Pönisch
    Language German
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2003
    HBZ-ID HT015376882
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: A Novel Polymer-Encapsulated Multi-Imaging Modality Fiducial Marker with Positive Signal Contrast for Image-Guided Radiation Therapy.

    Wang, Li / Sanders, Jeremiah / Ward, John F / Lee, Stephen R / Poenisch, Falk / Swanson, David Michael / Sahoo, Narayan / Zhu, Xiaorong Ronald / Ma, Jingfei / Kudchadker, Rajat J / Choi, Seungtaek L / Nguyen, Quynh-Nhu / Mayo, Lauren L / Shah, Shalin J / Frank, Steven J

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Background: Current fiducial markers (FMs) in external-beam radiotherapy (EBRT) for prostate cancer (PCa) cannot be positively visualized on magnetic resonance imaging (MRI) and create dose perturbation and significant imaging artifacts on computed ... ...

    Abstract Background: Current fiducial markers (FMs) in external-beam radiotherapy (EBRT) for prostate cancer (PCa) cannot be positively visualized on magnetic resonance imaging (MRI) and create dose perturbation and significant imaging artifacts on computed tomography (CT) and MRI. We report our initial experience with clinical imaging of a novel multimodality FM, NOVA.
    Methods: We tested Gold Anchor [G-FM], BiomarC [carbon, C-FM], and NOVA FMs in phantoms imaged with kilovoltage (kV) X-rays, transrectal ultrasound (TRUS), CT, and MRI. Artifacts of the FMs on CT were quantified by the relative streak artifacts level (rSAL) metric. Proton dose perturbations (PDPs) were measured with Gafchromic EBT3 film, with FMs oriented either perpendicular to or parallel with the beam axis. We also tested the performance of NOVA-FMs in a patient.
    Results: NOVA-FMs were positively visualized on all 4 imaging modalities tested. The rSAL on CT was 0.750 ± 0.335 for 2-mm reconstructed slices. In F-tests, PDP was associated with marker type and depth of measurement (
    Conclusions: NOVA-FMs were positively visible and produced less PDP than G-FMs or C-FMs. NOVA-FMs facilitated MRI/CT fusion and identification of regions of interest.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma.

    Cao, Wenhua / Li, Yupeng / Zhang, Xiaodong / Poenisch, Falk / Yepes, Pablo / Sahoo, Narayan / Grosshans, David / McGovern, Susan / Gunn, G Brandon / Frank, Steven J / Zhu, Xiaorong R

    Journal of applied clinical medical physics

    2023  Volume 24, Issue 7, Page(s) e13954

    Abstract: Purpose: We developed and tested a novel method of creating intensity modulated proton arc therapy (IMPAT) plans that uses computing resources similar to those for regular intensity-modulated proton therapy (IMPT) plans and may offer a dosimetric ... ...

    Abstract Purpose: We developed and tested a novel method of creating intensity modulated proton arc therapy (IMPAT) plans that uses computing resources similar to those for regular intensity-modulated proton therapy (IMPT) plans and may offer a dosimetric benefit for patients with ependymoma or similar tumor geometries.
    Methods: Our IMPAT planning method consists of a geometry-based energy selection step with major scanning spot contributions as inputs computed using ray-tracing and single-Gaussian approximation of lateral spot profiles. Based on the geometric relation of scanning spots and dose voxels, our energy selection module selects a minimum set of energy layers at each gantry angle such that each target voxel is covered by sufficient scanning spots as specified by the planner, with dose contributions above the specified threshold. Finally, IMPAT plans are generated by robustly optimizing scanning spots of the selected energy layers using a commercial proton treatment planning system (TPS). The IMPAT plan quality was assessed for four ependymoma patients. Reference three-field IMPT plans were created with similar planning objective functions and compared with the IMPAT plans.
    Results: In all plans, the prescribed dose covered 95% of the clinical target volume (CTV) while maintaining similar maximum doses for the brainstem. While IMPAT and IMPT achieved comparable plan robustness, the IMPAT plans achieved better homogeneity and conformity than the IMPT plans. The IMPAT plans also exhibited higher relative biological effectiveness (RBE) enhancement than did the corresponding reference IMPT plans for the CTV in all four patients and brainstem in three of them.
    Conclusions: The proposed method demonstrated potential as an efficient technique for IMPAT planning and may offer a dosimetric benefit for patients with ependymoma or tumors in close proximity to critical organs. IMPAT plans created using this method had elevated RBE enhancement associated with increased linear energy transfer (LET) in both targets and abutting critical organs.
    MeSH term(s) Humans ; Proton Therapy/methods ; Protons ; Radiotherapy Dosage ; Ependymoma/radiotherapy ; Radiotherapy, Intensity-Modulated/methods ; Radiotherapy Planning, Computer-Assisted/methods ; Organs at Risk
    Chemical Substances Protons
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.13954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stereotactic body proton therapy for early stage non-small cell lung cancer - Technical challenges and solutions: The MD Anderson experience.

    Zhu, X Ronald / Li, Yuting / Yang, Ming / Whitaker, Thomas J / Taylor, Paige A / Zhang, Xiaodong / Poenisch, Falk / Sahoo, Narayan / Liao, Zhongxing / Chang, Joe Y

    Journal of radiosurgery and SBRT

    2023  Volume 9, Issue 1, Page(s) 75–82

    Abstract: Our randomized clinical study comparing stereotactic body radiotherapy (SBRT) and stereotactic body proton therapy (SBPT) for early stage non-small cell lung cancer (NSCLC) was closed prematurely owing to poor enrollment, largely because of lack of ... ...

    Abstract Our randomized clinical study comparing stereotactic body radiotherapy (SBRT) and stereotactic body proton therapy (SBPT) for early stage non-small cell lung cancer (NSCLC) was closed prematurely owing to poor enrollment, largely because of lack of volumetric imaging and difficulty in obtaining insurance coverage for the SBPT group. In this article, we describe technology improvements in our new proton therapy center, particularly in image guidance with cone beam CT (CBCT) and CT on rail (CTOR), as well as motion management with real-time gated proton therapy (RGPT) and optical surface imaging. In addition, we have a treatment planning system that provides better treatment plan optimization and more accurate dose calculation. We expect to re-start the SBPT program, including for early stage NSCLC as well as for other disease sites soon after starting patient treatment at our new proton therapy center.
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 2156-4647
    ISSN (online) 2156-4647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Optimierung der Positronen-Emissions-Tomographie bei der Schwerionentherapie auf der Basis von Röntgentomogrammen

    Pönisch, Falk

    2003  

    Author's details von Falk Pönisch
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss--Dresden, 2003
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  6. Article ; Online: Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'.

    Cao, Wenhua / Khabazian, Azin / Yepes, Pablo / Lim, Gino / Poenisch, Falk / Grosshans, David / Mohan, Radhe

    Physics in medicine and biology

    2019  Volume 64, Issue 5, Page(s) 58002

    Abstract: In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, ... ...

    Abstract In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, it could be used to optimize LET efficiently while dose constraints are maintained.
    MeSH term(s) Linear Energy Transfer ; Organs at Risk ; Proton Therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/aaff72
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Conference proceedings: Feasibility Study of Proton-Based Stereotactic Body Radiation Therapy of Small Volume Skull-Base Tumors

    Alsanea, Fahed / Wang, He Catherine / Williamson, Tyler / Poenisch, Falk / Whitaker, Thomas / Hunter, Racher / Wang, Xin / Gunn, Gary / Lee, Anna / Frank, Steven / Phan, Jack

    Journal of Neurological Surgery Part B: Skull Base

    2023  Volume 84, Issue S 01

    Event/congress 32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0043-1762199
    Database Thieme publisher's database

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    Zs.A 3425: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: In reply to Mihaildis.

    Gomez, Daniel R / Poenisch, Falk / Mohan, Radhe

    International journal of radiation oncology, biology, physics

    2014  Volume 88, Issue 3, Page(s) 754

    MeSH term(s) Contraindications ; Defibrillators, Implantable ; Equipment Failure/statistics & numerical data ; Humans ; Male ; Pacemaker, Artificial ; Proton Therapy
    Language English
    Publishing date 2014-03-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2013.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Thesis: Optimierung der Positronen-Emissions-Tomographie bei der Schwerionentherapie auf der Basis von Röntgentomogrammen

    Pönisch, Falk

    (Wissenschaftlich-Technische Berichte ; 378)

    2003  

    Author's details Falk Pönisch
    Series title Wissenschaftlich-Technische Berichte ; 378
    Language German
    Size 102 S., Ill., graph. Darst.
    Publisher FZR
    Publishing place Dresden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Dresden, Univ., Diss., 2003
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model.

    Tang, Tien T / Zawaski, Janice A / Kesler, Shelli / Beamish, Christine A / Inoue, Taeko / Perez, Emma C / Bronk, Lawrence / Poenisch, Falk / Briere, Tina M / Sabek, Omaima M / Grosshans, David R / Waleed Gaber, M

    International journal of radiation oncology, biology, physics

    2021  Volume 112, Issue 2, Page(s) 554–564

    Abstract: Purpose: Compared with photon cranial radiation therapy (X-CRT), proton cranial radiation therapy (P-CRT) offers potential advantages in limiting radiation-induced sequalae in the treatment of pediatric brain tumors. This study aims to identify ... ...

    Abstract Purpose: Compared with photon cranial radiation therapy (X-CRT), proton cranial radiation therapy (P-CRT) offers potential advantages in limiting radiation-induced sequalae in the treatment of pediatric brain tumors. This study aims to identify cognitive, functional magnetic resonance and positron emission tomography imaging markers and molecular differences between the radiation modalities.
    Methods and materials: Juvenile rats received a single faction of 10 Gy (relative biological effectiveness-weighted dose) delivered with 6 MV X-CRT or at the midspread out Bragg peak of a 100 MeV P-CRT beam. At 3, 6, and 12 months post-CRT, executive function was measured using 5-choice serial reaction time task. At ∼12 months post-CRT, animals were imaged with
    Results: Irradiated animals had cognitive impairment with a higher number of omissions and lower incorrect and premature responses compared with sham (P ≤ .05). The accuracy of the animals' X-CRT was less than that of sham (P ≤ .001). No significant difference in rates of cognitive change were found between the radiation modalities. At 12 months post-CRT, glucose metabolism was significantly higher than sham in X-CRT (P = .04) but not P-CRT. Using diffusion tensor imaging, P-CRT brains were found to have higher white matter volume and fiber lengths compared with sham (P < .03). Only X-CRT animals had higher apparent diffusion coefficient values compared with sham (P = .04). P-CRT animals had more connectomic changes compared with X-CRT. Correlative analysis identified several imaging features with cognitive performance. Furthermore, microgliosis (P < .05), astrogliosis (P < .01), and myelin thinning (P <.05) were observed in both radiation modalities, with X-CRT showing slightly more inflammation.
    Conclusions: Both P-CRT and X-CRT lead to neurocognitive changes compared with sham. Although no significant difference was observed in neuroinflammation between the irradiated groups, differences were found in late-term glucose metabolism and brain connectome. Our results indicate that despite relative biological effectiveness weighting of the proton dose there are still differential effects which warrants further investigation.
    MeSH term(s) Animals ; Brain/pathology ; Cognition/radiation effects ; Cranial Irradiation/adverse effects ; Diffusion Tensor Imaging/methods ; Protons ; Rats
    Chemical Substances Protons
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1218: Show issues Location:
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